hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg21892/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0816 ( 1168 res) mbg21892 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Ldl_recept_b Low-density lipoprotein receptor repeat 521.2 7.6e-153 14 EGF EGF-like domain 68.5 1.4e-16 4 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- EGF 1/4 22 56 .. 1 39 [] 20.6 0.036 Ldl_recept_b 1/14 105 146 .. 1 47 [] 46.1 7.6e-10 Ldl_recept_b 2/14 148 189 .. 1 47 [] 44.8 2e-09 Ldl_recept_b 3/14 191 233 .. 1 47 [] 55.4 1.2e-12 Ldl_recept_b 4/14 235 276 .. 1 47 [] 42.6 8.7e-09 Ldl_recept_b 5/14 277 317 .. 1 47 [] 26.2 0.00075 EGF 2/4 326 363 .. 1 39 [] 35.3 1.4e-06 Ldl_recept_b 6/14 413 454 .. 1 47 [] 42.2 1.2e-08 Ldl_recept_b 7/14 456 497 .. 1 47 [] 48.4 1.6e-10 Ldl_recept_b 8/14 499 541 .. 1 47 [] 59.3 8.1e-14 Ldl_recept_b 9/14 543 583 .. 1 47 [] 20.1 0.037 Ldl_recept_b 10/14 584 625 .. 1 47 [] 12.7 0.36 EGF 3/4 633 668 .. 1 39 [] 32.2 1.2e-05 Ldl_recept_b 11/14 717 758 .. 1 47 [] 36.3 7.2e-07 Ldl_recept_b 12/14 760 801 .. 1 47 [] 46.0 8.2e-10 Ldl_recept_b 13/14 803 845 .. 1 47 [] 58.0 2e-13 Ldl_recept_b 14/14 847 884 .. 1 47 [] 22.6 0.0092 EGF 4/4 881 911 .. 1 39 [] 5.0 6 Alignments of top-scoring domains: EGF: domain 1 of 4, from 22 to 56: score 20.6, E = 0.036 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +nng+C + C++++++ytC Cp G f + + C mKIAA0816 22 CGDNNGGCTH--LCLPSGQNYTCACPTG--FRKINSHAC 56 Ldl_recept_b: domain 1 of 14, from 105 to 146: score 46.1, E = 7.6e-10 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi +++YWtD+s++ +is+a+ +G+ + ++++ l++P+g+a+D++ mKIAA0816 105 DHVYWTDVSTD---TISRAKWDGTGQEVVVDTS--LESPAGLAIDWV 146 <-* mKIAA0816 - - Ldl_recept_b: domain 2 of 14, from 148 to 189: score 44.8, E = 2e-09 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi ++lYWtD++++ +i+va+++Gs r +l+ e+ l+ P++I+v p mKIAA0816 148 NKLYWTDAGTD---RIEVANTDGSMRTVLIWEN--LDRPRDIVVEPM 189 <-* mKIAA0816 - - Ldl_recept_b: domain 3 of 14, from 191 to 233: score 55.4, E = 1.2e-12 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi g++YWtD++ ++i++a+++ s+r +++s++ l +Png+a+D+ mKIAA0816 191 GYMYWTDWGAS--PKIERAGMDASSRQVIISSN--LTWPNGLAIDYG 233 <-* mKIAA0816 - - Ldl_recept_b: domain 4 of 14, from 235 to 276: score 42.6, E = 8.7e-09 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi +rlYW D++ + +i+ a+l+Gs+r++l+ ++ l hP+g++++ + mKIAA0816 235 QRLYWADAGMK---TIEFAGLDGSKRKVLIGSQ--LPHPFGLTLYGQ 276 <-* mKIAA0816 - - Ldl_recept_b: domain 5 of 14, from 277 to 317: score 26.2, E = 0.00075 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi r+YWtD+ ++ + s+++l+G d r ++e+ l++ +I v+++ mKIAA0816 277 -RIYWTDWQTK--SIQSADRLTGLD-RETLQEN--LENLMDIHVFHR 317 <-* mKIAA0816 - - EGF: domain 2 of 4, from 326 to 363: score 35.3, E = 1.4e-06 *->CspnngpCsngGtCvdtpg..gytCeCppGdyfllytGkrC<-* C+ +ng+Cs+ C+++p+++g++C Cp G ll +Gk+C mKIAA0816 326 CAVENGGCSH--LCLRSPNpsGFSCTCPTG-INLLRDGKTC 363 Ldl_recept_b: domain 6 of 14, from 413 to 454: score 42.2, E = 1.2e-08 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi g++YW+Ds l+ +is+a l+Gs + +++ lq+ +g+avD i mKIAA0816 413 GKVYWSDSTLH---RISRASLDGSQHEDIITTG--LQTTDGLAVDAI 454 <-* mKIAA0816 - - Ldl_recept_b: domain 7 of 14, from 456 to 497: score 48.4, E = 1.6e-10 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi +++YWtD ++ +i+v +l+Gs r++l+ ++ l++P++I+++++ mKIAA0816 456 RKVYWTDTGTN---RIEVGNLDGSMRKVLVWQN--LDSPRAIVLYHE 497 <-* mKIAA0816 - - Ldl_recept_b: domain 8 of 14, from 499 to 541: score 59.3, E = 8.1e-14 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi g++YWtD+++ a++++ +++Gsdr +l++++ l +Png++vD + mKIAA0816 499 GFMYWTDWGEN--AKLERSGMDGSDRTVLINNN--LGWPNGLTVDKT 541 <-* mKIAA0816 - - Ldl_recept_b: domain 9 of 14, from 543 to 583: score 20.1, E = 0.037 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi l W D+ ++ +i+vadlnG++r+tl+s qhP g+++ + mKIAA0816 543 SQLLWADAHTE---RIEVADLNGANRHTLVSPV---QHPYGLTLLDS 583 <-* mKIAA0816 - - Ldl_recept_b: domain 10 of 14, from 584 to 625: score 12.7, E = 0.36 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngI.avDp ++YWtD+ +r si +ad ++ +l++++ l +I+avD mKIAA0816 584 -YIYWTDWQTR---SIHRADKSTGSNVILVRSN--LPGLMDIqAVDR 624 i<-* mKIAA0816 625 A 625 EGF: domain 3 of 4, from 633 to 668: score 32.2, E = 1.2e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + ng+Cs+ C++ p+g++C Cp G +l ++ k+C mKIAA0816 633 CGSRNGGCSH--LCLPRPSGFSCACPTG-IQLKGDRKTC 668 Ldl_recept_b: domain 11 of 14, from 717 to 758: score 36.3, E = 7.2e-07 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi g++Y tD+ l+ i +adlnGs+ t++ + l + +g+avD++ mKIAA0816 717 GKVYYTDVFLD---VIRRADLNGSNMETVIGHG--LKTTDGLAVDWV 758 <-* mKIAA0816 - - Ldl_recept_b: domain 12 of 14, from 760 to 801: score 46.0, E = 8.2e-10 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi ++lYWtD + +i++ +l+Gs r++l+++ l++P++Iav+p+ mKIAA0816 760 RNLYWTDTGRN---TIEASRLDGSCRKVLINNS--LDEPRAIAVFPR 801 <-* mKIAA0816 - - Ldl_recept_b: domain 13 of 14, from 803 to 845: score 58.0, E = 2e-13 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi g+l+WtD++ a+i++a+l+Gs+r++l++ d l +Png+++D+ mKIAA0816 803 GYLFWTDWGHI--AKIERANLDGSERKVLINTD--LGWPNGLTLDYD 845 <-* mKIAA0816 - - Ldl_recept_b: domain 14 of 14, from 847 to 884: score 22.6, E = 0.0092 *->grlYWtDsslrkIasisvadlnGsdrrtlfsededlqhPngIavDpi +r+YW+D+ l+ +i++adlnG+ r+++ + ++hP++++ + mKIAA0816 847 RRIYWVDAHLD---RIESADLNGKL-RQVLVSH--VSHPFALT---N 884 <-* mKIAA0816 - - EGF: domain 4 of 4, from 881 to 911: score 5.0, E = 6 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* + +ng+C + C +++ C Cp +G+ C mKIAA0816 881 -ALTNGGCTH--LCFARASDFVCACPDE-----PDGHPC 911 //