hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg05377/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0813 ( 1557 res) mbg05377 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- LRR_1 Leucine Rich Repeat 229.5 4.9e-65 21 EGF EGF-like domain 227.6 1.9e-64 9 Laminin_G_2 Laminin G domain 138.5 1.2e-37 1 Laminin_G_1 Laminin G domain 134.8 1.5e-36 1 LRRNT Leucine rich repeat N-terminal domain 133.1 5e-36 4 LRRCT Leucine rich repeat C-terminal domain 84.6 2.1e-21 6 EGF_2 EGF-like domain 72.3 1e-17 10 FNIP FNIP Repeat 17.7 0.04 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- LRRNT 1/4 59 86 .. 1 34 [] 43.6 4.4e-09 LRR_1 1/21 88 111 .. 1 25 [] 16.4 0.68 LRR_1 2/21 112 135 .. 1 25 [] 9.4 56 LRR_1 3/21 136 159 .. 1 25 [] 13.2 6.3 LRR_1 4/21 160 183 .. 1 25 [] 11.1 27 LRR_1 5/21 184 207 .. 1 25 [] 12.3 11 LRR_1 6/21 208 231 .. 1 25 [] 20.1 0.053 LRR_1 7/21 232 260 .. 1 25 [] 0.7 1.5e+03 LRRCT 1/6 265 290 .. 1 26 [] 26.5 0.00063 EGF_2 1/10 289 321 .. 1 37 [] -3.7 55 LRRNT 2/4 307 334 .. 1 34 [] 40.0 5.3e-08 LRR_1 8/21 336 359 .. 1 25 [] 5.8 2.1e+02 LRR_1 9/21 360 383 .. 1 25 [] 19.4 0.086 LRR_1 10/21 384 407 .. 1 25 [] 14.3 2.9 LRR_1 11/21 408 431 .. 1 25 [] 10.1 43 LRR_1 12/21 432 455 .. 1 25 [] 14.8 2.1 LRRCT 2/6 489 514 .. 1 26 [] 19.5 0.078 LRRNT 3/4 538 565 .. 1 34 [] 37.1 4.1e-07 LRR_1 13/21 567 588 .. 1 25 [] 6.9 1.5e+02 LRR_1 14/21 592 615 .. 1 25 [] 14.1 3.5 LRR_1 15/21 616 639 .. 1 25 [] 9.2 60 LRR_1 16/21 640 663 .. 1 25 [] 17.3 0.36 LRR_1 17/21 664 687 .. 1 25 [] 15.8 1 LRRCT 3/6 721 746 .. 1 26 [] 24.4 0.0026 LRRNT 4/4 759 786 .. 1 34 [] 34.8 2e-06 LRR_1 18/21 788 810 .. 1 25 [] 14.0 3.5 FNIP 1/1 777 816 .. 1 45 [] 17.7 0.04 LRR_1 19/21 811 834 .. 1 25 [] 16.6 0.58 LRR_1 20/21 835 858 .. 1 25 [] 17.7 0.27 LRR_1 21/21 859 882 .. 1 25 [] 11.5 21 LRRCT 4/6 916 941 .. 1 26 [] 25.7 0.0011 EGF 1/9 955 987 .. 1 39 [] 38.8 1.2e-07 EGF_2 2/10 955 987 .. 1 37 [] 26.4 0.00065 LRRCT 5/6 973 995 .. 1 26 [] 2.1 3.7e+02 EGF_2 3/10 994 1028 .. 1 37 [] 22.9 0.0075 EGF 2/9 994 1028 .. 1 39 [] 38.0 2.2e-07 EGF_2 4/10 1035 1066 .. 1 37 [] 17.1 0.27 EGF 3/9 1035 1066 .. 1 39 [] 32.5 9.5e-06 EGF_2 5/10 1073 1106 .. 1 37 [] 9.5 1.9 EGF 4/9 1073 1106 .. 1 39 [] 35.4 1.3e-06 EGF_2 6/10 1113 1144 .. 1 37 [] 16.1 0.34 EGF 5/9 1113 1144 .. 1 39 [] 41.6 1.7e-08 EGF_2 7/10 1154 1185 .. 1 37 [] 15.6 0.39 EGF 6/9 1154 1185 .. 1 39 [] 25.5 0.0012 Laminin_G_2 1/1 1217 1345 .. 1 141 [] 138.5 1.2e-37 Laminin_G_1 1/1 1217 1348 .. 1 154 [] 134.8 1.5e-36 EGF 7/9 1365 1396 .. 1 39 [] 28.0 0.00022 EGF_2 8/10 1365 1396 .. 1 37 [] 12.3 0.9 EGF_2 9/10 1404 1435 .. 1 37 [] 16.1 0.34 EGF 8/9 1404 1435 .. 1 39 [] 28.7 0.00014 EGF 9/9 1445 1476 .. 1 39 [] 23.2 0.0061 EGF_2 10/10 1445 1476 .. 1 37 [] 9.7 1.8 LRRCT 6/6 1473 1501 .. 1 26 [] 2.4 3.4e+02 Alignments of top-scoring domains: LRRNT: domain 1 of 4, from 59 to 86: score 43.6, E = 4.4e-09 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* aCpa CtC+ g++VdC+g gL+ a+P+ +P mKIAA0813 59 ACPALCTCT-----GTTVDCHGTGLQ-AIPKNIP 86 LRR_1: domain 1 of 21, from 88 to 111: score 16.4, E = 0.68 *->nLeeLdLsgCNpslsgslpps.l.glp<-* n e L+L+g N +++ ++++++ gl+ mKIAA0813 88 NTERLELNG-N-NIT-RIHKNdFaGLK 111 LRR_1: domain 2 of 21, from 112 to 135: score 9.4, E = 56 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L++L L N ++ g ++ +++++++ mKIAA0813 112 QLRVLQLME-N-QI-GAVERGaFdDMK 135 LRR_1: domain 3 of 21, from 136 to 159: score 13.2, E = 6.3 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +Le L+L++ N +l+ lp+ +++ + mKIAA0813 136 ELERLRLNR-N-QLQ-VLPELlFqNNQ 159 LRR_1: domain 4 of 21, from 160 to 183: score 11.1, E = 27 *->nLeeLdLsgCNpslsgslpps.l.glp<-* L LdLs N l+ +p +++g + mKIAA0813 160 ALSRLDLSE-N-FLQ-AVPRKaFrGAT 183 LRR_1: domain 5 of 21, from 184 to 207: score 12.3, E = 11 *->nLeeLdLsgCNpslsgslpps.l.glp<-* L++L L+ N ++s ++++++++ l+ mKIAA0813 184 DLKNLQLDK-N-RIS-CIEEGaFrALR 207 LRR_1: domain 6 of 21, from 208 to 231: score 20.1, E = 0.053 *->nLeeLdLsgCNpslsgslpps.l.glp<-* Le+L L++ N +++ ++p s+++++p mKIAA0813 208 GLEVLTLNN-N-NIT-TIPVSsFnHMP 231 LRR_1: domain 7 of 21, from 232 to 260: score 0.7, E = 1.5e+03 *->nLeeLdLsgCNpslsgs......lppsl.glp<-* +L++ +L++ N +l ++ + + l+ +l+ p mKIAA0813 232 KLRTFRLHS-N-HLF-CdchlawLSQWLrQRP 260 LRRCT: domain 1 of 6, from 265 to 290: score 26.5, E = 0.00063 *->dlrCasPeslrGqplldlppsdfsCp<-* +++C++P slrG+++++++ +fsC+ mKIAA0813 265 FTQCSGPASLRGLNVAEVQKGEFSCS 290 EGF_2: domain 1 of 10, from 289 to 321: score -3.7, E = 55 *->C...........CngshGtCvspngtstpcgkCvCdsgyedkyqGad C+++++ + + C s G C C+C+sg d mKIAA0813 289 CsgqgeaagapaCTLSSGSCPAM---------CSCSSGI------VD 320 C<-* C mKIAA0813 321 C 321 LRRNT: domain 2 of 4, from 307 to 334: score 40.0, E = 5.3e-08 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* Cpa+C Cs VdC+g+gLt a+P lP mKIAA0813 307 SCPAMCSCS-----SGIVDCRGKGLT-AIPANLP 334 LRR_1: domain 8 of 21, from 336 to 359: score 5.8, E = 2.1e+02 *->nLeeLdLsgCNpslsgslpps.l.glp<-* + +e++L+ N + +s+pp++++ + mKIAA0813 336 TMTEIRLEL-N-GI-KSIPPGaFsPYR 359 LRR_1: domain 9 of 21, from 360 to 383: score 19.4, E = 0.086 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ +dLs+ N ++ +++p++++gl+ mKIAA0813 360 KLRRIDLSN-N-QIA-EIAPDaFqGLR 383 LRR_1: domain 10 of 21, from 384 to 407: score 14.3, E = 2.9 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L +L L g N +++ +lp + ++gl mKIAA0813 384 SLNSLVLYG-N-KIT-DLPRGvFgGLY 407 LRR_1: domain 11 of 21, from 408 to 431: score 10.1, E = 43 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ L L+ N +++ ++ p+++++l+ mKIAA0813 408 TLQLLLLNA-N-KIN-CIRPDaFqDLQ 431 LRR_1: domain 12 of 21, from 432 to 455: score 14.8, E = 2.1 *->nLeeLdLsgCNpslsgslpps.l.glp<-* nL L+L + N +++ sl+++++ +l+ mKIAA0813 432 NLSLLSLYD-N-KIQ-SLAKGtFtSLR 455 LRRCT: domain 2 of 6, from 489 to 514: score 19.5, E = 0.078 *->dlrCasPeslrGqplldlppsdfsCp<-* +rCasP +l+ +++ ++ +++f C+ mKIAA0813 489 GARCASPRRLANKRIGQIKSKKFRCS 514 LRRNT: domain 3 of 4, from 538 to 565: score 37.1, E = 4.1e-07 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* aCp+ C+C+ ++vV Cs+++L ++P ++P mKIAA0813 538 ACPHKCRCE-----ASVVECSSLKLS-KIPERIP 565 LRR_1: domain 13 of 21, from 567 to 588: score 6.9, E = 1.5e+02 *->nLeeLdLsgCNpslsgslppsl.glp<-* + +eL+L++ N ++s l++ + ++ mKIAA0813 567 STTELRLNN-N-EIS-ILEA-TgLFK 588 LRR_1: domain 14 of 21, from 592 to 615: score 14.1, E = 3.5 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L++++Ls+ N ++s ++++++++g mKIAA0813 592 HLKKINLSN-N-KVS-EIEDGtFeGAA 615 LRR_1: domain 15 of 21, from 616 to 639: score 9.2, E = 60 *->nLeeLdLsgCNpslsgslpps.l.glp<-* ++ eL+L N +l+ s+ ++ ++gl mKIAA0813 616 SVSELHLTA-N-QLE-SIRSGmFrGLD 639 LRR_1: domain 16 of 21, from 640 to 663: score 17.3, E = 0.36 *->nLeeLdLsgCNpslsgslpps.l.glp<-* L++L L++ N ++s +++++++ gl+ mKIAA0813 640 GLRTLMLRN-N-RIS-CIHNDsFtGLR 663 LRR_1: domain 17 of 21, from 664 to 687: score 15.8, E = 1 *->nLeeLdLsgCNpslsgslpps.l.glp<-* n++ L+L + N +++ +++p++++ l+ mKIAA0813 664 NVRLLSLYD-N-HIT-TISPGaFdTLQ 687 LRRCT: domain 3 of 6, from 721 to 746: score 24.4, E = 0.0026 *->dlrCasPeslrGqplldlppsdfsCp<-* ++rC++P+ lr pl d+ + df C+ mKIAA0813 721 NPRCQNPDFLRQIPLQDVAFPDFRCE 746 LRRNT: domain 4 of 4, from 759 to 786: score 34.8, E = 2e-06 *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-* +Cp++C C ++vV Cs++ L+ a+P+++P mKIAA0813 759 QCPQECACL-----DTVVRCSNKHLQ-ALPKGIP 786 LRR_1: domain 18 of 21, from 788 to 810: score 14.0, E = 3.5 *->nLeeLdLsgCNpslsgslppsl.glp<-* n++eL+L+g N +++ +p l+ ++ mKIAA0813 788 NVTELYLDG-N-QFT-LVPGQLsTFK 810 FNIP: domain 1 of 1, from 777 to 816: score 17.7, E = 0.04 *->fNqpFlikgiLPpslkhLql.GdsfnqpleigsLPsSlksLifGks< + q+ l+kg +P+++++L+l+G+ f l++g+L s+ k+L++ + mKIAA0813 777 HLQA-LPKG-IPKNVTELYLdGNQFT--LVPGQL-STFKYLQL-VD 816 -* mKIAA0813 - - LRR_1: domain 19 of 21, from 811 to 834: score 16.6, E = 0.58 *->nLeeLdLsgCNpslsgslpps.l.glp<-* L+ +dLs+ N ++s sl++s++ +++ mKIAA0813 811 YLQLVDLSN-N-KIS-SLSNSsFtNMS 834 LRR_1: domain 20 of 21, from 835 to 858: score 17.7, E = 0.27 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L++L Ls+ N l+ ++pp +++gl+ mKIAA0813 835 QLTTLILSY-N-ALQ-CIPPLaFqGLR 858 LRR_1: domain 21 of 21, from 859 to 882: score 11.5, E = 21 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+ L+L+g N +s +l+++ + + + mKIAA0813 859 SLRLLSLHG-N-DVS-TLQEGiFaDVT 882 LRRCT: domain 4 of 6, from 916 to 941: score 25.7, E = 0.0011 *->dlrCasPeslrGqplldlppsdfsCp<-* +rCa+P+++ G+ ll++p+++f C+ mKIAA0813 916 IARCAGPPEMEGKLLLTTPAKKFECQ 941 EGF: domain 1 of 9, from 955 to 987: score 38.8, E = 1.2e-07 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C + pC+n GtC++ p + y+C Cp G y+G++C mKIAA0813 955 CLSS--PCQNQGTCHNDPLeVYRCTCPSG-----YKGRHC 987 EGF_2: domain 2 of 10, from 955 to 987: score 26.4, E = 0.00065 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C +++C++ +GtC+++ +C C+sg y G +C mKIAA0813 955 ClsspCQN-QGTCHNDPLE---VYRCTCPSG----YKGRHC 987 LRRCT: domain 5 of 6, from 973 to 995: score 2.1, E = 3.7e+02 *->dlrCasPeslrGqplldlppsdfsCp<-* +rC+ P+ ++G + ++ ++C+ mKIAA0813 973 VYRCTCPSGYKG-RHCEVS--LDGCS 995 EGF_2: domain 3 of 10, from 994 to 1028: score 22.9, E = 0.0075 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++++C++ +GtC+ ++g + C+C+sg + G++C mKIAA0813 994 CssnpCGN-GGTCHAQEGEDA-GFTCSCPSG----FEGPTC 1028 EGF: domain 2 of 9, from 994 to 1028: score 38.0, E = 2.2e-07 *->CspnngpCsngGtCvdtpg...gytCeCppGdyfllytGkrC<-* Cs+n pC ngGtC+ +g++ g+tC Cp G + G++C mKIAA0813 994 CSSN--PCGNGGTCHAQEGedaGFTCSCPSG-----FEGPTC 1028 EGF_2: domain 4 of 10, from 1035 to 1066: score 17.1, E = 0.27 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C ++ C + +G+Cv+ +g C+C+ y+G +C mKIAA0813 1035 CvkhaCVN-GGVCVDGVG----NYTCQCPLQ----YTGRAC 1066 EGF: domain 3 of 9, from 1035 to 1066: score 32.5, E = 9.5e-06 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++ C ngG Cvd+ g+ytC+Cp ytG+ C mKIAA0813 1035 CVKH--ACVNGGVCVDGVGNYTCQCPLQ-----YTGRAC 1066 EGF_2: domain 5 of 10, from 1073 to 1106: score 9.5, E = 1.9 *->C......CngshGtCvspngtstpcg.kCvCdsgyedkyqGadC<-* C+++ ++C+ +Cv +tp g++C+C g y+G+ C mKIAA0813 1073 CspdmnpCQH-EAQCV-----GTPDGpRCECMLG----YTGDNC 1106 EGF: domain 4 of 9, from 1073 to 1106: score 35.4, E = 1.3e-06 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* Csp+ +pC++ ++Cv tp+g++CeC G ytG++C mKIAA0813 1073 CSPDMNPCQHEAQCVGTPDGPRCECMLG-----YTGDNC 1106 EGF_2: domain 6 of 10, from 1113 to 1144: score 16.1, E = 0.34 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++++C++ + +Cv+ ++ C C g y+G C mKIAA0813 1113 CkdhkCQN-GAQCVDEVN----SYACLCVEG----YSGQLC 1144 EGF: domain 5 of 9, from 1113 to 1144: score 41.6, E = 1.7e-08 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++ C+ng++Cvd ++y C C +G y+G C mKIAA0813 1113 CKDH--KCQNGAQCVDEVNSYACLCVEG-----YSGQLC 1144 EGF_2: domain 7 of 10, from 1154 to 1185: score 15.6, E = 0.39 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++++C++ + Cv+++ C+C +g + G+ C mKIAA0813 1154 CegteCQN-GANCVDQGS----RPVCQCLPG----FGGPEC 1185 EGF: domain 6 of 9, from 1154 to 1185: score 25.5, E = 0.0012 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + C+ng+ Cvd ++ + C+C pG + G+ C mKIAA0813 1154 CEGT--ECQNGANCVDQGSRPVCQCLPG-----FGGPEC 1185 Laminin_G_2: domain 1 of 1, from 1217 to 1345: score 138.5, E = 1.2e-37 *->FRTatqpnGlLlyaggkglpdtadpksdKflaLeLvdGrlvlrydlG + T ++nG+Lly+g+ +d ++a+eL +G+++++yd G mKIAA0813 1217 VST-AEDNGILLYNGD----------ND-HIAVELYQGHVRVSYDPG 1251 sgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssdt s +++ ++s +++nDGq HtV+++ ++ v Ls+Dgg+++++++ g++ mKIAA0813 1252 SYPsSAIYSAeTINDGQFHTVELVTFDQMVNLSIDGGsPMtMdNFGKHY- 1300 lslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvringe +ln + ply+GG+p + s + +l+ n ++F+GCir+++in+e mKIAA0813 1301 -TLNSEAPLYVGGMPVDVNSAAFRLWQILN----GtSFHGCIRNLYINNE 1345 <-* mKIAA0813 - - Laminin_G_1: domain 1 of 1, from 1217 to 1348: score 134.8, E = 1.5e-36 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl ++T+e +G+Ll YnG+n+++ a+eL G+++vsyd mKIAA0813 1217 VSTAEDNGILL--YNGDNDHI-----------AVELYQGHVRVSYDP 1250 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervvdges Gs p + + ++++nDG+ H+vel+ + ++Ls+dg + ++++ mKIAA0813 1251 GSY----PSSAIYSAETINDGQFHTVELVTFDQMVNLSIDGGSP--MTMD 1294 psgpditsenLdldtppiLyvGGlPel..qksvkrrlaaistsFkGCird ++g+++ +L+ ++p LyvGG+P++ +++++ ++ ++tsF+GCir+ mKIAA0813 1295 NFGKHY---TLNSEAP--LYVGGMPVDvnSAAFRLWQILNGTSFHGCIRN 1339 vsingkpld<-* ++in++++d mKIAA0813 1340 LYINNELQD 1348 EGF: domain 7 of 9, from 1365 to 1396: score 28.0, E = 0.00022 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C + +C++ G+C++ +g+ C+C G + G +C mKIAA0813 1365 CRKL--YCLH-GICQPNATpGPVCHCEAG-----WGGLHC 1396 EGF_2: domain 8 of 10, from 1365 to 1396: score 12.3, E = 0.9 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++ C hG+C pn tp C+C+ g + G +C mKIAA0813 1365 CrklyCL--HGICQ-PN--ATPGPVCHCEAG----WGGLHC 1396 EGF_2: domain 9 of 10, from 1404 to 1435: score 16.1, E = 0.34 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++++C hG+Cv C+C +g y+Ga C mKIAA0813 1404 ChghkCV--HGKCVPLDAL---AYSCQCQDG----YSGALC 1435 EGF: domain 8 of 9, from 1404 to 1435: score 28.7, E = 0.00014 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+ + C + G+Cv++++ y+C+C+ G y+G C mKIAA0813 1404 CHGH--KCVH-GKCVPLDAlAYSCQCQDG-----YSGALC 1435 EGF: domain 9 of 9, from 1445 to 1476: score 23.2, E = 0.0061 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C C++ G C+ + +g +C C pG ++G+ C mKIAA0813 1445 CGGL--QCLH-GHCQASATkGAHCVCSPG-----FSGELC 1476 EGF_2: domain 10 of 10, from 1445 to 1476: score 9.7, E = 1.8 *->C....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C++ +C hG+C + +CvC++g ++G C mKIAA0813 1445 CgglqCL--HGHCQASATKGA---HCVCSPG----FSGELC 1476 LRRCT: domain 6 of 6, from 1473 to 1501: score 2.4, E = 3.4e+02 *->dlrCasPeslrGqplldlpp...sdfsCp<-* +C+ +++rG p++d+++ ++ +C+ mKIAA0813 1473 GELCEQESECRGDPVRDFHRvqrGYAICQ 1501 //