hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbh/mbh00053/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0782  ( 1147 res)   mbh00053

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGAP   RhoGAP domain                                  227.3    2.2e-64   1
PH       PH domain                                      183.0    4.8e-51   4
ArfGap   Putative GTPase activating protein for Arf      98.2    1.7e-25   1
RA       Ras association (RalGDS/AF-6) domain            58.6    1.3e-13   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PH         1/4      36   127 ..     1    92 []    61.1  2.5e-14
PH         2/4     149   237 ..     1    92 []    14.5      1.1
ArfGap     1/1     243   367 ..     1   137 []    98.2  1.7e-25
PH         3/4     452   558 ..     1    92 []    54.8  1.8e-12
RhoGAP     1/1     679   828 ..     1   155 []   227.3  2.2e-64
RA         1/1     880   969 ..     1    98 []    58.6  1.3e-13
PH         4/4     983  1093 ..     1    92 []    53.0  6.5e-12

Alignments of top-scoring domains:
PH: domain 1 of 4, from 36 to 127: score 61.1, E = 2.5e-14
                   *->vikeGwLlkkg..gkkswkkRyfvLfndvLlyykdkkkkpkgsipLs
                      vik GwL k  ++g   ++kR++ L  d+L y+++ k+ + + +   
   mKIAA0782    36    VIKAGWLDKNPpqGSYIYQKRWVRLDADYLRYFDSNKDAYSKRFVPV 82   

                   giqvekvpdnkrkncFeirt.dretlllqaeseeerkeWvkaiqsair<-
                    + ++ +p    +  Fe++t++r t+ ++aes+ er+eW++a+q+a+   
   mKIAA0782    83 ACICRVAPI--GDQKFEVITnNR-TFAFRAESDVERNEWMQALQQAVV   127  

                   *
                    
   mKIAA0782     -   -    

PH: domain 2 of 4, from 149 to 237: score 14.5, E = 1.1
                   *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk.kkpkgsipLsg
                      + + G L ++g      k y+ +++d   +yk+  ++ +   i   +
   mKIAA0782   149    PDRAGSLELRG---FKNKLYVAVTGDKVQLYKNLEeFHLGIGITFID 192  

                   iqvekvpdnkrkncFeirt.dretlllqaeseeerkeWvkaiqsair<-*
                   ++v  v++  ++ +F ++t+ r  + ++a+se e+++W++a q ai+   
   mKIAA0782   193 MNVGNVKEV-DRRSFDLTTpYR-IFSFSADSELEKEQWLEAMQGAIA    237  

ArfGap: domain 1 of 1, from 243 to 367: score 98.2, E = 1.7e-25
                   *->qrvlqlLrsldpgNkkCfDCgavpnPtWaSvnlGvflCieCSGiHRn
                       +v +++ +    N+ C+DCga + P+WaS+nl v++C +C+G HR+
   mKIAA0782   243    SEVAERIWAAA-PNRFCADCGA-AQPDWASINLCVVICKRCAGEHRG 287  

                   LfGvHiSkVnvRSltLD..sWtpeeLrklesckgGNenansfwEsnlddf
                   L G  +SkV  RSl++D++ Wt+  +++++   +GN   n fw +n+++ 
   mKIAA0782   288 L-GAGVSKV--RSLKMDrkVWTEALIQLFL--HLGNGPGNHFWAANVPPS 332  

                   slkpkdsdaaavKCqddrqkyesfiaaKYeeklf..vlkeeqee<-*
                   +  ++ s+         +  +     aKY+e ++++++++       
   mKIAA0782   333 EALEPSSS---------PGARRYHLEAKYREGKYrrYHPLFGNQ    367  

PH: domain 3 of 4, from 452 to 558: score 54.8, E = 1.8e-12
                   *->vikeGwLlkkg..........gkkswkkRyfvLfndvLlyykdkk.k
                      v ++G+L+k  + +++ +++++++++ +R++vL ++vL+yy+++   
   mKIAA0782   452    VSHSGFLYKTAsagkplqdrrAREEFSRRWCVLSDGVLSYYENERaV 498  

                   kpkgsipLsgiqvekvpdn...krkncFeirt.dretlllqaeseeerke
                   +p g i  s+i +  v++ ++++ +++Fe+ t++++ +l+  e++e ++e
   mKIAA0782   499 TPNGEIRASEIVCLAVSPLdthGFEHTFEVYTeGERLYLFGLENAELAHE 548  

                   Wvkaiqsair<-*
                   Wvk+i +a     
   mKIAA0782   549 WVKCIAKAFV    558  

RhoGAP: domain 1 of 1, from 679 to 828: score 227.3, E = 2.2e-64
                   *->PlivekCieflekrGLdtEGIyRvsGsksrikeLreafdrgedvdln
                      P iv++C++++ + GL++EGIyR++G +s+ ++L + ++++++ +++
   mKIAA0782   679    PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHL 725  

                   dleeedvhvvAslLKlFLReLPePLltfelyeefieaaaksedeeerlea
                    ++e+ v +v+s+LK+FLR+LP++L+t+++  +++e a ++edeee++++
   mKIAA0782   726 KEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLE-ASEIEDEEEKISR 774  

                   lrellrkLPpaNrdtLryLlahLnrVaqnsevNkMtahNLAivFgPtLlr
                   +rell  LPp+Nr+t ++L+ hL+ V+++s+ N+M+ hNLAivFgPtL++
   mKIAA0782   775 YRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFGPTLFQ 824  

                   ppdgdsad<-*
                   +     ++   
   mKIAA0782   825 T----DGQ    828  

RA: domain 1 of 1, from 880 to 969: score 58.6, E = 1.3e-13
                   *->dsgvlrVygedgtpgtyktilvskntTaeeViralLrKfgldaddpe
                      +++++ Vy+e  +++t  +++++ ++Taee+  ++L+++++  + ++
   mKIAA0782   880    GDFICTVYLEEKKVETEQHVKIPASMTAEELTLEILDRRNVSIREKD 926  

                   dyvLvEvslvlerggeerrvLpddEkPlqiqlqlkrdaqvrsrFlLrrre
                   ++ ++E   v e+++ er +L+  Ek+l i+  l+     +s++++++++
   mKIAA0782   927 YWTCFE---VNEKEEAER-PLHFAEKVLPIVHGLGI----DSHLVVKKYQ 968  

                   d<-*
                       
   mKIAA0782   969 S    969  

PH: domain 4 of 4, from 983 to 1093: score 53.0, E = 6.5e-12
                   *->vikeGwLlkkg.........gkkswkkRyfvLfndvLlyykdkk.kk
                       +k+G ++ +++++  + +   +++++Ryf+L +++L +yk+  +++
   mKIAA0782   983    DTKHGMMKFREdrsllglglPSGGFHDRYFILNSSCLRLYKEVRsHR 1029 

                   pkgsipLsgiqvekvpdn....krkncFeirt.dr....etlllqaesee
                   p + +p+++++v+  ++ + ++++  +F+++++++++++++++l+++++ 
   mKIAA0782  1030 PEKEWPVKSLKVYLGVKKklrpPTCWGFTVVHeTEkhekQQWYLCCDTQM 1079 

                   erkeWvkaiqsair<-*
                   e++eW++ + s+++   
   mKIAA0782  1080 ELREWFATFLSVQH    1093 

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