hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file: /cdna4/rodent/full/goal/mbg/mbg16847/w3open/interpro/cnk_1/seq.in
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Query: mKIAA0743 ( 1211 res) mbg16847
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
LamG Laminin G domain 595.4 2e-174 5
4.1m putative band 4.1 homologues' binding motif 32.1 7.9e-05 1
EGF Epidermal growth factor-like domain. 25.8 0.0061 2
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
LamG 1/5 37 171 .. 1 137 [] 141.0 1.3e-37
LamG 2/5 225 377 .. 1 137 [] 152.0 5.9e-41
EGF 1/2 404 438 .. 1 32 [] 22.6 0.054
LamG 3/5 463 601 .. 1 137 [] 101.7 8.7e-26
LamG 4/5 649 785 .. 1 137 [] 137.7 1.2e-36
EGF 2/2 819 853 .. 1 32 [] 11.1 27
LamG 5/5 881 1008 .. 1 137 [] 83.2 3.2e-20
4.1m 1/1 1157 1175 .. 1 19 [] 32.1 7.9e-05
Alignments of top-scoring domains:
LamG: domain 1 of 5, from 37 to 171: score 141.0, E = 1.3e-37
*->t.lsisfsFrTtspnGlLlyag.ggdflaleLvlEDsdgdGrlvlry
++ +i++sF+T++ nGl+l++g+ d++ l+L+ dG + l++
mKIAA0743 37 SsDEITLSFKTWQRNGLILHTGkSADYVNLALK------DGAVSLVI 77
dlGssttggparltsdsdrptplnDGqWHrVsverngrsvtLsVDggnpv
+lGs g+++ ++++ + ++nD+ WH+V+v+rn r+vt+sVDg +++
mKIAA0743 78 NLGS----GAFEAIVEPV-NGKFNDNAWHDVKVTRNLRQVTISVDGILTT 122
sges....t.LdldkeesgplylGGlPe......lpvspgFrGCirnlrv
+g+++++ t L +d + +y+GG P++ + +++pvs++F GC++++++
mKIAA0743 123 TGYTqedyTmLGSD----DFFYVGGSPStadlpgSPVSNNFMGCLKEVVY 168
ngk<-*
++
mKIAA0743 169 KNN 171
LamG: domain 2 of 5, from 225 to 377: score 152.0, E = 5.9e-41
*->t.lsisfsFrTtspnGlLlyag...............ggdflaleLv
+ +sisf+FrTt+pnGl+l+++++++++++ +++++++ df+a+eL
mKIAA0743 225 RmGSISFDFRTTEPNGLILFTHgkpqerkdvrsqkntKVDFFAVELL 271
lEDsdgdGrlvlrydlGssttggparltsdsdrptplnDGqWHrVsvern
dG+l+l +d+Gs g++++ +++ ++ nDG+W++V ++r+
mKIAA0743 272 ------DGNLYLLLDMGS----GTIKVKATQ---KKANDGEWYHVDIQRD 308
grsvtLsVDggnpvsges....t.LdldkeesgplylGGlPe........
grs+t+sV+ ++++ +++++++ Ldl+ g++ylGGlPe++ + +
mKIAA0743 309 GRSGTISVN-SRRTPFTAsgesEiLDLE----GDMYLGGLPEnraglilp 353
.....lpvspgFrGCirnlrvngk<-*
++ + + g++GCir+l+++g+
mKIAA0743 354 telwtAMLNYGYVGCIRDLFIDGR 377
EGF: domain 1 of 2, from 404 to 438: score 22.6, E = 0.054
*->eCa..pCsnGgtEqnGtCi....sytC.CpgpGytg.rCe<-*
C++ pC n+ ++C ++ + + C+C g Gy g++Ce
mKIAA0743 404 QCDsyPCKNN-----AVCKdgwnRFICdCTGTGYWGrTCE 438
LamG: domain 3 of 5, from 463 to 601: score 101.7, E = 8.7e-26
*->t.lsisfsFrTtspnGlLlyag...ggdflaleLvlEDsdgdGrlvl
+++sf+F + + GlL+ +++++ d l leL +Gr++l
mKIAA0743 463 EaEDVSFRFMSQRAYGLLVATTsrdSADTLRLELD------GGRVKL 503
rydlGsst.....tggparltsdsdrptplnDGqWHrVsverngrsvtLs
+++l++++ + ++++gp +l+++ ++lnD++WH+V+v+r g+s+ L+
mKIAA0743 504 MVNLDCIRincnsSKGPETLYAG----QKLNDNEWHTVRVVRRGKSLKLT 549
VDggnpvsges....t.LdldkeesgplylGGlPe....lpvspgFrGCi
VD + ++g+ +++t+L+++ ++ G + e++ ++v ++F G +
mKIAA0743 550 VD-DDVAEGTMvgdhTrLEFH-----NIETGIMTEkryiSVVPSSFIGHL 593
rnlrvngk<-*
++l++ng
mKIAA0743 594 QSLMFNGL 601
LamG: domain 4 of 5, from 649 to 785: score 137.7, E = 1.2e-36
*->t.lsisfsFrTtspnGlLlyag..ggdflaleLvlEDsdgdGrlvlr
t++++ f+F+Tts++G++l+++++g+df+a+eLv G+++++
mKIAA0743 649 TsMHLFFQFKTTSADGFILFNSgdGNDFIAVELV------KGYIHYV 689
ydlGssttggparltsdsdrptplnDGqWHrVsvern.grsvtLsVDggn
+dlG+ gp ++ +s ++plnD+qWH V+++r++ ++ +L+VD +
mKIAA0743 690 FDLGN----GPNVIKGNS--DRPLNDNQWHNVVITRDsSNTHSLKVD-TK 732
pvsges...t.LdldkeesgplylGGlPe.........lpvspgFrGCir
v++++++ ++Ldl+ g+ly Gl + ++ ++ +++++gF+GC+
mKIAA0743 733 VVTQVIngaKnLDLK----GDLYMAGLAQgmysnlpklVASRDGFQGCLA 778
nlrvngk<-*
++ +ng+
mKIAA0743 779 SVDLNGR 785
EGF: domain 2 of 2, from 819 to 853: score 11.1, E = 27
*->eCa..pCsnGgtEqnGtCi....sytC.CpgpGytg.rCe<-*
C+++ C n G+C +++tC+C y+g++C
mKIAA0743 819 TCQedSCANQ-----GVCMqqweGFTCdCSMTSYSGnQCN 853
LamG: domain 5 of 5, from 881 to 1008: score 83.2, E = 3.2e-20
*->t.lsisfsFrTtspnGlLlyag....ggdflaleLvlEDsdgdGrlv
++ ++ + F Tt ++G+L+ +++ ++ gdfl+l+++ +G++
mKIAA0743 881 RsDRLAVGFSTTVKDGILVRIDsapgLGDFLQLHIE------QGKIG 921
lrydlGssttggparltsdsdrptplnDGqWHrVsverngrsvtLsVDgg
++++ G ++ ++ + + +tp+nDG++H V+++rng+++tL+VD
mKIAA0743 922 VVFNIG------TVDISIKEE-RTPVNDGKYHVVRFTRNGGNATLQVD-N 963
npvsges......t.LdldkeesgplylGGlPelpvspgFrGCirnlrvn
pv+++ +++++ t ++++ +++ +GG F+G +++l+++
mKIAA0743 964 WPVNEHYptgrqlTiFNTQ----AQIAIGGKD---KGRLFQGQLSGLYYD 1006
gk<-*
g
mKIAA0743 1007 GL 1008
4.1m: domain 1 of 1, from 1157 to 1175: score 32.1, E = 7.9e-05
*->myrykkRdkGSYhtnEakg<-*
my+y++Rd+GSY ++E ++
mKIAA0743 1157 MYKYRNRDEGSYQVDETRN 1175
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