hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpm/mpm08199/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0728 ( 1589 res) mpm08199 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Spectrin Spectrin repeat 177.9 1.6e-49 11 DUF593 Protein of unknown function, DUF593 -34.3 0.96 1 vATP-synt_E ATP synthase (E/31 kDa) subunit -79.4 0.55 1 Not3 Not1 N-terminal domain, CCR4-Not complex -141.0 0.65 1 ERM Ezrin/radixin/moesin family -211.6 0.86 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Spectrin 1/11 30 137 .. 1 108 [] 13.0 0.062 Spectrin 2/11 140 246 .. 1 108 [] 26.5 0.00062 Spectrin 3/11 249 353 .. 1 108 [] 17.0 0.031 Not3 1/1 199 357 .. 1 272 [] -141.0 0.65 Spectrin 4/11 356 462 .. 1 108 [] -11.5 4.5 vATP-synt_E 1/1 347 483 .. 1 208 [] -79.4 0.55 DUF593 1/1 405 487 .. 1 94 [] -34.3 0.96 ERM 1/1 195 491 .. 1 390 [] -211.6 0.86 Spectrin 5/11 575 683 .. 1 108 [] 34.0 3.4e-06 Spectrin 6/11 686 792 .. 1 108 [] 52.7 7.9e-12 Spectrin 7/11 795 901 .. 1 108 [] 38.9 1.1e-07 Spectrin 8/11 904 1010 .. 1 108 [] 6.9 0.18 Spectrin 9/11 1013 1119 .. 1 108 [] -3.7 1.2 Spectrin 10/11 1122 1228 .. 1 108 [] 50.5 3.8e-11 Spectrin 11/11 1231 1336 .. 1 108 [] 32.1 1.3e-05 Alignments of top-scoring domains: Spectrin: domain 1 of 11, from 30 to 137: score 13.0, E = 0.062 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf + q+q ++ l ++e + lss + +++v ++l+ +++ mKIAA0728 30 VKSTQYQSLLRSLSGTLTELDDKLSSGLTSGaLPDAVNQQLEAAQRL 76 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++e++++ +++++ +e ++L + + + + e+ +le++ + +++++ mKIAA0728 77 KQEIEQQA-PKIKEAQEVCEDLSALVKEEYLKAELSRQLEGILKSFKDIE 125 elaaeRkqkLee<-* ++++ q L+ mKIAA0728 126 QKTENHVQHLQS 137 Spectrin: domain 2 of 11, from 140 to 246: score 26.5, E = 0.00062 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf +qFq+ +++++W++ k+++ ++ + l+ +++Ll +++f mKIAA0728 140 ASSHQFQQMSKDFQAWLDAKKEEQRDSPPISaKLDVLESLLNSQKDF 186 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl + + + +++ L+ + + + ++ +++ +l+ + W++ + mKIAA0728 187 GKTFTEQS-NIYEKTISEGENLLLKTQ-GAEKAALQLQLNTMKTDWDRFR 234 elaaeRkqkLee<-* ++++eR++kL + mKIAA0728 235 KQVKEREEKLKD 246 Spectrin: domain 3 of 11, from 249 to 353: score 17.0, E = 0.031 *->lllqqFqrdadelesWisekeallssedygkDlesvqaLlkkHeafe ++ ++ +++ l Wi+ + l + D+++ ++ + ++ ++ mKIAA0728 249 EKALKYREQVETLRPWIDRCQHSLDGVTFSLDPTESESSIAELKSLQ 295 aelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLle +e++ h ++ ++ ln +a++L++ d+e+++e + L e+ ++ e mKIAA0728 296 KEMDHH-FGMLELLNNTANSLLSVC--EVDKEAVTEENQSLMEKVNRVTE 342 laaeRkqkLee<-* +++ + Le+ mKIAA0728 343 QLQSKTVSLEN 353 Not3: domain 1 of 1, from 199 to 357: score -141.0, E = 0.65 *->makRKLQqEIDrvlKKvsEGvElFddIweKvhstdnaNQkqkhhkEK K +sEG + K + ++ a + mKIAA0728 199 --------------KTISEG----ENLLLKTQGAEKAALQ------- 220 lEaDLKKEIKKLQRlRDQIKtWlssseIKDKkvsasYedsLldnRrlIEt l+ + K + mKIAA0728 221 ----------------------LQLNTMKTD------------------- 229 aMErF.KvV.EKetKtKafSKeGLgaqeklDPkekGDDleKreardwlnn +rF+K V+E+e K K D ek l++re+++ l mKIAA0728 230 -WDRFrKQVkEREEKLK-------------DSLEK--ALKYREQVETLRP 263 vIdeLnkQvDqlEaElesLSntDlGkGkRlkkkKkKtdsdrqeriedlKr Id + +D l+ + +++i lK mKIAA0728 264 WIDRCQHSLDGVTFSLDPT--------------------ESESSIAELKS 293 kieRhkfHIekLEliLRlLdNdeLdpeqVnetiKDDieYYVEsnQDDfpD + H +LEl L + +N L++ V++ e E nQ mKIAA0728 294 LQKEMDHHFGMLEL-LNNTANSLLSVCEVDK------EAVTEENQS---L 333 FeEyDeiYddlevdEldEvelsesaqq<-* e + ++l + v l+ aq mKIAA0728 334 MEKVNRVTEQLQ---SKTVSLENMAQK 357 Spectrin: domain 4 of 11, from 356 to 462: score -11.5, E = 4.5 *->lllqqFqrdadelesWisekealls.sedygkDlesvqaLlkkHeaf +++ +Fq ++ + +++++++l+ ++g + + l ++a mKIAA0728 356 QKFKEFQEVSRDTQRQLQDTKEQLEvHHSLG-PQAYSNKHLSVLQAQ 401 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++ l++++ +vd+ laq+L+ e +d + ++ + e L e +L mKIAA0728 402 QKSLQTLK-QQVDEAKRLAQDLVVEAADSKGTSDVLLQAETLAEEHSELS 450 elaaeRkqkLee<-* ++++e+ Le mKIAA0728 451 QQVDEKCSFLET 462 vATP-synt_E: domain 1 of 1, from 347 to 483: score -79.4, E = 0.55 *->fIrqEAeeKAeeIkaeAeeEfeiekaeavqeaekkieeiyekkeKqA + ++ e +++ +e qe + +++ + ++q+ mKIAA0728 347 ----------KTVSLENMAQKFKEF----QEVSRDTQRQLQDTKEQL 379 Emekk...iiiSnakneaRlkvLnaReEvldevfeeakekLanlpedkde E+ + +++++Sn + vL+a+++ l++ + ++ e+ + l++d mKIAA0728 380 EVHHSlgpQAYSNKHLS----VLQAQQKSLQTLKQQVDEA-KRLAQD--- 421 YkellkkLivqalekLgepkviVrsReeDleLveslldkaaeeykektgk L+v+a+++ g+++v++ + + L e+ e+ mKIAA0728 422 -------LVVEAADSKGTSDVLL----QAETLAEE-----HSELS----- 450 dtveligepedfLpkGPksdhGidciGGVvleg.adGkIrvdNTLeaRLe ++++ c+ le+++ G+ + NT+++ ++ mKIAA0728 451 ----QQVDE--------------KCS---FLETkLQGLGHFQNTIREMFS 479 rvfeqllpeIrkaLF<-* ++ e mKIAA0728 480 QFTE----------- 483 DUF593: domain 1 of 1, from 405 to 487: score -34.3, E = 0.96 *->verLretveeerkalqdLyeELeeERnASAsAAnEAMaMIlRLQeEK + L+++v+e++ + qdL +E +A + ++ + ++L eE mKIAA0728 405 LQTLKQQVDEAKRLAQDLVVE-----AADSKGTSDVLLQAETLAEE- 445 AalqMEArQYqRmmEEqaehDqealqlLedlL.ykREkeiqaLekEle<- + E++Q ++E+ ++ +++lq L + ++ RE+ q+ e e mKIAA0728 446 ---HSELSQ---QVDEKCSFLETKLQGLGHFQnTIREMFSQFTECDDE 487 * mKIAA0728 - - ERM: domain 1 of 1, from 195 to 491: score -211.6, E = 0.86 *->NKKGTdLWLGVDALGLNIYekdDrLTPKIGFPWSEIRNISFnDKKFv NIYek IS mKIAA0728 195 ----------------NIYEKT----------------IS------- 202 IKPiDKKApdFvFYaprlRINKRILaLCmGNHELYMRRRKPDTIEVQQMK ++++ + ++ + L+L + MK mKIAA0728 203 ------EGENLLLKTQGAEKAALQLQLNT-------------------MK 227 aQA.rEEKalKqaE...RekLerEkkaREiaekekEeaEreqqEleerlk +r +K+ K+ E++ + Le + k R E+ E + + + + mKIAA0728 228 TDWdRFRKQVKEREeklKDSLEKALKYR-------EQVETLRPWIDRC-Q 269 qmeEdmrraqkeLeeseekaleLeeklkqeqeaaqkLekkqkeleeenrr + + + + e ++ ++eL++++k++ + Le + + + mKIAA0728 270 HSLDGVTFSLDPTESES-SIAELKSLQKEMDHHFGMLELLNNTANSLLSV 318 LeeeaaaseeErerLeaevdeataevakleeerekkeeEteqlqaelrea e ++a eE + L+++v ++t++ ++ ++++e ++ +++q+ r+ mKIAA0728 319 CEVDKEAVTEENQSLMEKVNRVTEQLQSKTVSLENMAQKFKEFQEVSRDT 368 qekeeeakeellevlaaptappmhhvsapeaELttdngeqleqddngeea q+ + +ke l + ++ + s+ + + +q+ + + mKIAA0728 369 QRQLQDTKEQLEVHHSLGPQAY----SNK------HLSVLQAQQKSLQTL 408 sadlePkEFiLtdedmkdrsnEiEeeRvteaekne...rlqtqLkaL... + ++ ++k+ + v ea +++++++ q +L ++ mKIAA0728 409 KQQVD---------EAKRL----AQDLVVEAADSKgtsDVLLQAETLaee 445 ksELaavrdesK...etanDil.HeENsvRaGrDKYkTLRqIRkGNTKqR sEL++ de + et + l+H N T+R+ ++ T + mKIAA0728 446 HSELSQQVDEKCsflETKLQGLgHFQN----------TIREMFSQFTECD 485 VDqFEsM<-* D+ M mKIAA0728 486 -DELDGM 491 Spectrin: domain 5 of 11, from 575 to 683: score 34.0, E = 3.4e-06 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf ++l++F+r+++e+ ++++e+ +s+ + +++ e + ++l+ ++ f mKIAA0728 575 EKLEEFHRKLEEFSTLLQKAEEHEESQGPVGtETETINQQLDVFKVF 621 e.aelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaL +++e++++q + +++n l+q Li++ ++ + +++ l+ +n+rW+ L mKIAA0728 622 QkEEIEPLQ-VKQQDVNWLGQGLIQSAAANTCTQGLEHDLDSVNSRWKTL 670 lelaaeRkqkLee<-* +++a+R +L+e mKIAA0728 671 NKKVAQRTSQLQE 683 Spectrin: domain 6 of 11, from 686 to 792: score 52.7, E = 7.9e-12 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf l+ +Fq ++ l+sW+ ++e+l++++ ++ + v+a+++ ++ + mKIAA0728 686 LHCGRFQDALESLLSWMADTEELVANQKPPSaEFKVVKAQIQEQKLL 732 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++ l+ ++ v+ + +++k+ ++ e + d +++ +l+ L++rWeaLl mKIAA0728 733 QRLLEDRK-STVEVIKREGEKIAASAE-PADRVKLTRQLSLLDSRWEALL 780 elaaeRkqkLee<-* +a++R ++Le mKIAA0728 781 SRAEARNRQLEG 792 Spectrin: domain 7 of 11, from 795 to 901: score 38.9, E = 1.1e-07 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf q+F+ ++ l++W++ e+ l++ ++ ++ ++ ++ +H+ + mKIAA0728 795 VVAQEFHETLEPLNEWLTAVEKKLANSEPIGtQAPKLEEQISQHKVL 841 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl e+++ +h +++q ++q+L+ ++ +d++ ++++l+ L + +++ mKIAA0728 842 EDDITNHS-KQLHQAVSIGQSLKVLSSR-EDKDLVQSKLDSLQVWYFEIQ 889 elaaeRkqkLee<-* e+ R ++L++ mKIAA0728 890 EKSHSRSELLQQ 901 Spectrin: domain 8 of 11, from 904 to 1010: score 6.9, E = 0.18 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf + F d el++W++e + ls + ++++e+++++ ++a+ mKIAA0728 904 CNAKIFGEDEVELMNWLNEVHGKLSKLSVQDhSPEALWRQRAELRAL 950 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++++ ++ vdq + +L+ + + +++ i+++le++ +r++++ mKIAA0728 951 QEDILLRK-QSVDQALLNGLELLKQTT-GDEVLIIQDKLEAIKARYKDIT 998 elaaeRkqkLee<-* +l a+ + Le mKIAA0728 999 KLSADVAKTLEH 1010 Spectrin: domain 9 of 11, from 1013 to 1119: score -3.7, E = 1.2 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf +l q+q +el +W+++ e +l s + + e++ + +++++++ mKIAA0728 1013 QLAGQLQSMHKELCNWLDKVEVELLSYETQGlKGEAASQVQERQKEL 1059 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++e+ ++ + vd+lne +L+e + + e ++++++e ner++ + mKIAA0728 1060 KNEVRSNK-ALVDSLNEVSSALLELVPW-RAREGLEKTIAEDNERYRLVS 1107 elaaeRkqkLee<-* + + ++ ++ ++ mKIAA0728 1108 DTITQKVEEIDA 1119 Spectrin: domain 10 of 11, from 1122 to 1228: score 50.5, E = 3.8e-11 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf l+ qqF + ad ++sWi+e+++ l s + + + + a+l+ ++af mKIAA0728 1122 LRSQQFEQAADAELSWITETQKKLMSLGDIRlEQDQTSAQLQVQKAF 1168 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++ h+ d +d+l + k+++ ++ +++ k++l+ + ++++a++ mKIAA0728 1169 TMDILRHK-DIIDELVTSGHKIMTTSS-EEEKQSMKKKLDKVLKKYDAVC 1216 elaaeRkqkLee<-* + eR+ +Le+ mKIAA0728 1217 QINSERHLQLER 1228 Spectrin: domain 11 of 11, from 1231 to 1336: score 32.1, E = 1.3e-05 *->lllqqFqrdadelesWisekeallssedygk.DlesvqaLlkkHeaf l qF +el W++e+++++s+ + + e + ++++ H+++ mKIAA0728 1231 SLVSQFWETYEELWPWLTETQRIISQLPAPAlEYETLRRQQEEHRQL 1277 eaelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLl ++ +a h+ +++d n+++ +L+e + + + +i+e+ + ++++ +++ mKIAA0728 1278 RELIAEHK-PHIDKMNKTGPQLLELS--PKEGIYIQEKYVAADTLYSQIK 1324 elaaeRkqkLee<-* e +++R L+e mKIAA0728 1325 EDVKKRAVVLDE 1336 //