hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg09316/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0722  ( 1004 res)   mbg09316

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       210.6    2.3e-59   1
Pkinase_Tyr Protein tyrosine kinase                      46.9    8.6e-15   1
Extensin_2  Extensin-like region                       -103.7      0.018   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Pkinase       1/1       1   231 [.     1   287 []   210.6  2.3e-59
Pkinase_Tyr   1/1       3   231 ..     1   272 []    46.9  8.6e-15
Extensin_2    1/1     204   591 ..     1   385 []  -103.7    0.018

Alignments of top-scoring domains:
Pkinase: domain 1 of 1, from 1 to 231: score 210.6, E = 2.3e-59
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                                         +k++        + k+ +  +k      
   mKIAA0722     1    ------------------SDKKN--------LAKSQTLLGK------ 15   

                   rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse
                     Ei+ilk+L+H+NIv l+d+ e  +++ylV+Eyc+gG    dL dyl+ 
   mKIAA0722    16 --EIKILKELKHENIVALYDFQEMANSVYLVMEYCNGG----DLADYLH- 58   

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv
                       ++l  sed+++ ++ Qi+ ++  LHs+giiHRDLKP+NILl++ g+
   mKIAA0722    59 --TMRTL--SEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGG 104  

                   vda.....flKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngy
                     a++++ ++KiaDFG+A+   ++s+  + t++G+p YmAPEv++ +++y
   mKIAA0722   105 RRAnpsniRVKIADFGFARY--LqSNMmAATLCGSPMYMAPEVIM-SQHY 151  

                   gtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefds
                   + k+D WS+G i+y+ ltGk PF+ +   s+ d +  ++k++   + +++
   mKIAA0722   152 DGKADLWSIGTIVYQCLTGKAPFQAS---SpQDLRLFYEKNKTLVPAIPR 198  

                   pewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-
                   +++                ++++L+  +L+++ ++R  ++e ++HP++  
   mKIAA0722   199 ETS---------------APLRQLLLALLQRNHKDRMDFDEFFHHPFL   231  

                   *
                    
   mKIAA0722     -   -    

Pkinase_Tyr: domain 1 of 1, from 3 to 231: score 46.9, E = 8.6e-15
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLkeigasseeie
                                          k               k+  a s+   
   mKIAA0722     3    --------------------K---------------KN-LAKSQT-- 11   

                   redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd
                      +l +E++i+k+l +H+NiV L+ +      +    +y+V+Ey+ gGd
   mKIAA0722    12 ---LLGkEIKILKEL-KHENIVALYDFQEM-ANS----VYLVMEYCNGGD 52   

                   LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV
                   L d+L++    r L+  +   f +QiA +M  L+sk+++HRDL   N+L+
   mKIAA0722    53 LADYLHTM---RTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILL 99   

                   se........nl.vVKIsDFGLaRdiynddyY.vrkkgggklPvkWmAPE
                   s++++++ ++++  VKI+DFG aR++      ++ + + +  P   mAPE
   mKIAA0722   100 SNpggrranpSNiRVKIADFGFARYL----QSnMMAATLCGSPM-YMAPE 144  

                   slkygkFtskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR
                   +++   +  k D WS G   +  +t G+ P ++  s+++ l l+ye++  
   mKIAA0722   145 VIMSQHYDGKADLWSIGTIVYQCLT-GKAP-FQASSPQD-LRLFYEKNKT 191  

                   Lpr..PenCPdelYdlMlqCWaedPedRPtFsel..verL<-*
                   L +  P+ +++ l +l l   +++ +dR  F e  ++ +L   
   mKIAA0722   192 LVPaiPRETSAPLRQLLLALLQRNHKDRMDFDEFfhHPFL    231  

Extensin_2: domain 1 of 1, from 204 to 591: score -103.7, E = 0.018
                   *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy
                      l +l++al+  +       +  +  P       + kSPP P+p y+ 
   mKIAA0722   204    LRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSPPVPVPSYPS 250  

                   k...SPPPpkkpYvYsSPP....PPs..yvykSPPPPkpyvYkSPPpPky
                    +++S   ++   +  SPP+ ++ P  +    SP     ++  S      
   mKIAA0722   251 SgsgSSSSSSSASHLASPPslgeMPQlqKTLTSPADAAGFLQGSRDSGGS 300  

                   vYkSPPpPvykYkSPPPPthsppPpyvykSPPPPpk............ky
                      S  +  ++      P      +     PPP +   ++++   + +  
   mKIAA0722   301 SKDSCDTDDFVMVPAQFPG-DLVAEAASAKPPPDSLlcsgsslvasagLE 349  

                   vykSpPpptPvYkYkSPPPPp........yvY.kspPpPvkk......ri
                        P p+P    +S P P++++++ ++  Y+ s P Pv+ + ++ +ri
   mKIAA0722   350 SHGRTPSPSP--TCSSSPSPSgrpgpfssNRYgASVPIPVPTqvhnyqRI 397  

                   pyvYkSPPPPpPYvYkSpPppvkkyiyksppppephkYvYkSPPPPpPYv
                   +   +SP         S+ + +       ++ p    +   SP PP+ + 
   mKIAA0722   398 EQNLQSPTQQQT-ARSSAIRRS------GSTSPLG--FGRASPSPPS-HT 437  

                   yesvpeqkikYvYkSPPPPkksYk.spsppkyVYkSpPpPvipykYkSPP
                      ++ +k       P  P++   + p  p++     P    + + +SP 
   mKIAA0722   438 DGAMLARKLSLGGGRPYTPSPQVGtIPERPSWSRVPSPQGADVRVGRSPR 487  

                   PPkkkyspaP...rkpyvYkSPPPPtyvYkSpPpPykpptppkiyksPPP
                   P + +++ +P+++       S P  +  +   P              P P
   mKIAA0722   488 PGSSVPEHSPrttGLGCRLHSAPNLSDFHVVRPK------------LPKP 525  

                   Pt.PvyvYkspPpippiksssppPvyvYkSpPppvysPPPP.yvYssPPP
                   Pt+P     spP       s p+P +  +S  p   sP  P+++ +sP P
   mKIAA0722   526 PTdPLGATFSPPQ-----TSAPQPCPGLQSCRPLRGSPKLPdFLQRSPLP 570  

                   PvyvynsaPvykksPPkhhYiYsSPPPphh<-*
                   P+           sP k   ++  P  p     
   mKIAA0722   571 PI---------LGSPTKAGPSFDFPKTPSS    591  

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