hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg00550/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0705  ( 1252 res)   mbg00550

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PDZ      Domain present in PSD-95, Dlg, and ZO-1/2.     365.1   4.4e-105   5
WW                                                       88.7      7e-22   2
GuKc     Guanylate kinase homologues.                     8.1    0.00023   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
GuKc       1/1       1   136 [.     1   203 []     8.1  0.00023
WW         1/2     148   180 ..     1    34 []    54.7  1.2e-11
WW         2/2     194   226 ..     1    34 []    36.4  3.9e-06
PDZ        1/5     279   355 ..     1    80 []    78.4  8.7e-19
PDZ        2/5     458   528 ..     1    80 []    62.5  5.5e-14
PDZ        3/5     631   707 ..     1    80 []    78.2    1e-18
PDZ        4/5     774   855 ..     1    80 []    81.2  1.2e-19
PDZ        5/5     993  1067 ..     1    80 []    84.9  9.4e-21

Alignments of top-scoring domains:
GuKc: domain 1 of 1, from 1 to 136: score 8.1, E = 0.00023
                   *->drRpivLsGpsGvGKstlkakLlqeyPdypkfgfsVshTTRppRpgE
                                                                     
   mKIAA0705     -    ----------------------------------------------- -    

                   vnGPvvDYhFvsLkeefeqdiksgkflEwgeysgnlyYGTskesvrqvae
                          Y F++ +eef++++ksg++lE+g+y++n yYGT+k++ +++  
   mKIAA0705     1 -------YIFIT-VEEFMELEKSGALLESGTYEDN-YYGTPKPPAEPA-- 39   

                   kGKhclLDidpqgvkqlkka.r.R.kselnpiviFIapPsleeleerlrg
                        ++D  + g+    + +r+R+ks  n+    I+pP+ ee+eer++ 
   mKIAA0705    40 -PLLNVTDQILPGATPSAEGkRkRnKSVTNMEKASIEPPE-EEEEERPV- 86   

                   aeqRgteteeriqkrlaaaaqkeaqeyskeahlFdlvivnddledayYke
                       +++    + + +++  +k+a+++    ++   + +  ++++   +e
   mKIAA0705    87 ---VNGNGVVITPESSEH-EDKSAGAS----GETPSQPYPAPVYSQP-EE 127  

                   Lkeileaeq<-*
                   Lk+ +++++   
   mKIAA0705   128 LKDQMDDTK    136  

WW: domain 1 of 2, from 148 to 180: score 54.7, E = 1.2e-11
                   *->plPpgWeerkdpdsGrpYYyNheTketqWekPre<-*
                      plP++We++++++ G +Y+++h+Tk+t+W +Pr+   
   mKIAA0705   148    PLPDNWEMAYTEK-GEVYFIDHNTKTTSWLDPRL    180  

WW: domain 2 of 2, from 194 to 226: score 36.4, E = 3.9e-06
                   *->plPpgWeerkdpdsGrpYYyNheTketqWekPre<-*
                       lP gWe++ dp    +YY++h++++tq+e P++   
   mKIAA0705   194    ELPYGWEKIDDPI-YGTYYVDHINRRTQFENPVL    226  

PDZ: domain 1 of 5, from 279 to 355: score 78.4, E = 8.7e-19
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                       g+Gf+i g++++++ + v+sv+p++pAa++G+     +  GDvI+ 
   mKIAA0705   279    MGFGFTIIGgdepdeFLQVKSVIPDGPAAQDGK-----METGDVIVY 320  

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   +N  + v g th+++v+l ++ +    G++v L+++Rg    
   mKIAA0705   321 INE-VCVLGHTHADVVKLFQSVPI---GQSVNLVLCRGY    355  

PDZ: domain 2 of 5, from 458 to 528: score 62.5, E = 5.5e-14
                   *->gglGfsivg...gifvssvvpGspAakaGrkslglLkvGDvIleVNG
                      +g+Gf+i+++++g  v+++++       G      L++GD I+e+N 
   mKIAA0705   458    QGFGFTIADsptGQRVKQILD--IQGCPG------LCEGDLIVEINQ 496  

                   etsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                    ++v++l+h e+vd+lk ++   vG++ +L++ Rgg   
   mKIAA0705   497 -QNVQNLSHTEVVDILKDCP---VGSETSLIIHRGG    528  

PDZ: domain 3 of 5, from 631 to 707: score 78.2, E = 1e-18
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                       g+Gf+i g+++++++i++  v++ + A+++Gr     L++GD+++ 
   mKIAA0705   631    SGFGFRILGgdepgqPILIGAVIAMGSADRDGR-----LHPGDELVY 672  

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   V+G ++v g+th  ++dl+  a ++g   +v Ltv+R+    
   mKIAA0705   673 VDG-IPVAGKTHRYVIDLMHHAARNG---QVNLTVRRKV    707  

PDZ: domain 4 of 5, from 774 to 855: score 81.2, E = 1.2e-19
                   *->gglGfsivg.............gifvssvvpGspAakaGrkslglLk
                      +g+Gf i ++ ++++++ + + ++ + ++++GspA+++ +     Lk
   mKIAA0705   774    EGFGFVIISslnrpesgatitvPHKIGRIIDGSPADRCAK-----LK 815  

                   vGDvIleVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   vGD+Il+VNG +s+ +++h+++v+l+k ag      +vtL +++++   
   mKIAA0705   816 VGDRILAVNG-QSIINMPHADIVKLIKDAGL-----SVTLRIIPQE    855  

PDZ: domain 5 of 5, from 993 to 1067: score 84.9, E = 9.4e-21
                   *->gglGfsivg......gifvssvvpGspAakaGrkslglLkvGDvIle
                      +g+Gfsi+g+++ +  ++v ++ +++pA + Gr     ++vGD+I+e
   mKIAA0705   993    KGFGFSIRGgreykmDLYVLRLAEDGPAIRNGR-----MRVGDQIIE 1034 

                   VNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   +NG +s++++th++a++l+k+ g+     +v+L+++Rg    
   mKIAA0705  1035 ING-ESTRDMTHARAIELIKSGGR-----RVRLLLKRGT    1067 

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