hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mpg/mpg00180/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0687  ( 1310 res)   mpg00180

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
CNH      Domain found in NIK1-like kinases, mouse cit   437.6   6.6e-127   1
S_TKc    Serine/Threonine protein kinases, catalytic    203.1    2.6e-56   1
TyrKc    Tyrosine kinase, catalytic domain               -4.0    6.9e-11   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
S_TKc      1/1      43   270 ..     1   231 []   203.1  2.6e-56
TyrKc      1/1      43   270 ..     1   280 []    -4.0  6.9e-11
CNH        1/1     992  1290 ..     1   375 []   437.6 6.6e-127

Alignments of top-scoring domains:
S_TKc: domain 1 of 1, from 43 to 270: score 203.1, E = 2.6e-56
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik......erilrEik
                      +el++++G G++G+Vy++r++ktg+l AiKv++ +++++e i+ Ei+
   mKIAA0687    43    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDvtedeeEEIKLEIN 89   

                   iLkk..dHPNIVkLydvfed.......dklylVmEyceGdlGdLfdllkk
                   +Lkk ++H NI ++y++f  +++++++d l+lVmE+c+   G+  dl k+
   mKIAA0687    90 MLKKysHHRNIATYYGAFIKksppghdDQLWLVMEFCGA--GSITDLVKN 137  

                   rgrrglrkvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds..
                    +++     l E++++++ r+il++L++LH +++iHRD+K +N+LL+++ 
   mKIAA0687   138 TKGNT----LKEdWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTEna 183  

                   hvKlaDFGlArql.......ttfvGTpeYmAPEvlgYgkpavDiWSlGci
                   +vKl DFG+++ql+++ ++++tf+G             k           
   mKIAA0687   184 EVKLVDFGVSAQLdrtvgrrNTFIG-------------K----------- 209  

                   lyElltGkpPFp..qldlifkkig............SpeakdLikklLvk
                         G pP ++ ++++ + +i ++++++ +++++S+ + ++i+++Lvk
   mKIAA0687   210 ------GPPPLCdmHPMRALFLIPrnppprlkskkwSKKFFSFIEGCLVK 253  

                   dPekRlta.eaLedeldikaHPff<-*
                   +  +R++ +++L+       HPf+   
   mKIAA0687   254 NYMQRPSTeQLLK-------HPFI    270  

TyrKc: domain 1 of 1, from 43 to 270: score -4.0, E = 6.9e-11
                   *->ltlgkkLGeGaFGeVykGtlk...ieVAVKtLkeda..keeFlrEak
                       +l ++ G+G +G+VykG+  ++++  A+K++    +++ee+  E++
   mKIAA0687    43    FELVEVVGNGTYGQVYKGRHVktgQLAAIKVMDVTEdeEEEIKLEIN 89   

                   iMkklGgkHpNiVkLlGvcteegrrFme....vePlmivmEymegGdLld
                   ++kk+  +H Ni   +G+ +++     ++++++++l++vmE++  G+  d
   mKIAA0687    90 MLKKY-SHHRNIATYYGAFIKK-----SppghDDQLWLVMEFCGAGSITD 133  

                   yLrknrpk.lslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvgenk
                     +++++++l+ +   +++  I +G ++L+ ++++HRD+   N+L++en 
   mKIAA0687   134 LVKNTKGNtLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENA 183  

                   vvKIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAPEslkd
                    vK  DFG s  l+             +    g++             ++
   mKIAA0687   184 EVKLVDFGVSAQLDRT-----------V----GRR-------------NT 205  

                   gkFtskSDVWSFGVlLWEiftlGeqPYpgeiqqfmsneevleylkkGyRl
                    +                    G+ P+p      ++   ++++     R 
   mKIAA0687   206 FI--------------------GKGPPPL-----CDMHPMRALFLIP-RN 229  

                   pkPendlpiSsvtCPdelYdlMlqCWaedPedRPtFsel..verl<-*
                   p+P       s   +++ ++ ++ C   +  +RP+ ++l ++ ++   
   mKIAA0687   230 PPPRL----KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLlkHPFI    270  

CNH: domain 1 of 1, from 992 to 1290: score 437.6, E = 6.6e-127
                   *->naakwnhpitcdqLWGkiLLvgTeeGLYvlnisrqlnkdhegtlekl
                      +++++n++i+c++LWG++LLvgTe+GL++l++s+q      g++++l
   mKIAA0687   992    YKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQ------GKVYPL 1032 

                   isrrsvtqiwvleennvLlmisGkkpqlyshpLsaltekkltqgntpiik
                   isrr+++q++vle++nvL++isGkk++l++++Ls+l++k           
   mKIAA0687  1033 ISRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNK----------- 1071 

                   dalgsarlviRknvlttkipdvkGNchlcavkvngkrtgilflcaalqss
                     l+++  v++k+++ t+++d++G c++++v v+++r  i+fl+ al+ss
   mKIAA0687  1072 -ILHNDPEVEKKQGW-TTVGDLEG-CVHYKV-VKYER--IKFLVIALKSS 1115 

                   VvllaqwynplkkfklvksSNNiLNNEledikkflkklivplplfvelvs
                   V+++a++++p++kf+ +ks                ++++ + pl+v+l++
   mKIAA0687  1116 VEVYAWAPKPYHKFMAFKS----------------FGELLHKPLLVDLTV 1149 

                   ssfelpkvciGsdkPVGGdaggdvvqfhqdphlNslkfkeslvskedlsl
                   ++ +++kv++Gs+       g+++v+++             + s++d++l
   mKIAA0687  1150 EEGQRLKVIYGSCA------GFHAVDVD-------------SGSVYDIYL 1180 

                   pfaseetssddaTCkpisvvqvqasdgGqRdelLlcydefgvfVNlqGle
                   p+++++++      kp+++++++++dg   +elL+cy+++gv+VN++G  
   mKIAA0687  1181 PTHIQCSI------KPHAIIILPNTDG---MELLVCYEDEGVYVNTYG-- 1219 

                   vrrsrkpiltwefmpesfayve.pyllafhsngieIrsiktgelNlqela
                    r +++++l+w++mp+s+ay+++++++++++++ieIrs++tg+l +++++
   mKIAA0687  1220 -RITKDVVLQWGEMPTSVAYIRsNQTMGWGEKAIEIRSVETGHL-DGVFM 1267 

                   drsiikarkiRlLgsCeisdrkIllsssp<-*
                   ++   +a+++++L++   +++k++++s +   
   mKIAA0687  1268 HK---RAQRLKFLCE---RNDKVFFASVR    1290 

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