hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpg/mpg00180/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0687  ( 1310 res)   mpg00180

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
CNH         CNH domain                                  369.7     3e-107   1
Pkinase     Protein kinase domain                       173.1    4.7e-48   1
Pkinase_Tyr Protein tyrosine kinase                      43.8    1.3e-14   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Pkinase       1/1      43   270 ..     1   287 []   173.1  4.7e-48
Pkinase_Tyr   1/1      43   270 ..     1   272 []    43.8  1.3e-14
CNH           1/1     997  1288 ..     1   363 []   369.7   3e-107

Alignments of top-scoring domains:
Pkinase: domain 1 of 1, from 43 to 270: score 173.1, E = 4.7e-48
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      +el+e++G G++G+Vyk++h++tg++ A+K++++ ++++++ k    
   mKIAA0687    43    FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--- 86   

                   rsEiqilkrL.sHpNIvrlidvfed......kdhlylVlEycegGLrlld
                     Ei +lk+ ++H NI +++++f  +++++++d l+lV+E+c+ G    +
   mKIAA0687    87 --EINMLKKYsHHRNIATYYGAFIKksppghDDQLWLVMEFCGAG----S 130  

                   LfdylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNI
                     d+++   ++++l   ed +  i ++ilrgl++LH + +iHRD+K +N+
   mKIAA0687   131 ITDLVK-NTKGNTL--KEDWIAYISREILRGLAHLHIHHVIHRDIKGQNV 177  

                   LldengvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggn
                   Ll en +v    K+ DFG++++l  +  ++ +tf G          +   
   mKIAA0687   178 LLTENAEV----KLVDFGVSAQL-DrTVGrRNTFIG----------K--- 209  

                   gygtkvDvWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplef
                                       G pP ++    ++ + l+li ++ +p+l++
   mKIAA0687   210 --------------------GPPPLCDM---HpMRALFLIPRNPPPRLKS 236  

                   dspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf
                     +                s+ + ++i++cL k+  +R++ e++l+HP++
   mKIAA0687   237 KKW----------------SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 270  

                   <-*
                      
   mKIAA0687     -     -    

Pkinase_Tyr: domain 1 of 1, from 43 to 270: score 43.8, E = 1.3e-14
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLkeigasseeie
                      ++l ++ G G +G VykG+      +t++  A+K++   + +++e  
   mKIAA0687    43    FELVEVVGNGTYGQVYKGRHV----KTGQLAAIKVM---DVTEDE-- 80   

                   redFlrEAsiMkklGdHpNiVrLlGvctkegePggpg.lyiVtEymegGd
                    e+   E++++kk+ +H Ni  ++G+ +k + Pg +++l++V+E++  G+
   mKIAA0687    81 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDqLWLVMEFCGAGS 130  

                   LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV
                     d  ++   g+ L+  +   ++++i +G+++L+ ++++HRD+   N+L+
   mKIAA0687   131 ITDLVKNT-KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLL 179  

                   senlvVKIsDFGLaRdiynddyYvrkkgggklPvkWmAPEslkygkFtsk
                   +en  VK  DFG + ++ +     r  +                      
   mKIAA0687   180 TENAEVKLVDFGVSAQL-DRTVG-RRNT---------------------- 205  

                   SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPde
                                +  G +P   +m + + l l+ ++     + ++ +++
   mKIAA0687   206 ------------FIGKGPPP-LCDMHPMRALFLIPRNPPPRLKSKKWSKK 242  

                   lYdlMlqCWaedPedRPtFsel..verL<-*
                    ++ +  C  ++  +RP+ ++l ++ ++   
   mKIAA0687   243 FFSFIEGCLVKNYMQRPSTEQLlkHPFI    270  

CNH: domain 1 of 1, from 997 to 1288: score 369.7, E = 3e-107
                   *->kvnwihaitggqnLLvGTeeGLYvlnrsdqhdaflgklvkiigrrsv
                      ++++ +a ++g+nLLvGTe+GL++l+rs+q     gk++++i+rr++
   mKIAA0687   997    NSEILCAALWGVNLLVGTESGLMLLDRSGQ-----GKVYPLISRRRF 1038 

                   tqlevieelnlLllLseGKkrhLylhpLsaLetekkdtaqgsskinklpe
                   +q++v+e+ln+L+++s GKk +L++++Ls+L                 ++
   mKIAA0687  1039 QQMDVLEGLNVLVTIS-GKKDKLRVYYLSWL-----------------RN 1070 

                   ktlarrfavskKipetkghCklccvgfiregycggtkFlcvvAlksddls
                   k+l+ +++v+kK ++t+++++++cv+ + + y+++ kFl++ Alks    
   mKIAA0687  1071 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI-KFLVI-ALKS---- 1114 

                   tsillyeWPlkeyklpnnyekllkfinrkktrfrkpkeldvpepvqsief
                    s+++y+W                        ++kp++++++++++    
   mKIAA0687  1115 -SVEVYAW------------------------APKPYHKFMAFKSFGELL 1139 

                   lkpslcvGcskgfeillvlfgss.gfhslsleGqseaaldlllPsndlsl
                   +kp+l++++++ +++l+v++gs+ gfh+++++  s++++d++lP + +++
   mKIAA0687  1140 HKPLLVDLTVEEGQRLKVIYGSCaGFHAVDVD--SGSVYDIYLPTHIQCS 1187 

                   efakklsQsvdalrakevvsaiqidrdeyLLCfsefgvfVNlqGrrsrkk
                   +            +++ ++++++ d++e+L+C++++gv+VN++Gr +++ 
   mKIAA0687  1188 I------------KPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDV 1225 

                   kdiselmWegaPesfayslypyllafhdngieIrsletgeltqeladrvq
                       +l+W ++P+s+ay+++++ +++++++ieIrs+etg+l+++++++ +
   mKIAA0687  1226 ----VLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRA 1271 

                   tillnkirllvslrsls<-*
                   + l+++++++++++++s   
   mKIAA0687  1272 QRLKFLCERNDKVFFAS    1288 

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