hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg06227/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0651  ( 985 res)   mbg06227

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   209.4    3.3e-58   1
PH       Pleckstrin homology domain.                     51.4    1.1e-10   1
C1       Protein kinase C conserved region 1 (C1) dom    45.1    9.4e-09   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
C1         1/1      40    86 ..     1    61 []    45.1  9.4e-09
RhoGEF     1/1     240   432 ..     1   211 []   209.4  3.3e-58
PH         1/1     474   574 ..     1    82 []    51.4  1.1e-10

Alignments of top-scoring domains:
C1: domain 1 of 1, from 40 to 86: score 45.1, E = 9.4e-09
                   *->Hkfvfrtf.kptfCdvCrksiwgsfkqaaksqglrCseCkvkcHkkC
                      H f + +++++t C+ C+ksi           +l C  C+v++H++C
   mKIAA0651    40    HLFTTISVsGMTMCYACNKSITAKE-------ALICPTCNVTIHNRC 79   

                   aekvpaqshksglsC<-*
                   ++ ++        +C   
   mKIAA0651    80 KDTLA--------NC    86   

RhoGEF: domain 1 of 1, from 240 to 432: score 209.4, E = 3.3e-58
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v++EL+qTE ++Vr+Lki+++ f+  +++e++      + p+ v+ l
   mKIAA0651   240    VIYELIQTELHHVRTLKIMTRLFRTGMLEELQ------MEPEVVQGL 280  

                   FgpNieeiyefHrrFLdeLeerveewllskdl.Ksernsviedsgerigd
                   F+ +++e+ ++H+rFL +L er+++ l    +++s+rn+vi+  g+++ +
   mKIAA0651   281 FP-CVDELSDIHTRFLNQLLERRRQAL----CpGSTRNFVIHRLGDLLIS 325  

                   vFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeies
                   +F+++ +ae++ k+Yse+cs+h++al+l+k+L+  + +++Fq+f+++  +
   mKIAA0651   326 QFSGS-NAEQMRKTYSEFCSRHTKALKLYKELY--ARDKRFQQFIRKMTR 372  

                   kpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLk
                   +++       r++ +++++++ QR+tkYp L++++l++++   e+++dL 
   mKIAA0651   373 SAVLK-----RHGVQECILLVTQRITKYPVLINRILQNSHGVEEEYQDLA 417  

                   kAleaikelasqvNe<-*
                    Al+++kel+s v++   
   mKIAA0651   418 SALGLVKELLSNVDQ    432  

PH: domain 1 of 1, from 474 to 574: score 51.4, E = 1.1e-10
                   *->vikeGwLlkks.k.swkkryfvLfngvLlyyksk.........kpkg
                      +i+eG Ll+k+  +++k++ + L ++vL++ ++k+++   ++ ++  
   mKIAA0651   474    LIHEGCLLWKTaTgRFKDVLLLLMTDVLVFLQEKdqkyiftslDKPS 520  

                   sipLsgcsvre.p.....cFeivt.dr.tlllqAeseeereeWvealqsa
                   +++L++++vr+ ++  +++F i+++  + ++++A s ++r+ W++ +q+ 
   mKIAA0651   521 VVSLQNLIVRDiAnqakgMFLISSgPPeMYEVHAASRDDRTTWIRVIQQS 570  

                   iaka<-*
                   ++ +   
   mKIAA0651   571 VRLC    574  

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