hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg06227/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0651  ( 985 res)   mbg06227

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PH       PH domain                                       60.2    4.5e-14   1
RhoGEF   RhoGEF domain                                   59.6    6.6e-14   1
C1_1     Phorbol esters/diacylglycerol binding domain    30.4    4.1e-05   1
C1_3     C1-like domain                                  14.8      0.061   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
C1_3       1/1      51    80 ..     1    30 []    14.8    0.061
C1_1       1/1      40    90 ..     1    55 []    30.4  4.1e-05
RhoGEF     1/1     240   432 ..     1   207 []    59.6  6.6e-14
PH         1/1     474   572 ..     1    92 []    60.2  4.5e-14

Alignments of top-scoring domains:
C1_3: domain 1 of 1, from 51 to 80: score 14.8, E = 0.061
                   *->ktCdaCglpidgdpfYsCseCdFvlHeeCa<-*
                        C+aC ++i      +C++C+  +H +C    
   mKIAA0651    51    TMCYACNKSITAKEALICPTCNVTIHNRCK    80   

C1_1: domain 1 of 1, from 40 to 90: score 30.4, E = 4.1e-05
                   *->HhFvhrwnfkqptfCdhCgellwgslgkqGlkCswCklnvHkrChek
                      H F    +  ++t C  C++++    +k +l C +C++++H+rC   
   mKIAA0651    40    HLFTTI-SVSGMTMCYACNKSI---TAKEALICPTCNVTIHNRCKDT 82   

                   VppeCgcg<-*
                   ++++ + +   
   mKIAA0651    83 LANCTKVK    90   

RhoGEF: domain 1 of 1, from 240 to 432: score 59.6, E = 6.6e-14
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v++El++TE   vr+L i  + ++  ++e+         p++++ +F
   mKIAA0651   240    VIYELIQTELHHVRTLKIMTRLFRTGMLEEL-----QMEPEVVQGLF 281  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaq.........r
                   +++ ++ ++h++FL   L +r ++              +++++++   +r
   mKIAA0651   282 PCVDELSDIHTRFLN-QLLERRRQ------------ALCPgstrnfvihR 318  

                   lGdlFlklk.....epflqvYgeYcsnkpyAqelleklrqaasnpqFaef
                   lGdl+++ +++++ e + + Y e+cs++  A +l + l   a+   F++f
   mKIAA0651   319 LGDLLISQFsgsnaEQMRKTYSEFCSRHTKALKLYKELY--ARDKRFQQF 366  

                   ldeveassntgAkddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpege
                   + +++ s+         +++ q  +l   qRi++Yp L++ +L  +    
   mKIAA0651   367 IRKMTRSAVLK------RHGVQECILLVTQRITKYPVLINRILQNSHG-- 408  

                   dqpdredLkkaldllqdlaksiNe<-*
                     ++++dL  al+l+++l++ +++   
   mKIAA0651   409 VEEEYQDLASALGLVKELLSNVDQ    432  

PH: domain 1 of 1, from 474 to 572: score 60.2, E = 4.5e-14
                   *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk.......kkpkg
                      +i+eG+Ll k++ +++k++ + L +dvL++ ++k+++   ++ ++  
   mKIAA0651   474    LIHEGCLLWKTATGRFKDVLLLLMTDVLVFLQEKDqkyiftsLDKPS 520  

                   sipLsgiqvekvpdnkrkncFeirt.dretlllqaeseeerkeWvkaiqs
                   +++L+++ v+++ ++  k +F i+++ +e ++++a+s ++r++W++ iq+
   mKIAA0651   521 VVSLQNLIVRDIANQ-AKGMFLISSgPPEMYEVHAASRDDRTTWIRVIQQ 569  

                   air<-*
                   ++r   
   mKIAA0651   570 SVR    572  

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