hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file: /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file: /cdna4/rodent/full/goal/mbg/mbg00030/w3open/interpro/cnk_1/seq.in
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Query: mKIAA0578 ( 1553 res) mbg00030
Scores for sequence family classification (score includes all domains):
Model Description Score E-value N
-------- ----------- ----- ------- ---
LamG Laminin G domain 696.4 8.2e-205 6
EGF Epidermal growth factor-like domain. 38.5 8.8e-07 3
4.1m putative band 4.1 homologues' binding motif 37.3 2e-06 1
Parsed for domains:
Model Domain seq-f seq-t hmm-f hmm-t score E-value
-------- ------- ----- ----- ----- ----- ----- -------
LamG 1/6 96 238 .. 1 137 [] 119.4 4.1e-31
EGF 1/3 262 302 .. 1 32 [] 15.9 5.7
LamG 2/6 350 492 .. 1 137 [] 123.5 2.3e-32
LamG 3/6 546 698 .. 1 137 [] 159.0 4.9e-43
EGF 2/3 725 759 .. 1 32 [] 27.3 0.0021
LamG 4/6 784 923 .. 1 137 [] 97.8 1.3e-24
LamG 5/6 971 1107 .. 1 137 [] 130.8 1.5e-34
EGF 3/3 1132 1166 .. 1 32 [] 11.4 25
LamG 6/6 1194 1351 .. 1 137 [] 81.0 1.4e-19
4.1m 1/1 1498 1516 .. 1 19 [] 37.3 2e-06
Alignments of top-scoring domains:
LamG: domain 1 of 6, from 96 to 238: score 119.4, E = 4.1e-31
*->t.lsisfsFrTtspnGlLlyag...ggdflaleLvlEDsdgdGrlvl
+++ sf+++T+s++Gl ly ++++ +dfl+l L ++Grl+l
mKIAA0578 96 CeSEMSFQLKTRSARGLVLYFDdegFCDFLELILT-----RGGRLQL 137
rydlGssttggparltsdsdrptplnDGqWHrVsverngrsvtLsVDg..
+++ + ++pa+l +d tp+nDG WH+V+++r+ r+ tL++D +
mKIAA0578 138 SFSIFC---AEPATLLAD----TPVNDGAWHSVRIRRQFRNTTLYIDRae 180
gnpvsges..t.LdldkeesgplylGGlPe.............lpvspgF
+v+ +s+++++ + + l++GGlP++ + + + ++ +++F
mKIAA0578 181 AKWVEVKSkrRdMTVF----SGLFVGGLPPelraaalkltlasVREREPF 226
rGCirnlrvngk<-*
+G ir++rvn+
mKIAA0578 227 KGWIRDVRVNSS 238
EGF: domain 1 of 3, from 262 to 302: score 15.9, E = 5.7
*->eCa........pCsnGgtEqnGtCi....sytC.CpgpGytg.rCe<
+C+ +++++++ C nG G+C ++ C+C G++g+ C
mKIAA0578 262 PCEageegeggVCLNG-----GVCSvvddQAVCdCSRTGFRGkDCS 302
-*
mKIAA0578 - -
LamG: domain 2 of 6, from 350 to 492: score 123.5, E = 2.3e-32
*->t.lsisfsFrTtspnGlLlyag.ggdflaleLvlEDsdgdGrlvlry
++ +i++sF+T + nGl+l++g+ d++ l+L+ +G + l++
mKIAA0578 350 SsDEITLSFKTLQRNGLMLHTGkSADYVNLALK------NGAVSLVI 390
dlGssttggparltsdsdrptplnDGqWHrVsvern........grsvtL
+lGs g+++ ++++ + ++nD+ WH+V+v+rn +++++ + vt+
mKIAA0578 391 NLGS----GAFEALVEPV-NGKFNDNAWHDVKVTRNlrqhsgigHAMVTI 435
sVDggnpvsges....t.LdldkeesgplylGGlPe......lpvspgFr
sVDg ++++g+++++ t L +d + +y+GG P++ + +++pvs++F
mKIAA0578 436 SVDGILTTTGYTqedyTmLGSD----DFFYVGGSPStadlpgSPVSNNFM 481
GCirnlrvngk<-*
GC++++++ ++
mKIAA0578 482 GCLKEVVYKNN 492
LamG: domain 3 of 6, from 546 to 698: score 159.0, E = 4.9e-43
*->t.lsisfsFrTtspnGlLlyag...............ggdflaleLv
+++sisf+FrTt+pnGl+l+++++++++++ ++++ + df+a+e+
mKIAA0578 546 KtGSISFDFRTTEPNGLILFSHgkprhqkdakhpqmiKVDFFAIEML 592
lEDsdgdGrlvlrydlGssttggparltsdsdrptplnDGqWHrVsvern
dG+l+l +d+Gs g++++ + + +++nDG+W++V ++r+
mKIAA0578 593 ------DGHLYLLLDMGS----GTIKIKALQ---KKVNDGEWYHVDFQRD 629
grsvtLsVDggnpvsges....t.LdldkeesgplylGGlPe........
grs+t+sV+ ++++ +++++++ Ldld + lylGGlPe++ + +
mKIAA0578 630 GRSGTISVN-TLRTPYTApgesEiLDLD----DELYLGGLPEnkaglvfp 674
.....lpvspgFrGCirnlrvngk<-*
++ + + + g++GCir+l+++g+
mKIAA0578 675 tevwtALLNYGYVGCIRDLFIDGQ 698
EGF: domain 2 of 3, from 725 to 759: score 27.3, E = 0.0021
*->eCa..pCsnGgtEqnGtCi....sytC.CpgpGytg.rCe<-*
+C+++pC n+ G C+++ + y C+C g Gy g++Ce
mKIAA0578 725 PCLsnPCKNN-----GMCRdgwnRYVCdCSGTGYLGrSCE 759
LamG: domain 4 of 6, from 784 to 923: score 97.8, E = 1.3e-24
*->t.lsisfsFrTtspnGlLlyag...ggdflaleLvlEDsdgdGrlvl
+++s++Fr + + G+L+ +++++ d l leL Gr++l
mKIAA0578 784 EaEDVSLRFRSQRAYGILMATTsrdSADTLRLELD------AGRVKL 824
rydlGsst.....tggparltsdsdrptplnDGqWHrVsverngrsvtLs
+++l++++ + ++++gp +l ++ + lnD++WH+V+v+r g+s+ L+
mKIAA0578 825 TVNLDCIRincnsSKGPETLFAG----YNLNDNEWHTVRVVRRGKSLKLT 870
VDggnpvsges....t.LdldkeesgplylGGlPe....lpvspgFrGCi
VD++ ++g +++t+L+++ ++ G + e++ + v ++F G +
mKIAA0578 871 VDDQQAMTGQMagdhTrLEFH-----NIETGIITErrylSSVPSNFIGHL 915
rnlrvngk<-*
++l++ng+
mKIAA0578 916 QSLTFNGM 923
LamG: domain 5 of 6, from 971 to 1107: score 130.8, E = 1.5e-34
*->t.lsisfsFrTtspnGlLlyag..ggdflaleLvlEDsdgdGrlvlr
t++++ f+F+Tts +Gl+ly++++g+df+ +eLv G+l+++
mKIAA0578 971 TsMHLFFQFKTTSLDGLILYNSgdGNDFIVVELV------KGYLHYV 1011
ydlGssttggparltsdsdrptplnDGqWHrVsvern.grsvtLsVDggn
+dlG+ g+ + +s ++plnD+qWH V ++r++ + t+++D +
mKIAA0578 1012 FDLGN----GANLIKGSS--NKPLNDNQWHNVMISRDtSNLHTVKIDTKI 1055
pvsges..t.LdldkeesgplylGGlPe.........lpvspgFrGCirn
+++ +++ ++Ldl+ ++ly+GG+ ++ ++ ++ + +gF+GC+ +
mKIAA0578 1056 TTQITAgaRnLDLK----SDLYIGGVAKetykslpklVHAKEGFQGCLAS 1101
lrvngk<-*
+ +ng+
mKIAA0578 1102 VDLNGR 1107
EGF: domain 3 of 3, from 1132 to 1166: score 11.4, E = 25
*->eCa..pCsnGgtEqnGtCi....sytC.CpgpGytg.rCe<-*
C+++ Csn G+C+ ++++C+C ++g+ C
mKIAA0578 1132 TCQedSCSNQ-----GVCLqqwdGFSCdCSMTSFSGpLCN 1166
LamG: domain 6 of 6, from 1194 to 1351: score 81.0, E = 1.4e-19
*->t.lsisfsFrTtspnGlLlyag....ggdflaleLvlEDsdgdGrlv
+ ++ + F T +++++L+ ++++++ gd+l+l+++ +G++
mKIAA0578 1194 RaDRLAIGFSTVQKEAVLVRVDsssgLGDYLELHIH------QGKIG 1234
lrydlGssttggparltsdsdrptplnDGqWHrVsverngrsvtLsVDgg
+ ++ G ++ a+ +s+ +nDG++H V+++r+g+++tL+VD +
mKIAA0578 1235 VKFNVGT---DDIAIEESN----AIINDGKYHVVRFTRSGGNATLQVD-S 1276
npvsges....................................t.Ldldk
pv ++ + +++++++ +++ + + ++ ++ +++++ t ++++
mKIAA0578 1277 WPVIERYpagnndnerlaiarqripyrlgrvvdewlldkgrqlTiFNSQ- 1325
eesgplylGGlPelpvspgFrGCirnlrvngk<-*
+ + +GG ++F+G +++l++ng
mKIAA0578 1326 ---ATIIIGGKE---QGQPFQGQLSGLYYNGL 1351
4.1m: domain 1 of 1, from 1498 to 1516: score 37.3, E = 2e-06
*->myrykkRdkGSYhtnEakg<-*
my+y++Rd+GSYh++E+++
mKIAA0578 1498 MYKYRNRDEGSYHVDESRN 1516
[output cut off at A = 10 top alignments]
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