hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg00030/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0578 ( 1553 res) mbg00030 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Laminin_G_2 Laminin G domain 693.2 1.3e-204 6 Laminin_G_1 Laminin G domain 290.2 2.6e-83 6 EGF EGF-like domain 61.0 2.6e-14 3 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Laminin_G_2 1/6 104 238 .. 1 141 [] 117.0 3.5e-31 Laminin_G_1 1/6 104 241 .. 1 154 [] 51.2 2.4e-11 EGF 1/3 263 301 .. 1 39 [] 15.6 0.56 Laminin_G_2 2/6 358 492 .. 1 141 [] 114.9 1.5e-30 Laminin_G_1 2/6 358 495 .. 1 154 [] 54.5 2.4e-12 Laminin_G_2 3/6 554 698 .. 1 141 [] 153.9 2.7e-42 Laminin_G_1 3/6 554 701 .. 1 154 [] 110.6 3.1e-29 EGF 2/3 726 758 .. 1 39 [] 29.1 0.0001 Laminin_G_2 4/6 792 923 .. 1 141 [] 98.9 1e-25 Laminin_G_1 4/6 792 926 .. 1 154 [] 20.5 0.00016 Laminin_G_2 5/6 979 1107 .. 1 141 [] 141.6 1.4e-38 Laminin_G_1 5/6 979 1110 .. 1 154 [] 61.4 1.9e-14 EGF 3/3 1133 1165 .. 1 39 [] 31.9 1.5e-05 Laminin_G_2 6/6 1202 1351 .. 1 141 [] 83.0 6e-21 Laminin_G_1 6/6 1202 1379 .. 1 154 [] 4.5 0.0043 Alignments of top-scoring domains: Laminin_G_2: domain 1 of 6, from 104 to 238: score 117.0, E = 3.5e-31 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLv.dGrlvlryd ++T +++ Gl+ly +++ +d fl L L ++Grl+l+++ mKIAA0578 104 LKT-RSARGLVLYFDDEgF--------CD-FLELILTrGGRLQLSFS 140 lGsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgss ++++l+ ++++nDG WH+V+++r+ r+ tL +D ++ ++ +++ mKIAA0578 141 IFCAEpATLLADtPVNDGAWHSVRIRRQFRNTTLYIDRAeAKwVeVKSKR 190 dtlslnlngplylGGlpessksslltltaaqn.lvvvs.gFvGCirdvri + + + + l++GGlp++ + +l+lt+a++++ +++F+G irdvr+ mKIAA0578 191 R--DMTVFSGLFVGGLPPELRAAALKLTLASVrE---RePFKGWIRDVRV 235 nge<-* n+ mKIAA0578 236 NSS 238 Laminin_G_1: domain 1 of 6, from 104 to 241: score 51.2, E = 2.4e-11 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleL.vdGrlevsyd +T++ Gl+l Y ++ + DFl l L+++Grl++s++ mKIAA0578 104 LKTRSARGLVL--YFDDEGFC--------DFLELILtRGGRLQLSFS 140 lGsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVd.geervvdg +pa++ + ++ +nDG WH+v ++r r+ tL++d+ e+ v + mKIAA0578 141 IFCA---EPATLLADTP-VNDGAWHSVRIRRQFRNTTLYIDrAEAKWVEV 186 espsgpditsenLdldtppiLyvGGlPel.qksvkrrlaaist...sFkG s+ +d+ +++ L+vGGlP++ ++ +++ +a+++++++FkG mKIAA0578 187 KSK-RRDM----TVFSG---LFVGGLPPElRAAALKLTLASVRerePFKG 228 Cirdvsingkpld<-* irdv++n+ +++ mKIAA0578 229 WIRDVRVNSSQAL 241 EGF: domain 1 of 3, from 263 to 301: score 15.6, E = 0.56 *->Cspnn....gpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +++++g C+ngG C +++ C+C ++ Gk+C mKIAA0578 263 CEAGEegegGVCLNGGVCSVVDDQAVCDCSRT----GFRGKDC 301 Laminin_G_2: domain 2 of 6, from 358 to 492: score 114.9, E = 1.5e-30 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F+T q nGl+l++g + + ++ L L++G + l+++l mKIAA0578 358 FKT-LQRNGLMLHTGKSaD-----------YVNLALKNGAVSLVINL 392 G..sgg.vlltsg.klnDGqWHtVsverngrs........vtLsVDgg.v G++ + ++ ++k+nD+ WH+V+v+rn r++++ ++ vt+sVDg + mKIAA0578 393 GsgAFEaLVEPVNgKFNDNAWHDVKVTRNLRQhsgighamVTISVDGIlT 442 v.g.spgssdtlslnlngplylGGlpessksslltltaaqnlvvvs.gFv +g +++ + +l + +y+GG p +++++ ++ s++F mKIAA0578 443 TtGyTQEDYT--MLGSDDFFYVGGSPSTADLPGSPV---------SnNFM 481 GCirdvringe<-* GC+++v++ ++ mKIAA0578 482 GCLKEVVYKNN 492 Laminin_G_1: domain 2 of 6, from 358 to 495: score 54.5, E = 2.4e-12 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F+T + +Gl l t + + D++ l+L +G + + +l mKIAA0578 358 FKTLQRNGLML----HTGKSA--------DYVNLALKNGAVSLVINL 392 GsghrlrpavvrsgdrvlnDGkWHrvelerngrk........gtLsVdge Gsg ++ v ++++ +nD+ WH v+++rn r++++ ++ +t+sVdg mKIAA0578 393 GSG-AFEALVEPVNGK-FNDNAWHDVKVTRNLRQhsgighamVTISVDGI 440 ervvdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaistsF ++ ++++ ++++ L d+ +yvGG P + ++ ++s F mKIAA0578 441 LTTTGYTQE-DYTM----LGSDDF--FYVGGSP---STADLPGSPVSNNF 480 kGCirdvsingkpld<-* GC+++v+ + + mKIAA0578 481 MGCLKEVVYKNNDVR 495 Laminin_G_2: domain 3 of 6, from 554 to 698: score 153.9, E = 2.7e-42 *->FRTatqpnGlLlyaggk.g...lp.dtadpksdKflaLeLvdGrlvl FRT t+pnGl+l+++gk+ ++++ ++++ k d f+a+e+ dG+l+l mKIAA0578 554 FRT-TEPNGLILFSHGKpRhqkDAkHPQMIKVD-FFAIEMLDGHLYL 598 rydlGsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.sp +d+Gsg+ + ++k+nDG+W++V + r+grs+t+sV+ ++ + ++ mKIAA0578 599 LLDMGSGTiKIKALQkKVNDGEWYHVDFQRDGRSGTISVNTLrTPyTaPG 648 gssdtlslnlngplylGGlpessksslltltaaqn.lvvvs.gFvGCird +s+ +l+l+ +lylGGlpe+ + ++ +++ l + g+vGCird mKIAA0578 649 ESE---ILDLDDELYLGGLPENKAGLVFPTEVWTAlL---NyGYVGCIRD 692 vringe<-* ++i+g+ mKIAA0578 693 LFIDGQ 698 Laminin_G_1: domain 3 of 6, from 554 to 701: score 110.6, E = 3.1e-29 *->FRTtepsGlLllgYn.Gtntdrrgkke...igdDFlaleLvdGrlev FRTtep+Gl+l +G+ ++ ++ k ++ i +DF+a+e+ dG+l++ mKIAA0578 554 FRTTEPNGLIL--FShGKPRHQKDAKHpqmIKVDFFAIEMLDGHLYL 598 sydlGsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervv +d Gsg + + + ++++nDG+W++v r gr+gt+sV+ ++ mKIAA0578 599 LLDMGSG----TIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRT-- 642 dgespsgpditsenLdldtppiLyvGGlPel....qksvkrrlaaistsF +++p+ ++i Ldld++ Ly+GGlPe++ + + ++ + a ++++ mKIAA0578 643 PYTAPGESEI----LDLDDE--LYLGGLPENkaglVFPTEVWTALLNYGY 686 kGCirdvsingkpld<-* +GCird+ i+g+ d mKIAA0578 687 VGCIRDLFIDGQSKD 701 EGF: domain 2 of 3, from 726 to 758: score 29.1, E = 0.0001 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C +n pC+n+G C+d+++ y C+C +y G+ C mKIAA0578 726 CLSN--PCKNNGMCRDGWNRYVCDCSGT----GYLGRSC 758 Laminin_G_2: domain 4 of 6, from 792 to 923: score 98.9, E = 1e-25 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl FR ++ G+L+ + ++++ d l LeL Gr++l+++l mKIAA0578 792 FRS-QRAYGILMATTSRdS--------AD-TLRLELDAGRVKLTVNL 828 G........sgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv. + + ++s+g+ +l+ g +lnD++WHtV+v+r+g+s+ L+VD++++++ mKIAA0578 829 DcirincnsSKGpETLFAGyNLNDNEWHTVRVVRRGKSLKLTVDDQqAMt 878 g.spgssdtlslnlngp.lylGGlpessksslltltaaqnlvvvs.gFvG g+ g+++ l+ + + G+ +++ + + ++F G mKIAA0578 879 GqMAGDHT--RLEFHNIeT---GIITERRYLSSV----------PsNFIG 913 Cirdvringe<-* ++++++ng mKIAA0578 914 HLQSLTFNGM 923 Laminin_G_1: domain 4 of 6, from 792 to 926: score 20.5, E = 0.00016 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl FR G+L+ +t +++ D l leL Gr++++++l mKIAA0578 792 FRSQRAYGILM----ATTSRDSA------DTLRLELDAGRVKLTVNL 828 .........GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdg + + + ++++g p+++++g + lnD++WH+v ++r g+++ L Vd+ mKIAA0578 829 dcirincnsSKG----PETLFAGYN-LNDNEWHTVRVVRRGKSLKLTVDD 873 eervvdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaists + +++ + g ++ e+ + +t G+ ++ r+l + + mKIAA0578 874 QQ--AMTGQMAGDHTRLEFHNIET-------GII----TERRYLSSVPSN 910 FkGCirdvsingkpld<-* F G ++++ +ng+ + mKIAA0578 911 FIGHLQSLTFNGMAYI 926 Laminin_G_2: domain 5 of 6, from 979 to 1107: score 141.6, E = 1.4e-38 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F+T t+ +Gl+ly++g+++ d f+ +eLv G+l++++dl mKIAA0578 979 FKT-TSLDGLILYNSGDgN---------D-FIVVELVKGYLHYVFDL 1014 G.sgg.vlltsg.klnDGqWHtVsverngrs.vtLsVDgg.vv.g.spgs G++ + +s+++lnD+qWH+V ++r+ ++ t+++D + + +++++ mKIAA0578 1015 GnGANlIKGSSNkPLNDNQWHNVMISRDTSNlHTVKIDTKiTTqItAGAR 1064 sdtlslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvri +l+l+++ly+GG+ ++ +sl++l +a +gF+GC+ +v + mKIAA0578 1065 ----NLDLKSDLYIGGVAKETYKSLPKLVHA------KeGFQGCLASVDL 1104 nge<-* ng+ mKIAA0578 1105 NGR 1107 Laminin_G_1: domain 5 of 6, from 979 to 1110: score 61.4, E = 1.9e-14 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F+Tt+ +Gl+l Yn + ++ DF+++eLv+G l++ +dl mKIAA0578 979 FKTTSLDGLIL--YN-SGDGN--------DFIVVELVKGYLHYVFDL 1014 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkg.tLsVd.geervvdg G+g + s+++ lnD++WH v ++r +++++t+++d++ + mKIAA0578 1015 GNG--ANLIKGSSNKP-LNDNQWHNVMISRDTSNLhTVKIDtKITT---Q 1058 espsgpditsenLdldtppiLyvGGlPelqksvkrrlaaistsFkGCird + g+ + Ldl+ Ly+GG ++ + +++l + +F GC+ + mKIAA0578 1059 ITA-GARN----LDLKSD--LYIGGVAKETYKSLPKLVHAKEGFQGCLAS 1101 vsingkpld<-* v++ng++ d mKIAA0578 1102 VDLNGRLPD 1110 EGF: domain 3 of 3, from 1133 to 1165: score 31.9, E = 1.5e-05 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+++ Csn G C++ ++g++C+C + +++G+ C mKIAA0578 1133 CQED--SCSNQGVCLQQWDGFSCDCSMT----SFSGPLC 1165 Laminin_G_2: domain 6 of 6, from 1202 to 1351: score 83.0, E = 6e-21 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F T q++++L + +++g +d +l L +++G++ + ++ mKIAA0578 1202 FST-VQKEAVLVRVDSSsG-------LGD-YLELHIHQGKIGVKFNV 1239 Gsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssd G+++ ++ s+ +nDG+ H V+++r+g+++tL+VD +v ++ + g++d mKIAA0578 1240 GTDDiAIEESNaIINDGKYHVVRFTRSGGNATLQVDSWpVIeRyPAGNND 1289 tl.............................slnlngplylGGlpessks + +++ + + ++ ++ +++++ +++n + + +GG mKIAA0578 1290 NErlaiarqripyrlgrvvdewlldkgrqltIFNSQATIIIGGKEQ---- 1335 slltltaaqnlvvvs.gFvGCirdvringe<-* ++F+G ++++++ng mKIAA0578 1336 --------------GqPFQGQLSGLYYNGL 1351 Laminin_G_1: domain 6 of 6, from 1202 to 1379: score 4.5, E = 0.0043 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F+T + +++L ++ + + D+l l ++ G++ v++++ mKIAA0578 1202 FSTVQKEAVLV--RVDSSSGLG-------DYLELHIHQGKIGVKFNV 1239 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeer...... G + + +nDGk+H v +r+g ++tL+Vd + ++ + mKIAA0578 1240 GTD----DIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVierypa 1285 .......................................vvdgespsgpd +++++++ +++ + + ++ ++ +++++ + ++ ++++ ++ mKIAA0578 1286 gnndnerlaiarqripyrlgrvvdewlldkgrqltifnsQATIIIGGKEQ 1335 itsenLdldtppiLyvGGlPelqksvkrrlaaistsFkGCirdvsingkp +++ + +l++ Ly Gl +l+++ ++ + + +++G +r ++++p mKIAA0578 1336 GQPFQGQLSG---LYYNGLKVLNMAAENDA---NIAIVGNVR--LVGEVP 1377 ld<-* mKIAA0578 1378 SS 1379 //