hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/msh/msh37311/w3open/interpro/cnk_1/seq.in
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  mKIAA0538  ( 826 res)   msh37311

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RasGAP   GTPase-activator protein for Ras-like GTPase   477.6     6e-139   1
C2       Protein kinase C conserved region 2 (CalB)     159.1    4.6e-43   2
PH       Pleckstrin homology domain.                     53.8    2.3e-11   1
BTK      Bruton's tyrosine kinase Cys-rich motif         27.8    0.00066   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
C2         1/2      30   127 ..     1    92 []    71.6  9.9e-17
C2         2/2     158   255 ..     1    92 []    87.5  1.6e-21
RasGAP     1/1     267   628 ..     1   390 []   477.6   6e-139
PH         1/1     590   698 ..     1    82 []    53.8  2.3e-11
BTK        1/1     698   734 ..     1    37 []    27.8  0.00066

Alignments of top-scoring domains:
C2: domain 1 of 2, from 30 to 127: score 71.6, E = 9.9e-17
                   *->tLtvkiisArnLp........DPYVkvs.......kTkvvkktlsgf
                      +L ++i++++nLp ++ ++++DPY++v+ ++ +  +T +v ktl   
   mKIAA0538    30    SLSIRIVEGKNLPakditgssDPYCIVKvdnepiiRTATVWKTL--- 73   

                   NPvWnEesetFeFevpp..s.LeieVyDk......dfiGrvtippnnahq
                   +P+W+E    +++++pp+ +++ + V+D++  +++d+iG+v++       
   mKIAA0538    74 CPFWGE---DYQVHLPPtfHtVAFYVMDEdalsrdDVIGKVCLT------ 114  

                   hsadglihlsell.ggrh.kl<-*
                            + l ++++       
   mKIAA0538   115 --------RDALAsHPKGfSG    127  

C2: domain 2 of 2, from 158 to 255: score 87.5, E = 1.6e-21
                   *->tLtvkiisArnLp........DPYVkvs......kTkvvkktlsgfN
                      +L++ +++Ar+L ++++++ +DP+V+v+ +++++ T+vvkk++    
   mKIAA0538   158    RLRCAVLEARDLApkdrngasDPFVRVHyngrtqETSVVKKSC---Y 201  

                   PvWnEesetFeFevpp...s.LeieVyDk......dfiGrvtippnnahq
                   P+WnE   tF+Fe+  + +  L +e +D++  + +df+G+v+++      
   mKIAA0538   202 PRWNE---TFDFELEKgasEaLLVEAWDWdlvsqnDFLGKVVVN------ 242  

                   hsadglihlsell.ggrh.kl<-*
                           +++l++ +  +++   
   mKIAA0538   243 --------VQRLCsAQQEeGW    255  

RasGAP: domain 1 of 1, from 267 to 628: score 477.6, E = 6e-139
                   *->lkqgelgslrlktvyttdfilpseaYeeLleLllesvd.vepltasl
                      + +g+lgsl+l+++++++++lps  Y++L++Ll+++v+ + ++++ l
   mKIAA0538   267    QGKGNLGSLQLEVRLRDETVLPSVCYQPLVQLLCQEVKlGTQGPGRL 313  

                   asaleevcsvldkdelAtkLvrlFlrrgrgkpfLraLidkEvertddpvn
                   + ++ee  s ++++e+At L++lFl++g++k+fL+ L++ E+ rt+++ n
   mKIAA0538   314 IPVIEETTSAECRQEVATTLLKLFLGQGLAKDFLDLLFQLELGRTSEA-N 362  

                   tlFRgNsLatKsmevymklvGnqYLhttLkpvLkkiveekkescEvDPsK
                   tlFR+NsLa+Ksme+++k++G++YLh  L+p++++++eekk ++E+DPsK
   mKIAA0538   363 TLFRSNSLASKSMESFLKVAGMRYLHGILGPIIDRVFEEKK-YVELDPSK 411  

                   levndv.iSf.gdpv.egedletnlenLlqyverlfdaIinSsdrlPygL
                   +ev+dv++S+ ++p++e e+le++++ L++++  l++aI +S++ +P  +
   mKIAA0538   412 VEVKDVgCSGlHRPQtEAEVLEQSAQTLRAHLVALLSAICRSVRTCPAII 461  

                   RdickqLrqaaekrFpsa.tqdvrykaVssFvFLRFfcPAIlSPklFnLv
                   R  ++qL++++++rFp+a++q+v ++aV sF++LRFf PAIlSPklF+L+
   mKIAA0538   462 RATFRQLFRRVRERFPNAqHQNVPFIAVTSFLCLRFFSPAILSPKLFHLR 511  

                   dehpdpttrRtLtLiAKvlQnLANlsesksklfgsKEpwmeplfkndflk
                   ++h+d++t+RtL+L+AK++Qn++N+++   +  ++KE wmepl  +++++
   mKIAA0538   512 ERHADARTSRTLLLLAKAVQNIGNMDT---PVSRAKESWMEPL--QPTVR 556  

                   qhkdrvkdFLdelssvdepsesLvdkveelptkskPVstisgrelsllHs
                   q + ++kdF+ +l+          d +e+ +        +++r l  +++
   mKIAA0538   557 QGVAQLKDFIMKLV----------DIEEKEE-------LDLQRALNSQAP 589  

                   lllengdalkrkknnnrDHKAlgedpldkllfklryfrltthkltngk<-
                    + e ++ ++r k+         ++pl    fk+ yf ltt+ l+ +k  
   mKIAA0538   590 PVKEGPLFIHRTKG---------KGPLASSSFKKLYFSLTTEALSFAK   628  

                   *
                    
   mKIAA0538     -   -    

PH: domain 1 of 1, from 590 to 698: score 53.8, E = 2.3e-11
                   *->vikeGwLlkks........k.swkkryfvLfngvLlyyksk..kpkg
                      ++keG L +  ++++++  ++s+kk yf L++  L++ k +++k++ 
   mKIAA0538   590    PVKEGPLFIHRtkgkgplaSsSFKKLYFSLTTEALSFAKTSssKKST 636  

                   sipLsgcsvre.p.........cFeivt.dr.....tlllqAeseeeree
                   +i L +++  e++++++ ++++  ++++ d  ++ +t +lq++   e+++
   mKIAA0538   637 FIKLASIRAAEkVeeksfgsshIMQVIYaDDvgraqTVYLQCKCVNELNQ 686  

                   Wvealqsaiaka<-*
                   W++al++a+ ++   
   mKIAA0538   687 WLSALRKASTNN    698  

BTK: domain 1 of 1, from 698 to 734: score 27.8, E = 0.00066
                   *->NnnllqkYHPsFwvdGkwlCCqqseKnApGCkpyeag<-*
                      N  ll +YHP+ +   kw+CC q +K+  GC + + +   
   mKIAA0538   698    NRGLLRSYHPGIFRGDKWSCCHQKDKTDQGCDKTHSR    734  

//