hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/msh/msh37311/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0538  ( 826 res)   msh37311

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
C2       C2 domain                                      214.0    2.2e-60   2
RasGAP   GTPase-activator protein for Ras-like GTPase   129.9    4.5e-35   1
PH       PH domain                                       44.2      3e-09   1
BTK      BTK motif                                       26.1      9e-05   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
C2         1/2      31   112 ..     1    88 []   107.3    3e-28
C2         2/2     159   240 ..     1    88 []   107.1  3.5e-28
RasGAP     1/1     346   536 ..     1   231 []   129.9  4.5e-35
PH         1/1     590   696 ..     1    92 []    44.2    3e-09
BTK        1/1     698   734 ..     1    37 []    26.1    9e-05

Alignments of top-scoring domains:
C2: domain 1 of 2, from 31 to 112: score 107.3, E = 3e-28
                   *->LrVtvieAknLppkDfkngksDPYVkvslggdkkdqkkkTkvikktl
                      L+++++e+knLp+kD ++g+sDPY+ v+++++++    +T +++ktl
   mKIAA0538    31    LSIRIVEGKNLPAKD-ITGSSDPYCIVKVDNEPI---IRTATVWKTL 73   

                   NPvWNEtFtFevpppdlqetLeieVyDydrfgrddflGevs<-*
                   +P W E+++++  pp+++  + + V+D+d ++rdd++G+v+   
   mKIAA0538    74 CPFWGEDYQVH-LPPTFHT-VAFYVMDEDALSRDDVIGKVC    112  

C2: domain 2 of 2, from 159 to 240: score 107.1, E = 3.5e-28
                   *->LrVtvieAknLppkDfkngksDPYVkvslggdkkdqkkkTkvikktl
                      Lr+ v+eA++L+pkD +ng sDP+V+v+++g     ++ T+v+kk++
   mKIAA0538   159    LRCAVLEARDLAPKD-RNGASDPFVRVHYNG----RTQETSVVKKSC 200  

                   NPvWNEtFtFevpppdlqe.tLeieVyDydrfgrddflGevs<-*
                    P+WNEtF+Fe  +++++++ L +e +D+d ++ +dflG+v+   
   mKIAA0538   201 YPRWNETFDFE--LEKGASeALLVEAWDWDLVSQNDFLGKVV    240  

RasGAP: domain 1 of 1, from 346 to 536: score 129.9, E = 4.5e-35
                   *->LvktllqkEIeSkaddpttlfRgNslaskmleqyfRrarGneYLrkt
                       +  l+q E+  ++++++tlfR Nslask++e++ ++a G  YL+ +
   mKIAA0538   346    FLDLLFQLELG-RTSEANTLFRSNSLASKSMESFLKVA-GMRYLHGI 390  

                   LrpvLkeIieskdWqHLscEiDPlkvykklVNqgelstsEldydlTnEev
                   L p++ ++ e+k+      E+DP+kv  k              d+     
   mKIAA0538   391 LGPIIDRVFEEKK----YVELDPSKVEVK--------------DVGCSGL 422  

                   ldeeekseaieenlrnLlkyteklleaItsSsdefPpeLryIckclrqsa
                          e +e +   L++ +  ll+aI  S+  +P  +r  +  l   +
   mKIAA0538   423 HRPQTEAEVLEQSAQTLRAHLVALLSAICRSVRTCPAIIRATFRQLFRRV 472  

                   cekFPdnatVKEKKENKKSVVSqRFeqvilsavGgfvFLRFinPAIvsPd
                    e FP++                    v  +av +f+ LRF+ PAI+sP+
   mKIAA0538   473 RERFPNA----------------QHQNVPFIAVTSFLCLRFFSPAILSPK 506  

                   lfnIidkspsaqaTTDqrRtLtliAKviQslANg<-*
                   lf +    ++a++    +RtL l+AK +Q+++N    
   mKIAA0538   507 LFHLRERHADART----SRTLLLLAKAVQNIGNM    536  

PH: domain 1 of 1, from 590 to 696: score 44.2, E = 3e-09
                   *->vikeGwLlkkg.......gkkswkkRyfvLfndvLlyykdkk...kk
                      ++keG L+   ++++++ + +s+kk yf L++  L++ k +++++++
   mKIAA0538   590    PVKEGPLFIHRtkgkgplASSSFKKLYFSLTTEALSFAKTSSskkST 636  

                   pkgsipLsgi.qvekvpdnkrkncFeirt.dr....etlllqaeseeerk
                    ++  +++ +++ve+ + +   +  +++  d  ++ +t++lq++   e++
   mKIAA0538   637 FIKLASIRAAeKVEEKSFG-SSHIMQVIYaDDvgraQTVYLQCKCVNELN 685  

                   eWvkaiqsair<-*
                   +W++a+++a+    
   mKIAA0538   686 QWLSALRKAST    696  

BTK: domain 1 of 1, from 698 to 734: score 26.1, E = 9e-05
                   *->NnnllqkYHPsfwvdGkwlCCqqteKnApGCkkveag<-*
                      N  ll  YHP+ +   kw+CC q +K+  GC k + +   
   mKIAA0538   698    NRGLLRSYHPGIFRGDKWSCCHQKDKTDQGCDKTHSR    734  

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