hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpf/mpf00179/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0534 ( 1444 res) mpf00179 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PSI Plexin repeat 156.9 3.5e-43 5 Kelch_1 Kelch motif 97.7 2.3e-25 5 Kelch_2 Kelch motif 75.6 1e-18 6 CUB CUB domain 62.8 7.5e-15 1 Lectin_C Lectin C-type domain 43.9 3.6e-09 1 EGF_2 EGF-like domain 42.4 1e-08 5 Laminin_EGF Laminin EGF-like (Domains III and V) 29.9 5.7e-05 2 DSL Delta serrate ligand -5.0 0.22 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- EGF_2 1/5 128 155 .. 1 37 [] 16.9 0.28 CUB 1/1 158 271 .. 1 116 [] 62.8 7.5e-15 EGF_2 2/5 276 309 .. 1 37 [] 15.0 0.45 DSL 1/1 284 345 .. 1 67 [] -5.0 0.22 EGF_2 3/5 314 345 .. 1 37 [] 33.9 3.7e-06 Kelch_2 1/6 369 415 .. 1 54 [] 8.0 22 Kelch_1 1/5 369 415 .. 1 45 [] 17.3 0.3 Kelch_2 2/6 419 467 .. 1 54 [] 27.2 0.00039 Kelch_1 2/5 419 467 .. 1 45 [] 26.6 0.0006 Kelch_1 3/5 531 583 .. 1 45 [] 6.4 4.9 Kelch_2 3/6 531 583 .. 1 54 [] 7.5 26 Kelch_1 4/5 585 639 .. 1 45 [] 30.3 4.5e-05 Kelch_2 4/6 585 639 .. 1 54 [] 18.7 0.14 Kelch_1 5/5 645 689 .. 1 45 [] 21.8 0.016 Kelch_2 5/6 645 689 .. 1 54 [] 14.2 3.2 PSI 1/5 679 722 .. 1 63 [] 16.1 0.018 PSI 2/5 731 774 .. 1 63 [] 29.0 0.00011 PSI 3/5 780 825 .. 1 63 [] 29.6 7.3e-05 Lectin_C 1/1 830 939 .. 1 125 [] 43.9 3.6e-09 PSI 4/5 954 1004 .. 1 63 [] 59.6 6.6e-14 PSI 5/5 1007 1077 .. 1 63 [] 50.8 3.1e-11 Kelch_2 6/6 1033 1078 .. 1 54 [] 4.0 75 EGF_2 4/5 1079 1105 .. 1 37 [] 2.0 13 Laminin_EGF 1/2 1079 1122 .. 1 59 [] 33.8 3.8e-06 EGF_2 5/5 1125 1153 .. 1 37 [] 5.0 5.8 Laminin_EGF 2/2 1125 1171 .. 1 59 [] 4.1 0.057 Alignments of top-scoring domains: EGF_2: domain 1 of 5, from 128 to 155: score 16.9, E = 0.28 *->C.....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+++++C G+Cv+ C Cd+g + G++C mKIAA0534 128 CertgsCF--SGRCVNS--------TCLCDPG----WVGDQC 155 CUB: domain 1 of 1, from 158 to 271: score 62.8, E = 7.5e-15 *->CGgtldltessGsitSPnYPnrdYppnkeCvWrIrappgyrvVeLtF C g++ lte+sG++t ++P +Y ++ C+W+I+ p+ L+F mKIAA0534 158 CQGRFKLTEPSGYLT--DGPI-NYKYKTKCTWLIEGYPNAV-LRLRF 200 qdFdlEdhdgaCryDyvEirDGdpssspllGrfCG.......gsgpPedi +F +E C +D+ ++DGd+ ++pl++ G ++ +g + + + mKIAA0534 201 NHFATE-----CSWDHMYVYDGDSIYAPLVAVLSGlivpevrGNETVPEV 245 rStsnrmlikFvsDasvqkrGFkAty<-* ++ts l+ F sDa + GF++ y mKIAA0534 246 VTTSGYALLHFFSDAAYNLTGFNIFY 271 EGF_2: domain 2 of 5, from 276 to 309: score 15.0, E = 0.45 *->C...CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+++C+g hG+C + + C+Cd+ + G +C mKIAA0534 276 CpnnCSG-HGKCTTSVS-VASQVYCECDKY----WKGEAC 309 DSL: domain 1 of 1, from 284 to 345: score -5.0, E = 0.22 *->WktdkhiggrtslGfnleyqiRvtCdenYYGegCnk.FCrPrdDafg +k ++ + + q+ Cd+++ Ge C ++C ++ + mKIAA0534 284 GKCTTSVSVAS--------QVYCECDKYWKGEACDIpYCKANCGSPD 322 HytCdenGnkl..ClnGWkGeyC<-* H Cd +G+kl C++ W+G++C mKIAA0534 323 HGYCDLTGEKLcvCNDSWQGPDC 345 EGF_2: domain 3 of 5, from 314 to 345: score 33.9, E = 3.7e-06 *->C...Cngs.hGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+ +C+ ++hG+C+ ++ + CvC+++ +qG+dC mKIAA0534 314 CkanCGSPdHGYCDLTGE-----KLCVCNDS----WQGPDC 345 Kelch_2: domain 1 of 6, from 369 to 415: score 8.0, E = 22 *->pryphasvvpggklyvvGGsfkgnrgtgngdesssdllvldpetnvW +r++h +v+ g + v+GG+ + +s+ +l +++e+ W mKIAA0534 369 GRASHKAVLHGKFMWVIGGY-------TFNYSSFQMVLNYNLESSIW 408 eklpalp<-* ++ mKIAA0534 409 NVGAVSR 415 Kelch_1: domain 1 of 5, from 369 to 415: score 17.3, E = 0.3 *->pRsgagvvvldgkiYviGGydg..qslnsvevYDpetntWtklpsmp R+++ +v ++ ++viGGy+ + +s+ v Y++e+ W ++ + mKIAA0534 369 GRASHKAVLHGKFMWVIGGYTFnySSFQMVLNYNLESSIWNVGAVSR 415 <-* mKIAA0534 - - Kelch_2: domain 2 of 6, from 419 to 467: score 27.2, E = 0.00039 *->pryphasvvpggklyvvGGsfkgnrgtgngdesssdllvldpetnvW +ry+h+++++++ ++++GG+ + ++ +++ l+v++ ++++W mKIAA0534 419 QRYGHSLALYQENIFMYGGR-----METSDGNVTDELWVFNVRSQSW 460 eklpalp<-* + ++ mKIAA0534 461 STKTPTV 467 Kelch_1: domain 2 of 5, from 419 to 467: score 26.6, E = 0.0006 *->pRsgagvvvldgkiYviGGydg....qslnsvevYDpetntWtklps R+g++ + ++ i+ GG+ +++++ ++ +v+++++++W+ ++ mKIAA0534 419 QRYGHSLALYQENIFMYGGRMEtsdgNVTDELWVFNVRSQSWSTKTP 465 mp<-* mKIAA0534 466 TV 467 Kelch_1: domain 3 of 5, from 531 to 583: score 6.4, E = 4.9 *->pRsgagvvv..ldgkiYviGGydg......qslnsvevYDpetntWt +g+++v++++ iYv GGy ++++ +++ ++Y + t tWt mKIAA0534 531 GGYGHTSVYdeVTKSIYVHGGYKAlpgnkyGLVDDLYKYEVNTRTWT 577 klpsmp<-* +l + + mKIAA0534 578 ILKESG 583 Kelch_2: domain 3 of 6, from 531 to 583: score 7.5, E = 26 *->pryphasv..vpggklyvvGGsfkgnrgtgngdesssdllvldpetn + y+h+sv + + +yv GG+ + +gn+ + +dl+ + +t+ mKIAA0534 531 GGYGHTSVydEVTKSIYVHGGY---KALPGNKYGLVDDLYKYEVNTR 574 vWeklpalp<-* +W+ l+ + mKIAA0534 575 TWTILKESG 583 Kelch_1: domain 4 of 5, from 585 to 639: score 30.3, E = 4.5e-05 *->pRsgagvvvldgkiYviGGydg..........qslnsvevYDpetnt +R+ +++v ++g + ++GG + ++++ +++ + ++ ++ +YD ++ mKIAA0534 585 ARYLHSAVLINGAMLIFGGNTHndtslsngakCFSADFLAYDIACDE 631 Wtklpsmp<-* W+ lp ++ mKIAA0534 632 WKTLPKPN 639 Kelch_2: domain 4 of 6, from 585 to 639: score 18.7, E = 0.14 *->pryphasvvpggklyvvGGs.fkgnrgtgngdesssdllvldpetnv ry h++v+++g ++++GG + ++ + + ++s d+l +d + mKIAA0534 585 ARYLHSAVLINGAMLIFGGNtHNDTSLSNGAKCFSADFLAYDIACDE 631 Weklpalp<-* W+ lp++ mKIAA0534 632 WKTLPKPN 639 Kelch_1: domain 5 of 5, from 645 to 689: score 21.8, E = 0.016 *->pRsgagvvvldgkiYviGGydgqslnsvevYDpetntWtklpsmp<- R g+++vv++g +Y++GG++++ ln++ vY p + + + ++ mKIAA0534 645 NRFGHSAVVINGSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELC 689 * mKIAA0534 - - Kelch_2: domain 5 of 6, from 645 to 689: score 14.2, E = 3.2 *->pryphasvvpggklyvvGGsfkgnrgtgngdesssdllvldpetnvW +r +h++vv++g +y++GG+ + +++d+lv++p + mKIAA0534 645 NRFGHSAVVINGSMYIFGGF---------SSVLLNDILVYKPPNCKA 682 eklpalp<-* + l+ mKIAA0534 683 FRDEELC 689 PSI: domain 1 of 5, from 679 to 722: score 16.1, E = 0.018 *->nCsqytsCssCLaardpfyCgWCssegrCtrgsaytsfyGeCpraep nC ++++ C +a + C W ++ +C +++ +G+ ++ mKIAA0534 679 NCKAFRDEELCRNAGPGIKCVWNKN--HCESWE-----SGNTNNIL- 717 endqwldwswssskCp<-* +kCp mKIAA0534 718 -----------RAKCP 722 PSI: domain 2 of 5, from 731 to 774: score 29.0, E = 0.00011 *->nCsqytsCssCLaardpfyCgWCssegrCtrgsaytsfyGeCpraep +C +y +C+sC+a+ +C+WC + ++C++ s+ +C+ ++ mKIAA0534 731 RCYRYADCASCTANTN--GCQWCDD-KKCISASS------NCSTSV- 767 endqwldwswssskCp<-* + kC mKIAA0534 768 ---------RNYTKCH 774 PSI: domain 3 of 5, from 780 to 825: score 29.6, E = 7.3e-05 *->nCsqytsCssCLaardpfyCgWCssegrCtrgsaytsfyGeCpraep C +tsC sC ++ +C+W+++++ C +a+ C +++ mKIAA0534 780 ICNKLTSCKSCSLNL---NCQWDQRQQECQALPAH-----LCGEGW- 817 endqwldwswssskCp<-* n ++++ C mKIAA0534 818 -N-------HVGDACL 825 Lectin_C: domain 1 of 1, from 830 to 939: score 43.9, E = 3.6e-09 *->esktWaeAelaCqkegghAHLvsIqsaeEqsfvvafltsltkksnty ++ +++ A+l+C ++ g+ L+s + E fv + ++++t + + mKIAA0534 830 SRESYDNAKLYCYNLSGN--LASLTTSKEVEFVLDEIQKFTQ-QKVS 873 aWIGLtdintegtwvwegwetdgspvnyt.enWapgePnnrgnhGgnEdC W+GL++in + +w w d+sp ++t+ W pgePn+ ++C mKIAA0534 874 PWVGLRKINIS-YWGW----EDMSPFTNTsLQWLPGEPND------SGFC 912 veiytdtdflaGkWnDepCdskl.pyvCef<-* + + + + ++ +pC s+ ++ vCe+ mKIAA0534 913 AYLERAAV---AGLKANPCTSMAdGLVCEK 939 PSI: domain 4 of 5, from 954 to 1004: score 59.6, E = 6.6e-14 *->nCsqytsCssCLaardpfyCgWCssegrCtrgsayt.sf.yGeCpra +Cs +tsC+ C+++ +C+WCss++rC+ +ay+ sf+yG+C ++ mKIAA0534 954 PCSLRTSCANCTSSGM--ECMWCSSTKRCVDSNAYIiSFpYGQCLEW 998 ependqwldwswssskCp<-* + +++C mKIAA0534 999 Q------------TATCS 1004 PSI: domain 5 of 5, from 1007 to 1077: score 50.8, E = 3.1e-11 *->nCsqytsCssCLaardpfyCgWCss.....egrCtrgsayt.s.... nCs++++C++CL+ + +CgWC++++++++g C+ gs++++++ + mKIAA0534 1007 NCSGLRTCGQCLEQP---GCGWCNDpsntgRGYCIEGSSRGpMklvg 1050 .......f.yGeCprae.pendqwldwswssskCp<-* ++++ +++ Cp +++e ws+ +Cp mKIAA0534 1051 vhnsdvvLdTSLCPKEKnYE--------WSFIQCP 1077 Kelch_2: domain 6 of 6, from 1033 to 1078: score 4.0, E = 75 *->pryphasvvpggklyvvGGsfkgnrgtgngdesssdllvldpetnvW +r+ ++ +++g + +vG + n d ++++ l+++++ ++W mKIAA0534 1033 GRGYCIEGSSRGPMKLVGVH--------NSDVVLDTSLCPKEKNYEW 1071 eklpalp<-* + ++++ mKIAA0534 1072 SFIQCPA 1078 EGF_2: domain 4 of 5, from 1079 to 1105: score 2.0, E = 13 *->C.CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+Cng h tC+++n+ c++C+ G +C mKIAA0534 1079 CqCNG-HSTCINNNV----CEQCKNLTT------GRQC 1105 Laminin_EGF: domain 1 of 2, from 1079 to 1122: score 33.8, E = 3.8e-06 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy C+Cn+h+ tC +C Ck +tGr+C +C+pGy mKIAA0534 1079 CQCNGHS-----TCIN--------NNVCEQCKNLTTGRQCQECMPGY 1112 yglpsgdpgqgC<-* yg+p+ + g +C mKIAA0534 1113 YGDPT-NGG-QC 1122 EGF_2: domain 5 of 5, from 1125 to 1153: score 5.0, E = 5.8 *->C.Cngs.hGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+C+g+ + +C+ +gkC C+ + G++C mKIAA0534 1125 CtCGGHaN-VCHLH------TGKCFCTTK---GIKGDQC 1153 Laminin_EGF: domain 2 of 2, from 1125 to 1171: score 4.1, E = 0.057 *->CdCnphGslsddtCdsddelfgeetGqClkCkp.nvtGrrCdrC..k C+C +h+ C++ +tG C C ++ G++C C+++ mKIAA0534 1125 CTCGGHA----NVCHL-------HTGKCF-CTTkGIKGDQCQLCdsE 1159 pGyyglpsgdpgqgC<-* y g+ ++ C mKIAA0534 1160 NRYVGN---PLRGTC 1171 //