hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpf/mpf00729/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0533 ( 1702 res) mpf00729 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Laminin_G_2 Laminin G domain 305.6 5.9e-88 5 Laminin_I Laminin Domain I 161.1 1.9e-44 1 Laminin_EGF Laminin EGF-like (Domains III and V) 92.0 1.2e-23 4 Laminin_II Laminin Domain II 55.7 1e-12 1 Laminin_G_1 Laminin G domain 47.9 2.3e-10 3 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Laminin_EGF 1/4 107 154 .. 1 59 [] 46.6 5.6e-10 Laminin_EGF 2/4 157 195 .. 1 59 [] 13.9 0.0059 Laminin_EGF 3/4 198 242 .. 1 59 [] 50.1 5.1e-11 Laminin_EGF 4/4 245 292 .. 1 59 [] 6.2 0.035 Laminin_I 1/1 319 543 .. 1 278 [] 161.1 1.9e-44 Laminin_II 1/1 634 775 .. 1 144 [] 55.7 1e-12 Laminin_G_2 1/5 790 923 .. 1 141 [] 11.5 0.061 Laminin_G_2 2/5 985 1114 .. 1 141 [] 51.2 2.2e-11 Laminin_G_1 1/3 985 1117 .. 1 154 [] 5.6 0.0035 Laminin_G_2 3/5 1168 1285 .. 1 141 [] 67.4 3.1e-16 Laminin_G_2 4/5 1378 1508 .. 1 141 [] 88.7 1.2e-22 Laminin_G_1 2/3 1382 1511 .. 1 154 [] 14.6 0.00054 Laminin_G_2 5/5 1558 1681 .. 1 141 [] 88.3 1.6e-22 Laminin_G_1 3/3 1558 1684 .. 1 154 [] 27.9 3.4e-05 Alignments of top-scoring domains: Laminin_EGF: domain 1 of 4, from 107 to 154: score 46.6, E = 5.6e-10 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy C+C++h+ d+C + +G C++C++n++G++C+rC+pG+ mKIAA0533 107 CQCHGHS----DRCLP-------GSGICVGCQHNTEGDQCERCRPGF 142 yg.lpsgdpgqgC<-* ++ps +p+ C mKIAA0533 143 VSsDPS-NPASPC 154 Laminin_EGF: domain 2 of 4, from 157 to 195: score 13.9, E = 0.0059 *->CdCnphGslsd..dtCdsddelfgeetGqClkCkpnvtGrrCdrCkp C C+++ +++ d C + + G+C+ rC++ mKIAA0533 157 CPCPLAVPSNNfaDGCVL-------RNGRCD------------RCLE 184 GyyglpsgdpgqgC<-* Gy+g+ +qgC mKIAA0533 185 GYFGF---EQCQGC 195 Laminin_EGF: domain 3 of 4, from 198 to 242: score 50.1, E = 5.1e-11 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy C+C p++ + ++C++ +GqC+ C+p++tG++C +C+pGy mKIAA0533 198 CACGPAA-KG-SECHP-------QSGQCH-CQPGTTGPQCLECAPGY 234 yglpsgdpgqgC<-* +gl gC mKIAA0533 235 WGL---PEK-GC 242 Laminin_EGF: domain 4 of 4, from 245 to 292: score 6.2, E = 0.035 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy C+C+ Cd+ +tG+C C p+ +G+rCd C + mKIAA0533 245 CQCPRGH------CDP-------HTGHCT-CPPGLSGERCDTCSQQH 277 y....glpsgdpgqgC<-* + +g p + g C mKIAA0533 278 QvpvpGKPG-GHGIHC 292 Laminin_I: domain 1 of 1, from 319 to 543: score 161.1, E = 1.9e-44 *->qLdsvGDAllnlNlTglspapyrkLselentakdLqtqLlerlspls qL+++ ++s+a++++L++l+++++dLq++L+++ +p+ mKIAA0533 319 QLQGI----------NASSAAWARLHRLNASIADLQSKLRSPPGPRY 355 kegiqidgaekklskLaqdaenLqekanqalakaqkvnaeiertlgnAkt ++q++ +e+++ +L qd+e+L+ +a a++ +q mKIAA0533 356 QAAQQLQTLEQQSISLQQDTERLGSQAELASRMGQ--------------- 390 LaeaiknlrdnikeilsklaglgeTlanaealpseaLsemlaeAqrmLee + +g a +++e+L +lae++r+L+ mKIAA0533 391 -------------------GSPGD----ALVPSGEQLRWALAEVERLLWD 417 tirsrdpftkhlqeaeaelkaAqeLLsrvtAqellqklqeenksLaealr +r rd ++++ ++aeael++Aq+L +rv qe+l + +een+sLa+ +r mKIAA0533 418 -MRTRD-LGAQGAVAEAELAEAQRLMARV--QEQLTSFWEENQSLATHIR 463 ddLndynakLsDlrelldeAqaktrdAerlnlanqkrlreieekkeevee d+L++y+ +L+Dlre+l++A++ tr+Ae+ln++nq+rl+e+ + k+e++ mKIAA0533 464 DQLAQYESGLMDLREALNQAVNTTREAEELNSRNQERLKEALQWKQELSQ 513 lkeqieetLatgrdsLdqanlElLqeldqal<-* +++++ +tL ++ +L + lLq +dqa+ mKIAA0533 514 DNATLKATLQAASLILGHVSE-LLQGIDQAK 543 Laminin_II: domain 1 of 1, from 634 to 775: score 55.7, E = 1e-12 *->sKemAdeAnetaaaVlkelepiqtnvsnikaslsklngdleetnklv ++ A+++ e + V+++l++ + ++ + ++ l+++ + ++ mKIAA0533 634 ALRQASRTWEMV--VQRGLAAGARQLLANSSALEETILGHQGRLG-- 676 sdpsankaiddArrsvrklnklapyLldkLkpl.........eklsvasq a+ ++ A+ + ++ ++L++++ +++ +++e+ + a mKIAA0533 677 ---LAQGRLQAAGIQLHNVWARKNQLAAQIQEAqamlamdtsETSEHA-- 721 srtdslsrnisriKelIaqARkaAnkIkVsvnfdGdsglelrppisltdl s++ ls+ni+r+++lIaqAR+aA+k+kVs++f+G+sg++lr+p++l+dl mKIAA0533 722 SLA--LSANIGRVRKLIAQARSAASKVKVSMKFNGRSGVRLRTPRDLADL 769 aaltsl<-* aa+t+l mKIAA0533 770 AAYTAL 775 Laminin_G_2: domain 1 of 5, from 790 to 923: score 11.5, E = 0.061 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl + + ++ly+g+++ ++d ++ ++L++ +++ +y+l mKIAA0533 790 ---KNTGDHFVLYMGSRqA-------TGD-YMGVSLRNQKVHWVYRL 825 Gsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssd G g+++l+ ++++ q Vs+ r + +++sV ++++ + +g+++ mKIAA0533 826 GKAGpTTLSIDeNIG-EQFAAVSIDRTLQFGHMSVTVEkQMvHeIKGDTV 874 tl......slnlngp.lylGGlpessksslltltaaqnlvvvs.gFvGCi ++++++ +l ++ +y+GG+p + ++ +++ +g+ GCi mKIAA0533 875 APgsegllNLHPDDFvFYVGGYPSNFTPPEPLR---------FpGYLGCI 915 rdvringe<-* + ++n e mKIAA0533 916 EMETLNEE 923 Laminin_G_2: domain 2 of 5, from 985 to 1114: score 51.2, E = 2.2e-11 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl +R + nG+++++ ++++ fl+L +++G+lvl yd+ mKIAA0533 985 LRL-VSYNGIIFFLKQEsQ-----------FLCLAVQEGTLVLFYDF 1019 G...sgg.vlltsg.klnDGqWHtVsverngrs.vtLsVDgg.vv.g.sp G++ +++ l ++ + + +V + +r++v + V +v +++++ mKIAA0533 1020 GsglKKAdPLQPPQaLTAASKAIQVFLLAGNRKrVLVRVERAtVFsVdQD 1069 gssdtlslnlngp.lylGGlpessksslltltaaqnlvvvs.gFvGCird ++ + +ylGG+p+++ + +l++ + + ++ +GCi++ mKIAA0533 1070 ------NMLEMADaYYLGGVPPEQLPLSLRQLFPS-----GgSVRGCIKG 1108 vringe<-* ++ g+ mKIAA0533 1109 IKALGK 1114 Laminin_G_1: domain 1 of 3, from 985 to 1117: score 5.6, E = 0.0035 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl R + +G+++ + + + l l+ + G l + yd+ mKIAA0533 985 LRLVSYNGIIF--FLKQESQF----------LCLAVQEGTLVLFYDF 1019 Gsghrlrpa..vvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervvdg Gsg l +a++++ + + + +k +v+l + +rk +L + ++ mKIAA0533 1020 GSG--LKKAdpLQPPQAL-TAASKAIQVFLLAGNRKRVLVRVERAT---- 1062 espsgpditsenLdldtppiLyvGGlPel.qksvkrrlaaistsFkGCir +++ d+ +++L + ++ y+GG P+++ + +r l +++ s +GCi+ mKIAA0533 1063 --VFSVDQ-DNMLEMADA--YYLGGVPPEqLPLSLRQLFPSGGSVRGCIK 1107 dvsingkpld<-* ++ gk +d mKIAA0533 1108 GIKALGKYVD 1117 Laminin_G_2: domain 3 of 5, from 1168 to 1285: score 67.4, E = 3.1e-16 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl FR tq+n lL y + +g + + ++L++G+++lr+ mKIAA0533 1168 FRG-TQDNNLLYYRTSPdG---------P-YQ-VSLREGHVTLRF-- 1200 Gsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssd ++ + +++ ++DG H V+++ n + v+L VD++ + + + ++ mKIAA0533 1201 ---MnQEVETQrVFADGAPHYVAFYSNVTGVWLYVDDQlQLvKsHERTTP 1247 tl..slnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvri l+ +++ +++l lGGlp s+ ++F GCi++v++ mKIAA0533 1248 MLqlQPEEPSRLLLGGLPVSGT---------------FhNFSGCISNVFV 1282 nge<-* mKIAA0533 1283 QRL 1285 Laminin_G_2: domain 4 of 5, from 1378 to 1508: score 88.7, E = 1.2e-22 *->FRT.atqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlryd +R++a +++GlLl +++ +g +s+ l L+L++G+ v + mKIAA0533 1378 VRPhA-ASQGLLLSTAPMsG-------RSP-SLVLFLNHGHFVAQTE 1415 lGsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgss g+++++ s ++ GqWH+Vsv++ ++++L+VDg+++ ++++ ++ mKIAA0533 1416 GP-GPrLQVQSRqHSRAGQWHRVSVRWGMQQIQLVVDGSqTWsQkALHHR 1464 dtlslnlngp.lylGGlpessksslltltaaqnlvvvs.gFvGCirdvri ++ ++ +l +GGlp ss ss l++ s gF GC++ +++ mKIAA0533 1465 VPRAERPQPYtLSVGGLPASSYSSKLPV---------SvGFSGCLKKLQL 1505 nge<-* + + mKIAA0533 1506 DKQ 1508 Laminin_G_1: domain 2 of 3, from 1382 to 1511: score 14.6, E = 0.00054 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl ++++GlLl +++ +r+ + l+l L++G+ + mKIAA0533 1382 ---AASQGLLL--STAPMSGRS-------PSLVLFLNHGHFVAQTEG 1416 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeer...... + v s + G+WHrv+++ ++++L Vdg ++ +++ mKIAA0533 1417 PGP----RLQVQSRQH-SRAGQWHRVSVRWGMQQIQLVVDGSQTwsqkal 1461 ...vvdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaists +++v++ e p p++ L vGGlP +s +++++s + mKIAA0533 1462 hhrVPRAERP-QPYT------------LSVGGLP---ASSYSSKLPVSVG 1495 FkGCirdvsingkpld<-* F+GC++++ ++++pl mKIAA0533 1496 FSGCLKKLQLDKQPLR 1511 Laminin_G_2: domain 5 of 5, from 1558 to 1681: score 88.3, E = 1.6e-22 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl R+ ++ Gl++++g++ + +++L + ++ l+ + mKIAA0533 1558 MRP-LAAAGLIFHLGQAlA--------TP-YMQLKVLTEQVLLQAND 1594 Gsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssd G g+ ++ ++ +kl+DG+WH+V+v++ + +++L+VD ++++++++ ++s mKIAA0533 1595 GAGEfSTWVTYpKLCDGRWHRVAVIMGRDTLRLEVDTQsNHtTgRLPES- 1643 tlslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvring + l+lG lp+ss ++ + ++GC+r + ing mKIAA0533 1644 --LAGSPALLHLGSLPKSSTARPE-----------LpAYRGCLRKLLING 1680 e<-* mKIAA0533 1681 A 1681 Laminin_G_1: domain 3 of 3, from 1558 to 1684: score 27.9, E = 3.4e-05 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl R + Gl++ +G++ +++ l+ ++ ++ + mKIAA0533 1558 MRPLAAAGLIF--HLGQALAT--------PYMQLKVLTEQVLLQAND 1594 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervvdges G+g ++ ++ ++l+DG+WHrv + + ++ + L Vd + +++ mKIAA0533 1595 GAG----EFSTWVTYPKLCDGRWHRVAVIMGRDTLRLEVDTQSN-HTTGR 1639 psgpditsenLdldtppiLyvGGlPelqksvkrrlaaistsFkGCirdvs ++ + L +G lP ks +r+ +++++GC+r++ mKIAA0533 1640 LPESLA-----GSPAL--LHLGSLP---KSSTARP--ELPAYRGCLRKLL 1677 ingkpld<-* ing p++ mKIAA0533 1678 INGAPVN 1684 //