hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05532/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0424  ( 520 res)   mbg05532

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   226.2    2.9e-63   1
SH3      Src homology 3 domains                          66.4    3.7e-15   1
PH       Pleckstrin homology domain.                     48.9    6.7e-10   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
SH3        1/1      15    70 ..     1    58 []    66.4  3.7e-15
RhoGEF     1/1     111   290 ..     1   211 []   226.2  2.9e-63
PH         1/1     323   431 ..     1    82 []    48.9  6.7e-10

Alignments of top-scoring domains:
SH3: domain 1 of 1, from 15 to 70: score 66.4, E = 3.7e-15
                   *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnrtGkeG
                      + + A++D+      EL Fk+GD+i vl+ s+ +Ww+G+++   +eG
   mKIAA0424    15    VSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQID--DEEG 59   

                   lfPsnYVeeie<-*
                   +fP+++V++     
   mKIAA0424    60 WFPASFVRLWV    70   

RhoGEF: domain 1 of 1, from 111 to 290: score 226.2, E = 2.9e-63
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v++E++ TEr+Y+++Lk + e++lk+++k+ +     ++s++++k +
   mKIAA0424   111    VINEIMSTERHYIKHLKDICEGYLKQCRKRRD-----MFSDEQLKVI 152  

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                   Fg Nie+iy+f++ F  +Le+  ++ +              ++  +ig +
   mKIAA0424   153 FG-NIEDIYRFQMGFVRDLEKQYNNDD--------------PHLSEIGPC 187  

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeiesk
                   Fl++   ++ f iYseYc+nh da   l+kLm   k++++q+f++ + + 
   mKIAA0424   188 FLEH---QDGFWIYSEYCNNHLDACMELSKLM---KDSRYQHFFEACRLL 231  

                   pncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLkk
                   ++++     +  ++ +L++PvQ ++kYpL L ellk+t  dh+d+  +  
   mKIAA0424   232 QQMI-----DIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAA 276  

                   AleaikelasqvNe<-*
                   Al++++++++q+Ne   
   mKIAA0424   277 ALAVMRNVTQQINE    290  

PH: domain 1 of 1, from 323 to 431: score 48.9, E = 6.7e-10
                   *->vikeGwLlkks..k.swkkryfvLfngvLlyyksk.......kpkgs
                      +i+ G + +  ++ ++ ++r f+Lf+++++++k++  +++   +kg+
   mKIAA0424   323    LIYTGEMAWIYqpYgRNQQRVFFLFDHQMVLCKKDlirrdilYYKGR 369  

                   ipLsgcsvre.p.............cFeivt.dr..tlllqAeseeeree
                   i++++++v + +++++++ + + +++F++++++ ++++l++A+  ee+ +
   mKIAA0424   370 IDMDKYEVIDiEdgrdddfnvsmknAFKLHNkETeeVHLFFAKKLEEKIR 419  

                   Wvealqsaiaka<-*
                   W++a+++  +     
   mKIAA0424   420 WLRAFREERKMV    431  

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