hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05532/w3open/interpro/cnk_1/seq.in
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  mKIAA0424  ( 520 res)   mbg05532

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   RhoGEF domain                                  129.1    8.3e-35   1
PH       PH domain                                       44.4    2.6e-09   1
SH3_1    SH3 domain                                      38.3    1.8e-07   1
SH3_2    Variant SH3 domain                              37.2    3.7e-07   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
SH3_1      1/1      15    69 ..     1    58 []    38.3  1.8e-07
SH3_2      1/1      16    69 ..     1    69 []    37.2  3.7e-07
RhoGEF     1/1     111   290 ..     1   207 []   129.1  8.3e-35
PH         1/1     323   429 ..     1    92 []    44.4  2.6e-09

Alignments of top-scoring domains:
SH3_1: domain 1 of 1, from 15 to 69: score 38.3, E = 1.8e-07
                   *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgGke
                        + A  D + +   EL Fk GDvi+vl+ s+ +WW g+ +   ++e
   mKIAA0424    15    VSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQID---DEE 58   

                   GliPsNYVepv<-*
                   G++P+++V++    
   mKIAA0424    59 GWFPASFVRLW    69   

SH3_2: domain 1 of 1, from 16 to 69: score 37.2, E = 3.7e-07
                   *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl
                       + a+ d+v    ++e      L++k+Gdv+kv+    + ++ +ww+
   mKIAA0424    16    SAEAVWDHVT-MANRE------LAFKAGDVIKVL----DASNKDWWW 51   

                   geslggGrrrRGlvPssaveel<-*
                   g    + ++  G++P+s+v+ +   
   mKIAA0424    52 GQI--DDEE--GWFPASFVRLW    69   

RhoGEF: domain 1 of 1, from 111 to 290: score 129.1, E = 8.3e-35
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v++E++ TE+ Y+++L ++  +y+k+ r+  + +   ++ ++++ iF
   mKIAA0424   111    VINEIMSTERHYIKHLKDICEGYLKQCRK--RRD--MFSDEQLKVIF 153  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                   +Niediy+f+  F +  Le+               +p+ + +G++Fl++ 
   mKIAA0424   154 GNIEDIYRFQMGFVR-DLEKQYNND----------DPHLSEIGPCFLEH- 191  

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                    + + +Y eYc+n+ +A   l+kl   ++   F+e +  +++  +     
   mKIAA0424   192 QDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMID----- 236  

                   davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkaldl
                         ++ +Ll Pvq i++YpL L eLLk+t    d++d+    +al+ 
   mKIAA0424   237 ----IAIDGFLLTPVQKICKYPLQLAELLKYTAQ--DHSDYRYVAAALAV 280  

                   lqdlaksiNe<-*
                   ++++ ++iNe   
   mKIAA0424   281 MRNVTQQINE    290  

PH: domain 1 of 1, from 323 to 429: score 44.4, E = 2.6e-09
                   *->vikeGwLlkkg.gkkswkkRyfvLfndvLlyykdkk.....kkpkgs
                      +i+ G++    +  ++ ++R f+Lf+++++++k++  +++   +kg 
   mKIAA0424   323    LIYTGEMAWIYqPYGRNQQRVFFLFDHQMVLCKKDLirrdiLYYKGR 369  

                   ipLsgiqvekvpdn.......krkncFeirt.dr.etlllqaeseeerke
                   i++++++v +++d+++++ +   kn+F++++++ +e++l++a+  ee+ +
   mKIAA0424   370 IDMDKYEVIDIEDGrdddfnvSMKNAFKLHNkETeEVHLFFAKKLEEKIR 419  

                   Wvkaiqsair<-*
                   W++a++++ +   
   mKIAA0424   420 WLRAFREERK    429  

//