hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbe/mbe05005/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0381  ( 1032 res)   mbe05005

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
FH2      Formin Homology 2 Domain                       505.5   3.9e-148   1
Drf_GBD  Diaphanous GTPase-binding Domain               204.3    1.9e-57   1
Drf_FH3  Diaphanous FH3 Domain                          142.7    6.6e-39   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
Drf_GBD    1/1      55   244 ..     1   322 []   204.3  1.9e-57
Drf_FH3    1/1     246   432 ..     1   234 []   142.7  6.6e-39
FH2        1/1     565   934 ..     1   413 []   505.5 3.9e-148

Alignments of top-scoring domains:
Drf_GBD: domain 1 of 1, from 55 to 244: score 204.3, E = 1.9e-57
                   *->lqmpsdeeLVdelFeellkedriflnLpedKreaLrnlsaekKWeli
                       + p  eeL +++F+el+ ++   l+L++++rea ++l+ ekKW+++
   mKIAA0381    55    GPIPNPEEL-NVRFAELV-DE---LDLTDKNREAVFALPPEKKWQIY 96   

                   cqylskndkgkkkksskselnekaiaSdileilteesspqeYiekLrsga
                   c++++ ++   k ++                     s+p+ Yi++ + +a
   mKIAA0381    97 CSKRKEQEDPNKLAT---------------------SWPEYYIDRINAMA 125  

                   lsekllscsssskehsaknkslgslSpstkvvddgLkvaelesLrVaLrt
                   + ++l  ++ +++e   +n          +v         +e+L++aLrt
   mKIAA0381   126 AMQNL--YETEDEETDKRN----------QV---------VEDLKTALRT 154  

                   npvsWVkaFgklgNkGliaLlkiLqtllkkkiyelestdsvesgvekskk
                   +p+++V++F++l+  Gl++Ll++L  ++  + ++                
   mKIAA0381   155 QPMRFVTRFIDLE--GLTCLLNFLRGMDHTTCES---------------- 186  

                   dspssedlskasprpsPqqnssqesksqqtlkllsqlsaqaqqlqkqqlq
                                                                     
   mKIAA0381     - -------------------------------------------------- -    

                   qsttliektlpsidkklqfecirClKaLMNnklGlkrvLsheesividtl
                                  ++++++i+C+KaLMNn++G+++vL+ +e+  i  +
   mKIAA0381   187 ---------------RIHTSLIGCIKALMNNSQGRAHVLAQPEA--ISII 219  

                   vlsLdssnlktrklaleLLaalClv<-*
                   ++sL ++n kt+ ++le+L+a+Clv   
   mKIAA0381   220 AQSLRTENSKTKVAVLEILGAVCLV    244  

Drf_FH3: domain 1 of 1, from 246 to 432: score 142.7, E = 6.6e-39
                   *->gGhelvleaiinfkevcdereRFrtlvsaldsfssgeedasleykva
                      gGh++vl+a+++ +    er+RF+tl ++ld+ s g++++ +++k+a
   mKIAA0381   246    GGHKKVLQAMLHYQAYAAERTRFQTLLNELDR-SLGRYRDEVNLKTA 291  

                   tmqFINalvvagnspedlqfRlhLRsEftelGLdeyleklkntssesdkL
                   +m+FINa+ +ag+++++l+fRlhLR+Ef++lG++ +++kl+ +  e+  L
   mKIAA0381   292 IMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQH--ENAIL 339  

                   ddqIklFeenmidvrellddantktkvledleeleerleelkesfaetsv
                   d+++++Fe+     r+            ed  el++r++ ++       +
   mKIAA0381   340 DKHLDFFEMV----RN------------EDDLELARRFDMVH-------I 366  

                   eldslssvaellsnllkltgaedlllSilQhllllredseeskLvsyikl
                   + +s+s+++el++ +l  +g  +       +l  l++ + ++  + ++ +
   mKIAA0381   367 DTKSASQMFELIHKKL--KGVDP-------DLAPLENFNVKN--IVNMLI 405  

                   leeivqqIllhrtkppdpkfeqslqenldegterlld<-*
                    e  v+q   +++    +kf+++  e+    ++r l+   
   mKIAA0381   406 NENEVKQ--WRDQ---AEKFRKEHMEL----MSR-LE    432  

FH2: domain 1 of 1, from 565 to 934: score 505.5, E = 3.9e-148
                   *->kkepkpkkkLKpLhWdKlnpsqdrgtsvWdkldeesfekkldldlse
                      k+ p+p  +LK+++W+Kln++ ++gt vW+++d+++ +    ldl++
   mKIAA0381   565    KRIPQPSHPLKSFNWVKLNEERVSGT-VWNEIDDSQVFR--ILDLED 608  

                   lEelFsakakkkkekksseksskskkkkkeisvLDpkrsQNiaIlLrkls
                   +E++Fsa++ ++   +    +s  ++k+ke+sv+D++r+QN+ IlL+kl 
   mKIAA0381   609 FEKMFSAYQRHQVRFG----PSITSRKVKELSVIDGRRAQNCIILLSKL- 653  

                   klppeeivqAilemDe.dvLgvvlflkemldllenLlkmaPtkeElkklq
                   kl+++ei+qAil+mDe++ L         +d+le+Llk++P+k ++++l 
   mKIAA0381   654 KLSNDEIRQAILRMDEqEDLA--------KDMLEQLLKFIPEKSDIDLL- 694  

                   ekeykgdekspskLgraEqqFLlelskliprleeRlrallFkstFeeeve
                     e+k++   +++++ra+ +FL+e+s+ i ++++Rl+al Fk+ F+e+ +
   mKIAA0381   695 -EEHKHE---IERMARAD-RFLYEMSR-IDHYQQRLQALFFKKKFQERLA 738  

                   elkpsletleaAseeLreSrkfkklLeliLalGNyMNsGtrrrGnAkGFk
                   e kp++e++  As eL  S+++k++Le++La+GN+MN+G+r  G+A+GF+
   mKIAA0381   739 EAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQR--GGAYGFR 786  

                   LssLlKLsdvKstidnktTLLHflvkeieesEGkrlEeyrKLklpelldf
                     sL+K++d+Ks+id++++LLH+l  ++e+            ++p++l+ 
   mKIAA0381   787 VASLNKIADTKSSIDRNISLLHYLIMILEK------------HFPDILNM 824  

                   sseLshVekAakvdleeLeadvkeLekglkklekelelseeSkvsdeeps
                   +seL+h+ +Aakv+l eLe++v+ L++gl+++e ele++ +   ++ +p+
   mKIAA0381   825 PSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRH---QARDPN 871  

                   dkFvevmkeFleeAeekldkLesllkeakelfkelteYFghggedpkdet
                   dkFv+vm++F+   ++++ +Le++l+ea+++f +++ +F   ge  + ++
   mKIAA0381   872 DKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHF---GEQES-KM 917  

                   speeFFkilrdFlnefk<-*
                   +p+eFF+i+++Fl++f    
   mKIAA0381   918 QPDEFFGIFDTFLQAFL    934  

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