hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg01404/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0369  ( 791 res)   mbg01404

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
S_TKc    Serine/Threonine protein kinases, catalytic    361.8   4.4e-104   1
DCX      Domain in the Doublecortin (DCX) gene produc   287.6    9.5e-82   2
TyrKc    Tyrosine kinase, catalytic domain               15.9      4e-12   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
DCX        1/2     104   195 ..     1    96 []   159.3  3.8e-43
DCX        2/2     233   321 ..     1    96 []   132.1    6e-35
TyrKc      1/1     442   696 ..     1   280 []    15.9    4e-12
S_TKc      1/1     442   698 ..     1   231 []   361.8 4.4e-104

Alignments of top-scoring domains:
DCX: domain 1 of 2, from 104 to 195: score 159.3, E = 3.8e-43
                   *->slvkpkrirvyRNGDrffkGvrlvvnrkrqfkSFeaLLqdlTelklv
                      s++k+k++r+yRNGDr+fkG++++++++r f+SFeaLL dlT+  l+
   mKIAA0369   104    SEKKAKKVRFYRNGDRYFKGIVYAISPDR-FRSFEALLADLTR-TLS 148  

                   vkldlpfaVRklYTldGgkkvtsldeledgDgvYVasgteEkFkkvdYg<
                   ++++lp++VR++YT+dG kk+ sld+l++g ++YV+++ e +Fkk++Y+ 
   mKIAA0369   149 DNVNLPQGVRTIYTIDGLKKISSLDQLVEG-ESYVCGSIE-PFKKLEYT  195  

                   -*
                     
   mKIAA0369     -    -    

DCX: domain 2 of 2, from 233 to 321: score 132.1, E = 6e-35
                   *->slvkpkrirvyRNGDrffkGvrlvvnrkrqfkSFeaLLqdlTelklv
                      ++ +pk ++++R+G++++k+vr+++n+k+ ++SFe++L+d+T+   +
   mKIAA0369   233    DFIRPKLVTIIRSGVKPRKAVRILLNKKT-AHSFEQVLTDITD---A 275  

                   vkldlpfaVRklYTldGgkkvtsldeledgDgvYVasgteEkFkkvdYg<
                   +kld++ +V++lYTldG k+v +l++++++D++++a+g e kF++ d++ 
   mKIAA0369   276 IKLDSG-VVKRLYTLDG-KQVMCLQDFFGDDDIFIACGPE-KFRYQDDF  321  

                   -*
                     
   mKIAA0369     -    -    

TyrKc: domain 1 of 1, from 442 to 696: score 15.9, E = 4e-12
                   *->ltlgkkLGeGaFGeVykGtlk...ieVAVKtLkeda....keeFlrE
                       + g+++G G+F +V +++ +++ +e A K +k+++ ++++ ++ +E
   mKIAA0369   442    YKVGRTIGDGNFAVVKECIERstaREYALKIIKKSKcrgkEHMIQNE 488  

                   akiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdLldyL
                    +i++++  kHpNiV L+     +         l++vmE+++gGdL d +
   mKIAA0369   489 VSILRRV--KHPNIVLLIEEMDVP-------TELYLVMELVKGGDLFDAI 529  

                   rknrpklslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvgenk...
                    ++ +  + +d   + +  A+   YL+s n+vHRD+   N Lv e ++++
   mKIAA0369   530 TSTSK-YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQdgs 578  

                   .vvKIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAPEslk
                   +  K +DFGL+  + d+         Y++    +g         APE + 
   mKIAA0369   579 kSLKLGDFGLA-TIVDG-------PLYTV----CGTP----TYVAPEIIA 612  

                   dgkFtskSDVWSFGVlLWEiftlGeqPYpgeiqqfmsneevleylkkGyR
                   +  +  k D+W+ GV  + i+  G +P  g      + e ++ ++  G  
   mKIAA0369   613 ETGYGLKVDIWAAGVITY-ILLCGFPPFRGG----DDQEVLFDQILMGQV 657  

                   lpkPendlpiSs...vtCPdelYdlMlqCWaedPedRPtFselverl<-*
                     + ++      ++     +el ++Ml     + ++R +  ++ e     
   mKIAA0369   658 DFPSPY-----WdnvSDSAKELINMMLL---VNVDQRFSAVQVLEHP    696  

S_TKc: domain 1 of 1, from 442 to 698: score 361.8, E = 4.4e-104
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik........erilrE
                      Y++++++G G F++V+ +++++t r++A+K+ik+++ ++++ +i++E
   mKIAA0369   442    YKVGRTIGDGNFAVVKECIERSTAREYALKIIKkskcrgkeHMIQNE 488  

                   ikiLkk.dHPNIVkLydvfed.dklylVmEyceGdlGdLfdllkkrgrrg
                   ++iL++ +HPNIV L++ ++ +++lylVmE++ G  GdLfd + +  +  
   mKIAA0369   489 VSILRRvKHPNIVLLIEEMDVpTELYLVMELVKG--GDLFDAITSTSK-- 534  

                   lrkvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds......h
                       ++E++a  +++ ++sa++YLHs++I+HRD+KPeN+L+ +++++++ 
   mKIAA0369   535 ----YTErDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEhqdgskS 580  

                   vKlaDFGlArql....ttfvGTpeYmAPEvl...gYgkpavDiWSlGcil
                   +Kl+DFGlA++++++ +t++GTp Y+APE++ ++gYg  +vDiW+ G+i 
   mKIAA0369   581 LKLGDFGLATIVdgplYTVCGTPTYVAPEIIaetGYGL-KVDIWAAGVIT 629  

                   yElltGkpPFp...qldlifkkig..............SpeakdLikklL
                   y+ll+G pPF+++++++++f++i+ +  + +++++++ S++ak+Li+ +L
   mKIAA0369   630 YILLCGFPPFRggdDQEVLFDQILmgqvdfpspywdnvSDSAKELINMML 679  

                   vkdPekRlta.eaLedeldikaHPff<-*
                    ++ ++R +a ++Le       HP++   
   mKIAA0369   680 LVNVDQRFSAvQVLE-------HPWV    698  

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