hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbe/mbe05003/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0362  ( 806 res)   mbe05003

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   225.4    4.8e-63   1
PH       Pleckstrin homology domain.                     61.6      1e-13   1
SPEC     Spectrin repeats                                34.5    1.4e-05   1
SH3      Src homology 3 domains                          29.2    0.00056   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
SPEC       1/1       4    87 ..     1   104 []    34.5  1.4e-05
RhoGEF     1/1     268   443 ..     1   211 []   225.4  4.8e-63
PH         1/1     463   580 ..     1    82 []    61.6    1e-13
SH3        1/1     715   772 ..     1    58 []    29.2  0.00056

Alignments of top-scoring domains:
SPEC: domain 1 of 1, from 4 to 87: score 34.5, E = 1.4e-05
                   *->qqFlrdadeleaWleekeqllssedlgeskDlesveallkkHqalea
                      q+                 +++ +d+g  ++l++v+ llk + a+e+
   mKIAA0362     4    QK-----------------IAAFTDVG--NSLAHVQHLLKDLTAFEE 31   

                   elaaheervdalnelgeqLieesghpdaeeIeerleeLnerWeeLlelae
                     +   ++  al  +g+qLie+  h++ ++I  ++eeL++  ++    + 
   mKIAA0362    32 KSSVAVDKARALSLEGQQLIEN-RHYAVDSIHPKCEELQHLCDHFASEVT 80   

                   eRrqkLe<-*
                   +Rr  L    
   mKIAA0362    81 RRRGLLS    87   

RhoGEF: domain 1 of 1, from 268 to 443: score 225.4, E = 4.8e-63
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v++ELl+TEr+YV++L +++e++  +++++++ +l+    ++++++l
   mKIAA0362   268    VMNELLDTERAYVEELLCVLEGYAAEMDNPLMAHLISTGLQNKKNIL 314  

                   FgpNieeiyefH.rrFLdeLeerveewllskdlKsernsviedsgerigd
                   Fg N+eeiy fH+r+FL eLe +++                   +e++g+
   mKIAA0362   315 FG-NMEEIYHFHnRIFLRELESCIDC------------------PELVGR 345  

                   vFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeies
                   +Fl+    +e f+iY +Yc+n+p++++l+++ +   ++++F++++++   
   mKIAA0362   346 CFLER---MEEFQIYEKYCQNKPRSESLWRQ-C---SDCPFFQECQKKLD 388  

                   kpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLk
                   +         +l+L+s+L+kPvQR+tkY+LLLke+lk+++ ++e  edL+
   mKIAA0362   389 H---------KLSLDSYLLKPVQRITKYQLLLKEMLKYSK-HCEGAEDLQ 428  

                   kAleaikelasqvNe<-*
                   +Al +i  ++++vN+   
   mKIAA0362   429 EALSSILGILKAVND    443  

PH: domain 1 of 1, from 463 to 580: score 61.6, E = 1e-13
                   *->vikeGwLlkks.............k.swkkryfvLfngvLlyyksk.
                      ++++G  ++++++++++++ +   + + ++r+++L+++ +l++k+++
   mKIAA0362   463    LLMQGSFSVWTdhkkghtkvkelaRfKPMQRHLFLHEKAVLFCKKRe 509  

                   ............kpkgsipLsgcsvre.p.....cFeivt.dr..tlllq
                   +++++ ++ ++ ++k s++++ + ++e+++++ + Fei+++ r++++++q
   mKIAA0362   510 engegyekapsySYKQSLNMTAVGITEnVkgdtkKFEIWYnAReeVYIIQ 559  

                   AeseeereeWvealqsaiaka<-*
                   A+++e +  Wv+ +++++ ++   
   mKIAA0362   560 APTPEIKAAWVNEIRKVLTSQ    580  

SH3: domain 1 of 1, from 715 to 772: score 29.2, E = 0.00056
                   *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnrtGkeG
                      +++ ++ D e  ++d L ++ GD+++v+e+  +g w+++  ++ keG
   mKIAA0362   715    GKYTVVMDDEKGGPDTLAMRSGDMVEVVEEGAEGLWYVRDLTSSKEG 761  

                   lfPsnYVeeie<-*
                   ++P++ +  +    
   mKIAA0362   762 WVPASSLSTLL    772  

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