hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbe/mbe05003/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0362  ( 806 res)   mbe05003

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   RhoGEF domain                                  171.9    1.1e-47   1
PH       PH domain                                       57.1      4e-13   1
SH3_2    Variant SH3 domain                              21.4      0.021   1
SH3_1    SH3 domain                                      13.6     0.0065   1
Spectrin Spectrin repeat                                  0.0        0.6   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
Spectrin   1/1       2    88 ..     1   108 []     0.0      0.6
RhoGEF     1/1     268   443 ..     1   207 []   171.9  1.1e-47
PH         1/1     463   578 ..     1    92 []    57.1    4e-13
SH3_1      1/1     715   771 ..     1    58 []    13.6   0.0065
SH3_2      1/1     716   771 ..     1    69 []    21.4    0.021

Alignments of top-scoring domains:
Spectrin: domain 1 of 1, from 2 to 88: score 0.0, E = 0.6
                   *->lllqqFqrdadelesWisekeallssedygkDlesvqaLlkkHeafe
                                      +s+k a  ++   g++l++vq Llk + afe
   mKIAA0362     2    ----------------MSQKIAAFTDV--GNSLAHVQHLLKDLTAFE 30   

                   aelaahqqdrvdqlnelaqkLieegedhpdseeikerleeLnerWeaLle
                   +   +   d+ ++l  ++q+Lie    h++ + i  ++eeL ++ ++   
   mKIAA0362    31 EKSSVAV-DKARALSLEGQQLIENR--HYAVDSIHPKCEELQHLCDHFAS 77   

                   laaeRkqkLee<-*
                    + +R+ +L     
   mKIAA0362    78 EVTRRRGLLSK    88   

RhoGEF: domain 1 of 1, from 268 to 443: score 171.9, E = 1.1e-47
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaiss.kpvltpddieti
                      v +Ell TE++Yv++L  ++ +y+++++++ +    +   +++++++
   mKIAA0362   268    VMNELLDTERAYVEELLCVLEGYAAEMDNPLMAHlISTGLQNKKNIL 314  

                   FsNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlkl
                   F+N+e+iy fh+++++ +Le +i                ++ +G +Fl++
   mKIAA0362   315 FGNMEEIYHFHNRIFLRELESCIDC--------------PELVGRCFLER 350  

                   kepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAk
                     +++q+Y++Yc+nkp+++ l+++     s + F+++++++  +      
   mKIAA0362   351 -MEEFQIYEKYCQNKPRSESLWRQ----CSDCPFFQECQKKLDH------ 389  

                   ddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkald
                       kl+L+s+LlkPvqRi++Y+LLLke Lk++++   +++ edL++al+
   mKIAA0362   390 ----KLSLDSYLLKPVQRITKYQLLLKEMLKYSKH---CEGAEDLQEALS 432  

                   llqdlaksiNe<-*
                    +  ++k +N+   
   mKIAA0362   433 SILGILKAVND    443  

PH: domain 1 of 1, from 463 to 578: score 57.1, E = 4e-13
                   *->vikeGwLlkkg............gkkswkkRyfvLfndvLlyykdkk
                      + ++G +++++++++++++ ++ ++ ++ +R+++L+++  l++k++ 
   mKIAA0362   463    LLMQGSFSVWTdhkkghtkvkelARFKPMQRHLFLHEKAVLFCKKRE 509  

                   ...........kkpkgsipLsgiqvekvpdnkrkncFeirt.dr.etlll
                   +++++ ++ +++++k s+++  + +++ +++ +   Fei+ + r+e++++
   mKIAA0362   510 engegyekapsYSYKQSLNMTAVGITENVKG-DTKKFEIWYnAReEVYII 558  

                   qaeseeerkeWvkaiqsair<-*
                   qa+++e +  Wv+ i++++    
   mKIAA0362   559 QAPTPEIKAAWVNEIRKVLT    578  

SH3_1: domain 1 of 1, from 715 to 771: score 13.6, E = 0.0065
                   *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgGke
                       k+++  D e+ ++d L ++ GD ++v+e+  +g W++r+++++ ke
   mKIAA0362   715    GKYTVVMDDEKGGPDTLAMRSGDMVEVVEEGAEGLWYVRDLTSS-KE 760  

                   GliPsNYVepv<-*
                   G++P++ +      
   mKIAA0362   761 GWVPASSLSTL    771  

SH3_2: domain 1 of 1, from 716 to 771: score 21.4, E = 0.021
                   *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl
                      ++ +++d +   +++       L+ + Gd v+v     +++ +g w+
   mKIAA0362   716    KYTVVMDDEK-GGPDT------LAMRSGDMVEVV----EEGAEGLWY 751  

                   geslggGrrrRGlvPssaveel<-*
                   ++ l+  ++  G+vP+s+++ l   
   mKIAA0362   752 VRDLTSSKE--GWVPASSLSTL    771  

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