hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg04270/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0343 ( 1202 res) mbg04270 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- fn3 Fibronectin type III domain 240.2 2.9e-68 4 I-set Immunoglobulin I-set domain 229.2 5.8e-65 5 ig Immunoglobulin domain 191.0 1.8e-53 6 V-set Immunoglobulin V-set domain 47.3 3.4e-10 3 C2-set_2 CD80-like C2-set immunoglobulin domain 1.7 0.41 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- ig 1/6 71 131 .. 1 65 [] 18.9 0.12 I-set 1/5 56 150 .. 1 97 [] 19.7 0.00032 ig 2/6 170 230 .. 1 65 [] 15.1 1.7 ig 3/6 295 352 .. 1 65 [] 36.3 6.9e-07 V-set 1/3 280 368 .. 1 130 [] 16.4 0.014 I-set 2/5 278 368 .. 1 97 [] 50.9 2.9e-11 ig 4/6 385 444 .. 1 65 [] 29.6 7.4e-05 C2-set_2 1/1 372 455 .. 1 101 [] 1.7 0.41 V-set 2/3 371 460 .. 1 130 [] 8.0 0.096 I-set 3/5 371 460 .. 1 97 [] 46.9 4.5e-10 ig 5/6 479 537 .. 1 65 [] 44.4 2.6e-09 I-set 4/5 464 553 .. 1 97 [] 60.1 4.9e-14 ig 6/6 570 628 .. 1 65 [] 46.8 4.9e-10 I-set 5/5 556 644 .. 1 97 [] 51.6 1.7e-11 V-set 3/3 555 644 .. 1 130 [] 22.9 0.0032 fn3 1/4 647 733 .. 1 84 [] 66.0 7.9e-16 fn3 2/4 746 834 .. 1 84 [] 50.9 2.8e-11 fn3 3/4 845 940 .. 1 84 [] 65.1 1.5e-15 fn3 4/4 952 1041 .. 1 84 [] 71.3 2.1e-17 Alignments of top-scoring domains: ig: domain 1 of 6, from 71 to 131: score 18.9, E = 0.12 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq e ++C+++ g p+++++W+rng++ + + ++ g++t mKIAA0343 71 RENIVIQCEAK--GKPPPSFSWTRNGThFDiDKDPLVTMKPGSGT-- 113 tsLtitnvtpeDggtYtCvv<-* L+i+ ++++ ++tY v mKIAA0343 114 --LVINIMSEGKAETYEGVY 131 I-set: domain 1 of 5, from 56 to 150: score 19.7, E = 0.00032 *->PkFtqkp.kdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvll P++tq+ +kd + e ++ +C+++G P+P+ sW+++G mKIAA0343 56 PTITQQSpKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDI--- 99 psdrfkvtydgGsgtytLtIsnv....qpdDsGkYtCvAtNsaGeaeasa ++ vt + g tL+I+ ++++ +G+Y C+A+N+ G a + mKIAA0343 100 -DKDPLVTMKP--GSGTLVINIMsegkAETYEGVYQCTARNERGAAVSNN 146 eLtVq<-* + V+ mKIAA0343 147 IV-VR 150 ig: domain 2 of 6, from 170 to 230: score 15.1, E = 1.7 *->GesvtLtCsvsgfgppdvtvtWlrng.k.lt.gvlvtssenngdsty G+s+ L+C+ g p++ ++W n+ ++l+++++v + n++ mKIAA0343 170 GQSLVLPCRPP-IGLPPAIIFWMDNSfQrLPqSERVSQGLNGD---- 211 qtsLtitnvtpe.DggtYtCvv<-* L ++nv pe+ + Y C++ mKIAA0343 212 ---LYFSNVLPEdTREDYICYA 230 ig: domain 3 of 6, from 295 to 352: score 36.3, E = 6.9e-07 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ ++L C + +g p + ++W ++++ l+ + + ++ mKIAA0343 295 GNVLSLECIA--EGLPTPIIYWIKEDGmLPaNRTFYRNFKKT----- 334 tsLtitnvtpeDggtYtCvv<-* L+it v++ D+g+Y C + mKIAA0343 335 --LQITHVSEADSGNYQCIA 352 V-set: domain 1 of 3, from 280 to 368: score 16.4, E = 0.014 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss +t ++ ++ + +G ++L C + + mKIAA0343 280 FLTPEG-NES----------HKEELRGNVLSLECIAE---GLP---- 308 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn ++ +yW + + + n t++ fk+ + mKIAA0343 309 TP-IIYWIK-EDG------ML----------PANRTFYRNFKK--T---- 334 pskgdfsLtIsnlqlsDsGtYyCa........gggtrLtVl<-* L+I++++ +DsG Y C ++ + ++ + +tV+ mKIAA0343 335 -------LQITHVSEADSGNYQCIaknalgavHHTISVTVK 368 I-set: domain 2 of 5, from 278 to 368: score 50.9, E = 2.9e-11 *->PkFtqkp...kdveVqeGesarfeCkVtGtPePtVsWfKdGqplssv P+F+++ ++++ e G +++eC ++G P+P + W K + +l++ mKIAA0343 278 PTFLTPEgneSHKEELRGNVLSLECIAEGLPTPIIYWIKEDGMLPA- 323 llpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeL + f +++ tL I v +DsG Y C+A+N G + ++++ mKIAA0343 324 ---NRTFYRNFKK-----TLQITHVSEADSGNYQCIAKNALGAVHHTISV 365 tVq<-* tV+ mKIAA0343 366 TVK 368 ig: domain 4 of 6, from 385 to 444: score 29.6, E = 7.4e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge tL C++ g+p ++++Wl ng +++ + s +gd mKIAA0343 385 GENGTLICRA--NGNPKPRISWLTNGVpIEiALDDPSRKIDGDT--- 426 tsLtitnvtpeDggtYtCvv<-* ++nv+++ +++Y C + mKIAA0343 427 --IIFSNVQESSSAVYQCNA 444 C2-set_2: domain 1 of 1, from 372 to 455: score 1.7, E = 0.41 *->peIeppasllegeksenlevvatCvlpysagGkPapritWyldgkel +I++p+ l+ + +++ +++C a+G+P pri+W+++g++ mKIAA0343 372 YWIVAPQNLVLSP---GENGTLICR----ANGNPKPRISWLTNGVPI 411 vpeekteaitt..sseqdpesglytvtStLklvpsredhgqsltCqvsyg e + +++s ++d+++ ++ +++ + +++ + + ++ +yg mKIAA0343 412 ------EIALDdpSRKIDGDTIIFSNVQESSSAVY-QCNASN-----KYG 449 alrgsk<-* l ++ mKIAA0343 450 YLLANA 455 V-set: domain 2 of 3, from 371 to 460: score 8.0, E = 0.096 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss + ++ + p ++ ++G++ tL C +++ mKIAA0343 371 PYWIVA--PQ----------NLVLSPGENGTLICRAN---GNP---- 398 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn ++ +++W ++ p +i+ +++ r + mKIAA0343 399 KP-RISWLT----NGVPIEIA-------------------LDDPSR-KID 423 pskgdfsLtIsnlqlsDsGtYyCa........gggtrLtVl<-* ++ ++ sn+q s s++Y C +++ + + Vl mKIAA0343 424 GD----TIIFSNVQESSSAVYQCNasnkygylLANAFVNVL 460 I-set: domain 3 of 5, from 371 to 460: score 46.9, E = 4.5e-10 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+ + p++++ + Ge ++ C++ G+P+P +sW+ +G p+ l+ mKIAA0343 371 PYWIVAPQNLVLSPGENGTLICRANGNPKPRISWLTNGVPIEI-ALD 416 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtVq ++ k++ d ++snvq + s +Y C A+N++G a a+++V mKIAA0343 417 DPSRKIDGDT------IIFSNVQESSSAVYQCNASNKYGYLLANAFVNVL 460 <-* mKIAA0343 - - ig: domain 5 of 6, from 479 to 537: score 44.4, E = 2.6e-09 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq + ++ L C fg+p++t+ W+++ k+ ++++++ ++ng+ mKIAA0343 479 NRPALLDCAF--FGSPMPTIEWFKGTKgSAlHEDIYVLHDNGT---- 519 tsLtitnvtpeDggtYtCvv<-* L i +++++ +gtYtCv+ mKIAA0343 520 --LEIPVAQKDSTGTYTCVA 537 I-set: domain 4 of 5, from 464 to 553: score 60.1, E = 4.9e-14 *->PkFtqkp.kdveVqeGesarfeCkVtGtPePtVsWfKd..Gqplssv P++++ + +V +a ++C G+P Pt++WfK+++G+ l++ mKIAA0343 464 PRILTSAnTLYQVIANRPALLDCAFFGSPMPTIEWFKGtkGSALHE- 509 llpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeL + v +d+ tL+I+ +q+d G+YtCvA+N+ G a+ +++L mKIAA0343 510 -----DIYVLHDN----GTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 550 tVq<-* ++ mKIAA0343 551 EIK 553 ig: domain 6 of 6, from 570 to 628: score 46.8, E = 4.9e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G++v++ C+v++ ++ +t+ Wl+++++l+++++ ++ ++ mKIAA0343 570 GSKVSFECRVKHDHTLIPTIMWLKDNGeLPnDERFSTDKDH------ 610 tsLtitnvtpeDggtYtCvv<-* L++++v+ +DggtYtC++ mKIAA0343 611 --LVVSDVKDDDGGTYTCTA 628 I-set: domain 5 of 5, from 556 to 644: score 51.6, E = 1.7e-11 *->PkFtqkpkdveVqeGesarfeCkVtGtPe..PtVsWfKdGqplssvl +++++p+ ++Vq G+ ++feC+V+ + + Pt+ W+Kd+ +l++ mKIAA0343 556 TRIIKQPEYAVVQRGSKVSFECRVKHDHTliPTIMWLKDNGELPN-- 600 lpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLt ++rf+ + d+ L++s+v+ dD G+YtC+A +a+asa L mKIAA0343 601 --DERFSTDKDH------LVVSDVKDDDGGTYTCTANTTLDSASASAVLR 642 Vq<-* V mKIAA0343 643 VV 644 V-set: domain 3 of 3, from 555 to 644: score 22.9, E = 0.0032 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss + + +p+ + +v++G +v++ C ++ d+ mKIAA0343 555 PTRIIK-QPE----------YAVVQRGSKVSFECRVK---HDH--TL 585 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn + ++ W + + ++++ rfs++ mKIAA0343 586 IP-TIMWLK-DNG--------------------------ELPNDERFSTD 607 pskgdfsLtIsnlqlsDsGtYyCa........gggtrLtVl<-* + +L s+++ +D GtY+C +++ ++ + +L V+ mKIAA0343 608 KD----HLVVSDVKDDDGGTYTCTanttldsaSASAVLRVV 644 fn3: domain 1 of 4, from 647 to 733: score 66.0, E = 7.9e-16 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyR.qpkngge P +P +l t++ + s++l+W+p +++n+pit++ ++y + + + g mKIAA0343 647 PNPPFDLELTNQLDKSVQLTWTPGDdNNSPITKFIIEYEdAMHDAGL 693 wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* w+++ + t + L P+++Y++rV A n +G++++S mKIAA0343 694 WRHQAEVSGTQTTAQLKLSPYVNYSFRVMAENSIGrSMPS 733 fn3: domain 2 of 4, from 746 to 834: score 50.9, E = 2.8e-11 *->P.saPtnltvtdvtstsltlsWsppt...gngpitgYevtyRqpkng P+ P + ++ +++l+++W+p + + ngp Y+v++Rq++++ mKIAA0343 746 PdQNPMAVEGLGTEPDNLVITWKPLNgfqSNGPGLQYKVSWRQKDGD 792 gewneltvpgtttsytltgLkPgteYevrVqAvnggG..GpeS<-* ew+++ v +++ y+++g ++Y ++VqA+n++G ++ mKIAA0343 793 DEWTSVVVANVS-KYIVSGTPTFVPYLIKVQALNDVGfaPEPA 834 fn3: domain 3 of 4, from 845 to 940: score 65.1, E = 1.5e-15 *->P.saPtnltvtdvtstsltlsWsppt...gngpitgYevtyRqpkng P aP+n++v+ v+st + ++W+p ++++ +g+++gY++ y +++ + mKIAA0343 845 PmVAPGNVRVSVVNSTLAEVHWDPVPpksVRGHLQGYRIYY-WKTQS 890 ge........wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS +++++++ +++ lt gt+t+ +l gL+P++ Y + V+ vng+G+Gp S mKIAA0343 891 SSkrnrrhieKKILTFQGTKTHGMLPGLQPYSHYALNVRVVNGKGeGPAS 940 <-* mKIAA0343 - - fn3: domain 4 of 4, from 952 to 1041: score 71.3, E = 2.1e-17 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge. PsaP+ l++ + t +sltl+W+pp+++ng +t Y ++y qp n+ ++ mKIAA0343 952 PSAPSSLKIVNPTLDSLTLEWDPPShPNGILTEYILQY-QPINSTHe 997 ...wneltvpgtttsytltgLkPgteYevrVqAvnggG..GpeS<-* ++ + l +p ++t+ tl++L+ t+Y+++ +A++ +G++++ + mKIAA0343 998 lgpLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSVGpgSQIT 1041 //