hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/meh/meh01738/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0279 ( 1484 res) meh01738 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Laminin_G_2 Laminin G domain 199.5 5.1e-56 2 EGF EGF-like domain 153.2 4.5e-42 6 7tm_2 7 transmembrane receptor (Secretin family 145.1 1.2e-39 1 GPS Latrophilin/CL-1-like GPS domain 103.4 4.3e-27 1 Laminin_G_1 Laminin G domain 73.0 6e-18 2 HRM Hormone receptor domain 71.9 1.3e-17 1 Laminin_EGF Laminin EGF-like (Domains III and V) 8.7 0.02 3 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- EGF 1/6 27 80 .. 1 39 [] 27.1 0.0004 EGF 2/6 87 118 .. 1 39 [] 33.4 5.1e-06 Laminin_EGF 1/3 69 132 .. 1 59 [] -11.4 2 EGF 3/6 127 160 .. 1 39 [] 33.9 3.7e-06 Laminin_G_2 1/2 190 349 .. 1 141 [] 123.3 4.6e-33 Laminin_G_1 1/2 190 352 .. 1 154 [] 64.9 1.8e-15 EGF 4/6 373 404 .. 1 39 [] 38.8 1.2e-07 Laminin_G_2 2/2 439 565 .. 1 141 [] 81.1 2.2e-20 Laminin_G_1 2/2 439 568 .. 1 154 [] 12.1 0.00089 EGF 5/6 592 623 .. 1 39 [] 26.3 0.0007 EGF 6/6 627 661 .. 1 39 [] 30.1 5.3e-05 Laminin_EGF 2/3 612 684 .. 1 59 [] -12.5 2.6 Laminin_EGF 3/3 719 764 .. 1 59 [] 50.7 3.2e-11 HRM 1/1 768 825 .. 1 76 [] 71.9 1.3e-17 GPS 1/1 1110 1163 .. 1 55 [] 103.4 4.3e-27 7tm_2 1/1 1168 1391 .. 1 296 [] 145.1 1.2e-39 Alignments of top-scoring domains: EGF: domain 1 of 6, from 27 to 80: score 27.1, E = 0.0004 *->CspnngpCsngGtCvdtpg......................gytCeC C + pC n +Cv++ + +++ + +++ ++ ++ +g +C+C mKIAA0279 27 CLRE--PCENYMRCVSVLRfdssapfiasssvlfrpihpvgGLRCRC 71 ppGdyfllytGkrC<-* ppG +tG++C mKIAA0279 72 PPG-----FTGDYC 80 EGF: domain 2 of 6, from 87 to 118: score 33.4, E = 5.1e-06 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C + pC +G+C++ +ggytC C G ytG++C mKIAA0279 87 CYSR--PCGPHGRCRSREGGYTCLCLDG-----YTGEHC 118 Laminin_EGF: domain 1 of 3, from 69 to 132: score -11.4, E = 2 *->CdCnphGslsddtCdsddelf.............geetGqClkCkpn C C+p ++ d C + +l+ +++ +++++ ++ e + Cl C+++ mKIAA0279 69 CRCPPGF-TG-DYCETEVDLCysrpcgphgrcrsREGGYTCL-CLDG 112 vtGrrCdrCkpGyyglpsgdpgqgC<-* +tG++C+ + + g+ ++pg C mKIAA0279 113 YTGEHCE--ASTHSGR--CTPG-VC 132 EGF: domain 3 of 6, from 127 to 160: score 33.9, E = 3.7e-06 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+p C+ngGtCv++ +g++C+Cp G ++ ++C mKIAA0279 127 CTPG--VCKNGGTCVNLLVgGFKCDCPSG----DFEKPFC 160 Laminin_G_2: domain 1 of 2, from 190 to 349: score 123.3, E = 4.6e-33 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F T + nGlLly+g + k+d f+aLe+++ +++l+++ mKIAA0279 190 FAT-KERNGLLLYNGRFnE-------KHD-FVALEVIQEQVQLTFSA 227 G.sgg.vlltsg.klnDGqWHtVsverngrs................vtL G+s+++v+ + ++ ++DGqWHtV++ + ++ ++++ ++++++++ +++ mKIAA0279 228 GeSTTtVSPFVPgGVSDGQWHTVQLKYYNKPllgqtglpqgpseqkvAVV 277 sVDgg.vv.g.spgssdtl..............slnlngplylGGlpess sVDg+++ + + g ++ + +++++++++sl+l+gpl lGG+p+ + mKIAA0279 278 SVDGCdTGvAlRFGAMLGNyscaaqgtqggskkSLDLTGPLLLGGVPDLP 327 ksslltltaaqnlvvvs.gFvGCirdvringe<-* +s +++ ++FvGC++d++++++ mKIAA0279 328 ESFPVR----------MrHFVGCMKDLQVDSR 349 Laminin_G_1: domain 1 of 2, from 190 to 352: score 64.9, E = 1.8e-15 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F+T+e +GlLl YnG +++ DF+ale + +++++++ mKIAA0279 190 FATKERNGLLL--YNGRFNEKH-------DFVALEVIQEQVQLTFSA 227 GsghrlrpavvrsgdrvlnDGkWHrveler................ngrk G + + ++ ++++ ++DG+WH+v+l++ +++ ++++ ++++++++ mKIAA0279 228 GEST--TTVSPFVPGG-VSDGQWHTVQLKYynkpllgqtglpqgpsEQKV 274 gtLsVdgeer...............vvdgespsgpditsenLdldtppiL +++sVdg++++ + + ++ + ++g++ ++++ Ldl++p L mKIAA0279 275 AVVSVDGCDTgvalrfgamlgnyscAAQGTQGGSKKS----LDLTGP--L 318 yvGGlPelqksvkrrlaais.tsFkGCirdvsingkpld<-* +GG P ++++ +++ + F+GC++d+ ++++ +d mKIAA0279 319 LLGGVP-----DLPESFPVRmRHFVGCMKDLQVDSRHID 352 EGF: domain 4 of 6, from 373 to 404: score 38.8, E = 1.2e-07 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++ C+ngGtCv+ ++ ++CeCp G + Gk C mKIAA0279 373 CDSS--ICHNGGTCVNQWNAFSCECPLG-----FGGKSC 404 Laminin_G_2: domain 2 of 2, from 439 to 565: score 81.1, E = 2.2e-20 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl FRT +q++G+Ll a +++ ++L+L+ G++vl++ mKIAA0279 439 FRT-RQADGVLLQAVTRgR---------S-TITLQLRAGHVVLSVEG 474 G.sgg.vlltsg.klnDGqWHtVsverngrs....vtLsVDgg.vv.g.s + ++++l + +++ nDG WH+ ++ + +++++ Ls D+g++ +++ mKIAA0279 475 TgLQAsSLRLEPgRANDGDWHHAQLALGASGgpghAILSFDYGqQKaEgN 524 pgssdtlslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCird g+ + +++ +GG+p ++ +gF+GC+++ mKIAA0279 525 LGPRL--HGLHLSNITVGGVPGPASGV-------------ArGFRGCLQG 559 vringe<-* vr+ mKIAA0279 560 VRVSET 565 Laminin_G_1: domain 2 of 2, from 439 to 568: score 12.1, E = 0.00089 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl FRT++ +G+Ll ++ r++ + + l+L+ G++ +s+ mKIAA0279 439 FRTRQADGVLL-----QAVTRGR------STITLQLRAGHVVLSVEG 474 GsghrlrpavvrsgdrvlnDGkWHrvelerngr....kgtLsVd.geerv + ++r ++ nDG WH+ +l ++++++++Ls d g + mKIAA0279 475 TGL---QASSLRLEPGRANDGDWHHAQLALGASggpgHAILSFDyGQQK- 520 vdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaistsFkGC e ++gp + L l++ + vGG P +++ + ++F+GC mKIAA0279 521 --AEGNLGPRLHG--LHLSN---ITVGGVP-----GPASG--VARGFRGC 556 irdvsingkpld<-* ++ v++++ p + mKIAA0279 557 LQGVRVSETPEG 568 EGF: domain 5 of 6, from 592 to 623: score 26.3, E = 0.0007 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++n pC + C + +++y+C C G y G++C mKIAA0279 592 CDSN--PCPTNSYCSNDWDSYSCSCVLG-----YYGDNC 623 EGF: domain 6 of 6, from 627 to 661: score 30.1, E = 5.3e-05 *->CspnngpCsngGtCvdtpg...gytCeCppGdyfllytGkrC<-* C+ n pC + C++ p++++gy CeC p y G++C mKIAA0279 627 CDLN--PCEHQSVCTRKPNtphGYICECLPN-----YLGPYC 661 Laminin_EGF: domain 2 of 3, from 612 to 684: score -12.5, E = 2.6 *->CdCnphGslsd...dtCdsddelf.........geetGqClkCkpnv C C +G ++d+ + Cd++++ +++ ++++++ ++ C C+pn+ mKIAA0279 612 CSC-VLGYYGDnctNVCDLNPCEHqsvctrkpnTPHGYICE-CLPNY 656 tGrrCdr.....CkpGyyglpsgdpgqgC<-* G+ C+ + +++C G +g p+++p+ +C mKIAA0279 657 LGPYCETridqpCPRGWWGHPTCGPC-NC 684 Laminin_EGF: domain 3 of 3, from 719 to 764: score 50.7, E = 3.2e-11 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy CdC p Gsls Cd+ e GqC+ Ckp+v Gr+CdrC + mKIAA0279 719 CDCYPTGSLS-RVCDP-------EDGQCP-CKPGVIGRQCDRCDNPF 756 yglpsgdpgqgC<-* +gC mKIAA0279 757 AE----VTTNGC 764 HRM: domain 1 of 1, from 768 to 825: score 71.9, E = 1.3e-17 *->glgCpatwDgivCWPrtpaGqlvvvpCPdyfsGfnydttgedfgnay ++ Cp+ ++ +++WPrt +G +++ pCP++ G+ a mKIAA0279 768 YDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGT-----------AV 803 RnCtenGwwerhpsnwpwpnysaCtsney<-* R+C+e +w +pn+++Cts ++ mKIAA0279 804 RHCDEHRGWL-------PPNLFNCTSVTF 825 GPS: domain 1 of 1, from 1110 to 1163: score 103.4, E = 4.3e-27 *->tnpiCvfWdessl.estgvWstdrGCevveenkpshttCsCnHLTtF t+piCvfW++s l ++tg+Ws+ rGCevv++n+ sh++C+CnH+T+F mKIAA0279 1110 TKPICVFWNHSILvSGTGGWSA-RGCEVVFRNE-SHVSCQCNHMTSF 1154 Avlmdvppn<-* Avlmd +++ mKIAA0279 1155 AVLMDMSRR 1163 7tm_2: domain 1 of 1, from 1168 to 1391: score 145.1, E = 1.2e-39 *->lllLkviytVGyslSSLvaLllAiaifllfRkLhCtRnyIHlNLfas l Lk +++V +++ L+aL+l+++ + l+R L+++ + I NL a+ mKIAA0279 1168 ILPLKTLTYVALGVT-LAALMLTFLFLTLLRALRSNQHGIRRNLTAA 1213 fiLralsfLikdavlfnsvglseadqlsweeslhcsasagkitmivvVgC + L++l+fL+++++ + +++ C mKIAA0279 1214 LGLAQLVFLLGINQADLPFA-----------------------------C 1234 kvvavflhYfflaNFfWmLVEGlYLhtllvvtvevffserkrfwwYlliG +v+a++lh+ +l++F W L+E+l+L+++l +ev+ + +++Y+ +G mKIAA0279 1235 TVIAILLHFLYLCTFSWALLEALHLYRAL---TEVRDVNASPMRFYYMLG 1281 WGvPavfvgiwaivrpdkwagygnegCCWlsnedngyfwWiikGPvllvI WGvPa ++g++++++p+ gygn+++CWls + ++W+++GPv++++ mKIAA0279 1282 WGVPAFITGLAVGLDPE---GYGNPDFCWLSV--YDTLIWSFAGPVAFAV 1326 lvNfilFinilriLvqKlridkslspqmgetdqyrkkrlakstLlLlPLL + ++l i+ +r ++ r + + + + ++s+++ l+LL mKIAA0279 1327 SMSVFLYILSARASCAAQR------QGFEKKGPVS---GLRSSFTVLLLL 1367 GitwvlflfapeddsqGvssivflylfliLnSfQGffVavlYCFlNgEV< tw+l+l+++++d + f+ylf+ mKIAA0279 1368 SATWLLALLSVNSD-----TLLFHYLFAA-------------------- 1391 -* mKIAA0279 - - //