hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05659/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0277  ( 584 res)   mbg05659

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RasGEF   RasGEF domain                                  178.6      1e-49   1
RasGEF_N Guanine nucleotide exchange factor for Ras-l    30.7    3.3e-05   1
RA       Ras association (RalGDS/AF-6) domain            11.3       0.49   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RasGEF_N   1/1      69   131 ..     1    66 []    30.7  3.3e-05
RA         1/1     244   324 ..     1    98 []    11.3     0.49
RasGEF     1/1     345   529 ..     1   227 []   178.6    1e-49

Alignments of top-scoring domains:
RasGEF_N: domain 1 of 1, from 69 to 131: score 30.7, E = 3.3e-05
                   *->ydkvgsikggtleNiaLieyLvETRiDALtdlesedlnFvet.....
                         ++ +++gt e  +++e+L+        dl  ++    et++  +
   mKIAA0277    69    LSDRYVVVSGTPE--KILEHLL-------NDLHLAEVQHKETetlld 106  

                   .FLltYrsFittqelldlLikrYnl<-*
                   +FLltY +F+tt +l+++L ++Y     
   mKIAA0277   107 dFLLTYTVFMTTDDLCQALLRHYSA    131  

RA: domain 1 of 1, from 244 to 324: score 11.3, E = 0.49
                   *->dsgvlrVygedgtpgtyktilvskntTaeeViralLrKfgldaddpe
                       + ++ Vy + ++   y ++++  ++Ta+e+++ +++K+       e
   mKIAA0277   244    EEIFCHVYITEHS---YISVKAKVSSTAQEILKVVAEKLQR---AEE 284  

                   dyvLvEvslvlerggeerrvLpddEkPlqiqlqlkrdaqvrsrFlLrrre
                   d +Lv     +   ge +  + +++      l        ++r+++ r++
   mKIAA0277   285 DLALV----AITFSGEKH-EFQPNDLAISKSLEA------SGRIYVYRKD 323  

                   d<-*
                       
   mKIAA0277   324 L    324  

RasGEF: domain 1 of 1, from 345 to 529: score 178.6, E = 1e-49
                   *->LllDplelAkQLTLlEhelfkkItpfefLgsKmKHEGPqvWgkksfk
                      L    ++lA +L  ++ +lf +I   e+ +         + ++    
   mKIAA0277   345    LGMNTWDLALELMSFDWSLFNSIHEQELIY--------FTFSRQ--- 380  

                   gkeerspnidktiknfNqltnfvsetIlkqeFPTNPEFSKkvdpkkRaev
                   g+ e ++n+ ++  + N+++ +v+++Il+                kR+++
   mKIAA0277   381 GNGENTVNLSLLLQRCNEVQLWVATEILLCS-----------QLGKRVQL 419  

                   iqkfIqVAdhcReLnNFnSllaIisALysspIyRLkkTWekvppqslklI
                   ++kfI +A hc++ +N+nS +aI+ +L++++++RL+ TWek+p + +kl 
   mKIAA0277   420 VKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKL- 468  

                   feeLnkLmdsdrNfsnyRelLksigplappnLdddfvraPCVPFfGvYLs
                   f+eL+ L+d++ N++ yR+  k++ p             P +PF +++L+
   mKIAA0277   469 FSELESLTDPSLNHKAYRDAFKKMKP-------------PKIPFMPLLLK 505  

                   DLtfleeGnpdyleekKINtnlvNFsKrrk<-*
                   D tf++eGn+++l       nlvNF+K ++   
   mKIAA0277   506 DVTFIHEGNKTFLD------NLVNFEKLHM    529  

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