hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbj/mbj00675/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0253  ( 720 res)   mbj00675

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
Nicastrin     Nicastrin                                 505.8   3.2e-148   1
Peptidase_M28 Peptidase family M28                      -59.3       0.45   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
Peptidase_M28   1/1     285   480 ..     1   225 []   -59.3     0.45
Nicastrin       1/1     285   510 ..     1   260 []   505.8 3.2e-148

Alignments of top-scoring domains:
Peptidase_M28: domain 1 of 1, from 285 to 480: score -59.3, E = 0.45
                   *->evlllgAHyDSvpvgkdapgdsgeigpGAtDnAsGv.AvlLElARvL
                      +v++ +  +DS++    +    + ++pGA  +A+   ++ L++A +L
   mKIAA0253   285    RVVVAATRLDSRS----FF---WNVAPGAE-SAVASfVTQLAAAEAL 323  

                   aaqqgpqp.ekrsvvFlffgAEEAfeeWpdGLlGShafaekWelPphk..
                    + ++   ++ r+v+F+ff +E       +   GS   +  +e+  +++ 
   mKIAA0253   324 HK-APDVTtLSRNVMFVFFQGET------FDYIGSSRMVYDMEN-GKFpv 365  

                   elkkiraviNLDmiGsggpallfqggpTanaygnlps....IE.rLll.l
                    l++i+ ++ L  ++ + +  l+ +++    +++++s ++++E+ L+   
   mKIAA0253   366 RLENIDSFVELGQVALRTSLDLWMHTD--PMSQKNESvknqVEdLLATlE 413  

                   .lleayleaaahpfgttlgldvfqegggpgrsDhapFlndkaGvPgl...
                   ++ +++ e + +  +++ +l +              Fl   +++ g+   
   mKIAA0253   414 kSGAGVPEVVLRRLAQSQALPPS---------SLQRFL-RARNISGVvla 453  

                   .dlaagpnkdgqaagggtagdafgpvYHTpaDtldnidldtlq<-*
                   ++ +++                 +++Y + +Dt++ni+ +      
   mKIAA0253   454 dHSGSFH----------------NRYYQSIYDTAENINVTYPE    480  

Nicastrin: domain 1 of 1, from 285 to 510: score 505.8, E = 3.2e-148
                   *->kvvlVtaRlDstsmFddvslGAdSsvsgfvvlLaAAdaLGTQIskll
                      +vv++++RlDs+s+F++v++GA+S+v++fv++LaAA+aL    +k+ 
   mKIAA0253   285    RVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEAL----HKA- 326  

                   pdistlkrNVlFvfFnGEsyDYIGSqRfvYdlenGkFPQmIRSdrThvkP
                   pd++tl+rNV+FvfF+GE++DYIGS+R+vYd+enGkFP            
   mKIAA0253   327 PDVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFP------------ 364  

                   IsldnIDlvLEiGqvgkatsrginllyvHvDPmaarnqsvktqvldlLak
                   ++l+nID+++E+Gqv+++ts++   l++H+DPm+++n+svk+qv+dlLa+
   mKIAA0253   365 VRLENIDSFVELGQVALRTSLD---LWMHTDPMSQKNESVKNQVEDLLAT 411  

                   iekSlrsgfekvlkqsasspglPPsSlqSFLRanpnfsaVvLadfdteFe
                   +ekS+++++e+vl+++a+s++lPPsSlq+FLRa+ n+s+VvLad++++F+
   mKIAA0253   412 LEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRAR-NISGVVLADHSGSFH 460  

                   NrfYhSIyDdaeNinstYantskKYDFTQLedldLGdeeDLnekdslqms
                   Nr+Y+SIyD+aeNin+tY+++++             +eeDLn++++++++
   mKIAA0253   461 NRYYQSIYDTAENINVTYPEWQS-------------PEEDLNFVTDTAKA 497  

                   vvnaAslvAraLY<-*
                   ++n+A+++AraLY   
   mKIAA0253   498 LANVATVLARALY    510  

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