hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpm/mpm11210/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0246 ( 1789 res) mpm11210 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Fasciclin Fasciclin domain 245.4 8.2e-70 3 EGF EGF-like domain 139.3 6.7e-38 16 Xlink Extracellular link domain 117.7 2.1e-31 1 EGF_CA Calcium binding EGF domain 1.0 0.55 1 Laminin_EGF Laminin EGF-like (Domains III and V) -2.0 0.23 2 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- EGF 1/16 5 34 .. 1 39 [] 9.5 2.2 EGF 2/16 41 78 .. 1 39 [] 9.5 2.2 EGF_CA 1/1 41 78 .. 1 55 [] 1.0 0.55 EGF 3/16 84 121 .. 1 39 [] 25.7 0.0011 EGF 4/16 127 164 .. 1 39 [] 11.5 1.4 EGF 5/16 170 206 .. 1 39 [] 13.7 0.86 Fasciclin 1/3 219 339 .. 1 145 [] 60.6 3.3e-14 EGF 6/16 551 586 .. 1 39 [] 14.9 0.66 Laminin_EGF 1/2 558 604 .. 1 59 [] 4.0 0.058 EGF 7/16 598 630 .. 1 39 [] 14.8 0.68 EGF 8/16 639 672 .. 1 39 [] 13.8 0.84 EGF 9/16 678 714 .. 1 39 [] 15.8 0.53 EGF 10/16 720 757 .. 1 39 [] 17.9 0.24 EGF 11/16 763 800 .. 1 39 [] 17.0 0.41 Fasciclin 2/3 815 929 .. 1 145 [] 72.0 1.2e-17 Fasciclin 3/3 955 1085 .. 1 145 [] 112.7 7.2e-30 EGF 12/16 1189 1224 .. 1 39 [] 24.2 0.0031 Laminin_EGF 2/2 1186 1239 .. 1 59 [] 2.6 0.08 EGF 13/16 1236 1268 .. 1 39 [] 19.8 0.064 EGF 14/16 1278 1307 .. 1 39 [] 13.5 0.9 EGF 15/16 1313 1348 .. 1 39 [] 16.5 0.46 EGF 16/16 1354 1391 .. 1 39 [] 21.6 0.018 Xlink 1/1 1425 1518 .. 1 104 [] 117.7 2.1e-31 Alignments of top-scoring domains: EGF: domain 1 of 16, from 5 to 34: score 9.5, E = 2.2 *->CspnngpCsng....GtCvdtpggytCeCppGdyfllytGkrC<-* C C+n+++++G C+++ C+pG ++G++C mKIAA0246 5 CVHG--LCDNRpgsgGVCQQG------TCAPG-----FQGRFC 34 EGF: domain 2 of 16, from 41 to 78: score 9.5, E = 2.2 *->Cspnn..gpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C ++ pC+ ++ Cv +g +C C+ G ++++G C mKIAA0246 41 CGSTGlaQPCHSDAHCVIQEGVARCVCHDG---FEGNGFSC 78 EGF_CA: domain 1 of 1, from 41 to 78: score 1.0, E = 0.55 *->DvDECat..gtlhvCpDpdentvCvNtiGSFeCvarkdCpeGYeVpv C +++ + C + +++Cv +G +Cv C +G+e mKIAA0246 41 ----CGStgLA-QPC---HSDAHCVIQEGVARCV----CHDGFE--- 72 sennedgtnC<-* ++g+ C mKIAA0246 73 ----GNGFSC 78 EGF: domain 3 of 16, from 84 to 121: score 25.7, E = 0.0011 *->Cspnn.gpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* Cs ++g+Cs +++Cv+++ ++++C+C++G +++G+ C mKIAA0246 84 CSRPDrGGCSENAECVPGDLgTHHCICHKG---WSGDGRIC 121 EGF: domain 4 of 16, from 127 to 164: score 11.5, E = 1.4 *->Cspnn.gpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C +++g+C+ ++ C +++ + +C C+ G ++++G C mKIAA0246 127 CGLDTrGGCHADALCSYVGPgQSRCTCKLG---FAGNGYEC 164 EGF: domain 5 of 16, from 170 to 206: score 13.7, E = 0.86 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C ng+C++ +tC ++g+ C Cpp+ ++++G C mKIAA0246 170 CRVGNGGCHGLATCKAVGGgQRVCTCPPH---FGGDGFSC 206 Fasciclin: domain 1 of 3, from 219 to 339: score 60.6, E = 3.3e-14 *->gfstfvallkaagLvdtLneangkGpfTvFAPtneAFaklpppgtld +fs f ++ k + ++ ++ ++T ++P+ A +l ++ + mKIAA0246 219 HFSAFSQWFKNSSITLPA---DS--RVTALVPSESAIRRLSLEDQAF 260 aLlkelpenkekLknlLkyHvvpggv.ys.l.kdslssadLkngsnvttt +L + L +l + H + g +++++l + l ++ ++s +tt mKIAA0246 261 WLQP------KMLPELARAHFLQGAFsEEeLaR--LNGQQVATLS-ATT- 300 laGsltvnvsvngggqidvvvndgvnnArvvqaDieatNGViHvIDkVLl + +++ + + ++v+v + A+v +D atNG+ H++ +VLl mKIAA0246 301 -----RWQIH--NIS-GKVWVQN----ATVDVPDLLATNGILHIVSQVLL 338 P<-* P mKIAA0246 339 P 339 EGF: domain 6 of 16, from 551 to 586: score 14.9, E = 0.66 *->Cspnn.gpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+ +g Cs++G+C+d ++ +C+C++G ++G C mKIAA0246 551 CPGGLgGVCSGHGQCQDRFLgNGECRCQEG-----FHGTAC 586 Laminin_EGF: domain 1 of 2, from 558 to 604: score 4.0, E = 0.058 *->CdCnphGslsddtCdsddelfgeetGqClkCkpnvtGrrCdrCkpGy C++hG +C G+C+ C++++ G+ C+ C+ G mKIAA0246 558 -VCSGHG-----QCQDRFL----GNGECR-CQEGFHGTACEMCELGR 593 yglpsg.dpgqgC<-* yg p++++ + +C mKIAA0246 594 YG-PTCsGVC-DC 604 EGF: domain 7 of 16, from 598 to 630: score 14.8, E = 0.68 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* Cs C++ G C+++ +++ +C C+ G ++G rC mKIAA0246 598 CSGVC-DCDH-GLCQEGLRgNGSCVCHAG-----WQGLRC 630 EGF: domain 8 of 16, from 639 to 672: score 13.8, E = 0.84 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C++ C+ ++ C++ ++ + C C+ G ++++G +C mKIAA0246 639 CPK---KCDPNANCIQDSAgIPACVCAAG---YSGNGSYC 672 EGF: domain 9 of 16, from 678 to 714: score 15.8, E = 0.53 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C++ +g+Cs + C+ + + tC C+ G + ++G+ C mKIAA0246 678 CASGHGGCSPYANCTKVAPgQRTCTCQDG---YTGDGELC 714 EGF: domain 10 of 16, from 720 to 757: score 17.9, E = 0.24 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGk...rC<-* C +ng+C+ +++C++t+ + +C C +G y+G++ ++C mKIAA0246 720 CLVHNGGCHVHAECIPTGPqQVSCSCREG-----YSGDgiqTC 757 EGF: domain 11 of 16, from 763 to 800: score 17.0, E = 0.41 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* Cs+nng+Cs + C +t+++ tC C+ + ++G++C mKIAA0246 763 CSQNNGGCSPYAVCKSTGDgQRTCSCDAT--HTVGDGITC 800 Fasciclin: domain 2 of 3, from 815 to 929: score 72.0, E = 1.2e-17 *->gfstfvallkaagLvdtLneangkGpfTvFAPtneAFaklpppgtld +f + ll+ +L +g+GpfTvF+P + +++ +++l+ mKIAA0246 815 SFFSLH-LLEYKEL-------KGDGPFTVFVPHADLISNM-SQDELA 852 aLlkelpenkekLknlLkyHvvpggvyslkdslssadLkngsnvtttlaG ++ + + + +yHvv ++ k l s + + + +tt l+G mKIAA0246 853 RIRA-------HRQLVFRYHVVGCR----K--LWSQEMLDQGYITT-LSG 888 s.ltvnvsvngggqidvvvndgvnnArvvqaDieatNGViHvIDkVLlP< +l+v+ + +g+ ++ nd Arvv++D e NGV H ID VLlP mKIAA0246 889 HtLRVSER--EGS---IYLND---FARVVSSDLEVVNGVLHFIDHVLLP 929 -* mKIAA0246 - - Fasciclin: domain 3 of 3, from 955 to 1085: score 112.7, E = 7.2e-30 *->gfstfvallkaagLvdtLneangkGpfTvFAPtneAFaklpppgtld g+++f +ll+ agL+++L++a++ pfT+++Pt+ A+++l pp+ + mKIAA0246 955 GYKIFSRLLTVAGLLPMLQDASHR-PFTMLWPTDSALQAL-PPDRKN 999 aLlkelpenk.ekLknlLkyHvvpggvyslkdslssadLkngsnvtttla +L+ e++++kL+++L+ H++ + ++dL n+++++t + mKIAA0246 1000 WLFH---EDHrDKLAAILRGHMIRNI----E--ALASDLPNLGQLRT-MH 1039 Gs.ltvnvsvngggqidvvvndgvnnArvvqaDieatNGViHvIDkVLlP G+++++++++++ g+ v + A++vq+ + G ++ID++L P mKIAA0246 1040 GNtISFSCGLTRPGELIVGEDE----AHIVQRHLTFEGGLAYGIDQLLEP 1085 <-* mKIAA0246 - - EGF: domain 12 of 16, from 1189 to 1224: score 24.2, E = 0.0031 *->Cspnn.gpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+ +++pCs +G C+d+ +++ +C C+pG ++G C mKIAA0246 1189 CPGGPrSPCSDHGVCLDGIRgSGQCNCHPG-----FAGTAC 1224 Laminin_EGF: domain 2 of 2, from 1186 to 1239: score 2.6, E = 0.08 *->C.dCnphGslsddtCdsddelf...geetGqClkCkpnvtGrrCdrC C++C++ + C sd +++ ++ + +GqC C p+++G+ C+ C mKIAA0246 1186 ChACPGGP--R-SPC-SDHGVCldgIRGSGQCN-CHPGFAGTACELC 1227 kpGyyglpsgdpgqgC<-* +pG +g +q C mKIAA0246 1228 APGAFG----PQCQAC 1239 EGF: domain 13 of 16, from 1236 to 1268: score 19.8, E = 0.064 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+ C +G+C ++ g++ +C+C++G +tG rC mKIAA0246 1236 CQAC--RCTQHGRCDEGLGgSGSCFCDEG-----WTGARC 1268 EGF: domain 14 of 16, from 1278 to 1307: score 13.5, E = 0.9 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+p pC + C+ + +CeC G ++++G+ C mKIAA0246 1278 CTP---PCAPQAVCRLGN---SCECSLG---YEGDGRVC 1307 EGF: domain 15 of 16, from 1313 to 1348: score 16.5, E = 0.46 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++ +g+Cs ++ C +++ tC C p ++++G C mKIAA0246 1313 CQKGHGGCSKHANCSQVGTVVTCTCLPD---YEGDGWSC 1348 EGF: domain 16 of 16, from 1354 to 1391: score 21.6, E = 0.018 *->Cspnn.gpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C + ++g+Cs ++ C++t+ ++ +CeC++G + ++G +C mKIAA0246 1354 CLDGHrGGCSEHADCLNTGPnTRRCECHVG---YVGDGLQC 1391 Xlink: domain 1 of 1, from 1425 to 1518: score 117.7, E = 2.1e-31 *->GeVFhyrapsgRYkltFeEAqaaClrqgAriATtgQLyAAwkgGfdq ++VFh a sg Y ltF EA++aC+ qgA++A+ QL AA + Gf++ mKIAA0246 1425 AGVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHV 1471 CdAGWLADgsVRYPIvkPRenCgGdkdgfpGVRtyYlfpNQTGfpddpss C GWLA gs +P+v+P + Cg + GV + G++ + s+ mKIAA0246 1472 CFVGWLANGSAAHPVVTPAADCGNNR---VGVVSL-------GVRKNLSE 1511 rYDvYCF<-* ++D+YC+ mKIAA0246 1512 LWDAYCY 1518 //