hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mib/mib13036/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0216 ( 2048 res) mib13036 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Myosin_head Myosin head (motor domain) 222.6 5.7e-63 1 PDZ PDZ domain (Also known as DHR or GLGF) 45.4 1.3e-09 1 IQ IQ calmodulin-binding motif 23.7 0.0045 1 Filament Intermediate filament protein -192.1 0.81 1 Myosin_tail_1 Myosin tail -343.4 0.0018 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PDZ 1/1 233 321 .. 1 82 [] 45.4 1.3e-09 Myosin_head 1/1 420 1182 .. 1 795 [] 222.6 5.7e-63 IQ 1/1 1198 1218 .. 1 21 [] 23.7 0.0045 Filament 1/1 1559 1908 .. 1 359 [] -192.1 0.81 Myosin_tail_1 1/1 1129 1938 .. 1 863 [] -343.4 0.0018 Alignments of top-scoring domains: PDZ: domain 1 of 1, from 233 to 321: score 45.4, E = 1.3e-09 *->evtlekevkrgglGfsikggsdk...........givvsevlpGsga e+ l+++ g +Gfs+++ + ++ ++++ ++ ++ +e+ +G mKIAA0216 233 ELELQRR-PTGDFGFSLRRTTMLdrapegqayrrVVHFAEPGAG-TK 277 AeagGrLkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-* + a G L +GD+++++NGq+ven s +++v+++++sg+ +v+L+++ mKIAA0216 278 DLALG-LVPGDRLVEINGQNVENKSRDEIVEMIRQSGD-SVRLKVQ 321 Myosin_head: domain 1 of 1, from 420 to 1182: score 222.6, E = 5.7e-63 *->veDlveLtylnEpsvLhNLkkRYtsgdlIYTYsGlvLvsvNPYkrlp +eDl+ L ylnE svLh L++RY + l +TY G++L ++ + + +p mKIAA0216 420 LEDLASLVYLNESSVLHTLRQRYG-ASLLHTYAGPSLLVLST-RGAP 464 .iYteeiiakYrGkrrgElpPHiFAiAdeAYRsMlsdkeNQsIlisGESG +Y+e+++++++G rr++++PHi+A+A AYR+Ml +++QsI++ G SG mKIAA0216 465 aVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIVLLGSSG 514 AGKTEntKkvmqYlAsvsgstpkvesaevtpnkeegsledqiLqsNPiLE GKT++ ++ qYlA ++g+++ + + + + + + +LE mKIAA0216 515 SGKTTSFQHLVQYLATIAGTSG--------TKVFSVEKWQALST---LLE 553 AFGNAKTtRNNNSSRFGKfieIqFdatGsiNvTlvGgkIetYLLEKSRVv AFGN T+ N +RF ++ + Fd +G++ +++ I+t LLEK RV+ mKIAA0216 554 AFGNSPTIMNGSATRFSQILSLDFDQAGQV----ASASIQTMLLEKLRVA 599 yQtegERNFHIFYQLLagasaqeekkeLkLtspadpkdYaYLnqsgTynP + ++ E +F +FY+LLa +a + + eL+L L ++ mKIAA0216 600 RRPASEATFNVFYYLLACGDATL-RTELHLN---------HLAENN---- 635 cytv...yrrDdgiDDaeeFkdtrkAlkiiGftdeeqrsifrilAAILhL + + + + a+ F ++ A+k++ ++ eeq++++ ilA+I hL mKIAA0216 636 VFGIvplSKPEEKQKAAQQFSKLQAAMKVLAISPEEQKTCWLILASIYHL 685 GNieGFkqdqatTGkeeqAGvtvsedteealeiiaeLLGvDaeeLekaLl G +++ +e+ G + + ++e ++++a LLG + eeL a+ mKIAA0216 686 GAAG-ATKEA----AEA--GRKQFARHEW-AQKAAYLLGCSLEELSSAIF 727 srriktG....gggkrretvtkpq...nveqAryaRDALAKaiYsRLFdW + ++k G+ ++ ++r +++++++ A + +A+++Ys LF mKIAA0216 728 KHQLKGGtlqrSTSFRQGPEESGLgegTKLSALECLEGMASGLYSELFTL 777 iVekiNkaLsakeQasdSrGGqaaegdDTVSITVVdlPraaldkranfIG +++ +N+aL++ + + + mKIAA0216 778 LISLVNRALKSSQ------------------------------HSLCSMM 797 vLDIyGF......EIFaekNSFEQLcINYvNEKLQQfFNhhmFklEQEEY + D +GF++++ + SFE Lc NY+ +LQ +F +++F E E Y mKIAA0216 798 IVDTPGFqnpewgGSA-RGASFEELCHNYAQDRLQRLFHERTFLQELERY 846 krEgIeWtfIdyglDnqacid...............LIEkKmkPpGIlsl k +Ie + +D+ ++ d++ ++ ++ ++L ++ G+l l mKIAA0216 847 KEDNIE---LAF-DDLEPVADdsvaavdqashlvrsLAHAD-EARGLLWL 891 LDEeCrfPkatDqtFldKLlqtfsskhprlthFaqkpgrfkkgksrqgkt L+Ee ++P at++ +ld L++ + p k+g+ ++ + + ++ mKIAA0216 892 LEEEALVPGATEDALLDRLFSYY---GP--QEG-DKKGQSPLLR-SSKPR 934 eFiikHYAGd..VeYnaegfle...KNkDpLfddlisllksSsdvpllae +F + H G++ VeYn+ g+l ++ N p +++ + ll+ S++ +++++ mKIAA0216 935 HFLLGHSHGTnwVEYNVAGWLNytkQN--PATQNAPRLLQDSQK-KIISN 981 LFpeeelseaAnrrnkapdfeadfdeeeaaaksaklgsgkgksgkkknfl LF + ++ ++ + + + a + a + +++ g+ + ++ mKIAA0216 982 LFLGRAG----SATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKK 1027 eTvgsqfkeslgeLmktLsstAnlnPHfvRCIKPNekKkag......... + + +q+k ++++L+ t+ Hfv C P + +g++++ ++++ mKIAA0216 1028 KSLCIQIKLQVDALIDTIKRS---KMHFVHCFLPVAEGWPGeprsassrr 1074 ....................qFDaslVlhQlrclGvLEigiRirraGFPn +++++ + +++++ + + q+D sl + Qlr + +L+ R r+G+P mKIAA0216 1075 vsssseldlppgdpceagllQLDVSLLRAQLRGSRLLD-AMRMYRQGYPD 1123 RitfdeFlqRYrlLapktwpsgfrpkwvgdakkgceliLqslrqtpgnld ++f+eF++R+ +Lap+ ++ r v d+k+++e +L+sl +l+ mKIAA0216 1124 HMVFSEFRRRFDVLAPHLTKKHGRNYIVVDEKRAVEELLESL-----DLE 1168 keeyrfGkTKiFfR<-* k+ +G +++FfR mKIAA0216 1169 KSSCCLGLSRVFFR 1182 IQ: domain 1 of 1, from 1198 to 1218: score 23.7, E = 0.0045 *->rraaikIQaawRGylaRkryk<-* r +++Qaa+RGylaR+++k mKIAA0216 1198 SRHLTLFQAACRGYLARQHFK 1218 Filament: domain 1 of 1, from 1559 to 1908: score -192.1, E = 0.81 *->nEKeqmQnLNDRLAsYIdKVRfLEqqNkeLevkieelrqkqsrggpa + K q +L s ++ LEq++ +Le + e+ rq +s+ mKIAA0216 1559 KVKDQEEELDEQAGS----IQMLEQAKLRLEMEMERMRQTHSK---- 1597 svsrlyslYeteieeLRrqidqltner....................... + ++ e+ + ++++ q++++ +++ +++++ +++++ +++ ++ mKIAA0216 1598 EMESRDEEVEEARQSCQKKLKQMEVQLeeeyedkqkalrekrelesklst 1647 ...........................arlqlEidnl......realedf +++ ++++ +++++ +++ ++++ a++q+ +d+l+++ +++ +++++ mKIAA0216 1648 lsdqvnqrdfesekrlrkdlkrtkallADAQIMLDHLknnapsKREIAQL 1697 rkKyedKeDLaaQnqlkdlEialntkeaeLaTaL.eRqeaEndlvgLRaQ ++++e+ ++ +a a + R ++E ++++L mKIAA0216 1698 KNQLEE--------------SEF-----TCAAAVkARKAMEVEMEDL--- 1725 iAklEslaaRkdlDeaTLarvDLEnkvEsLq...EElaFLKknHeEEvke + D+ a++ LE ++ Lq+++ E+ + +E ++e mKIAA0216 1726 ---------HLQIDDIAKAKTALEEQLSRLQrekNEIQNRLEEDQEDMNE 1766 LqaqiqdtgqvnVEmDaarqqEwklDLtkaLrEiRaQYEeiAeknrqeaE L + + + V a+r D+++ +++++aQ Ee +k +qe+ mKIAA0216 1767 LMKKHKAA----V-AQASR------DMAQ-MNDLQAQIEE-SNKEKQELQ 1803 ew...YksKleeLqtaaarngealrsaKeEitElRRqiQ...sLeiELqs e + +s++e L ++ + + +++++ i El +++ +++ +L++ mKIAA0216 1804 EKlqaLQSQVEFLEQSMV-DKSLVSRQEAKIRELETRLEfekTQVKRLEN 1852 lksqnasLErqlaElEeryeaelaqyqalisqlEeeLqqlreEMarqLrE l s + +l+E ++ +a+ + ++ +l+++L++++eEM+ + r mKIAA0216 1853 LASRLKETMEKLTEERDQRAAAENREKEQNKRLQRQLRDTKEEMSELARK 1902 YQeLLdVKlaLDiEIATYRKLLEGEEsR<-* E E sR mKIAA0216 1903 ----------------------EAEASR 1908 Myosin_tail_1: domain 1 of 1, from 1129 to 1938: score -343.4, E = 0.0018 *->dlerqkreleeqlkrkeselsqlslklEdEqalvaqLqkkikeleaR + +r + l l +k i +e R mKIAA0216 1129 EFRRRFDVLAPHLTKKHGR---------N----------YIVVDEKR 1156 .IeELeEeLEaERaAR....aKaEkqRaDLsrELEeLsERLeEagG.aTa +eEL E L++E+ + + +++ + L+ RLeE+ ++ T+ mKIAA0216 1157 aVEELLESLDLEKSSCclglSRVFFRAGTLA--------RLEEQRDeQTS 1198 aQiElnkKREaELaKLRrdLEEanlqhEealatLRKKHqd..ainElsdQ + +l + L ++H ++++i++l+ mKIAA0216 1199 RHL--------------------TLFQAACRGYLARQHFKkrKIQDLA-- 1226 ieqLqKqKakaEKeKsqlqaEvddlaaqldqiaKaKlnaEKkakqlEsql i qK+ + K K+ l ++++ + l+ E ++ + ++ + mKIAA0216 1227 IRCVQKN---IKKNKGVKDWPWWKLFTTVRPLIQVQLSEEQIRNK-DEEI 1272 sElqvKldElqRqlnDltsqKsRLqsENsdLtrqleEaEaqvsqlsklKs + l++Kl+ ++++n+l + RL + s+Lt +l + + ++s mKIAA0216 1273 QQLRSKLEKVEKERNELRLSSDRLETRISELTSELTDE----RNTGESAS 1318 qlesQLEeAkRslEEEsReRanLqaqlrnlehDlDslrEqlE....EEsE ql l+ E+ eR+ + +++ l+ +D+l+ q+E + E E mKIAA0216 1319 QL----------LDAETAERLRTEKEMKELQTQYDALKKQMEvmemEVME 1358 AKaeleRqLsKanaeiq......qwrsKfEsEgalraE........ElEE A+ l R+ ++ n e+++++ +++wr K+E+ +++ + ++++ ++ElE+ mKIAA0216 1359 AR--LIRA-AEINGEVDdddaggEWRLKYERAVRE-VDftkkrlqqELED 1404 .......lKkKlnqkisElEeaaEaanaKcssLEKtKsRLqsElEDlqie + + +++ ++ l+ ++ +l+ ++ + + ++L K +RL++El D + mKIAA0216 1405 kmeveqqSRRQLERRLGDLQADSDESQRALQQLKKKCQRLTAELQDTKLH 1454 vEranaaaseLEKKqknFDKilaEwKkkvdelqaE...letAqreaRnls +E ++ + eLEKKq+ FD +E+ + +e+q E+ ++e +qre l mKIAA0216 1455 LEGQQVRNHELEKKQRRFD---SELSQAHEETQREklqREKLQREKDMLL 1501 tElfrlKneleElkDqvEaLrRENKnLqdEikDLtdqLgEgGRnvHELEK +E+f+lK + eE+ +++++ + +L E+ D +q + ++ K mKIAA0216 1502 AEAFSLKQQMEEKDLDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKK 1551 arRrLEaEkdELqaALeEAEaALeqeEsKvlRaqvElsqiRsEiERRLaE +R LEa + L+E + ++ E+++lR++ E+ +R+ + + mKIAA0216 1552 QLRDLEAKVKDQEEELDEQAGSIQMLEQAKLRLEMEMERMRQTHSKEMES 1601 KEEEfEntRKnhqraiesLqasLaEaEaKgKaEalRlKKKLEgdInELEi ++EE E+ R + q+++ ++++ L E+E K+ alR K LE+ ++ L mKIAA0216 1602 RDEEVEEARQSCQKKLKQMEVQL-EEEYEDKQKALREKRELESKLSTLS- 1649 aLDhaNkanaeaqKnvKkyqqqvkeLQtqvEeeQRaredareqlavaERR D N+ e +K ++k + k L + ++Q ++ ++++ a + R mKIAA0216 1650 --DQVNQRDFESEKRLRKDLKRTKALLA---DAQIMLDHLKNN-APSKRE 1693 ataLqaElEELrvaLeqaeRaRKqAEtElaEaservneLtaqnssLiaqK ++L++ lEE ++a aRK+ E E ++++ ++ + + + ++L +q mKIAA0216 1694 IAQLKNQLEESEFTCAAAVKARKAMEVEMEDLHLQIDDIAKAKTALEEQL 1743 RKLEgelaalqsDLDEavnElkaAeERakKAqaDaarLaeELrqEQehsq ++L e + +q L+E + + k A a+a r ++ Q +++ mKIAA0216 1744 SRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMNDLQAQIE 1793 klErlRKqLEsqvKeLqvRLdEaEaaAlkgGKkvIqKLEaRVReLEaELd + + L + + Lq + + +E+ + + ++ Ea++ReLE+ L+ mKIAA0216 1794 ESNKEKQELQEKLQALQSQVEFLEQSMVDK--SLVSRQEAKIRELETRLE 1841 gEqRRhaetqKnlRKaeRrvKE.LqfQvEE.DkKnlerlQDLvDKLqaKi E + ++K l r+KE+++ +EE+D++ ++++ K q+K mKIAA0216 1842 FE----KTQVKRLENLASRLKEtMEKLTEErDQRAAAENRE---KEQNK- 1883 KtyKRQl....EEaEEiaqinlsKyRkaQreLEdAEERADqAEsslnk.l + RQl++++EE+ E+a ++ Rk +eLE E+ ++A++sl+ +l mKIAA0216 1884 -RLQRQLrdtkEEMSELARKEAEASRK-KHELEMDLESLEAANQSLQAdL 1931 RqreaKsRr<-* + a R mKIAA0216 1932 K--LAFKRI 1938 //