hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05341/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0213  ( 1502 res)   mbg05341

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       257.2    2.2e-73   1
Pkinase_Tyr Protein tyrosine kinase                      75.7    9.4e-19   1
RIO1        RIO1 family                                -102.4       0.48   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
RIO1          1/1    1250  1394 ..     1   203 []  -102.4     0.48
Pkinase_Tyr   1/1    1237  1495 ..     1   272 []    75.7  9.4e-19
Pkinase       1/1    1237  1495 ..     1   287 []   257.2  2.2e-73

Alignments of top-scoring domains:
RIO1: domain 1 of 1, from 1250 to 1394: score -102.4, E = 0.48
                   *->nVYhAvsyaedgedptevAvKiyrtgtteFkkrkkYrdgdfRFrdrk
                       VY + s +  ge    +A+K  r + ++ k +k+  d  + F+ +k
   mKIAA0213  1250    KVYTCIS-VDTGE---LMAMKEIRFQPNDHKTIKETADELKIFEGIK 1292 

                   sktswrklvrlWAeKEfrNLkRLyeaGvpVPkPiavnrhvLVMEfIgded
                                   + NL+R  +           ++  + ME+++   
   mKIAA0213  1293 ----------------HPNLVRYFGVE------LHREEMYIFMEYCD--- 1317 

                   GvpAPrLkdveleldlseeeaeelYdeiirEymrrlYkeagLVHGDLSEY
                      +  +  +     l e  ++ lY + i    +  ++e+g+VH D    
   mKIAA0213  1318 EGTLEEVSRLG----LQEHVIR-LYTKQIT-VAINVLHEHGIVHRDIKGA 1361 

                   NiLvhddgkpviIDvsQaVetdHPnAlefLeRDieNIinFFrrkgvdkrv
                   Ni+++  g + + D++ +V                      +  +     
   mKIAA0213  1362 NIFLTSSGLIKLGDFGCSVK--------------------LKNNAQT--- 1388 

                   vdvrel<-*
                   +  ++    
   mKIAA0213  1389 MPGEVN    1394 

Pkinase_Tyr: domain 1 of 1, from 1237 to 1495: score 75.7, E = 9.4e-19
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLk.eigasseei
                       + g k+GeG++G+Vy ++      +t+   A K ++ +   +++  
   mKIAA0213  1237    WQRGNKIGEGQYGKVYTCISV----DTGELMAMKEIRfQ-PNDHKT- 1277 

                   eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd
                    +++   E++i   + +HpN+Vr+ Gv ++ +e     +yi +Ey+  G 
   mKIAA0213  1278 -IKETADELKIFEGI-KHPNLVRYFGVELH-REE----MYIFMEYCDEGT 1320 

                   LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV
                   L +       +  L  +    +  Qi  + + L+++++vHRD+   N+ +
   mKIAA0213  1321 LEE---VS--RLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFL 1365 

                   senlvVKIsDFGLaRdiynddyYvrkkgggklPv...kWmAPEslkygk.
                   ++++ +K +DFG +  + + +   ++ g+     ++   mAPE++   k+
   mKIAA0213  1366 TSSGLIKLGDFGCSVKL-KNNAQ-TMPGEVNSTLgtaAYMAPEVITRAKg 1413 

                   ..FtskSDVWSFGVlLWEiftlGeqPFYpgm.sneevlellyedGyRLpr
                   ++   + D+WS G++  E++t G+ P + + + n++++ ++   G+  p+
   mKIAA0213  1414 egHGRAADIWSLGCVVIEMVT-GKRP-WHEYeHNFQIMYKV-GMGHKPPI 1460 

                   PenCPdelYdlMlqCWaedPedRPtFsel..verL<-*
                   Pe  ++e      +C + dP+ R t s+l ++ +    
   mKIAA0213  1461 PERLSPEGKAFLSHCLESDPKIRWTASQLldHAFV    1495 

Pkinase: domain 1 of 1, from 1237 to 1495: score 257.2, E = 2.2e-73
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      ++++ k+G+G +G+Vy ++ ++tg++ A+K+i+ + +++k  k+ + 
   mKIAA0213  1237    WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD 1283 

                   rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse
                     E++i   ++HpN vr+++v   + ++y+ +Eyc+ G     L      
   mKIAA0213  1284 --ELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEG----TLE----- 1322 

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv
                     ++ +l  +e++++ + +Qi  +++ LH++gi+HRD+K +NI+l + g 
   mKIAA0213  1323 EVSRLGL--QEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGL 1370 

                   vdaflKiaDFGlAkkls....t.ssslttfvGTpwYmAPEvll..ggngy
                   +    K++DFG++ kl+++ +t +++ ++  GT  YmAPEv+ + +g+g+
   mKIAA0213  1371 I----KLGDFGCSVKLKnnaqTmPGEVNSTLGTAAYMAPEVITraKGEGH 1416 

                   gtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdsp
                   g+++D+WSlG++++e++tGk P+ +       +++ i  + g   + ++p
   mKIAA0213  1417 GRAADIWSLGCVVIEMVTGKRPWHEY-----EHNFQIMYKVGMGHKPPIP 1461 

                   ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-*
                   e  s             +e+k +++ cL+ DP+ R+ta ++l H ++   
   mKIAA0213  1462 ERLS-------------PEGKAFLSHCLESDPKIRWTASQLLDHAFV    1495 

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