hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj34112/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0167  ( 1029 res)   mfj34112

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
ArfGap   Putative GTP-ase activating proteins for the   219.9    2.2e-61   1
PH       Pleckstrin homology domain.                     65.4    7.2e-15   1
RAS      Ras subfamily of RAS small GTPases              -8.2    3.1e-07   1
RAB      Rab subfamily of small GTPases                 -31.6      3e-06   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RAB        1/1     264   426 ..     1   172 []   -31.6    3e-06
RAS        1/1     261   429 ..     1   167 []    -8.2  3.1e-07
PH         1/1     534   749 ..     1    82 []    65.4  7.2e-15
ArfGap     1/1     768   888 ..     1   139 []   219.9  2.2e-61

Alignments of top-scoring domains:
RAB: domain 1 of 1, from 264 to 426: score -31.6, E = 3e-06
                   *->FKiilIGDSGVGKSsLLsRFtddkF.......sedsksTIGVDFktk
                      +++ ++GD   GKSsL++RF +++++  ++ +se++k    VD +t+
   mKIAA0167   264    LRLGVLGDVRSGKSSLIHRFLTGSYqvlekieSEQYKKEMLVDGQTH 310  

                   tiev....dGkrvKLQIWDTAGQERFRSiTssYYRGAvGalLVYDiTnre
                    + ++++ +    K   W                  A+++++V+ + +++
   mKIAA0167   311 LVLIreeaGAPDAKFSGW------------------ADAVIFVFSLEDES 342  

                   SFenlkn...WlkelreyadpppenvvimLVGN..KsDLeeqRqVstEea
                   SF+ +++ ++ l+ lr        +    LVG ++ +  ++ R+V   +a
   mKIAA0167   343 SFQAVSRlhgQLSSLRGEGRG---GLALALVGTqdRISASSPRVVGDARA 389  

                   ekficDcAeehgllFifETSAKtntNVeeAFeelakkIlkr<-*
                   +++   c +   ++++ ET A  ++NV+ +F+e+a+k++ +   
   mKIAA0167   390 RAL---CTDMKRCSYY-ETCATYGLNVDRVFQEVAQKVVTL    426  

RAS: domain 1 of 1, from 261 to 429: score -8.2, E = 3.1e-07
                   *->mreYKlVVlGgGGVGKSALTiQFiqghF..vdeYDPTIE.DSYRKqi
                      ++e +l VlG+   GKS+L  +F +g ++ +++    IE+ +Y+K+ 
   mKIAA0167   261    IPELRLGVLGDVRSGKSSLIHRFLTGSYqvLEK----IEsEQYKKEM 303  

                   eiDgevalLDILDTAGQeEFsAMRdqYmRtGeGFlLVYSitsrqSFeeik
                    +Dg++ l  I   AG  +       ++   +  + V+S+ + +SF+ ++
   mKIAA0167   304 LVDGQTHLVLIREEAGAPD-----AKFSGWADAVIFVFSLEDESSFQAVS 348  

                   kfreqI..lRVKdrddvPivLVGNKcDLene...RqVsteEGkeLAkqln
                   +++ q+++lR  +r    + LVG   D+ + +++R+V  + +++L ++++
   mKIAA0167   349 RLHGQLssLRGEGRGGLALALVGT-QDRISAsspRVVGDARARALCTDMK 397  

                   .cpFlEtSAKerinVdeaFydL...VReirks<-*
                   +c ++Et A +  nVd +F+++ ++V   rk+   
   mKIAA0167   398 rCSYYETCATYGLNVDRVFQEVaqkVVTLRKQ    429  

PH: domain 1 of 1, from 534 to 749: score 65.4, E = 7.2e-15
                   *->vikeGwLlkks....k.swkkryfvLfngvLlyyksk.......kpk
                      +ik+ +Llk+s+++ ++ wkk+y++L ++ +l+y+++ ++  ++++ 
   mKIAA0167   534    PIKQSFLLKRSgnslNkEWKKKYVTLSSNGFLLYHPSindyihsTHG 580  

                   gsipLsgcsvre.p....................................
                   ++++L   +v+++ +++++  +  +++ + ++  ++ +    +++++ + 
   mKIAA0167   581 KEMDLLRTTVKVpGkrppraisafgpsasinglvkdmstvqmgegpeast 630  

                   ..................................................
                   + +++++++++   + +  +++  +++++  +  + +  ++++ ++ +++
   mKIAA0167   631 pmpspspspsslqlptdqtskhllkpdrnlaralstdctpsgdlsplsre 680  

                   .................................cFeivt.dr.tlllqAe
                   +++++  ++ ++++ + +++ +++    ++++  F iv+++++t+++ A 
   mKIAA0167   681 pppspmvkkqrrkklstpsktegsavqaeeenfEFLIVSsTGqTWHFEAA 730  

                   seeereeWvealqsaiaka<-*
                   s eer+ Wv+a++s i  +   
   mKIAA0167   731 SFEERDAWVQAIESQILAS    749  

ArfGap: domain 1 of 1, from 768 to 888: score 219.9, E = 2.2e-61
                   *->eealqlLRsikpgNkkCfDCGavpnPtWaSvnlGvflCieCSGiHRs
                      + a+q +R+ k gN+ C+DCGa pnPtWaS+nlG+++CieCSGiHR+
   mKIAA0167   768    AVAIQAIRNAK-GNSTCVDCGA-PNPTWASLNLGALICIECSGIHRN 812  

                   LfGvHiSkVnvRSltLDtWteeeLrllesckgGNenansfwesnlddfsl
                   L G+H+S+V  RSl+LD+W++ eL+l++ +++GN++an++wes+++ +++
   mKIAA0167   813 L-GTHLSRV--RSLDLDDWPR-ELTLVL-TAIGNDTANRVWESDTRGRAK 857  

                   kpkdsdaaasvKCeddrqkyesfiaaKYeeklfrvdkesaee<-*
                   +++ds+          r+++es+i+aKYe++lf + ++++ e   
   mKIAA0167   858 PTRDSS----------REERESWIRAKYEQLLF-LAPLGTTE    888  

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