hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj21098/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0154  ( 724 res)   mfj21098

Scores for sequence family classification (score includes all domains):
Model           Description                             Score    E-value  N 
--------        -----------                             -----    ------- ---
VHS             VHS domain                              250.9    1.8e-71   1
Alpha_adaptinC2 Adaptin C-terminal domain               179.8    4.5e-50   1
GAT             GAT domain                              174.8    1.4e-48   1
Extensin_2      Extensin-like region                   -131.7       0.24   1

Parsed for domains:
Model           Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------        ------- ----- -----    ----- -----      -----  -------
VHS               1/1       7   148 ..     1   155 []   250.9  1.8e-71
GAT               1/1     212   313 ..     1   106 []   174.8  1.4e-48
Extensin_2        1/1     328   677 ..     1   385 []  -131.7     0.24
Alpha_adaptinC2   1/1     592   716 ..     1   125 []   179.8  4.5e-50

Alignments of top-scoring domains:
VHS: domain 1 of 1, from 7 to 148: score 250.9, E = 1.8e-71
                   *->mpsssasplerliekATdpslreeaeDwsliLdicDlInekiYqetg
                      m+++++++le++++kAT+ps+r+e  Dw++i+ +cD+In++    +g
   mKIAA0154     7    MAEAEGESLESWLNKATNPSNRQE--DWEYIIGFCDQINKE---LEG 48   

                   PkeAvrlIkKrinstknphvallALtlLdaCVkNCGsrFHlevaskeFln
                   P+ Avrl++++i+s +++++a++ALt+L+aC+kNCG+r+H+ev++++Fln
   mKIAA0154    49 PQIAVRLLAHKIQS-PQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLN 97   

                   eLvklitrsppgrpakdkVkekileliqeWadafCKhnknkpdlsyivdl
                   eL+k+++++++g+++++kVk+k++el+++W++a+       p+  +i+d+
   mKIAA0154    98 ELIKVVSPKYLGDRVSEKVKTKVIELLFSWTLAL-------PEEAKIKDA 140  

                   yklLkrkG<-*
                   y++Lkr+G   
   mKIAA0154   141 YHMLKRQG    148  

GAT: domain 1 of 1, from 212 to 313: score 174.8, E = 1.4e-48
                   *->lrpEkisKllselEeVrnnVrlLseMLsaydPgdaepddsElLqeLy
                      +r++k++K+l++lEeV+nnV+lL eML +y+++ ++++d El++eL+
   mKIAA0154   212    ARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEYSSDADKELMKELF 258  

                   erCrkmqprifqLlsdteDnDSDAellaeiLqaNDnLnnvilrYkrivrg
                   +rC+++++++f+L+s+teDnD   ++l++iLqa+DnL++vi++Yk+i++g
   mKIAA0154   259 DRCENKRRTLFKLASETEDND---NSLGDILQASDNLSRVINSYKTIIEG 305  

                   rtrvlgaaa<-*
                   +  v+g+++   
   mKIAA0154   306 QI-VNGEVT    313  

Extensin_2: domain 1 of 1, from 328 to 677: score -131.7, E = 0.24
                   *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy
                          ++ l  l  ps++s    +   PP +       P +P      
   mKIAA0154   328    NQGALIDLAELDAPSNSS----PALAPPTS-----GIPILP------ 359  

                   kSPPPpkkpYvYsSPPPPs..yvykSPPPPkp..............yvYk
                     PPP        S PP s++      PP + ++++  +  +++   +  
   mKIAA0154   360 --PPPQ------TSGPPRSrsSSQAEAPPGSDstnnalslldeellCLGL 401  

                   SPPpPkyvYkSPPpPvykYkSPPPPthsppPpyvykSPPPPpkkyvykSp
                     P P+   +SP +  +      PP+        + SP P p      S 
   mKIAA0154   402 TDPAPTAPKESPGSSQWHLFQNEPPS-----DLDFFSPRPVP----VASC 442  

                   PpptPvYkYkSPPPPp.yvYkspPpPvkkripyvYkSPPPPpPYvYkSpP
                   P   P    + PPP ++     +P P           P P +P    S+P
   mKIAA0154   443 PSDGP----QLPPPVStSSMSQAPLPAAF--------PAPVVP---ASAP 477  

                   ppvk.kyiyksppppephkYvYkSPPPPpPYvyesvpeqkikYvYkSPPP
                     + + ++++s p+p    ++     P  P    s   ++     +    
   mKIAA0154   478 THSTgSFMFSSGPAPALA-PKAEPKGPEYP---SSSTSHRLDALDQL--- 520  

                   PkksYkspsp.pkyVYkSpPpPvipykYkSPPPPkkkyspaPrkpyvYkS
                     +  k  s   k+V    P P+      SP  P     +aP +p    S
   mKIAA0154   521 -LEEAKVTSGlVKPVSCFSPGPT-----ASPLLP----ASAPARPLLPFS 560  

                   PPPPtyvYkSpPpPyk.......pptppkiyksPPPPtPvyvY.kspPpi
                     P ++ ++S   P+k+++ +  + ++p     P    Pv  Y+k   +i
   mKIAA0154   561 TGPGSPLFQSQGSPQKgpelslaSVHVPLESIKPSSALPVTAYdKNGFRI 610  

                   ppik.........sssppPvyvYkSpPppvysPPPPyvYssPPPPvyvyn
                    +   ++ +++++  +   v + + +P pv+s     v ++  P     +
   mKIAA0154   611 LFHFakecppgrpDVLVVVVSMLNTAPLPVKS----IVLQAAVP-----K 651  

                   saPvykksPPkhhYiYsSP..PPphh<-*
                   s  v  ++P     +  SP +PP      
   mKIAA0154   652 SMKVKLQPPSGTELSPFSPiqPPAAI    677  

Alpha_adaptinC2: domain 1 of 1, from 592 to 716: score 179.8, E = 4.5e-50
                   *->pkpawlpsivvyessgLqIgltferrg.pespglgritltftNkssq
                      +kp+++ ++++y+++g++I ++f ++++p++p+++++++ + N+++ 
   mKIAA0154   592    IKPSSALPVTAYDKNGFRILFHFAKECpPGRPDVLVVVVSMLNTAPL 638  

                   pitnfvfqaAVPKslkLqLqpqsgsvlpaggpgaqP.aitQvlrvsnpqd
                   p+  +v+qaAVPKs+k++Lqp+sg++l++++p+++P aitQv+ + np  
   mKIAA0154   639 PVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPaAITQVMLLANPM- 687  

                   nkkplrlrikltYnlggqsvqeqgevsklP<-*
                    k+++rlr+klt+ lg q   e gev+++P   
   mKIAA0154   688 -KEKVRLRYKLTFALGEQLSTELGEVDQFP    716  

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