hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg20462/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0142  ( 809 res)   mbg20462

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   157.4    1.4e-42   1
SH3      Src homology 3 domains                         100.7    1.7e-25   1
CH       Calponin homology domain                        57.4    1.8e-12   1
PH       Pleckstrin homology domain.                     46.1    4.6e-09   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
CH         1/1      30   134 ..     1   100 []    57.4  1.8e-12
SH3        1/1     193   248 ..     1    58 []   100.7  1.7e-25
RhoGEF     1/1     281   456 ..     1   211 []   157.4  1.4e-42
PH         1/1     486   586 ..     1    82 []    46.1  4.6e-09

Alignments of top-scoring domains:
CH: domain 1 of 1, from 30 to 134: score 57.4, E = 1.8e-12
                   *->eeeallrWinsll...........kvtnfssdlkDGvvLckLlnsls
                      + e+ + W+  l+  ++++++ ++++ +++++lkDGvvLc+Ll++l 
   mKIAA0142    30    SAEQTVTWLITLGvlespkktisdPEVFLQASLKDGVVLCRLLERLL 76   

                   Pagsvdkkk.....rfkkleNinlalsfaeklgafLGvgkvvlfdpeDlv
                   P g+++k+ +++++++++l Ni+ +l ++ +         ++ fd++Dl+
   mKIAA0142    77 P-GTIEKVYpeprnESECLSNIREFLRACGAS------LRLETFDANDLY 119  

                   egnenkklilgviwtLirl<-*
                    g     ++ +v+  L+ l   
   mKIAA0142   120 QG----QNFNKVLSSLVTL    134  

SH3: domain 1 of 1, from 193 to 248: score 100.7, E = 1.7e-25
                   *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnrtGkeG
                       +v+A+++++ +nedELsF+kGD+i+v++ +++gWweG++n  G++G
   mKIAA0142   193    LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHN--GRTG 237  

                   lfPsnYVeeie<-*
                   +fPsnYV+ei+   
   mKIAA0142   238 WFPSNYVREIK    248  

RhoGEF: domain 1 of 1, from 281 to 456: score 157.4, E = 1.4e-42
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      vl+ +l+TE +Y ++L+ ++ ++l+pL+ ++       ls      l
   mKIAA0142   281    VLQNILETEHEYSKELQSVLSTYLRPLQTSD------KLSSANTSYL 321  

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                   +g N+eei +f++ + ++Lee+ +  +                ++r+g +
   mKIAA0142   322 MG-NLEEISSFQQVLVQSLEECTKSPE---------------AQQRVGGC 355  

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeiesk
                   Fl l  ++++  +Y +Yc+nhp+a+++l++     +++++ +f++   ++
   mKIAA0142   356 FLSL--MPQMRTLYLAYCANHPSAVSVLTE-----HSEDLGEFMETKGAS 398  

                   pncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLkk
                   ++ +      l L++ L+kP+ Rl kYp LLkel++h+++ h+dr+d++k
   mKIAA0142   399 SPGI------LVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQK 442  

                   AleaikelasqvNe<-*
                      a k+l +q++e   
   mKIAA0142   443 SMTAFKNLSAQCQE    456  

PH: domain 1 of 1, from 486 to 586: score 46.1, E = 4.6e-09
                   *->vikeGwLlkks..k.swkkryfvLfngvLlyyksk......kpkgsi
                      v++  +++++  +++   +ry+ Lf++ Ll    +++ ++  ++g++
   mKIAA0142   486    VTYMSQVTIQCagSeEKNERYLLLFPNLLLMLSASprmsgfIYQGKL 532  

                   pLsgcsvre.p.......cFeivt.dr.tlllqAeseeereeWvealqsa
                   p +g+++++ +++++++++Fei+ +  +++l+++ s+++++eWve+lq+ 
   mKIAA0142   533 PTTGMTITKlEdsenhrnAFEISGsMIeRILVSCTSQQDLHEWVEHLQKQ 582  

                   iaka<-*
                   ++     
   mKIAA0142   583 TKVT    586  

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