hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg20462/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0142  ( 809 res)   mbg20462

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
SH3_1    SH3 domain                                      88.1    1.7e-22   1
RhoGEF   RhoGEF domain                                   82.1    1.2e-20   1
SH3_2    Variant SH3 domain                              70.6    3.4e-17   1
PH       PH domain                                       57.0    4.1e-13   1
CH       Calponin homology (CH) domain                   54.4    2.5e-12   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
CH         1/1      30   139 ..     1   121 []    54.4  2.5e-12
SH3_1      1/1     193   247 ..     1    58 []    88.1  1.7e-22
SH3_2      1/1     194   247 ..     1    69 []    70.6  3.4e-17
RhoGEF     1/1     281   456 ..     1   207 []    82.1  1.2e-20
PH         1/1     486   584 ..     1    92 []    57.0  4.1e-13

Alignments of top-scoring domains:
CH: domain 1 of 1, from 30 to 139: score 54.4, E = 2.5e-12
                   *->qekellrWinsvlagypgnkdtlPippvritnfftdwlkDGlaLcaL
                      + +  + W+  + +   ++k        + + f +  lkDG++Lc L
   mKIAA0142    30    SAEQTVTWLITLGVLESPKKT-----ISDPEVFLQASLKDGVVLCRL 71   

                   lnklrPglidkkkvpslsrfdkleNlnlaldaaekeGlgiilvlidpeDi
                   l++l Pg+i+k+  +++++ ++l N++ +l a+ +    + l+ +d++D+
   mKIAA0142    72 LERLLPGTIEKVYPEPRNESECLSNIREFLRACGASL--R-LETFDANDL 118  

                   vegnpdPDeklvltllwqLirrfq<-*
                   ++g +   + +vl  l +L ++     
   mKIAA0142   119 YQGQN---FNKVLSSLVTLNKVTA    139  

SH3_1: domain 1 of 1, from 193 to 247: score 88.1, E = 1.7e-22
                   *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgGke
                       +v+A++ ++++++dELsF kGDvi+v   +++gWW+g  +   G++
   mKIAA0142   193    LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHN---GRT 236  

                   GliPsNYVepv<-*
                   G++PsNYV+++   
   mKIAA0142   237 GWFPSNYVREI    247  

SH3_2: domain 1 of 1, from 194 to 247: score 70.6, E = 3.4e-17
                   *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl
                      ++ra +++   t+++e      Ls+ kGdv++v+      + +gww+
   mKIAA0142   194    VVRAKFNFQQ-TNEDE------LSFSKGDVIHVT----RVEEGGWWE 229  

                   geslggGrrrRGlvPssaveel<-*
                   g+   +Gr+  G++Ps++v+e+   
   mKIAA0142   230 GTH--NGRT--GWFPSNYVREI    247  

RhoGEF: domain 1 of 1, from 281 to 456: score 82.1, E = 1.2e-20
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      vl  +leTE +Y ++L  ++ +y++pL+ +       l++   + + 
   mKIAA0142   281    VLQNILETEHEYSKELQSVLSTYLRPLQTSD-----KLSSANTSYLM 322  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                   +N+e+i +f++ + + sLe++  s+           + +qr+G +Fl+l 
   mKIAA0142   323 GNLEEISSFQQVLVQ-SLEECTKSP-----------EAQQRVGGCFLSLM 360  

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                     +  +Y +Yc+n+p+A+ +l+       ++++ ef + ++ass  g   
   mKIAA0142   361 PQMRTLYLAYCANHPSAVSVLTE-----HSEDLGEFMETKGASSP-G--- 401  

                   davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkaldl
                       l L + L+kP  R+ +Yp LLkeL  h      +pdr+d +k++ +
   mKIAA0142   402 ---ILVLTTGLSKPFMRLDKYPTLLKELERHMED--YHPDRQDIQKSMTA 446  

                   lqdlaksiNe<-*
                    ++l+ +  e   
   mKIAA0142   447 FKNLSAQCQE    456  

PH: domain 1 of 1, from 486 to 584: score 57.0, E = 4.1e-13
                   *->vikeGwLlkkg.gkkswkkRyfvLfndvLlyykdkk....kkpkgsi
                      v+++  ++ +  g ++  +Ry+ Lf++ Ll+   +++ +++ ++g++
   mKIAA0142   486    VTYMSQVTIQCaGSEEKNERYLLLFPNLLLMLSASPrmsgFIYQGKL 532  

                   pLsgiqvekvpdn.krkncFeirt.dretlllqaeseeerkeWvkaiqsa
                   p  g++++k++d+++++n+Fei+ ++ e++l++++s+++++eWv+++q++
   mKIAA0142   533 PTTGMTITKLEDSeNHRNAFEISGsMIERILVSCTSQQDLHEWVEHLQKQ 582  

                   ir<-*
                    +   
   mKIAA0142   583 TK    584  

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