hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm10011/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0135  ( 1389 res)   mpm10011

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
S_TKc    Serine/Threonine protein kinases, catalytic    276.4    2.1e-78   1
PAS      PAS domain                                      63.7    2.4e-14   2
TyrKc    Tyrosine kinase, catalytic domain              -39.9    1.1e-08   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PAS        1/2     125   192 ..     1    68 []    41.7    1e-07
PAS        2/2     339   406 ..     1    68 []    22.0    0.084
TyrKc      1/1    1065  1315 ..     1   280 []   -39.9  1.1e-08
S_TKc      1/1    1065  1317 ..     1   231 []   276.4  2.1e-78

Alignments of top-scoring domains:
PAS: domain 1 of 2, from 125 to 192: score 41.7, E = 1e-07
                   *->erlraileslpdgiivld.ldGrilyaNpaaeellGyspeeliGksl
                      + l++ + + + +++ +d  + +il aN++a+ llGys ++liG+ l
   mKIAA0135   125    SLLSTPVCNPNKAVFTVDaKTTEILVANDKACSLLGYSSHDLIGQKL 171  

                   lelihpedrlleevqe.lqrlla<-*
                   ++++   d   e v++  +++++   
   mKIAA0135   172 AQFFLKSDS--EVVEAlSEEHVE    192  

PAS: domain 2 of 2, from 339 to 406: score 22.0, E = 0.084
                   *->erlraileslpdgiivldldGrilyaNpaaeellG.yspeeliGksl
                       + +  +  +  g+i l +dG+i  +N++++ +l +y + el+Gk++
   mKIAA0135   339    YQASVWVFCTISGLITLLPDGTIYGVNHSFALMLFgYGKTELLGKNI 385  

                   lelihpedrlleevqe.lqrlla<-*
                   + li+  ++   + +    +++    
   mKIAA0135   386 TFLIPGFYH--YMDLTyDSSVQL    406  

TyrKc: domain 1 of 1, from 1065 to 1315: score -39.9, E = 1.1e-08
                   *->ltlgkkLGeGaFGeVykGtlk...ieVAVKtLkeda...........
                         +  LG+GaFG V+ ++ k+ + eV VK +k+++  ++   ++++
   mKIAA0135  1065    YNTISPLGSGAFGFVWTAVEKecnKEVVVKFIKKEKvledcwiedpk 1111 

                   keeFlrEakiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmE.yme
                   +     E+ i++k+  +H Ni+k l +   +       e   +vmE++ +
   mKIAA0135  1112 LGRVTLEIAILSKV--DHANIIKVLDIFENQ-------EFFQLVMEkHGS 1152 

                   gGdLldyLrknrpklslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcL
                   g dL  ++ +++p l  +    +  Q  +   YL+s++++HRD+   N+ 
   mKIAA0135  1153 GMDLFAFI-DHHPCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIKDENIV 1201 

                   vgenkvvKIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAP
                   ++e++++K  DFG + +l+ +      k  Y+     +g     i  +AP
   mKIAA0135  1202 IAEDFTIKLIDFGSAAYLERG------KLFYTF----CGT----IEYCAP 1237 

                   Esl.........kdgkFtskSDVWSFGVlLWEiftlGeqPYpgeiqqfms
                   E+l +++ ++++ +         WS GV+L+   tl  +  p      ++
   mKIAA0135  1238 EVLignpyrgpeLEM--------WSLGVTLY---TLIFEENPF-----CE 1271 

                   neevleylkkGyRlpkPendlpiSsvtCPdelYdlMlqCWaedPedRPtF
                    ee +e + +      P           ++el +l +   +  Pe+R t 
   mKIAA0135  1272 VEETMEAVIHP-----PFL--------VSQELMSLLSGLLQPCPEQRTTL 1308 

                   selverl<-*
                   + l+++    
   mKIAA0135  1309 EKLIRDP    1315 

S_TKc: domain 1 of 1, from 1065 to 1317: score 276.4, E = 2.1e-78
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik..............
                      Y  + +lG+GaFG V+ a++k+ +++v +K ik+++  ++   ++++
   mKIAA0135  1065    YNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKkekvledcwiedpk 1111 

                   .erilrEikiLkk.dHPNIVkLydvfed.dklylVmEyceGdlGdLfdll
                     r+  Ei+iL+k dH NI+k +d+fe+++++ lVmE  +  + dLf ++
   mKIAA0135  1112 lGRVTLEIAILSKvDHANIIKVLDIFENqEFFQLVMEKHGS-GMDLFAFI 1160 

                   kkrgrrglrkvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds
                   +++++      l+E+ a f+frQ++sa+ YLHsqgIiHRD+K eNi + +
   mKIAA0135  1161 DHHPC------LDEpLASFIFRQLVSAVGYLHSQGIIHRDIKDENIVIAE 1204 

                   ..hvKlaDFGlArql......ttfvGTpeYmAPEvl...gYgkpavDiWS
                   + ++Kl+DFG+A+ l++++  +tf+GT eY+APEvl +++Y +p+  +WS
   mKIAA0135  1205 dfTIKLIDFGSAAYLergklfYTFCGTIEYCAPEVLignPYRGPELEMWS 1254 

                   lGcilyElltGkpPFp.qldlifkkig.....SpeakdLikklLvkdPek
                   lG++ly l+  + PF++ ++++  +i ++   S+e+ +L+++lL+  Pe+
   mKIAA0135  1255 LGVTLYTLIFEENPFCeVEETMEAVIHppflvSQELMSLLSGLLQPCPEQ 1304 

                   Rlta.eaLedeldikaHPff<-*
                   R t +++ +       +P++   
   mKIAA0135  1305 RTTLeKLIR-------DPWV    1317 

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