hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm10011/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0135  ( 1389 res)   mpm10011

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       267.1    2.3e-76   1
PAS         PAS fold                                     15.5      0.094   1
Pkinase_Tyr Protein tyrosine kinase                     -18.4    9.9e-11   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
PAS           1/1     125   239 ..     1   123 []    15.5    0.094
Pkinase_Tyr   1/1    1065  1315 ..     1   272 []   -18.4  9.9e-11
Pkinase       1/1    1065  1317 ..     1   287 []   267.1  2.3e-76

Alignments of top-scoring domains:
PAS: domain 1 of 1, from 125 to 239: score 15.5, E = 0.094
                   *->edlrailesnlpdgifvvDvedGrilyvNaaaeellGlsreeviGks
                       +l++ + +    ++f vD + ++il +N++a++llG+s +++iG+ 
   mKIAA0135   125    SLLSTPVCN-PNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQK 170  

                   lldlipeeddaeclvaelllqaleqgee..rgvevsfrvsgqrflvrdgr
                   l+ ++   d+    v +l +++ e+ ++    +++ ++       +r g+
   mKIAA0135   171 LAQFFLKSDSEV--VEALSEEHVEADGHaaVVFGTVVDI-----VSRIGE 213  

                   pihvevraspvrdaggeilgflgvlrDi<-*
                    i+v v+ + +    g   + ++vl ++   
   mKIAA0135   214 KIPVSVWIKRLQQDRGL--CCVVVLEPV    239  

Pkinase_Tyr: domain 1 of 1, from 1065 to 1315: score -18.4, E = 9.9e-11
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLkeigasseei.
                         +  LG+GaFG V+ ++ k    + + +V VK +k+     e++ 
   mKIAA0135  1065    YNTISPLGSGAFGFVWTAVEK----ECNKEVVVKFIKK-EKVLEDCw 1106 

                   .e...redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEym
                    e++++     E++i++k  dH Ni++ l +    +e       +V+E  
   mKIAA0135  1107 iEdpkLGRVTLEIAILSKV-DHANIIKVLDIFEN-QEF----FQLVMEKH 1150 

                   egG.dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAA
                     G dL  f  +h   + L+ +    + +Q  ++  YL+s++++HRD+  
   mKIAA0135  1151 GSGmDLFAFIDHH---PCLDEPLASFIFRQLVSAVGYLHSQGIIHRDIKD 1197 

                   RNcLVsenlvVKIsDFGLaRdiynddyY.vrkkgggklPvkWmAPEslky
                    N+ ++e++++K  DFG a ++ + +   ++  g     +  +APE+l  
   mKIAA0135  1198 ENIVIAEDFTIKLIDFGSAAYL-ERGKLfYTFCG----TIEYCAPEVLIG 1242 

                   gkF...tskSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRL
                   + ++++  +   WS GV+L+ ++   e PF   + +ee++e +       
   mKIAA0135  1243 NPYrgpELE--MWSLGVTLYTLIF-EENPF---CEVEETMEAV------I 1280 

                   prPenCPdelYdlMlqCWaedPedRPtFselverL<-*
                    +P + ++el +l     +  Pe+R t + l+++    
   mKIAA0135  1281 HPPFLVSQELMSLLSGLLQPCPEQRTTLEKLIRDP    1315 

Pkinase: domain 1 of 1, from 1065 to 1317: score 267.1, E = 2.3e-76
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      y ++++lGsG+fG V+ a++k  +k+V+vK ikk+k  +++++++ +
   mKIAA0135  1065    YNTISPLGSGAFGFVWTAVEKECNKEVVVKFIKKEKVLEDCWIEDPK 1111 

                   r....sEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfd
                   +++ + Ei+il +++H NI++ +d+fe+     lV+E ++ G   +dLf+
   mKIAA0135  1112 LgrvtLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSG---MDLFA 1158 

                   ylsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld
                   ++     + +l  +e  a +i++Q+++++ YLHs+giiHRD+K eNI + 
   mKIAA0135  1159 FID---HHPCL--DEPLASFIFRQLVSAVGYLHSQGIIHRDIKDENIVIA 1203 

                   engvvdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngyg
                   e+ ++    K++DFG+A+   ++++  ++tf+GT++Y+APEvl g+++ g
   mKIAA0135  1204 EDFTI----KLIDFGSAAY--LeRGKlFYTFCGTIEYCAPEVLIGNPYRG 1247 

                   tkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspe
                   ++  +WSlGv+ly l++ + PF++         + ++ + +pp+  +   
   mKIAA0135  1248 PELEMWSLGVTLYTLIFEENPFCEV-------EETMEAVIHPPFLVS--- 1287 

                   wdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-*
                                   +e+ +L++++L+++P++R t e +  +Pw+   
   mKIAA0135  1288 ----------------QELMSLLSGLLQPCPEQRTTLEKLIRDPWV    1317 

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