hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05662/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0067  ( 1162 res)   mbg05662

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
SET           SET domain                                247.9    1.4e-70   1
Pre-SET       Pre-SET motif                             167.8    1.8e-46   1
MBD           Methyl-CpG binding domain                  94.5    2.2e-24   1
Metallothio_2 Metallothionein                           -15.7       0.18   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
MBD             1/1     468   542 ..     1   118 []    94.5  2.2e-24
Metallothio_2   1/1     601   664 ..     1    84 []   -15.7     0.18
Pre-SET         1/1     555   667 ..     1   124 []   167.8  1.8e-46
SET             1/1     669  1144 ..     1   261 []   247.9  1.4e-70

Alignments of top-scoring domains:
MBD: domain 1 of 1, from 468 to 542: score 94.5, E = 2.2e-24
                   *->krtkredrlpLppGWrRetvqRksGssanNnngkfDvyYysPvtGkk
                      +r+k++++ pL++++rR+t +R++++++      f+v+Y +P +G++
   mKIAA0067   468    YRGKNPLLVPLLYDFRRMTARRRVNRKM-----GFHVIYKTP-CGLC 508  

                   fRsksevirYLgkngdsrkayldaesrtdlhSedrradsrrkrlkklnkK
                   +R+++e++rYL+++g                                   
   mKIAA0067   509 LRTMQEIERYLFETG----------------------------------- 523  

                   gkvtslkledFdFttrlevgr<-*
                     +++l+le+F+++++  v+r   
   mKIAA0067   524 --CDFLFLEMFCLDPYVLVDR    542  

Metallothio_2: domain 1 of 1, from 601 to 664: score -15.7, E = 0.18
                   *->MSCCGGnCGCGSsCkCGsgCCggCkmYpDlsesekktTtteTlVlG.
                      +      C+C+ +C   ++C  +      l+ +   +T       G+
   mKIAA0067   601    VG-----CDCKDGCR--DKC-ACHQ----LTIQATACTP------Gg 629  

                   .VAPekkhfegsemsevaaeesanGCKCGsnCkCdPCnC<-*
                   +V P+ ++++   ++   ++       C   C+CdP  C   
   mKIAA0067   630 qVNPNSGYQYKRLEECLPTGV----YECNKRCNCDPNMC    664  

Pre-SET: domain 1 of 1, from 555 to 667: score 167.8, E = 1.8e-46
                   *->DisrgkEsvpIplvENeVDldkpiPedFtYIneyiygqsviliqseW
                      Di++gkE vp+++v Ne+D+ +p P +  Y++e+i+g++v+++ ++ 
   mKIAA0067   555    DITYGKEDVPLSCV-NEIDTTPP-P-QVAYSKERIPGKGVFINTGP- 597  

                   WSlaftsGCdCtddkgsCspadsskCaCarlsgnggaypPg.l.fpneey
                      +f++GCdC+d   +C+    +kCaC++l+++++a++Pg++ +pn++y
   mKIAA0067   598 ---EFLVGCDCKD---GCR----DKCACHQLTIQATACTPGgQvNPNSGY 637  

                   dndgilvepgplIYECNsrCkCgp.sCkNR<-*
                   +++++  + ++++YECN+rC+C+p++C NR   
   mKIAA0067   638 QYKRLEECLPTGVYECNKRCNCDPnMCTNR    667  

SET: domain 1 of 1, from 669 to 1144: score 247.9, E = 1.4e-70
                   *->vqkgrwarlegfktegkGwGlratedIpkGefiiEYpGelitseeae
                      vq+g ++rl++fkt++kGwG+r+++dI+kG+f++ Y+G+++t++ a+
   mKIAA0067   669    VQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFAD 715  

                   kreddllgpkyydddgdksldeYlfdldalfLlrEkleSWkpYiiLPtys
                   k +      + + d+       Y+ +ld+                     
   mKIAA0067   716 KEG------LEMGDE-------YFANLDH--------------------- 731  

                   PlfWseeeleLkGTqllevdkeeleeydllaeeievflqhk.lFp.dv..
                                                    ie+++++k+++++dv++
   mKIAA0067   732 ---------------------------------IESVENFKeGYEsDVpt 748  

                   ...................e.eefsfed..........flWaasivsSRa
                   ++++++ + ++++++++++e++e+s +d+++++  +++ ++++s+++S+a
   mKIAA0067   749 ssdssgvdmkdqedgnsgsEdPEESNDDssddnfckdeDFSTSSVWRSYA 798  

                   fsl...............................................
                    +++++++++++ ++ +++++++++ ++++ + +++ + ++ ++++++++
   mKIAA0067   799 TRRqtrgqkenelsemtskdsrppdlgpphvpipssvsvggcnppsseet 848  

                   ..................................................
                   ++++  +  + ++ ++++  +++++++ +++++++++ ++++++ ++ ++
   mKIAA0067   849 pknkvaswlscnsvseggfadsdsrssfktseggdgragggrgeaerast 898  

                   ..................................................
                   ++ + +++++++++++++++++++ +  ++++++++++++ ++++ +++ 
   mKIAA0067   899 sglsfkdegdnkqpkkedpenrnkmpvvtegsqnhghnppmkseglrrsa 948  

                   ..................................................
                   ++ +  ++++  +++++++++  + +++++++++++++++++ ++++ + 
   mKIAA0067   949 skmsvlqsqrvvtstqsnpddiltlssstesegesgtsrkptaghtsata 998  

                   ..................................................
                    ++++ ++ ++++++++ +++++ +++++++   +++++   +++++   
   mKIAA0067   999 vdsddiqtissgsdgddfedkknlsgptkrqvavkstrgfalksthgiai 1048 

                   ..........ve..gv..n.reeensegslelviDAtrkGNiaRFiNHSC
                   ++++  + +++e+ +v++n+r+++++e+s +++iDA+  GN++R++NHSC
   mKIAA0067  1049 kstnmasvdkGEsaPVrkNtRQFYDGEES-CYIIDAKLEGNLGRYLNHSC 1097 

                   ePNcevqvvfvdgedlgdsdvtDeaglepgdprivlfAlrdIpaGeELty
                   +PN++vq+vfvd++dl             ++p++++fA + I+aG+ELt+
   mKIAA0067  1098 SPNLFVQNVFVDTHDL-------------RFPWVAFFASKRIRAGTELTW 1134 

                   dYgydksnge<-*
                   dY+y+ + +e   
   mKIAA0067  1135 DYNYEVGSVE    1144 

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