hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mkg/mkg00303/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0046  ( 696 res)   mkg00303

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Voltage_CLC Voltage gated chloride channel              506.7   1.7e-148   1
CBS         CBS domain pair                              61.2    2.3e-14   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Voltage_CLC   1/1      21   399 ..     1   455 []   506.7 1.7e-148
CBS           1/1     430   685 ..     1   114 []    61.2  2.3e-14

Alignments of top-scoring domains:
Voltage_CLC: domain 1 of 1, from 21 to 399: score 506.7, E = 1.7e-148
                   *->fslvlvllaalLvkkfaPaAaGSGIPEiKtiLnGikivdgkgylrlr
                      f+l +v+la+lLv  ++P AaGSGIPEiK++LnG+k+   +g++rlr
   mKIAA0046    21    FNLTFVFLASLLVL-IEPVAAGSGIPEIKCYLNGVKV---PGIVRLR 63   

                   tllvKvvGlalsvgsGLslGKEGPfVHiGaciaalLskggStslrlqfsl
                   tll+Kv+G+++sv++GL++GKEGP++H+Ga+++a+L +++S+slr++++ 
   mKIAA0046    64 TLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFN 113  

                   fkyseedrRkdrRdLlaaGaAaGvAaAFgAPiGGVLFslEievssenarf
                   f+y+++dr  d+Rd+++aGaAaGvAaAFgAPiGG LFslE e+ss   ++
   mKIAA0046   114 FPYFRSDR--DKRDFVSAGAAAGVAAAFGAPIGGTLFSLE-EGSS---FW 157  

                   nvkllwrsLFFasavaafvlrlinsffvsgkcgdFgtglalFdvsfrtdr
                   n++l+w++ +F+s++a+f+l++++s  ++g++g+           f+ + 
   mKIAA0046   158 NQGLTWKV-LFCSMSATFTLNFFRSGIQFGSWGS-----------FQLP- 194  

                   fpwtlfElplFillGifgGllGalFnrlnrkilkfrkKnrylskklkkpp
                                                           +l       +
   mKIAA0046   195 ---------------------------------------GLL-----NLR 200  

                   vlevalvglltavlsfplplllgcagglelvee................r
                   vle++lv+l+t v++f+++++lg   + ++ + +++++++ + + +++++
   mKIAA0046   201 VLESLLVSLVTTVVVFVASMVLG--ECRQMSSTsqtgngsfqlqvtsedV 248  

                   tlnilfdnCtwgeyndlasllcntpedavlslFhwnipgegdffaftlLl
                   ++ i+ ++C++++ynd+a+l++n +e+a+l+lFh+++     f+++ +L 
   mKIAA0046   249 NSTIKAFFCPNDTYNDMATLFFNSQESAILQLFHQDG----TFSPV-TLA 293  

                   llliakflltlltfGigvPgGlFvPslaiGAalGrlvGifverlimavls
                   l++i++fll+++tfG++vP+GlFvPsl++GAa+Grlv+++++++i     
   mKIAA0046   294 LFFILYFLLACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYI----- 338  

                   HdwfpfgifcegfpdcilePGlYAvlGAAAflGGvvrmTvslaVImfElT
                              g+ + ++  G++A++GAAAflGGvvrmT+sl+VI++E T
   mKIAA0046   339 -----------GLGHLYS--GTFALIGAAAFLGGVVRMTISLTVILIEST 375  

                   GnlsvilPlMvAvliaklvadslg<-*
                   + ++++lP+Mv++++ak+++d ++   
   mKIAA0046   376 NEITYGLPIMVTLMVAKWTGDLFN    399  

CBS: domain 1 of 1, from 430 to 685: score 61.2, E = 2.3e-14
                RF    xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx xxxxxxxxxx
                   *->dvmtkdvvtvdpedttl.ealklmrengisrlPVvd.edgklvGivt
                      d+m +++ +v+p +t ++  + ++r + ++++PVv ++ g+      
   mKIAA0046   430    DIMEPNLTYVYP-HTRIqSLVSILRTTVHHAFPVVTeNRGN------ 469  

                RF xxxxxxxxx                                         
                   erDlllral.........................................
                   e++ +++     +++ + ++++  ++ ++ ++++ + ++ ++++ ++  +
   mKIAA0046   470 EKE-FMKGNqlisnnikfkkssiltrageqrkrgqsmksypsselrnvcd 518  

                RF                                                   
                   ..................................................
                   ++  ++++ ++++      +++ ++ ++  ++ +++++ + +++ ++ + 
   mKIAA0046   519 ehvaseepaekedllqqmlerrytpypnlypdqspsedwtmeerfrpltf 568  

                RF                                                   
                   ..................................................
                   ++   ++   +   ++   +++ ++ + ++ +  +  ++ ++ ++ ++ +
   mKIAA0046   569 hglvlrsqlvtllvrgvcysesqssasqprlsyaemaedyprypdihdld 618  

                RF          xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx
                   .........tpvsdiMtrpPvitvppdtsl.ealelmlehgirhrrlpVv
                    +  +++  ++v  +M+++P +tv+p+t +++++ l++  g+r + lpVv
   mKIAA0046   619 ltllnprmiVDVTPYMNPSP-FTVSPNTHVsQVFNLFRTMGLR-H-LPVV 665  

                RF xxxxxxxxxxxxxxxxxxxx   
                   DedgklvGivtreDilrala<-*
                   +  g++vGi+tr+++  +++   
   mKIAA0046   666 NAVGEIVGIITRHNLTNEFL    685  

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