hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05393/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0032  ( 938 res)   mbg05393

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
HECT     HECT-domain (ubiquitin-transferase)            475.1   5.5e-139   1
RCC1     Regulator of chromosome condensation (RCC1)    122.3    8.8e-33   5

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RCC1       1/5       1    42 [.     1    68 []    12.5     0.21
RCC1       2/5      45    95 ..     1    68 []    38.8  1.2e-07
RCC1       3/5      98   147 ..     1    68 []    44.3  2.8e-09
RCC1       4/5     150   199 ..     1    68 []    21.0    0.025
RCC1       5/5     203   267 ..     1    68 []    18.3    0.048
HECT       1/1     640   938 .]     1   366 []   475.1 5.5e-139

Alignments of top-scoring domains:
RCC1: domain 1 of 5, from 1 to 42: score 12.5, E = 0.21
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                             G+     GqLGl ++++             vP l+     
   mKIAA0032     1    -------GS----DGQLGLMTTEDSVA----------VPRLI----- 21   

                   ssslsekVvsvasGgqHtval<-*
                      ++   ++v++G+ H  al   
   mKIAA0032    22 QKLNQQTILQVSCGNWHCLAL    42   

RCC1: domain 2 of 5, from 45 to 95: score 38.8, E = 1.2e-07
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      dG+ +++G   +  GqLGlg e               +P+ v     
   mKIAA0032    45    DGQFFTWGK--NSHGQLGLGKEFPSQT----------SPQRV----- 74   

                   ssslsekVvsvasGgqHtval<-*
                    s +  +  +va+Gg H +al   
   mKIAA0032    75 RSLEGIPLAQVAAGGAHSFAL    95   

RCC1: domain 3 of 5, from 98 to 147: score 44.3, E = 2.8e-09
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      +G V+++G+  ++ GqLGl  e +             +P  v     
   mKIAA0032    98    SGAVFGWGM--NNAGQLGLSDEKDRE-----------SPCHV----- 126  

                   ssslsekVvsvasGgqHtval<-*
                   +  +  kVv  ++G  Ht++l   
   mKIAA0032   127 KLLRTQKVVYISCGEEHTAVL    147  

RCC1: domain 4 of 5, from 150 to 199: score 21.0, E = 0.025
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      +G V+++G   g  GqLG +   +e             P  v     
   mKIAA0032   150    SGGVFTFGA--GSCGQLGHDSVNDEV-----------NPRRV----- 178  

                   ssslsekVvsvasGgqHtval<-*
                          V + a+G qHt al   
   mKIAA0032   179 LELMGSEVTQIACGRQHTLAL    199  

RCC1: domain 5 of 5, from 203 to 267: score 18.3, E = 0.048
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLK..
                      +G +Y++Gc  g  GqLG+g +   +            P  v  K++
   mKIAA0032   203    SGLIYAFGC--GAKGQLGTGHTCNVK-----------CPSPV--Kgh 234  

                   ..srsssls........ekVvsvasGgqHtval<-*
                       ss+ls + ++ + ++V + +sGg+ t++l   
   mKIAA0032   235 waAHSSQLSaradrfkyRVVKQIFSGGDQTFVL    267  

HECT: domain 1 of 1, from 640 to 938: score 475.1, E = 5.5e-139
                   *->tLlsrelfnPdygLFeysdnseakseeddsysgyvedsytlfpnPls
                      +Ll +el+nP yg+F+y                 ++ds+ l+++ ++
   mKIAA0032   640    LLLLKELLNPIYGMFTY-----------------YQDSNLLWFSDTC 669  

                   gesnpehervlkyFkflGrilGlAlydgrllDlpFsraFyKklLmagkps
                   ++        +++F+++G+ +GlA+y+++++Dl+F++a+yKklL  +++ 
   mKIAA0032   670 FVE-------HNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLL--NVK- 709  

                   igivtleDlesvDPelynSLkwllendgdKkIedsLLgsledveedLeLt
                      ++leDl++++P+ ++SL++ll++ g+            d+ee+++L+
   mKIAA0032   710 ---PSLEDLKELSPTEGRSLQELLDYPGE------------DIEETFCLN 744  

                   FsveeessvgfeadarffGgtktveELkPnGrnipVTneNkeeYvelyvd
                   F+v+ es   +       G++++   L+P+G+ ++V ++N++e+v++yv+
   mKIAA0032   745 FTVCRES---Y-------GVIEQKK-LIPGGDRVAVCKDNRQEFVDAYVN 783  

                   yrLnkgiekQfeAFrkGFsevipsrlLslFdpeELelLicGspeeiDvdd
                   y+++ ++ + + AF +GF +v+++++L+lF+p EL+ +++G+  ++D+++
   mKIAA0032   784 YIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNS-NYDWEE 832  

                   LkenTeYdggYtedsplktiqwFWevleeftneeraklLqFvTGssRlPv
                   L+e ++Y+g Y++++p  t++ FWe ++ef+ e+++k+L F TGs+R+P+
   mKIAA0032   833 LEETAVYRGDYSSTHP--TVKLFWETFHEFPLEKKKKFLLFLTGSDRIPI 880  

                   gGFkaLqgGsnGpPkFtIvrkegggdddrLPtAhTCFNrLkLPpYsSkei
                    G+++Lq         +I+ +   +++++LP+AhTC+N+L+LP+YsSkei
   mKIAA0032   881 YGMASLQ--------IIIQST--ATGEEYLPVAHTCYNLLDLPKYSSKEI 920  

                   LrekLllAInEgseGFgle<-*
                   ++ +L++A+  + eGF+l+   
   mKIAA0032   921 MKARLTQAL-DNYEGFSLA    938  

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