hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbh/mbh01716/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0021  ( 853 res)   mbh01716

Scores for sequence family classification (score includes all domains):
Model           Description                             Score    E-value  N 
--------        -----------                             -----    ------- ---
Reprolysin      Reprolysin (M12B) family zinc metallo   373.5   2.2e-108   1
Pep_M12B_propep Reprolysin family propeptide            169.6    5.3e-47   1
Disintegrin     Disintegrin                             127.6    2.2e-34   1
EGF_2           EGF-like domain                          29.6    7.5e-05   1
EGF             EGF-like domain                          15.1       0.63   1
Plasmod_Pvs28   Plasmodium ookinete surface protein P   -93.2       0.33   1

Parsed for domains:
Model           Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------        ------- ----- -----    ----- -----      -----  -------
Pep_M12B_propep   1/1      88   203 ..     1   119 []   169.6  5.3e-47
Reprolysin        1/1     220   414 ..     1   203 []   373.5 2.2e-108
Disintegrin       1/1     431   507 ..     1    80 []   127.6  2.2e-34
EGF               1/1     652   681 ..     1    39 []    15.1     0.63
EGF_2             1/1     652   681 ..     1    37 []    29.6  7.5e-05
Plasmod_Pvs28     1/1     505   715 ..     1   231 []   -93.2     0.33

Alignments of top-scoring domains:
Pep_M12B_propep: domain 1 of 1, from 88 to 203: score 169.6, E = 5.3e-47
                   *->hLeknrsllapdftvttYdedGtlvteepliqddHCyYqGyVeGypn
                      hLe+n++ll++df+v+tYd++G+l +++p++q  HC+Y GyVeG+ n
   mKIAA0021    88    HLERNTDLLPNDFVVYTYDKEGSLLSDHPNVQ-SHCHYRGYVEGVQN 133  

                   SaVslSTCsGgLRGilqlenlsYgIEPlessdgfeHiiYqienlktepsp
                   SaV++S C G LRG+l+len s+gIEPl +s++feHi Y+++  ++ep+ 
   mKIAA0021   134 SAVAVSACFG-LRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLR 182  

                   cgecgslstsadssygirsass<-*
                   cg ++  +t ++  +g+ + ++   
   mKIAA0021   183 CGVSN-RDTEKEGTQGDEEEHP    203  

Reprolysin: domain 1 of 1, from 220 to 414: score 373.5, E = 2.2e-108
                   *->rYiELvIVvDhgmytkygsdlnkirqrVhqivNlvNeiYrpqLNIrV
                      rY+EL+IVvD+++y+++g++++++r+ ++ ++N+++++Y++ LNIr+
   mKIAA0021   220    RYVELFIVVDKERYDMMGRNQTAVREEMIRLANYLDSMYIM-LNIRI 265  

                   vLvgLEIWsdgDkInvqsdandTLhsFgeWRetdLlkrksHDnAqLLtgi
                   vLvgLEIW+d+++In+ + a d+L +F++WRe++L++r++HD AqL+  +
   mKIAA0021   266 VLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 315  

                   dfdgntiGaAyvggmCspkrSvGVvqdhspivllvAvtMAHELGHNLGmt
                    f+g t G+A+vg++Cs+++++G++ +++++v+ +A ++AHELGHNLGm+
   mKIAA0021   316 GFGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMN 364  

                   HDdkntdgCtCegggsCIMnpvassspskKkFSnCSkddyqkFltkqkpq
                   HDd++  +C+C g++sCIMn++as+s+    FS+CS +d++k+ ++ ++ 
   mKIAA0021   365 HDDGR--ECFC-GAKSCIMNSGASGSRN---FSSCSAEDFEKLTLNKGGS 408  

                   CLlNkP<-*
                   CLlN P   
   mKIAA0021   409 CLLNIP    414  

Disintegrin: domain 1 of 1, from 431 to 507: score 127.6, E = 2.2e-34
                   *->EggEeCDCGspedCqnkdpCCdaktCkLkpGAqCsPsnGpCCknCqf
                      ++gEeCDCG+ ++C + dpCC+ +tCkLk  A+C+   G CCk+Cqf
   mKIAA0021   431    DPGEECDCGTAKEC-EVDPCCEGSTCKLKSFAECA--YGDCCKDCQF 474  

                   kpkgtvCRpatgeCDlpeyCnGtSaeCPpdpyv<-*
                   +p g  CR+ t+eCD peyCnG+S  CPpd+++   
   mKIAA0021   475 LPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFI    507  

EGF: domain 1 of 1, from 652 to 681: score 15.1, E = 0.63
                   *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-*
                      C+ +   C+++G C++      C+C  G     ++ ++C   
   mKIAA0021   652    CDIQG-KCHGHGVCNSNK---NCHCEDG-----WAPPHC    681  

EGF_2: domain 1 of 1, from 652 to 681: score 29.6, E = 7.5e-05
                   *->C.....CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-*
                      C+ +++C+g hG+C+s+ +       C+C++g    +  ++C   
   mKIAA0021   652    CdiqgkCHG-HGVCNSNKN-------CHCEDG----WAPPHC    681  

Plasmod_Pvs28: domain 1 of 1, from 505 to 715: score -93.2, E = 0.33
                   *->kySfiFLffIqLairytnAKVTvdTiCknGkliQMSnHfECkCsdGf
                              fIq      n K      C nG    M   +   C+  f
   mKIAA0021   505    -------VFIQNGYPCQNSK----AYCYNG----MCQYYDAQCQVIF 536  

                   vLknENt...C..EpkvkCdkleNinKvCGeYavCvNqannalekaLkCe
                   + k    +++C  E   k d+  N +    eY  C+ ++ nal   L+Ce
   mKIAA0021   537 GSKAKAAprdCfiEVNSKGDRFGNCGFSGSEYKKCA-TG-NALCGKLQCE 584  

                   CvnGy....ilsqevCkP...tkCnnveCgaGKCILDpaNpnnpvCSCdI
                    v   +  +i+   + +P+++tkC++v+   G  + Dp+ +n  +  Cd 
   mKIAA0021   585 NVQDMpvfgIVPAIIQTPsrgTKCWGVDFQLGSDVPDPGMVNEGT-KCDA 633  

                   GkiLdqngKC..tgtGqtkCsL..KCKAqEECKltgk.yYeCVaKgqapg
                   Gki   n  C +  +    C  ++KC     C    + + e    ++  +
   mKIAA0021   634 GKIC-RNFQCvnASVLNYDCDIqgKCHGHGVCNSNKNcHCEDGWAPPHCD 682  

                   tggGaGsGGeGsGGeGsGGeGsGgdtpansSlMNGmsiiSIialfviYia
                   t g  Gs    sG            t  + S    ++    +++f ++++
   mKIAA0021   683 TKGYGGS--VDSG-----------PTYNAKS----TALRDGLLVF-FFLI 714  

                   v<-*
                   v   
   mKIAA0021   715 V    715  

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