hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/msj/msj04008/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0012  ( 727 res)   msj04008

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
TIR      TIR domain                                     164.9    1.4e-45   1
LRR_1    Leucine Rich Repeat                             81.5    1.7e-20  11
LRRCT    Leucine rich repeat C-terminal domain           26.0    0.00087   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
LRR_1      1/11      5    28 ..     1    25 []     9.6       52
LRR_1      2/11     29    48 ..     1    25 []     8.4       81
LRR_1      3/11     50    74 ..     1    25 []    12.7      9.1
LRR_1      4/11     75    98 ..     1    25 []     4.1  4.1e+02
LRR_1      5/11    308   331 ..     1    25 []     7.6  1.1e+02
LRR_1      6/11    334   357 ..     1    25 []     8.4       82
LRR_1      7/11    359   379 ..     1    25 []     8.9       67
LRR_1      8/11    381   403 ..     1    25 []    15.3      1.4
LRR_1      9/11    404   425 ..     1    25 []    12.2       13
LRR_1     10/11    426   449 ..     1    25 []     8.9       68
LRR_1     11/11    450   471 ..     1    25 []     3.2  5.9e+02
LRRCT      1/1     488   513 ..     1    26 []    26.0  0.00087
TIR        1/1     574   710 ..     1   150 []   164.9  1.4e-45

Alignments of top-scoring domains:
LRR_1: domain 1 of 11, from 5 to 28: score 9.6, E = 52
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L++L +s+ N +l+  l  s ++  +   
   mKIAA0012     5    KLRVLIMSY-N-RLQ-YLNISvFkFNT    28   

LRR_1: domain 2 of 11, from 29 to 48: score 8.4, E = 81
                   *->nLeeLdLsgCNpslsgslppslglp<-*
                      +Le+LdLs+ N +l + +    + +   
   mKIAA0012    29    ELEYLDLSH-N-EL-KVILC--HPT    48   

LRR_1: domain 3 of 11, from 50 to 74: score 12.7, E = 9.1
                   *->nLeeLdLsgCNpslsgs..lppsl.glp<-*
                      +L++LdLs  N  + +  ++ +++++++   
   mKIAA0012    50    SLKHLDLSF-N-AF-DAlpICKEFgNMS    74   

LRR_1: domain 4 of 11, from 75 to 98: score 4.1, E = 4.1e+02
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L+ L Lsg + +++ s +   + +l    
   mKIAA0012    75    QLQFLGLSG-S-RVQ-SSSVQlIaHLN    98   

LRR_1: domain 5 of 11, from 308 to 331: score 7.6, E = 1.1e+02
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L++L+L+  N +l + l++  l + +   
   mKIAA0012   308    RLKTLSLQK-N-QL-KNLENIiLtSAK    331  

LRR_1: domain 6 of 11, from 334 to 357: score 8.4, E = 82
                   *->nLeeLdLsgCNpslsgs....lppslglp<-*
                      +L++Ld+s  N sl + +++++p     +   
   mKIAA0012   334    SLQKLDISQ-N-SL-RYsdggIPC--AWT    357  

LRR_1: domain 7 of 11, from 359 to 379: score 8.9, E = 67
                   *->nLeeLdLsgCNpslsgslppslglp<-*
                      +L +L+Ls+ N +l+gs+     lp   
   mKIAA0012   359    SLLVLNLSS-N-MLTGSVFR--CLP    379  

LRR_1: domain 8 of 11, from 381 to 403: score 15.3, E = 1.4
                   *->nLeeLdLsgCNpslsgslppsl.glp<-*
                      ++++LdL++ N ++  s+p++  +l+   
   mKIAA0012   381    KVKVLDLHN-N-RIM-SIPKDVtHLQ    403  

LRR_1: domain 9 of 11, from 404 to 425: score 12.2, E = 13
                   *->nLeeLdLsgCNpslsgslppsl.glp<-*
                       L+eL++ + N sl+ +lp  ++ ++   
   mKIAA0012   404    ALQELNVAS-N-SLT-DLPG-CgAFS    425  

LRR_1: domain 10 of 11, from 426 to 449: score 8.9, E = 68
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L +L +++ N s+s + +++ +++++   
   mKIAA0012   426    SLSVLVIDH-N-SVS-HPSEDfFqSCQ    449  

LRR_1: domain 11 of 11, from 450 to 471: score 3.2, E = 5.9e+02
                   *->nLeeLdLsgCNpslsgslppsl.glp<-*
                      n+++L  ++ N +++ +  + l+++    
   mKIAA0012   450    NIRSLTAGN-N-PFQ-CTCE-LrDFV    471  

LRRCT: domain 1 of 1, from 488 to 513: score 26.0, E = 0.00087
                   *->dlrCasPeslrGqplldlppsdfsCp<-*
                      ++rC++Pes rG+ l+d+++s +sC+   
   mKIAA0012   488    SYRCDYPESSRGTALRDFHMSPLSCD    513  

TIR: domain 1 of 1, from 574 to 710: score 164.9, E = 1.4e-45
                   *->vFisfsgksrsnddrdtFvshllkeLeekkqpginlfiddrDelpGe
                      +F+s+sg     +d  ++ ++ll++Le +    i+ ++++r+++pG+
   mKIAA0012   574    AFVSYSG-----HDSAWVKNELLPNLEKD---DIQICLHERNFVPGK 612  

                   silenlfeaIekSRiaivifSsnyasSeLWCLdELveimkcaleqgnkkv
                   si+en+ + IekS ++i+++S+++++Se WC++EL +++++ +++g + +
   mKIAA0012   613 SIVENIINFIEKSYKSIFVLSPHFIQSE-WCHYELYFAHHNLFHEGSDNL 661  

                   ilpiFykVdpsdvrp.kqtgkFgkaflktlkwsgdktersqsdrikfWkk
                   il+ + +++++++  +++++k +++ +++l+w+ +k     ++++ fW +
   mKIAA0012   662 ILILLAPIPQYSIPTnYHKLKTLMSRRTYLEWPTEK-----NKHGLFWAN 706  

                   alya<-*
                   ++++   
   mKIAA0012   707 LRAS    710  

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