hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg07794/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mFLJ00376 ( 931 res) mbg07794 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- I-set Immunoglobulin I-set domain 122.6 7.5e-33 2 fn3 Fibronectin type III domain 115.8 8.2e-31 3 ig Immunoglobulin domain 103.0 5.6e-27 2 V-set Immunoglobulin V-set domain 17.8 0.01 2 Y_Y_Y Y_Y_Y domain 5.3 0.76 1 C1-set Immunoglobulin C1-set domain -14.4 0.8 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- ig 1/2 63 119 .. 1 65 [] 46.8 4.7e-10 V-set 1/2 52 133 .. 1 130 [] 7.2 0.12 I-set 1/2 47 136 .. 1 97 [] 48.5 1.5e-10 ig 2/2 155 211 .. 1 65 [] 56.2 7.1e-13 C1-set 1/1 144 222 .. 1 92 [] -14.4 0.8 V-set 2/2 140 225 .. 1 130 [] 10.5 0.054 I-set 2/2 141 227 .. 1 97 [] 74.1 3e-18 fn3 1/3 288 378 .. 1 84 [] 33.0 6.8e-06 fn3 2/3 423 510 .. 1 84 [] 57.8 2.4e-13 Y_Y_Y 1/1 449 519 .. 1 69 [] 5.3 0.76 fn3 3/3 529 619 .. 1 84 [] 27.5 0.0003 Alignments of top-scoring domains: ig: domain 1 of 2, from 63 to 119: score 46.8, E = 4.7e-10 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+s+ L C + +g p+++vtW ++g ++ +++++ +n mFLJ00376 63 GQSLILECVA--SGIPPPRVTWAKDGSsIAaYNKTRFLLSN------ 101 tsLtitnvtpeDggtYtCvv<-* L i +++eD+gtY+C++ mFLJ00376 102 --LLIDTTSEEDSGTYRCMA 119 V-set: domain 1 of 2, from 52 to 133: score 7.2, E = 0.12 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss +++ ++ + +v G+s+ L C s + mFLJ00376 52 PLEAQT--------------V-IVTKGQSLILECVAS----GI---- 75 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn + +v+W + + i+ y+ k r+ +s+ mFLJ00376 76 PPPRVTWAK-DGS-----SIA-------AYN----------KTRFLLSN- 101 pskgdfsLtIsnlqlsDsGtYyCa......gggtrLtVl<-* L I + +DsGtY C +++ + +g ++ mFLJ00376 102 -------LLIDTTSEEDSGTYRCMasngvgDPGAAVILY 133 I-set: domain 1 of 2, from 47 to 136: score 48.5, E = 1.5e-10 *->PkFtqkp..kdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvl +++ +++ + v V+ G+s+ +eC ++G P+P V+W KdG+ + + mFLJ00376 47 ARIIYPLeaQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAA-- 91 lpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeL. + ++ ++ L I+ +DsG+Y+C A+N +G a + L mFLJ00376 92 --YNKTRFLLSN------LLIDTTSEEDSGTYRCMASNGVGDPGAAVILy 133 tVq<-* +Vq mFLJ00376 134 NVQ 136 ig: domain 2 of 2, from 155 to 211: score 56.2, E = 7.1e-13 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+s++LtC+v g+p+++v Wlrn +lt++++ + s++ mFLJ00376 155 GQSAKLTCEV--RGNPPPSVLWLRNAVpLTsSQRLRLSRRA------ 193 tsLtitnvtpeDggtYtCvv<-* L++ +v peD+g+Y C++ mFLJ00376 194 --LRVVSVGPEDEGVYQCMA 211 C1-set: domain 1 of 1, from 144 to 222: score -14.4, E = 0.8 *->ppgspepel....gkpntLvClVtgFyPpdItVtWlkNGqevtegve + +l + g+++ L+C V g Pp+ +V Wl+N +++t+ + mFLJ00376 144 TV-ELS-QLvipwGQSAKLTCEVRG-NPPP-SVLWLRNAVPLTSSQR 186 steplpkngDgtYqlsSyLtftasepesgdsYtCrVeHesLkvenePlt< ++++ ++ + + pe++ +Y C+ e + ++ + ++ mFLJ00376 187 LRLSRR--------ALRVVSVG---PEDEGVYQCMAENAVGSA--HAVV 222 -* mFLJ00376 - - V-set: domain 2 of 2, from 140 to 225: score 10.5, E = 0.054 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss + +vt + ++ + G+s++L+C ++ +++ mFLJ00376 140 PPEVTV-ELS----------QLVIPWGQSAKLTCEVR---GNP---- 168 gtgsvyWyrq.qppGekpeliiisyytyysysegngtvserfkgrvrfsg + sv W r+ p+ t s r++ ++r mFLJ00376 169 PP-SVLWLRNaVPL----------------------TSSQRLRLSRR--- 192 npskgdfsLtIsnlqlsDsGtYyCa......gggtrLtVl<-* L+ ++ ++D+G+Y C ++ + +++ + mFLJ00376 193 --A-----LRVVSVGPEDEGVYQCMaenavgSAHAVVQLR 225 I-set: domain 2 of 2, from 141 to 227: score 74.1, E = 3e-18 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+ t +++ +++ G+sa+++C+V+G+P+P+V W+++ pl+s mFLJ00376 141 PEVTVELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLTS---- 183 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtVq s+r++ + + L++ v p+D+G+Y C A+N +G+a a ++L mFLJ00376 184 SQRLRLSRRA------LRVVSVGPEDEGVYQCMAENAVGSAHAVVQLRTA 227 <-* mFLJ00376 - - fn3: domain 1 of 3, from 288 to 378: score 33.0, E = 6.8e-06 *->P.saPtnltvtdv.tstsltlsWsppt...gngpitgYevtyRqpkn P aP l+ ++ ++s l W p +++ + pi +Y v+ R+ +n mFLJ00376 288 PaEAPIILSSPRTsKTDSYELVWRPRHegsSRTPILYYVVKHRKVTN 334 ggewnelt.vpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* + ++ +++++p ++++ tlt L Pg+ Yev +A+n +G+G+ mFLJ00376 335 SSDDWTISgIPANQHRLTLTRLDPGSLYEVEMAAYNCAGeGQTA 378 fn3: domain 2 of 3, from 423 to 510: score 57.8, E = 2.4e-13 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge. P aP ++t++ ++ts+ ++W p +g+ pi++++v+y ++ + ++ mFLJ00376 423 PEAPDRPTISTASETSVYVTWIPRGnGGFPIQSFRVEY-KKLKKVGd 468 ..wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* + +p++ s+++tgL+ g Y++rV+A+n G++++S mFLJ00376 469 wiLATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGeSEPS 510 Y_Y_Y: domain 1 of 1, from 449 to 519: score 5.3, E = 0.76 *->nydgpenllYrYrlegfdgeWveltdysten..elsytnLppGk.Yt + ++ Y+ ++ g+W+ +t+ ++ ++ ++++t L+ G +Y+ mFLJ00376 449 GGFPIQSFRVEYKKLKKVGDWILATSAIPPSrlSVEITGLEKGIsYK 495 ikvkakdkdgnwsyddiasltftvl<-* ++v+a +++g++++ + s +++v mFLJ00376 496 FRVRALNMLGESEPSA-PSRPYVVS 519 fn3: domain 3 of 3, from 529 to 619: score 27.5, E = 0.0003 *->PsaPtnltvtdv.tstsltlsWsppt...gngpitgYevtyRqpkng P a +t+td ++t++ l W + +++n pi g+ + yR p+++ mFLJ00376 529 PVAGPYITFTDAvNETTIMLKWMYIPasnNNTPIHGFYIYYR-PTDS 574 ge...wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* +++ + +v g+ + + ++ L+P t Y ++ q n+gG++++S mFLJ00376 575 DNdsdYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGeSEFS 619 //