hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mpf/mpf00869/w3open/interpro/cnk_1/seq.in
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Query:  mFLJ00274  ( 1530 res)   mpf00869

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PH       Pleckstrin homology domain.                     98.7    6.8e-25   2
RhoGEF   Guanine nucleotide exchange factor for Rho/R    73.6    2.4e-17   1
FYVE     Protein present in Fab1, YOTB, Vac1, and EEA    69.0    6.1e-16   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1     962  1150 ..     1   211 []    73.6  2.4e-17
PH         1/2    1181  1276 ..     1    82 []    59.0  6.2e-13
FYVE       1/1    1301  1369 ..     1    81 []    69.0  6.1e-16
PH         2/2    1432  1530 .]     1    82 []    39.9  3.5e-07

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 962 to 1150: score 73.6, E = 2.4e-17
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      +++ELl +E++YV++L+ l   f  + ++ ++      + ++  + l
   mFLJ00274   962    IAQELLSSEKAYVQMLQHLSLDFHGAVLRALE-----NVEQEGREPL 1003 

                   Fg.......pNieeiyefHrrFLdeLeerveewllskdlKsernsvieds
                     ++ +++   ++ i+++H+  L++Le+r+ +                  
   mFLJ00274  1004 AQeelrqglRELPAICDLHQGILESLEQRLGD--------------CGEG 1039 

                   gerigdvFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkf
                   +++++d+Fl+    e+ f+ +++ + ++++ l ll++   +  +p++++ 
   mFLJ00274  1040 QPQVADIFLAR---EQEFEHHAAHILQFDRYLGLLAE--SCLLSPRLATT 1084 

                   lkeieskpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhe
                   ++e+e +++ +     ++++++ ++ +vQRl +Y+ LL ++l +  pd+ 
   mFLJ00274  1085 VREFEQSSQGG-----GQSMKHRMLRVVQRLFQYQVLLTDYLNNLCPDSA 1129 

                   dredLkkAleaikelasqvNe<-*
                   ++++ + Al +i +++++ Ne   
   mFLJ00274  1130 EYDNTQSALTLISKVTDRANE    1150 

PH: domain 1 of 2, from 1181 to 1276: score 59.0, E = 6.2e-13
                   *->vikeGwLlkksk.swkkryfvLfngvLlyyksk.....kpkgsipLs
                      ++keG+L++  ++s+++r+++L n++Lly+++ ++++ ++k s+p+ 
   mFLJ00274  1181    FLKEGTLMRVRGkSRHPRHLFLMNDTLLYTHPQkdgkyRLKSSLPVA 1227 

                   gcsvre.p......cFeivt.drtlllqAeseeereeWvealqsaiaka<
                   +++v++++ ++ + +++i t++ +l+l+A+s  er+eW  +l +a+ +  
   mFLJ00274  1228 NMKVSRpVmdkvpyALKIETpESCLTLSASSCAERDEWHYCLSRALPED  1276 

                   -*
                     
   mFLJ00274     -    -    

FYVE: domain 1 of 1, from 1301 to 1369: score 69.0, E = 6.1e-16
                   *->etaphWvpDeeasnClmnCgkeFtlvtrRrHHCRnCGrifCskCssk
                      e+ p+ vp   a++C mnCg+ F+l t+RrHHC++CG+i+C++Cs++
   mFLJ00274  1301    ERLPTLVPVTHAMMC-MNCGCDFSL-TVRRHHCHACGKIVCRNCSRN 1345 

                   kaplpklgkekkngknedftpvRVCdsCyerlsk<-*
                   k pl  l+++           ++VCd C+ +l+    
   mFLJ00274  1346 KYPLKCLKNR----------MAKVCDGCFRELKL    1369 

PH: domain 2 of 2, from 1432 to 1530: score 39.9, E = 3.5e-07
                   *->vikeGwLlkks..k.swkkryfvLfngvLlyyksk...kpkgsipLs
                        ++G+L++++++k++wkk ++v++++vL+ y  ++++   +sipL 
   mFLJ00274  1432    SAISGYLSRCKsgKrRWKKLWLVIKGKVLYTYLASedkVAMESIPLL 1478 

                   gcsvre.p.........cFeivt.dr.tlllqAeseeereeWvealqsai
                   g ++ +++++++++ +++F +++++   + ++Ae++ ++++W+ea+++a+
   mFLJ00274  1479 GFTIAPeKeegssevgpVFHLYHkKTlFYSFKAEDSNSAQRWMEAMEDAS 1528 

                   aka<-*
                     +   
   mFLJ00274  1529 V-L    1530 

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