FASTA searches a protein or DNA sequence data bank version 3.4t11 Apr 17, 2002 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 ../query/mKIAA4178.ptfa, 1796 aa vs ./tmplib.26680 library 1767221 residues in 2168 sequences Expectation_n fit: rho(ln(x))= 12.6061+/-0.00938; mu= -8.9543+/- 0.612 mean_var=757.5101+/-190.019, 0's: 0 Z-trim: 18 B-trim: 78 in 1/35 Lambda= 0.0466 FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 41, opt: 29, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2168) mKIAA1096 ( 2062 res) mbg00585 (2062) 1464 115 1.7e-25 mKIAA4231 ( 1467 res) mfj06028 (1467) 686 63 7.6e-10 mKIAA0458 ( 882 res) mbg00904 ( 882) 352 40 0.0032 mKIAA1172 ( 1200 res) mfj66157 (1200) 355 40 0.0034 mKIAA0595 ( 1646 res) mbg04268 (1646) 356 41 0.0039 >>mKIAA1096 ( 2062 res) mbg00585 (2062 aa) initn: 1526 init1: 497 opt: 1464 Z-score: 550.2 bits: 115.2 E(): 1.7e-25 Smith-Waterman score: 2621; 33.884% identity (42.132% ungapped) in 1936 aa overlap (1-1700:10-1802) 10 20 30 40 50 mKIAA4 GPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRM : ..:.::::::..:.::.:::::::: :: .:: ::::::::::.:.::: mKIAA1 VSTEMSEKSGQSTKAKDGKKYATLSLFNTYKGKSLETQKTTVAARHGLQSLGKVGISRRM 10 20 30 40 50 60 60 70 80 90 100 110 mKIAA4 PPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQT ::::::::::::::::::::..:::::::::::::: . ... :: .: mKIAA1 PPPANLPSLKAENKGNDPNVNIVPKDGTGWASKQEQHEEEKA-------PEVSP------ 70 80 90 100 120 130 140 150 160 170 mKIAA4 PASNQPKRPPTAPENTPSVPSGVKSWAQASVTHGAHGDGGRASNLLSRFSREEFPTLQAA ::: .:: : : . :::: : .:..::: ... :.: ..:::.:::: mKIAA1 ---AQPKPGVAAP---PEVAPAPKSWA--SNKQGGQGDGIQVN---SQF-QQEFPSLQAA 110 120 130 140 150 180 190 200 210 220 mKIAA4 GDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGG---GRGPDDLE----GPDSKLHHGH :::.: ::.:. ... :::::::: : . ::::: : .: . : : . mKIAA1 GDQEK--KEKEANDENYGPGPSLRPPNVACWRDGGKCAGSPSSDQDEKQLGQDESTAITS 160 170 180 190 200 210 230 240 250 260 mKIAA4 DPRGGLQ------PSGPPQFP-----P-----YRGMMPPFMYP--PYLPFPPPYGPQGPY . :. :::: : ::.::::.:. : . .:: .::. mKIAA1 EQNDILKVVEKRIACGPPQAKLNGQQPALASQYRAMMPPYMFQQYPRMAYPPLHGPM--- 220 230 240 250 260 270 270 280 290 300 310 320 mKIAA4 RYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKE---FDQLDQENDDGWAG :.: :: . :: ::: . :::::. ..::: ::.:: : :.:::: mKIAA1 RFP----PSLSEANKSLRGRGPPPSWASEPERPSILSASELKELDKFDNLDAEADEGWAG 280 290 300 310 320 330 340 350 360 370 mKIAA4 AHEEVDYTEKLKFSDE-EDGRDSDEEGAEGHKDSQSAAAEE--PETDGKKGTSPGSELP- :. ::::::.:.:::. :.: : .:.. . ... . : :.: ..:. .:..: mKIAA1 AQMEVDYTEQLNFSDDDEQGSTSPKESSSEDQTAKTPESTENRKEVDEASSTKSSSQIPA 330 340 350 360 370 380 380 390 400 410 420 430 mKIAA4 -PPKTAWTENARPSETEPAPPTPKPPPPPPHRGPVGNWGPPGD--YPDRGGP-PCKPPAP :: : . : .. :. . :::: . . . :: : : : :: : :::.: mKIAA1 QPPVTKSPYGKGPPFNQERGPSSHLPPPP--KLLAQQHPPPPDRQIPGRQGPFPSKPPVP 390 400 410 420 430 440 440 450 460 470 480 490 mKIAA4 EDEDEAWRQRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDK :.:: :.:::::.: ::: ::::::.:::::::::.:.:.::::::::.::::.: .: mKIAA1 -DNDEIWKQRRKQQS-EISAAVERARKRREEEERRMEEQRKAACAEKLKQLDEKLGIIEK 450 460 470 480 490 500 500 510 520 530 540 550 mKIAA4 RLKAEPAAPPVTPAAPALPPVVPKEIPAAPALPPTPTPTPEKEPEEPAQAPPVQAAPSPG .:. : .:. ..: :. : mKIAA1 ----QPS--PEELREREREKERERELEKEKERELEKEQEKQREMERARQQEKELEQQREK 510 520 530 540 550 560 570 580 590 600 mKIAA4 VAPVPTLVSGGGCTANSNSSGSFEASPVEPQL-PSKEGPEPP-----EEVPPPTTPPAPK . : ... .. : :: . :. :. : :: : : . . mKIAA1 EQELQRLREQEKEGEPKEQEKEEKVEPQEPVVEPATENQESENNCKKEEEPIFTRQDSNR 560 570 580 590 600 610 610 620 630 640 650 660 mKIAA4 MEPKGDGVGSTRQPPSQGLGYPKY----QKSLPPRFQRQQQEQLLKQQQQQQQWQQQQQG : . : . .: : . : : ::::::::::::.. .:::: ::: :::::: mKIAA1 SEKETTQVVQEAEPESGAQPRPGYFKQFQKSLPPRFQRQQEQ--MKQQQWQQQQQQQQQG 620 630 640 650 660 670 670 680 690 700 710 720 mKIAA4 TAPPAPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYV . : . :: .: . :.:: ::: . :: .: . :.:::::.:. :. mKIAA1 VLPQT-VPSQPSN----GSVP-----PPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYM 680 690 700 710 720 730 740 750 760 770 780 mKIAA4 DPRLLQGRPPLDFYP--PG-VHPSGLVPRERSDSGGSSSEPFERHAPPLLRERGTPPVDP :::...::: .:. : :: . :. :. :.. ... .::: :: : :..: .: mKIAA1 DPRMISGRPAMDIPPIHPGMIPPKPLIRRDQMEGSPNSSESFE-HIARSARDHGISLSEP 730 740 750 760 770 780 790 800 mKIAA4 KLAWVGDVFTTTPT------------DPRPLTS----------PLRQ-----------AA .. : .: . . : : :: :. :... : mKIAA1 RMMWGSDPYHAEPQQAATPKSAEETGDARPETAMDHEHMTAAYPVEHSQLETHSKTDVAR 790 800 810 820 830 840 810 820 830 840 850 860 mKIAA4 DEEE--------KSMRSETPPVPPPPPYLANYPGFPENGTPGPPISRFPLEESAPPGPRP : : .:... : : . . ... : :. :: : : mKIAA1 DSTETEGQKFLSRSLEDVKPRHVDTNTQSACFDVIDQKSLPTSAEERISALESQPARKRS 850 860 870 880 890 900 870 880 890 900 910 mKIAA4 LPWPPGNDEAAKMQAPPPKKEPSKEEPPQLSGPEAGRKPA---------RGGQGPPPPR- . .. . :. : :. : ... :. .:: :...:: : . mKIAA1 VSHGSNHAQNAEEQRNEPSVSIPKVINRCMDSKETVEKPEEKPRKDGFLRSSEGPKPEKV 910 920 930 940 950 960 920 930 940 mKIAA4 RENRTETRWGPRPGSCRRGIPPEEPGVPPRRAGPIKKP---------------------- ....::::::::.: :: : : ::.:::::: mKIAA1 YKSKSETRWGPRPSSNRR---EEGNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKLEK 970 980 990 1000 1010 1020 950 960 970 980 mKIAA4 --PPPVKVEE---------LPPKSLEQGDETPKV-----PKPDA-----LKTAKGKVGPK ::.:. ::: . : . : : :.:. .: : . mKIAA1 VTEKVVKAEKPEKKDLPLPLPPPAPAQPQPQPLVSPPVQPEPEKPPSTETSTLTQKPSQD 1030 1040 1050 1060 1070 1080 990 1000 1010 mKIAA4 ETP--PGGNLS--P-----------APRLR----------RDYSYERVGPTS-------- : : : :... : :: .. .: . :: : : mKIAA1 EKPLEPVGSVQVEPVVKTVNQQSVAAPTVKEEKPPEKVINKDVGIERSRPDSRLAVKKDS 1090 1100 1110 1120 1130 1140 1020 1030 1040 1050 mKIAA4 ---------------------CRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFR ::::::::..:::..::.:::::::.:.. : : ..: mKIAA1 SLPTRTYWKEARDRDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHT-REYPQYR 1150 1160 1170 1180 1190 1060 1070 1080 1090 1100 mKIAA4 GDDGRGGGSGGTNH-PSAP-RGRTASETRSEGSEYEEIPKRRRQRGSET--GSETHES-- . : :.: ::.: : : ::::::.:..: .::::::::::: ::.::: mKIAA1 DNKPR------TEHVPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEVHESAS 1200 1210 1220 1230 1240 1250 1110 1120 1130 1140 1150 mKIAA4 --DLA-----PSDKEAPPPKEGVLGQVPLAPPQP---GAPPSPAPARFSTARGGRVFTPR : . :. .: : :. : : . : . : : .. : :. mKIAA1 DKDSVSKGKLPKREERPENKKPVKPQSSFKPENHVRIDNRPLEKPYIREEDKSKPGFLPK 1260 1270 1280 1290 1300 1310 1160 1170 1180 1190 mKIAA4 GVPSRRGRGG-----GRPP------PVC--------SGWSPPAKSLVPKKPPTGPLPPSK : :.:::::: :: : :. . :. ... : :: : :: . mKIAA1 GEPTRRGRGGTFRRGGRDPGGRPSRPATLRRPAYRDNQWN--TRQAEPPKPEDGG-PPRR 1320 1330 1340 1350 1360 1370 1200 1210 1220 1230 1240 1250 mKIAA4 EPLKEKLISGPLSPMSRAGNMGVGMEDG-ERPRRRRHGRAQQQDKPPRFRRLKQERENAA . :... :. .: .. .. . :::::.: : .::::::::::. ::: :. mKIAA1 H---EQFM--PIPADKRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLR-EREAAS 1380 1390 1400 1410 1420 1260 1270 1280 1290 1300 1310 mKIAA4 RGADGKPPSLTLAASTPGPEETLTAATVPPPPRRTAAKSPDLSNQNS-DQANEEWETASE . .. :: : .... : :: .. :.:::::::: :::::::::::: mKIAA1 KTSEVLVPS-------NGTANNVVQEPVNPPADISGNKTPDLSNQNSSDQANEEWETASE 1430 1440 1450 1460 1470 1320 1330 1340 1350 1360 1370 mKIAA4 SSDFASERRGDKETPPAALMTSKAVGTPGANAGGAGPGISAMSRGDLSQRAKDLSKRSFS :::: .::: ... : :.:.:: : .. : . ....::::: mKIAA1 SSDF-NERR-ERDEKKNADMSSQAVVKAGESV--------------LPPK-REIAKRSFS 1480 1490 1500 1510 1520 1380 1390 1400 1410 1420 1430 mKIAA4 SQRPGMDRQNRRPGTGGKTGSGGGSSGGGGAGPGGRTGPGRGDKRSWPSPKNRSRPP-EE :::::.:::::: :..: :: . :: : :...:. : :. .: : .. mKIAA1 SQRPGVDRQNRR-GNNGPPKSGRNFSG-----P-------RNERRNGPPSKGGKRGPFDD 1530 1540 1550 1560 1440 1450 1460 1470 1480 1490 mKIAA4 RPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGNVTAPGGHPRPKPGPPQ . : : ..:: : . :. .. .: .:... : . :::: . mKIAA1 QASGTAGADPVSGNSA--------H-HQEGVPNGAGQKNSKDA---AGKKREDTKPGPKK 1570 1580 1590 1600 1610 1500 1510 1520 1530 1540 1550 mKIAA4 APQGSSPRPPTRYDPPRASSAISSDPHFEEPGPMVRGVGGTPRDSAGVNPFPPKRRERPP . . ...: .:.. : : : ... .. :.. .. :...: mKIAA1 PKEKVDAL--SQFDLNNYASVVIIDDHPEVT--VIEDPQSNLNDDGFTEVVSKKQQKRLQ 1620 1630 1640 1650 1660 1670 1560 1570 1580 1590 1600 1610 mKIAA4 RKPELLQEETVPASHSSGFLGSKPEVPGPQEESRDSGTEALTPHIWNRLHTATSRKSYQP . . .:: : :. .: :..: : : : :.. .. :.:.. . : mKIAA1 DEERRKKEEQVVQVWSKKNIG---------EKGR-SQTSKLPPRFAKKQATGTQQIQAPP 1680 1690 1700 1710 1720 1620 1630 1640 1650 1660 1670 mKIAA4 GSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGSAEGPPK .. : . :.. ... . : . . : .. : : .: : . : mKIAA1 SAPVPVSSSAPGLTAPAAAAPASTPAPVPILA-SATALVPVS---TPAPVLTSCPAPVPT 1730 1740 1750 1760 1770 1680 1690 1700 1710 1720 1730 mKIAA4 RPGGPSPLN-AVPGESASGSEPSEPPRRRPPASHEGERKELPREQPLPPGPIGTERSQRT ..: : . . : ..:.:.:: : mKIAA1 SASAPVPASTSSPVTASSSSQPSVPAPTPVLASASTTVSVPILTSASIPILASALAPATV 1780 1790 1800 1810 1820 1830 >>mKIAA4231 ( 1467 res) mfj06028 (1467 aa) initn: 226 init1: 123 opt: 686 Z-score: 269.1 bits: 62.7 E(): 7.6e-10 Smith-Waterman score: 886; 27.338% identity (32.888% ungapped) in 1262 aa overlap (554-1751:75-1187) 530 540 550 560 570 580 mKIAA4 APALPPTPTPTPEKEPEEPAQAPPVQAAPSPGVAPVPTLVSGGGCTANSNSSGSFEASPV : : : . : :. . : .:. mKIAA4 SRDVWKPEPCQICVCDSGSVLCDDIICDEEPLDCPNPEIPFGECCAICPQPS-----TPA 50 60 70 80 90 590 600 610 620 630 640 mKIAA4 EPQLPSKEGPEPPEEVPPPTTPPAPKMEPKGDGVGSTRQPPSQGLGYPKYQKSLPPRFQR : ::. .::. :. : : :. . .: : . :: : : .: : : mKIAA4 -PVLPDGHGPQGPKGDPGPPGIPGRNGDPGLPGQPGLPGPP----GSPGICESCPTGGQN 100 110 120 130 140 150 650 660 670 680 690 mKIAA4 QQQEQLLKQQQQQQQWQQQQQGTAPPAPVPPSPP----QPVTLGAVPAPQAPPPPPKALY . . . .. . : : : : ::.:: .: . :. :. :.:: : mKIAA4 YSPQFDSYDVKSGVGGMGGYPGPAGP-PGPPGPPGSSGHPGSPGS-PGYQGPPGEPGQAG 160 170 180 190 200 210 700 710 720 730 740 750 mKIAA4 PGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRP--PLDF---YPPGVH-PSGL--VPR :.. :: :: . : : : . .::: : . :::.. :.:. : mKIAA4 PAG----PPGPPGALGPAG---PAGKDGE--SGRPGRPGERGLPGPPGIKGPAGMPGFPG 220 230 240 250 260 760 770 780 790 800 mKIAA4 ERSDSG--GSSSEPFERHAPPLLRERGTPPVDPKLAWVGDVFTTTPTDPRPLTS------ .. : : ..: : :: : : : : :: . : :: . mKIAA4 MKGHRGFDGRNGEKGETGAPGLKGENGLP---------GDNGAPGPMGPRGAPGERGRPG 270 280 290 300 310 810 820 830 840 850 860 mKIAA4 -PLRQAADEEEKSMRSETPPVPPPPPYLANYPGFP-ENGTPGPPISRFPLEESAPPGPRP : .: .. . :. : :: :: :..:: : .: :: : : ...: : : mKIAA4 LPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGS--PGSNGSP-GQRG 320 330 340 350 360 370 870 880 890 900 910 920 mKIAA4 LPWPPGNDEAAKMQAPPPKKEPSKEEPPQLSGPEAGRKPARGGQGPPP-PRRENRTETRW : : :. : :.:: :: .: .:. : .:: : . .: mKIAA4 EPGPQGH---AGAQGPPG--------PPGNNGSPGGK----GEMGPAGIPGAPGLIGAR- 380 390 400 410 930 940 950 960 970 mKIAA4 GPRPGSCRRGIPPEEPGVPPRRAGPIKKPPPPVKVEELPPKSLEQGDE-TPKVPKPDALK :: :: : :.: : :: .: : : :.:. .: .: : : mKIAA4 GP-PG------PAGTNGIPGTR-GPSGEPGKNGAKGE-PGARGERGEAGSPGIPGP---K 420 430 440 450 460 980 990 1000 1010 1020 1030 mKIAA4 TAKGKVG-PKETPPGGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGR :: : : : ::.: :. .: ::. :::: : mKIAA4 GEDGKDGSPGE--PGANGLPGAAGER-------GPS---------------GFRGPAGPN 470 480 490 1040 1050 1060 1070 1080 1090 mKIAA4 GRGARSREFRSYREFRGDDGRGGGSGGTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRG : .. .: :. :: : :..::: .:.: .:. : : . : mKIAA4 GIPGE----------KGPPGERGGPG----PAGPRG-VAGEPGRDGTPGG--PGIRGMPG 500 510 520 530 540 1100 1110 1120 1130 1140 1150 mKIAA4 SETGSETHESDLAPSDKEAPPPKEGVLGQVPLAPPQPGAP-PSPAPARFSTARGGRVFTP : : . . : .:: ..: :. : .:: :..: .:. : .:. mKIAA4 SPGGP-------GNDGKPGPPGSQGESGR-P-GPPGPSGPRGQPGVMGFPGPKGND---- 550 560 570 580 1160 1170 1180 1190 1200 1210 mKIAA4 RGVPSRRGRGGGRPPPVCSGWSPPAKSLVPKKPPTGPLPPSKEPLKEKLISGPLSPMSRA :.:.. :. :: : : . :. :: :: :. . : ::: .:.. mKIAA4 -GAPGKNGERGGPGGPGLPGPAGKNGETGPQGPP-GPTGPAGD----KGDSGPPGPQGLQ 590 600 610 620 630 640 1220 1230 1240 1250 1260 1270 mKIAA4 GNMGVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQERENAARGADGKP--PSLTLAASTP : :.: :: . . : . : . . :: : :. .:. : mKIAA4 GIPGTGGPPGENGKPGEPGPKGEVGAPGAPGGKGDSGAPGERGPPGTAGIPGARGGAGPP 650 660 670 680 690 700 1280 1290 1300 1310 1320 mKIAA4 GPEETLTAATVPPPPRRTAAKSPDLSNQNSDQA--------NEEWETASESSDFASERRG ::: : : :: :. :: :... .... .:. : .. ..: . . : mKIAA4 GPEGGKGPAGPPGPP--GASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDG 710 720 730 740 750 760 1330 1340 1350 1360 1370 1380 mKIAA4 DKETPPAALMTSKAVGTPGANAGGAGPGISAMS--RGDLSQRAKDLSKRSFSSQRPGMDR . : . . .: :: .. :..::. ... :: ..:.. . :: mKIAA4 PR-GPAGPIGPPGPAGQPGDKGEGGSPGLPGIAGPRGGPGERGEHGPPGP--AGFPGAPG 770 780 790 800 810 1390 1400 1410 1420 1430 mKIAA4 QNRRPGTGGKTGSGGGSSGGGGAGPGGRTG-------PG----RGDKRSWPSPKNRSRPP :: .::. :. :. : .. :: ::.: :: :: .:.. : .: . . : mKIAA4 QNGEPGAKGERGAPGEKGEGGPPGPAGPTGSSGPAGPPGPQGVKGERGSPGGPGTAGFPG 820 830 840 850 860 870 1440 1450 1460 1470 1480 mKIAA4 EER---PPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQ--LSSRQGNVTAPGGHPR . ::: : ::. :.. : .::: . . .. ... .:.. :: mKIAA4 GRGLPGPPGNNGNPGPPGPSGAPGKDG--PPGPAGNSGSPGNPGIAGPKGDAGQPG---- 880 890 900 910 920 930 1490 1500 1510 1520 1530 1540 mKIAA4 PKPGPP--QAPQGS-SPRPPTRYDPPRASSAISSDPHFE-EPGPM-VRGVGGTPRDSAGV . ::: :.: :: .: . :. .. . : . :::. ..: .: : :. mKIAA4 -EKGPPGAQGPPGSPGPLGIAGLTGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHN 940 950 960 970 980 990 1550 1560 1570 1580 1590 1600 mKIAA4 NPFPPKRRERPPRKPELLQE---ETVPASHSS-GFLGSKPEVPGPQEESRDSGTEALTPH . : . : .: : . :.: .. : :: : : . :. . :. . : mKIAA4 GERGPPGPQGLPGQPGTAGEPGRDGNPGSDGQPGRDGS-PGGKGDRGENGSPGAPGAPGH 1000 1010 1020 1030 1040 1050 1610 1620 1630 1640 1650 1660 mKIAA4 IWNRLHTATSRKSYQPGSIEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQR .. : :: . : : .: ::.. . . .: ::. : ..: mKIAA4 PGPPGPVGPSGKSGDRGETGPAGPSGAP--GPAGARGAPGPQGP--RGDK----GETGER 1060 1070 1080 1090 1100 1670 1680 1690 1700 1710 mKIAA4 SSPDGGLKGSAEGPPKRPGGPSPLNAVPGESASGSE-PSEPPRRRPPASHEGERKELPRE .: .:.:: .: : :: :. .:. ..: :: :. : : : . : :. mKIAA4 GS--NGIKGH-RGFPGNPGPPGSPGAAGHQGAIGSPGPAGP--RGPVGPHGPPGKDGTSG 1110 1120 1130 1140 1150 1720 1730 1740 1750 1760 1770 mKIAA4 QPLPPGPIGTERSQRTDRGPEPGPLRPAHRPGSQVEFGTTNKDSDLCLVVGDTLKGEKEL .: : :: : :..: .:: : .: .:.. :: mKIAA4 HPGPIGPPGP-RGNRGERGSEGSPGHPGQ-PGPPGPPGAPGPCCGGGAAAIAGVGGEKSG 1160 1170 1180 1190 1200 1210 1780 1790 mKIAA4 VASARGRSHIQRLGAAP mKIAA4 GFSPYYGDDPMDFKINTEEIMSSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKS 1220 1230 1240 1250 1260 1270 >>mKIAA0458 ( 882 res) mbg00904 (882 aa) initn: 173 init1: 116 opt: 352 Z-score: 150.1 bits: 39.9 E(): 0.0032 Smith-Waterman score: 453; 24.349% identity (30.112% ungapped) in 998 aa overlap (518-1487:29-863) 490 500 510 520 530 540 mKIAA4 EKFGAPDKRLKAEPAAPPVTPAAPALPPVVPKEIPAA--PALPPTPTPTP-EKEPEEPAQ ::.: . : :.: :.. . :: mKIAA0 EISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQ 10 20 30 40 50 550 560 570 580 590 600 mKIAA4 APPVQAAPSPGVAPVPTLVSGGGCTANSNSSGSFEASPVEPQLPSKEGPEPPEEVPPPTT .:: : :: .:. .: :. : : ::::.. :: : . :: mKIAA0 QQMLQAQPPALQAP------SGAASAPST------APPGTPQLPTQ-GPTPSATAVPPQG 60 70 80 90 100 610 620 630 640 650 660 mKIAA4 PPAPKMEPKGDGVGSTRQPPSQGLGYPKYQKSLPPRFQRQ-QQEQLLKQQQQQQQWQQQQ :: : :::.: :... : . . :: :. . . : mKIAA0 SPA------------TSQPPNQT------QSTVAPAAHTHIQQAPTLHPPRLPSPHPPLQ 110 120 130 140 670 680 690 700 710 720 mKIAA4 QGTAPPAPVPPSP-PQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFDPRWMMIP ::::. .: ::: : :.:: : ..: : : . : ::. : .: mKIAA0 PMTAPPSQSSAQPHPQPSLHG-----QGPPGP-HSLQTGPLLQHPG-PPQPFG-----LP 150 160 170 180 190 730 740 750 760 770 780 mKIAA4 PYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAPPLLRERGTPPVDP .: ::. :: : ..:: . . :.: . .: . :: ::. ::. mKIAA0 S--QPS--QGQGPLGPSPAAAHPHSTIQLPASQS---ALQP---QQPP--REQPLPPAPL 200 210 220 230 240 790 800 810 820 830 mKIAA4 KLAWVGDVFTTTPTDPRPLTSPLRQAADEEEKSMRSETPPVPPPP---PYLANYPGFPEN . . ::: : . .. : : . .:::: : . : . mKIAA0 AMPHIKPP-PTTPIPQLPAPQAHKHPPHLSGPSPFSLNANLPPPPALKPLSSLSTHHPPS 250 260 270 280 290 300 840 850 860 870 880 890 mKIAA4 GTPGPPISRFPLEESAPPGPRPLPWPPGNDEAAKMQAPPPKKEPS---KEEPPQLSGPEA . : ::.. .: . : .: ::: .. .. :: ..:. .. : : :. mKIAA0 AHP-PPLQLMPQSQPLPSSP---AQPPGLTQSQSLP-PPAASHPTTGLHQVPSQSPFPQH 310 320 330 340 350 900 910 920 930 940 950 mKIAA4 GRKPARGGQGPPPPRRENRTETRWGPRPGSCRRGIPPEEPGVPPRRAGPIKKPPPPVKVE :. :::: : :: :: ..:: ::: .. :: .. mKIAA0 PFVPG----GPPPIT------------PPSC----PPT--STPP--AGPSSSSQPPCSAA 360 370 380 390 960 970 980 990 1000 1010 mKIAA4 ELPPKSLEQGDETPKVPKPDALKTAKGKVGPKETPPGGNLSPAPRLRRDYSYERVGPTSC :. . : .: . . : .. :.:: ::.:. :: mKIAA0 VSSGGSVPGAPSCP-LPAVQIKEEALDEAEEPESPPPPPRSPSPE-----------PTVV 400 410 420 430 440 1020 1030 1040 1050 1060 1070 mKIAA4 RGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGSGGTNHPSAPRGRT ... :: : . :: .. .: . . :. . .. . . mKIAA0 DTPSHASQSAR---FY-KHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQK 450 460 470 480 490 1080 1090 1100 1110 1120 1130 mKIAA4 ASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPPPKEGVLGQVPLAPPQPG : : : . .: :. .:.:.: :. .. :. : . . : : . : : mKIAA0 AREEREREKEKEKEREREREREREAERAAKASSSAHEGRLSDPQLSGPGHMRPSFEP--- 500 510 520 530 540 550 1140 1150 1160 1170 1180 1190 mKIAA4 APPSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPVCSGWSPPAKSLVPKKPPTGPLP ::. : .: .:. : . : : :: .. .: :: mKIAA0 -PPTTIAA-----------VPPDTPALRTLSEYARPHV---MSPTNRN----HPFYMPLN 560 570 580 590 1200 1210 1220 1230 1240 1250 mKIAA4 PSKEPLKEKLISGPLSPMSRAGNMGVGMEDGERPRRRRHGRAQQQDKPPRFRRLKQEREN :. :: . : ..: :: :.:. : .. : :.: :: mKIAA0 PTD----------PLLAYHMPGLYNVDPTIRERELREREIR----EREIREREL---RER 600 610 620 630 1260 1270 1280 1290 1300 mKIAA4 AARGADGKPPSLTLAASTPGPEETL---TAATVPPP--PRRTAAKSPDLSNQNSDQ---A : . ::: : . .: : . .: :.:: :. :. : :. . .. : mKIAA0 MKPGFEVKPPELDPLHPATNPMEHFARHSALTIPPAAGPHPFASFHPGLNPLERERLALA 640 650 660 670 680 690 1310 1320 1330 1340 1350 1360 mKIAA4 NEEWETASESSD------FASERRGDKETPPAALMTSKAVGTPGANAGGAGPGISAMSRG . . . : . .:: .. . : : . : :: . . :. mKIAA0 GPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNV-TPHHHQHS-----HIHSHL 700 710 720 730 740 750 1370 1380 1390 1400 1410 1420 mKIAA4 DLSQRAKDLSKRSFSSQRPGMDRQNRRPGTGGKTGSGGGSSGGGGAGPGGRTGPGRGDKR : :. : . : . .: .: : :.: . :: .: :. mKIAA0 HLHQQ-DPLHQGSAGPVHPLVD-----PLTAGPHLARFPYP------PGTLPNPLLGQP- 760 770 780 790 1430 1440 1450 1460 1470 mKIAA4 SWPSPKNRSRPP---EERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQG : .. : : : :: ::: :.: .: :..:.. : .:. . . .: mKIAA0 --PHEHEMLRHPVFGTPYPRDLPGAIPPPMSAA-HQL-QAMHAQSAELQRLAMEQQWLHG 800 810 820 830 840 850 1480 1490 1500 1510 1520 1530 mKIAA4 NVTAPGGHPRPKPGPPQAPQGSSPRPPTRYDPPRASSAISSDPHFEEPGPMVRGVGGTPR . ::: mKIAA0 HPHMHGGHLPSQEDYYSRLKKEGDKQL 860 870 880 >>mKIAA1172 ( 1200 res) mfj66157 (1200 aa) initn: 205 init1: 130 opt: 355 Z-score: 149.8 bits: 40.3 E(): 0.0034 Smith-Waterman score: 471; 22.735% identity (26.806% ungapped) in 1126 aa overlap (103-1151:156-1187) 80 90 100 110 120 mKIAA4 LVPKDGTGWASKQEQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPT---------A :. :.... ..:. . :: : mKIAA1 KIVRVLNLWQKNGVFKIEIIQPLLDMAAGTSNAAPVAENVTNNEGSPPPPVKISSELAQA 130 140 150 160 170 180 130 140 150 160 170 180 mKIAA4 PENT-PSVPSGVKSWAQASVTHGAHG-DGGRASNLLSRFSREEFPTLQAAGDQDKAAKER : :. :.: . .: : :.:.. . .: . ...:. :.. : : . : . mKIAA1 PTNSMPTVAQLPSSDAFAAVAQLFQTTQGQQLQQILQTFQQPPQPQSPALDSAVMAQVQA 190 200 210 220 230 240 190 200 210 220 230 mKIAA4 ESAEQSSGPGPSLRPQNSTTW------RDGGGRGPDDLEGPDSKLHHGHD-PRGGLQPSG .:. ...: . :...:.. : :. .: ::: . . ..: .. mKIAA1 ITAQLKTAP--TQPPEQKTAFDKKLLDRFDYDDEPEAVE--DSKKEDAAAISTAALATAA 250 260 270 280 290 300 240 250 260 270 280 290 mKIAA4 PPQFPPYRGMMPPFMYPPYLPFPPPYGPQGPYRYPTPDGPSRFPRVAGPRGSGPPMRLVE :: . . : ::: :: :. :: :: .. : . .. : . mKIAA1 PPAPTAATPAVATAVPVPSATSPPP--PQTPFGYPG-DGVQQ-PACTQHQS----MDQFQ 310 320 330 340 350 300 310 320 330 340 350 mKIAA4 PVGRPSILKEDNLKEFDQLDQEND-DGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGH : : ...:.... : ... :.. . . : . . : mKIAA1 PRMMP--IQQDTMHHQVPLPPNGQMPGFGLLSAPPPFPPM-----PQPGMPQPGMAQPGL 360 370 380 390 400 360 370 380 390 400 410 mKIAA4 KDSQSAAAEEPETDGKKGTSPGSELPPPKTAWTENARPSETEPAPPTPKPPPP---PPHR . : :. . : . : : :.:. .:: : : : : : mKIAA1 AQPGMAQPTMPQPGMPQPGMPQPGMAQPGLAQPGMAQPGMPQPAMPQPAMPQPGMAQPGV 410 420 430 440 450 460 420 430 440 450 mKIAA4 GPVGNWGP-------PGDYPDRGGP----------PCKPPAPEDEDEAWRQRRKQSSSEI .:. : : . : : :: . . :. ..: .. . . mKIAA1 SPAPPVQPTFQSTFQPQNEPHSQKPHQQVEMEVEQPCVTEVKRHVPESRKSRSRSPKRRR 470 480 490 500 510 520 460 470 480 490 500 510 mKIAA4 SLAVERARRRREEEER-RMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPVTPAAPA : . :.:: :... : : ...:: . . .. .. ..: :. : : .. . mKIAA1 SRSGSRSRRSRHRRSRSRSRDRRRHSPRSRSQERRDREKERERRQKGLPQIKSETASVCS 530 540 550 560 570 580 520 530 540 550 560 mKIAA4 LPPVVPKEIPAAPALPPTPTPTPEKEP-EEPAQAPP------VQAAPSPGVAPVPTLVSG : . . . . . : : : . :: :.. . . . : : mKIAA1 TTLWVGQ-LDKRTTQQDVASLLEEFGPIESINMIPPRGCAYIVMVHRQDAYRALQKL-SR 590 600 610 620 630 640 570 580 590 600 610 620 mKIAA4 GGCTANSNSSGSFEA--SPVEPQLPSKEGPEPPEEVPPPTTPPAPKMEP--KGDGVGSTR :. .:..: : . .. . . : : : ..: .: . : mKIAA1 GNYKVNQKSIKIAWALNKGIKADYKQYWDVELGVTYIPWDKVKAEELESFCEGGMLDSDT 650 660 670 680 690 700 630 640 650 660 670 mKIAA4 QPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQQWQQQQQGTAP---PAPVPPSP-P :. : :: . .. . :. . . . . : :.:::: : : mKIAA1 LNPDWK-GIPK------------KPDNEVAQNGGAETSHTEPVSPIPKPVPVPVPPIPVP 710 720 730 740 750 680 690 700 710 720 730 mKIAA4 QPVTLGAVPAPQAPP--P-PP--KALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQG :.: :: ::.:: : :: :: : :. : ::: .: : . :: : : : mKIAA1 APIT---VPPPQVPPHQPGPPVVGALQPPAFTPPLGMPPPGFGPG-VPPPPPPPPFLRPG 760 770 780 790 800 740 750 760 770 780 790 mKIAA4 RPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFERHAPPLLRERGTPPVD-PKLAWVGDVF :. . ::: : : : : :: :::.. :.:. : mKIAA1 FNPMHL-PPGFLPPGPPP---------PITPPVSIPPP-----HTPPISIPNLV-SGARG 810 820 830 840 850 800 810 820 830 840 mKIAA4 TTTPTDPRPLTSPLRQAADEEEKSMRSETPPVPPPPPYLANY---PGFPENGTPGPPISR .. : .. . .: :::: : :.. :: : : .: . mKIAA1 NAESGD----SAKMYGSAGPPAAPTSLPTPPVTQPVSLLGTQGVAPG-PVIGLQAPSTGL 860 870 880 890 900 850 860 870 880 890 900 mKIAA4 FPLEESAPPGPRPLPWPPGNDEAAKMQAPPPKKEPSKEEPPQLSGPEA---GRKPARGGQ . .: :: :: ::: :::. . ::. :. : :. :: mKIAA1 L----GARPGLIPLQRPPG--------MPPPHLQRFPMMPPRPMPPHMMHRGPPPGPGGF 910 920 930 940 950 910 920 930 940 950 960 mKIAA4 GPPPPRRENRTETRWGP--RPGSCRR-GIPPEEPGVPPRRAGPIKKPPPPVKVEELPPKS . :::. . :: :::. : : ::. : : ..: .. :: . mKIAA1 AMPPPHGMKGPFPPHGPFVRPGGMPGLGGPGPGPGASEDRDGRQQQP------QQQPPPQ 960 970 980 990 1000 970 980 990 1000 1010 1020 mKIAA4 LEQGDETPKVPKPDALKTAKGKVGPKETPPGGNLSPAPRLRRDYSYERVGPTSCRGRGRG .: .. :. : .. :.. : .. .: :..: : . . . . :: mKIAA1 QQQQQQQPQQPPQQS---------PSQQPAPAQQQP-PQFRNDSRQQFNSGRDQERFGRR 1010 1020 1030 1040 1050 1030 1040 1050 1060 1070 1080 mKIAA4 EYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGSGGTNHPSAPRGRTASETRS . .: .. : ::.:. :. : ::. :: . . .. :.: .: :. mKIAA1 SFGSRVENDRERYGSRNDD-RDNSNRERREW----GRRSPDRDRHRDLEERSRRSSGHRD 1060 1070 1080 1090 1100 1110 1090 1100 1110 1120 1130 mKIAA4 EGSEYEEIPKRRRQRGSETGSETHE-SDLAPSDKEAPPP--KEGVLGQVP-LAPPQPGAP . . .. .::... :. .: :: .: : ..: . :: . :.. : : . : mKIAA1 RDRDSRDRESRREKE--ENRKEKHEVADRAGGNKAVEPPLSQVGTIDTVSELNKGEAMAT 1120 1130 1140 1150 1160 1170 1140 1150 1160 1170 1180 1190 mKIAA4 ---PSPAPARFSTARGGRVFTPRGVPSRRGRGGGRPPPVCSGWSPPAKSLVPKKPPTGPL : .::. .. : mKIAA1 VVKPEESPAEATSPVGPEKDPGSAAEPPR 1180 1190 1200 >>mKIAA0595 ( 1646 res) mbg04268 (1646 aa) initn: 139 init1: 103 opt: 356 Z-score: 148.7 bits: 40.6 E(): 0.0039 Smith-Waterman score: 415; 22.875% identity (29.904% ungapped) in 953 aa overlap (364-1129:618-1533) 340 350 360 370 380 mKIAA4 LKFSDEEDGRDSDEEGAEGHKDSQSAAAEEPETDGKKGTSPGSELP------PPKT-AWT : ::: :. .: : . : : mKIAA0 PAVGNAAPGDQASSGTELVGSLPVGPNLTSPVLADKKGIEPAVAVPTSDNLSPADVLANT 590 600 610 620 630 640 390 400 410 420 430 440 mKIAA4 ENARPSETEPAPPTP---KPPPPPPHRGPVGNWGPP-GDYPD-RGGPPCKPPAPEDEDEA : : ..::: : : : :.:. .. . :. :. ... : .:: .: . mKIAA0 VAADPVPNDPAPADPVLVKCRPTDPRRAAAAAAAAAQGSRPSLQSADHPKVVSPEGKDVV 650 660 670 680 690 700 450 460 470 480 490 500 mKIAA4 WRQRRKQSSSEISL-AVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAE . . :.: . : : : ..::.:.. .: :. mKIAA0 GPLKVEGSTSATTQEAKPRPLSLSEYRQRRQQRQTEAE---------------DRN---- 710 720 730 740 510 520 530 540 550 mKIAA4 PAAPPVTPAAPALP--PV----VPKEIPAAPALPPTPTPTPEKEPEE-PAQAPPVQAAPS . :::. :.:: :. .: .:.::: .: .: :: . . ::. .: mKIAA0 -SQPPVVGKWPSLPETPTELADIPCLVPSAPARKTAPQRSPIAVPETVSVGSNPVSPTPE 750 760 770 780 790 800 560 570 580 590 600 mKIAA4 PGVAPVPTLVSGGGCTANSNSSGSFEASPVEPQLPS--KEGPEP---PEEVP--PPTTPP :... . .:: . ..:. . . : : ::: :: : : .: ::..:: mKIAA0 PSASKL--MVSTHSEQVSSHEM-PLAVRPPPPPLPSVSPAGPIPSTVPAPLPPFPPSVPP 810 820 830 840 850 860 610 620 630 640 650 660 mKIAA4 APKMEPKGDGVGSTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQQQQWQQQQQGT .. : :: :: : : : ....:: . : :. . . mKIAA0 LLSLPSGGHGVPRLPPPPLQPPGLPVSMRQMPP--------DPYTQYAPVPPWSCYPS-V 870 880 890 900 910 670 680 690 700 mKIAA4 APPAP--VPPSPPQPVTLG-----AVP----APQAPPPPPKALYP-----GALG-----R .::. .:: : .:.. : ::: .: .::: : . : :.:: . mKIAA0 SPPGYSCLPPPPTMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSCAYGSLGWGPGLQ 920 930 940 950 960 970 710 720 730 740 750 mKIAA4 PPPM------PPMNFDPRWMMIPPY-VDPRLLQGRPPLDFYPPGVHPS--------GLVP ::. ::.. : .:: :.: . :: : : : :: . : mKIAA0 QPPFWSTVSPPPLSSVPTGRAVPPTPVEPSGDPASPPEDVLPGPVTPSLSSGPASPAAPP 980 990 1000 1010 1020 1030 760 770 780 790 800 mKIAA4 RE--RSDSGGSSSEPFERHAPPLLRERGTPPVDPKLAWVGDVFTTTPTD--------PRP : . .. : .: : . . : :. : :: . .. :: mKIAA0 VEPTKPEAQPVPVSPQPKHKVSTLVQSPQIKAPPTLSTEGVVFEESVSERLKSETQENRP 1040 1050 1060 1070 1080 1090 810 820 830 840 850 mKIAA4 LTSPLRQAADEEEKSMRSETPPVPP-PPPYLANYPGFPENGTPGPP------ISRFPLEE .:. : .: . .: : : . .: . :: ::.. .: mKIAA0 KEKPISTAIKSVPVPKQSAVAKLPAVHPARLRKLSFLPTPRAQGPEDVVQAFISEIGIEA 1100 1110 1120 1130 1140 1150 860 870 mKIAA4 S----------APPGPRPLPWPPGNDEAA-----------------KMQAP--------- : . . : : . : : ..::: mKIAA0 SDLSSLLEQFEKSEAKKECPLPASADSLAVGNSGSIDIPQEKKPLDRLQAPELANVAGLT 1160 1170 1180 1190 1200 1210 880 890 900 910 920 mKIAA4 PPKKEP-------------SKEEPPQLSGPEAGRKPARGGQGPPPPRRENRTETRWGPRP :: : .: . :. .. :. :: .: :: : .: : mKIAA0 PPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKP-EGITEAKPPATACLQEGAHSPSP 1220 1230 1240 1250 1260 1270 930 940 950 mKIAA4 ---GS-----CRRG-IPPEE-PGVPPRRAG--------------PI-----KKPPPPVKV :: : :. ::.. :.. ..: :. :: : . mKIAA0 VHVGSGDHDYCVRSRTPPKRMPALVISEVGSRWNVKRHQDITIKPVLSLGSAAPPLPCTA 1280 1290 1300 1310 1320 1330 960 970 980 990 1000 1010 mKIAA4 EELPP----KSLEQGDETPKVPKPDALKTAKGKVGPKETPPGGNLSPAPRLRRDYSYERV : :.::.: . :..: . ... : .. .. : : ... : mKIAA0 TSQEPLDHRTSVEQADPSAPCFAPSTLLSPEAS--PCRSEMNARTPPEPSDKQQSM--RC 1340 1350 1360 1370 1380 1390 1020 1030 1040 mKIAA4 GPTSCRG---RGRGEYFARGRGFRGTYGGRGRGA----------------RSREF----- .::. .:: :::. :.. .: .: . ::: : mKIAA0 YRKACRSVSPSSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSRSFSPPNK 1400 1410 1420 1430 1440 1450 1050 1060 1070 1080 1090 1100 mKIAA4 RSYREFRGDDGRGGGSGGTNHPSAPRGRTASETRSEGSEYEEIPKRRRQRGSETGSETHE : : ...::. .... :. . .:..:: . . :::. .: ... .. mKIAA0 RWRRSSCSSSGRSRRCSSSSSSSSSSSSCSSRSRSPSVSPCRRSDRRRRYSSYRANDHYQ 1460 1470 1480 1490 1500 1510 1110 1120 1130 1140 1150 1160 mKIAA4 SDLAPSDKEAPPPKEGV-LGQVPLAPPQPGAPPSPAPARFSTARGGRVFTPRGVPSRRGR . . . ..: .. : .:..: mKIAA0 RQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQGDNYGFVTY 1520 1530 1540 1550 1560 1570 1796 residues in 1 query sequences 1767221 residues in 2168 library sequences Scomplib [34t11] start: Mon Mar 27 11:04:12 2006 done: Mon Mar 27 11:04:14 2006 Scan time: 1.440 Display time: 0.930 Function used was FASTA [version 3.4t11 Apr 17, 2002]