# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mpm08036.fasta.nr -Q ../query/mKIAA1008.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2
FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
mKIAA1008, 451 aa
vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library
2727779818 residues in 7921681 sequences
statistics sampled from 60000 to 7919512 sequences
Expectation_n fit: rho(ln(x))= 4.8594+/-0.000182; mu= 12.3859+/- 0.010
mean_var=67.9303+/-13.270, 0's: 44 Z-trim: 62 B-trim: 0 in 0/66
Lambda= 0.155612
FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 37, opt: 25, open/ext: -10/-2, width: 16
The best scores are: opt bits E(7921681)
gi|148668130|gb|EDL00460.1| RIKEN cDNA 2810028N01, ( 946) 2621 597.7 4e-168
gi|166231533|sp|Q9CSH3.4|RRP44_MOUSE RecName: Full ( 958) 2621 597.7 4.1e-168
gi|148668131|gb|EDL00461.1| RIKEN cDNA 2810028N01, ( 781) 2613 595.8 1.2e-167
gi|149050096|gb|EDM02420.1| similar to mitotic con ( 939) 2585 589.6 1.1e-165
gi|187469071|gb|AAI66824.1| Dis3 protein [Rattus n ( 957) 2585 589.6 1.1e-165
gi|168278787|dbj|BAG11273.1| exosome complex exonu ( 928) 2489 568.1 3.3e-159
gi|33440520|gb|AAH56143.1| DIS3 mitotic control ho ( 958) 2489 568.1 3.4e-159
gi|159149063|dbj|BAF92610.1| DIS3 [Homo sapiens] ( 958) 2487 567.6 4.6e-159
gi|52545700|emb|CAH56266.1| hypothetical protein [ ( 958) 2481 566.3 1.2e-158
gi|71296758|gb|AAH38101.1| DIS3 protein [Homo sapi ( 796) 2468 563.3 7.7e-158
gi|149730276|ref|XP_001495267.1| PREDICTED: DIS3 m ( 958) 2467 563.1 1e-157
gi|75775553|gb|AAI04535.1| DIS3 protein [Bos tauru ( 628) 2450 559.2 1.1e-156
gi|20071792|gb|AAH27357.1| DIS3 mitotic control ho ( 566) 2436 556.0 8.7e-156
gi|148668132|gb|EDL00462.1| RIKEN cDNA 2810028N01, ( 588) 2436 556.0 8.9e-156
gi|126337588|ref|XP_001365109.1| PREDICTED: simila ( 959) 2402 548.5 2.6e-153
gi|171847251|gb|AAI61523.1| Dis3 protein [Xenopus ( 951) 2196 502.3 2.1e-139
gi|54035109|gb|AAH84092.1| LOC495005 protein [Xeno ( 953) 2186 500.0 1e-138
gi|194672086|ref|XP_001249406.2| PREDICTED: DIS3 m ( 940) 2132 487.9 4.5e-135
gi|26327903|dbj|BAC27692.1| unnamed protein produc ( 687) 2120 485.1 2.3e-134
gi|125804058|ref|XP_001336850.1| PREDICTED: DIS3 m ( 950) 2077 475.6 2.3e-131
gi|210131741|gb|EEA79409.1| hypothetical protein B ( 625) 1723 395.9 1.4e-107
gi|5262619|emb|CAB45749.1| hypothetical protein [H ( 632) 1706 392.1 2e-106
gi|215506779|gb|EEC16273.1| salivary protein Is3, ( 956) 1692 389.1 2.5e-105
gi|190585024|gb|EDV25093.1| hypothetical protein T ( 931) 1615 371.8 3.9e-100
gi|194185352|gb|EDW98963.1| GE23472 [Drosophila ya ( 982) 1588 365.8 2.7e-98
gi|156553452|ref|XP_001601829.1| PREDICTED: simila ( 985) 1588 365.8 2.7e-98
gi|194151385|gb|EDW66819.1| GJ23805 [Drosophila vi ( 979) 1586 365.3 3.7e-98
gi|194168510|gb|EDW83411.1| GK22331 [Drosophila wi ( 981) 1586 365.3 3.7e-98
gi|194121434|gb|EDW43477.1| GM26588 [Drosophila se ( 989) 1584 364.9 5e-98
gi|193893646|gb|EDV92512.1| GH18811 [Drosophila gr ( 979) 1582 364.5 6.8e-98
gi|194200634|gb|EDX14210.1| GD21090 [Drosophila si ( 957) 1580 364.0 9.1e-98
gi|190656642|gb|EDV53874.1| GG11280 [Drosophila er ( 982) 1577 363.3 1.5e-97
gi|15292611|gb|AAK93574.1| SD10981p [Drosophila me ( 982) 1574 362.7 2.4e-97
gi|193916738|gb|EDW15605.1| GI10069 [Drosophila mo ( 979) 1571 362.0 3.8e-97
gi|7301148|gb|AAF56281.1| Dis3 [Drosophila melanog ( 982) 1570 361.8 4.4e-97
gi|190618480|gb|EDV34004.1| GF20740 [Drosophila an ( 983) 1569 361.5 5.2e-97
gi|194111906|gb|EDW33949.1| GL21852 [Drosophila pe ( 978) 1549 357.0 1.2e-95
gi|198132293|gb|EAL28283.2| GA19573 [Drosophila ps ( 978) 1549 357.0 1.2e-95
gi|110761130|ref|XP_397381.3| PREDICTED: similar t ( 980) 1538 354.6 6.4e-95
gi|13446610|emb|CAC35051.1| putative exoribonuclea ( 983) 1509 348.1 5.9e-93
gi|167877510|gb|EDS40893.1| mitotic control protei ( 970) 1468 338.9 3.4e-90
gi|91088779|ref|XP_967442.1| PREDICTED: similar to ( 943) 1449 334.6 6.4e-89
gi|116128315|gb|EAA09476.3| AGAP005191-PA [Anophel ( 967) 1446 333.9 1e-88
gi|115660722|ref|XP_787332.2| PREDICTED: hypotheti (1412) 1393 322.1 5.3e-85
gi|108871997|gb|EAT36222.1| mitotic control protei ( 970) 1385 320.2 1.4e-84
gi|187028531|emb|CAP32286.1| C. briggsae CBR-DIS-3 (1019) 1332 308.3 5.5e-81
gi|163777265|gb|EDQ90882.1| predicted protein [Mon ( 951) 1327 307.2 1.1e-80
gi|221222479|sp|Q17632.2|RRP44_CAEEL RecName: Full ( 961) 1320 305.6 3.4e-80
gi|210105397|gb|EEA53409.1| hypothetical protein B ( 893) 1309 303.1 1.8e-79
gi|60462398|gb|EAL60619.1| putative exoribonucleas (1006) 1226 284.5 8e-74
>>gi|148668130|gb|EDL00460.1| RIKEN cDNA 2810028N01, iso (946 aa)
initn: 2613 init1: 2613 opt: 2621 Z-score: 3174.6 bits: 597.7 E(): 4e-168
Smith-Waterman score: 2621; 98.250% identity (99.250% similar) in 400 aa overlap (52-451:177-576)
30 40 50 60 70 80
mKIAA1 KKKWQVSCQKTTIHVSSRLNTVPRYLNLKIVTYFSGEEYVKSLTANPELIDRLAYLSDEM
. :. ::::::::::::::::::::::::
gi|148 HLKRVAADSQLQVILITNDRKNKEKAVQEGIPAFTCEEYVKSLTANPELIDRLAYLSDEM
150 160 170 180 190 200
90 100 110 120 130 140
mKIAA1 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
210 220 230 240 250 260
150 160 170 180 190 200
mKIAA1 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
270 280 290 300 310 320
210 220 230 240 250 260
mKIAA1 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
330 340 350 360 370 380
270 280 290 300 310 320
mKIAA1 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
390 400 410 420 430 440
330 340 350 360 370 380
mKIAA1 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
450 460 470 480 490 500
390 400 410 420 430 440
mKIAA1 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
510 520 530 540 550 560
450
mKIAA1 KSVINSKVSV
:::::::.:.
gi|148 KSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGALTLSSPEIR
570 580 590 600 610 620
>>gi|166231533|sp|Q9CSH3.4|RRP44_MOUSE RecName: Full=Exo (958 aa)
initn: 2613 init1: 2613 opt: 2621 Z-score: 3174.6 bits: 597.7 E(): 4.1e-168
Smith-Waterman score: 2621; 98.250% identity (99.250% similar) in 400 aa overlap (52-451:189-588)
30 40 50 60 70 80
mKIAA1 KKKWQVSCQKTTIHVSSRLNTVPRYLNLKIVTYFSGEEYVKSLTANPELIDRLAYLSDEM
. :. ::::::::::::::::::::::::
gi|166 HLKRVAADSQLQVILITNDRKNKEKAVQEGIPAFTCEEYVKSLTANPELIDRLAYLSDEM
160 170 180 190 200 210
90 100 110 120 130 140
mKIAA1 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|166 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
220 230 240 250 260 270
150 160 170 180 190 200
mKIAA1 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|166 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
280 290 300 310 320 330
210 220 230 240 250 260
mKIAA1 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|166 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
340 350 360 370 380 390
270 280 290 300 310 320
mKIAA1 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|166 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
400 410 420 430 440 450
330 340 350 360 370 380
mKIAA1 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|166 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
460 470 480 490 500 510
390 400 410 420 430 440
mKIAA1 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|166 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
520 530 540 550 560 570
450
mKIAA1 KSVINSKVSV
:::::::.:.
gi|166 KSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGALTLSSPEIR
580 590 600 610 620 630
>>gi|148668131|gb|EDL00461.1| RIKEN cDNA 2810028N01, iso (781 aa)
initn: 2613 init1: 2613 opt: 2613 Z-score: 3166.1 bits: 595.8 E(): 1.2e-167
Smith-Waterman score: 2613; 99.492% identity (100.000% similar) in 394 aa overlap (58-451:18-411)
30 40 50 60 70 80
mKIAA1 SCQKTTIHVSSRLNTVPRYLNLKIVTYFSGEEYVKSLTANPELIDRLAYLSDEMNEIESG
::::::::::::::::::::::::::::::
gi|148 PITRKSISIPSLMSTISEEYVKSLTANPELIDRLAYLSDEMNEIESG
10 20 30 40
90 100 110 120 130 140
mKIAA1 KIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQGIKHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 KIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQGIKHLN
50 60 70 80 90 100
150 160 170 180 190 200
mKIAA1 RAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 RAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGR
110 120 130 140 150 160
210 220 230 240 250 260
mKIAA1 VVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRIIVAIDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 VVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRIIVAIDG
170 180 190 200 210 220
270 280 290 300 310 320
mKIAA1 WPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 WPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDM
230 240 250 260 270 280
330 340 350 360 370 380
mKIAA1 KNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNALDQESA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 KNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNALDQESA
290 300 310 320 330 340
390 400 410 420 430 440
mKIAA1 RRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 RRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINS
350 360 370 380 390 400
450
mKIAA1 KVSV
:.:.
gi|148 KASLTYAEAQMRIDSAAMNDDITTSLRGLNQLAKILKKGRIEKGALTLSSPEIRFHMDSE
410 420 430 440 450 460
>>gi|149050096|gb|EDM02420.1| similar to mitotic control (939 aa)
initn: 2577 init1: 2577 opt: 2585 Z-score: 3131.0 bits: 589.6 E(): 1.1e-165
Smith-Waterman score: 2585; 96.500% identity (98.750% similar) in 400 aa overlap (52-451:170-569)
30 40 50 60 70 80
mKIAA1 KKKWQVSCQKTTIHVSSRLNTVPRYLNLKIVTYFSGEEYVKSLTANPELIDRLAYLSDEM
. :. :::::::::::::::::: :::::
gi|149 EHLKMSAENQLQVILITNDKKNKEKAAEEGIPAFTCEEYVKSLTANPELIDRLACLSDEM
140 150 160 170 180 190
90 100 110 120 130 140
mKIAA1 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
gi|149 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEDEKEILIQ
200 210 220 230 240 250
150 160 170 180 190 200
mKIAA1 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
:.::::::.:::::::::::.::::::::::: :::::::::::::::::::::::::::
gi|149 GLKHLNRAIHEDIVAVELLPKSQWVAPSSVVLHDEGQNEDDVEKDEERELLLKTAVSEKM
260 270 280 290 300 310
210 220 230 240 250 260
mKIAA1 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|149 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
320 330 340 350 360 370
270 280 290 300 310 320
mKIAA1 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
gi|149 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWS
380 390 400 410 420 430
330 340 350 360 370 380
mKIAA1 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|149 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
440 450 460 470 480 490
390 400 410 420 430 440
mKIAA1 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|149 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
500 510 520 530 540 550
450
mKIAA1 KSVINSKVSV
:::::::.:.
gi|149 KSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNKLAKILKRGRIEKGALTLSSPEIR
560 570 580 590 600 610
>>gi|187469071|gb|AAI66824.1| Dis3 protein [Rattus norve (957 aa)
initn: 2577 init1: 2577 opt: 2585 Z-score: 3130.9 bits: 589.6 E(): 1.1e-165
Smith-Waterman score: 2585; 96.500% identity (98.750% similar) in 400 aa overlap (52-451:188-587)
30 40 50 60 70 80
mKIAA1 KKKWQVSCQKTTIHVSSRLNTVPRYLNLKIVTYFSGEEYVKSLTANPELIDRLAYLSDEM
. :. :::::::::::::::::: :::::
gi|187 EHLKMSAENQLQVILITNDKKNKEKAAEEGIPAFTCEEYVKSLTANPELIDRLACLSDEM
160 170 180 190 200 210
90 100 110 120 130 140
mKIAA1 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
gi|187 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEDEKEILIQ
220 230 240 250 260 270
150 160 170 180 190 200
mKIAA1 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
:.::::::.:::::::::::.::::::::::: :::::::::::::::::::::::::::
gi|187 GLKHLNRAIHEDIVAVELLPKSQWVAPSSVVLHDEGQNEDDVEKDEERELLLKTAVSEKM
280 290 300 310 320 330
210 220 230 240 250 260
mKIAA1 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|187 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
340 350 360 370 380 390
270 280 290 300 310 320
mKIAA1 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
gi|187 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWS
400 410 420 430 440 450
330 340 350 360 370 380
mKIAA1 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|187 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
460 470 480 490 500 510
390 400 410 420 430 440
mKIAA1 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|187 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
520 530 540 550 560 570
450
mKIAA1 KSVINSKVSV
:::::::.:.
gi|187 KSVINSKASLTYAEAQMRIDSAAMNDDITTSLRGLNKLAKILKRGRIEKGALTLSSPEIR
580 590 600 610 620 630
>>gi|168278787|dbj|BAG11273.1| exosome complex exonuclea (928 aa)
initn: 2480 init1: 2480 opt: 2489 Z-score: 3014.6 bits: 568.1 E(): 3.3e-159
Smith-Waterman score: 2489; 86.480% identity (94.872% similar) in 429 aa overlap (23-451:131-558)
10 20 30 40 50
mKIAA1 SPLLVHLKTATVYLNIINKSFKKKWQVSCQKTTIHVSSRLNTVPRYLNLKIV
:: ... : .: ... . . .. . .
gi|168 TYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIE-EGI
110 120 130 140 150
60 70 80 90 100 110
mKIAA1 TYFSGEEYVKSLTANPELIDRLAYLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQG
:. :::::::::::::::::: ::.: ::::::::::::::::::::::::::.::::
gi|168 PAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQG
160 170 180 190 200 210
120 130 140 150 160 170
mKIAA1 TFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVV
:::::::::::::::::::.::.:::..::.::::::::::::::::::.::::::::::
gi|168 TFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVV
220 230 240 250 260 270
180 190 200 210 220 230
mKIAA1 LDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESR
: ::::::.::::.:::: .::::::::::.:::::::::::::::::::::::::::::
gi|168 LHDEGQNEEDVEKEEERERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESR
280 290 300 310 320 330
240 250 260 270 280 290
mKIAA1 RHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETE
::::::::::::::::::::::.:::::::::::::::::::::::::.:::::::::::
gi|168 RHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETE
340 350 360 370 380 390
300 310 320 330 340 350
mKIAA1 TEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDA
::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::::::
gi|168 TEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDA
400 410 420 430 440 450
360 370 380 390 400 410
mKIAA1 LHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|168 LHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
460 470 480 490 500 510
420 430 440 450
mKIAA1 SLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKVSV
::. .:::::::::::::::::::::.:::::::::.:.
gi|168 SLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTS
520 530 540 550 560 570
gi|168 LRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLL
580 590 600 610 620 630
>>gi|33440520|gb|AAH56143.1| DIS3 mitotic control homolo (958 aa)
initn: 2480 init1: 2480 opt: 2489 Z-score: 3014.4 bits: 568.1 E(): 3.4e-159
Smith-Waterman score: 2489; 86.480% identity (94.872% similar) in 429 aa overlap (23-451:161-588)
10 20 30 40 50
mKIAA1 SPLLVHLKTATVYLNIINKSFKKKWQVSCQKTTIHVSSRLNTVPRYLNLKIV
:: ... : .: ... . . .. . .
gi|334 TYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIE-EGI
140 150 160 170 180
60 70 80 90 100 110
mKIAA1 TYFSGEEYVKSLTANPELIDRLAYLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQG
:. :::::::::::::::::: ::.: ::::::::::::::::::::::::::.::::
gi|334 PAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQG
190 200 210 220 230 240
120 130 140 150 160 170
mKIAA1 TFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVV
:::::::::::::::::::.::.:::..::.::::::::::::::::::.::::::::::
gi|334 TFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVV
250 260 270 280 290 300
180 190 200 210 220 230
mKIAA1 LDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESR
: ::::::.::::.:::: .::::::::::.:::::::::::::::::::::::::::::
gi|334 LHDEGQNEEDVEKEEERERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESR
310 320 330 340 350 360
240 250 260 270 280 290
mKIAA1 RHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETE
::::::::::::::::::::::.:::::::::::::::::::::::::.:::::::::::
gi|334 RHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETE
370 380 390 400 410 420
300 310 320 330 340 350
mKIAA1 TEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDA
::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::::::
gi|334 TEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDA
430 440 450 460 470 480
360 370 380 390 400 410
mKIAA1 LHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|334 LHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
490 500 510 520 530 540
420 430 440 450
mKIAA1 SLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKVSV
::. .:::::::::::::::::::::.:::::::::.:.
gi|334 SLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTS
550 560 570 580 590 600
gi|334 LRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLL
610 620 630 640 650 660
>>gi|159149063|dbj|BAF92610.1| DIS3 [Homo sapiens] (958 aa)
initn: 2478 init1: 2478 opt: 2487 Z-score: 3012.0 bits: 567.6 E(): 4.6e-159
Smith-Waterman score: 2487; 86.480% identity (94.872% similar) in 429 aa overlap (23-451:161-588)
10 20 30 40 50
mKIAA1 SPLLVHLKTATVYLNIINKSFKKKWQVSCQKTTIHVSSRLNTVPRYLNLKIV
:: ... : .: ... . . .. . .
gi|159 TYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIE-EGI
140 150 160 170 180
60 70 80 90 100 110
mKIAA1 TYFSGEEYVKSLTANPELIDRLAYLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQG
:. :::::::::::::::::: ::.: ::::::::::::::::::::::::::.::::
gi|159 PAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQG
190 200 210 220 230 240
120 130 140 150 160 170
mKIAA1 TFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVV
:::::::::::::::::::.::.:::..::.::::::::::::::::::.::::::::::
gi|159 TFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVV
250 260 270 280 290 300
180 190 200 210 220 230
mKIAA1 LDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESR
: ::::::.::::.:::: .::::::::::.:::::::::::::::::::::::::::::
gi|159 LHDEGQNEEDVEKEEERERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESR
310 320 330 340 350 360
240 250 260 270 280 290
mKIAA1 RHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETE
::::::::::::::::::::::.:::::::::::::::::::::::::.:::::::::::
gi|159 RHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETE
370 380 390 400 410 420
300 310 320 330 340 350
mKIAA1 TEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDA
::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::::::
gi|159 TEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDA
430 440 450 460 470 480
360 370 380 390 400 410
mKIAA1 LHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|159 LHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
490 500 510 520 530 540
420 430 440 450
mKIAA1 SLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKVSV
::. .:::::::::::::::::::::.:::::::::.:.
gi|159 SLQCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTS
550 560 570 580 590 600
gi|159 LRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLL
610 620 630 640 650 660
>>gi|52545700|emb|CAH56266.1| hypothetical protein [Homo (958 aa)
initn: 2497 init1: 2472 opt: 2481 Z-score: 3004.7 bits: 566.3 E(): 1.2e-158
Smith-Waterman score: 2481; 86.247% identity (94.639% similar) in 429 aa overlap (23-451:161-588)
10 20 30 40 50
mKIAA1 SPLLVHLKTATVYLNIINKSFKKKWQVSCQKTTIHVSSRLNTVPRYLNLKIV
:: ... : .: ... . . .. . .
gi|525 TYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIE-EGI
140 150 160 170 180
60 70 80 90 100 110
mKIAA1 TYFSGEEYVKSLTANPELIDRLAYLSDEMNEIESGKIIFSEHLPLSKLQQGIKSGSYLQG
:. :::::::::::::::::: ::.: ::::::::::::::::::::::::::.::::
gi|525 PAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQG
190 200 210 220 230 240
120 130 140 150 160 170
mKIAA1 TFRASRENYLEATVWIHGDKEEEKEILIQGIKHLNRAVHEDIVAVELLPRSQWVAPSSVV
:::::::::::::::::::.::.:::..::.::::::::::::::::::.::::::::::
gi|525 TFRASRENYLEATVWIHGDSEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVV
250 260 270 280 290 300
180 190 200 210 220 230
mKIAA1 LDDEGQNEDDVEKDEERELLLKTAVSEKMLRPTGRVVGIIKRNWRPYCGMLSKSDIKESR
: ::::::.::::.:: : .::::::::::.:::::::::::::::::::::::::::::
gi|525 LHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESR
310 320 330 340 350 360
240 250 260 270 280 290
mKIAA1 RHLFTPADKRIPRIRIETRQASALEGRRIIVAIDGWPRNSRYPNGHFVKNLGDVGEKETE
::::::::::::::::::::::.:::::::::::::::::::::::::.:::::::::::
gi|525 RHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETE
370 380 390 400 410 420
300 310 320 330 340 350
mKIAA1 TEVLLLEHDVPHQPFSQAVLSFLPRMPWSITEEDMKNREDLRHLCVCSVDPPGCTDIDDA
::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::::::
gi|525 TEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDA
430 440 450 460 470 480
360 370 380 390 400 410
mKIAA1 LHCRELSNGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|525 LHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLC
490 500 510 520 530 540
420 430 440 450
mKIAA1 SLRSNVDRLAFSCIWEMNHNAEILKTRFTKSVINSKVSV
::. .:::::::::::::::::::::.:::::::::.:.
gi|525 SLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTS
550 560 570 580 590 600
gi|525 LRGLNKLAKILKKRRIEKGALTLSSSEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLL
610 620 630 640 650 660
>>gi|71296758|gb|AAH38101.1| DIS3 protein [Homo sapiens] (796 aa)
initn: 2485 init1: 2460 opt: 2468 Z-score: 2990.0 bits: 563.3 E(): 7.7e-158
Smith-Waterman score: 2468; 91.250% identity (97.250% similar) in 400 aa overlap (52-451:27-426)
30 40 50 60 70 80
mKIAA1 KKKWQVSCQKTTIHVSSRLNTVPRYLNLKIVTYFSGEEYVKSLTANPELIDRLAYLSDEM
. :. :::::::::::::::::: ::.:
gi|712 MSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEG
10 20 30 40 50
90 100 110 120 130 140
mKIAA1 NEIESGKIIFSEHLPLSKLQQGIKSGSYLQGTFRASRENYLEATVWIHGDKEEEKEILIQ
::::::::::::::::::::::::::.:::::::::::::::::::::::.::.:::..:
gi|712 NEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDSEENKEIILQ
60 70 80 90 100 110
150 160 170 180 190 200
mKIAA1 GIKHLNRAVHEDIVAVELLPRSQWVAPSSVVLDDEGQNEDDVEKDEERELLLKTAVSEKM
:.::::::::::::::::::.::::::::::: ::::::.::::.:: : .:::::::::
gi|712 GLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKM
120 130 140 150 160 170
210 220 230 240 250 260
mKIAA1 LRPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASALEGRRI
:.:::::: ::::::::::::::::::::::::::::::::::::::::::::.::::::
gi|712 LKPTGRVVVIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRI
180 190 200 210 220 230
270 280 290 300 310 320
mKIAA1 IVAIDGWPRNSRYPNGHFVKNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPRMPWS
:::::::::::::::::::.:::::::::::::::::::::::::::::::::::.::::
gi|712 IVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWS
240 250 260 270 280 290
330 340 350 360 370 380
mKIAA1 ITEEDMKNREDLRHLCVCSVDPPGCTDIDDALHCRELSNGNLEVGVHIADVSHFIRPGNA
:::.::::::::::::.:::::::::::::::::::: ::::::::::::::::::::::
gi|712 ITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNA
300 310 320 330 340 350
390 400 410 420 430 440
mKIAA1 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEMNHNAEILKTRFT
:::::::::::::::::::::::::::::::::. .:::::::::::::::::::::.::
gi|712 LDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFT
360 370 380 390 400 410
450
mKIAA1 KSVINSKVSV
:::::::.:.
gi|712 KSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVR
420 430 440 450 460 470
451 residues in 1 query sequences
2727779818 residues in 7921681 library sequences
Tcomplib [34.26] (2 proc)
start: Tue Mar 17 12:49:46 2009 done: Tue Mar 17 12:56:38 2009
Total Scan time: 927.330 Total Display time: 0.150
Function used was FASTA [version 34.26.5 April 26, 2007]