# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mph01533.fasta.nr -Q ../query/mKIAA1149.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 mKIAA1149, 373 aa vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library 2727779818 residues in 7921681 sequences statistics sampled from 60000 to 7919829 sequences Expectation_n fit: rho(ln(x))= 4.8496+/-0.000179; mu= 11.8604+/- 0.010 mean_var=66.5480+/-13.296, 0's: 31 Z-trim: 39 B-trim: 0 in 0/67 Lambda= 0.157220 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7921681) gi|26340362|dbj|BAC33844.1| unnamed protein produc ( 501) 2541 585.2 1e-164 gi|6685233|sp|P56819.1|BACE1_RAT RecName: Full=Bet ( 501) 2541 585.2 1e-164 gi|18268203|sp|P56818.2|BACE1_MOUSE RecName: Full= ( 501) 2541 585.2 1e-164 gi|26337869|dbj|BAC32620.1| unnamed protein produc ( 501) 2535 583.8 2.7e-164 gi|110278889|sp|Q2HJ40.1|BACE1_BOVIN RecName: Full ( 501) 2521 580.6 2.4e-163 gi|73955096|ref|XP_546508.2| PREDICTED: similar to ( 429) 2520 580.3 2.5e-163 gi|114640542|ref|XP_001158264.1| PREDICTED: beta-s ( 401) 2512 578.5 8.4e-163 gi|119587719|gb|EAW67315.1| beta-site APP-cleaving ( 401) 2512 578.5 8.4e-163 gi|109108794|ref|XP_001094263.1| PREDICTED: beta-s ( 501) 2513 578.8 8.5e-163 gi|114640540|ref|XP_508778.2| PREDICTED: beta-site ( 415) 2512 578.5 8.6e-163 gi|193786733|dbj|BAG52056.1| unnamed protein produ ( 427) 2512 578.5 8.8e-163 gi|6470293|gb|AAF13715.1|AF200193_1 memapsin 2 [Ho ( 488) 2512 578.6 9.8e-163 gi|6685248|sp|P56817.1|BACE1_HUMAN RecName: Full=B ( 501) 2512 578.6 1e-162 gi|23273579|gb|AAH36084.1| Beta-site APP-cleaving ( 501) 2512 578.6 1e-162 gi|167887469|gb|ACA05927.1| beta-secretase 1 precu ( 501) 2501 576.1 5.6e-162 gi|126326602|ref|XP_001370781.1| PREDICTED: simila ( 500) 2459 566.6 4.1e-159 gi|149606590|ref|XP_001509790.1| PREDICTED: simila ( 498) 2389 550.7 2.5e-154 gi|118101972|ref|XP_417908.2| PREDICTED: hypotheti ( 423) 2370 546.3 4.3e-153 gi|224083132|ref|XP_002189188.1| PREDICTED: beta-s ( 531) 2352 542.3 8.8e-152 gi|112419063|gb|AAI21913.1| Beta-site APP-cleaving ( 502) 2252 519.6 5.6e-145 gi|185177712|pdb|2ZHR|A Chain A, Crystal Structure ( 411) 2181 503.4 3.4e-140 gi|189339636|pdb|3CKP|A Chain A, Crystal Structure ( 412) 2181 503.4 3.4e-140 gi|195927261|pdb|2QU2|A Chain A, Bace1 With Compou ( 415) 2181 503.4 3.4e-140 gi|126030622|pdb|2HM1|A Chain A, Crystal Structure ( 406) 2176 502.3 7.4e-140 gi|88191839|pdb|1YM4|A Chain A, Crystal Structure ( 408) 2176 502.3 7.4e-140 gi|55670609|pdb|1W50|A Chain A, Apo Structure Of B ( 411) 2176 502.3 7.5e-140 gi|160286142|pdb|2VA5|A Chain A, X-Ray Crystal Str ( 455) 2176 502.3 8.1e-140 gi|126030615|pdb|2HIZ|A Chain A, Crystal Structure ( 455) 2176 502.3 8.1e-140 gi|169791850|pdb|3BRA|A Chain A, Bace-1 Complexed ( 409) 2174 501.9 1e-139 gi|222447065|pdb|3EXO|A Chain A, Crystal Structure ( 413) 2167 500.3 3.1e-139 gi|166235438|pdb|2VIE|A Chain A, Human Bace-1 In C ( 392) 2143 494.8 1.3e-137 gi|190016335|pdb|3CIB|A Chain A, Structure Of Bace ( 390) 2135 493.0 4.5e-137 gi|169791700|pdb|2QK5|A Chain A, Structure Of Bace ( 395) 2135 493.0 4.6e-137 gi|88191836|pdb|1YM2|A Chain A, Crystal Structure ( 402) 2135 493.0 4.6e-137 gi|88192961|pdb|2FDP|A Chain A, Crystal Structure ( 388) 2130 491.9 9.9e-137 gi|48425684|pdb|1SGZ|A Chain A, Crystal Structure ( 389) 2130 491.9 9.9e-137 gi|11514162|pdb|1FKN|A Chain A, Structure Of Beta- ( 391) 2130 491.9 1e-136 gi|145580015|pdb|2OF0|A Chain A, X-Ray Crystal Str ( 402) 2130 491.9 1e-136 gi|221046549|pdb|2ZJN|A Chain A, Crystal Structure ( 405) 2130 491.9 1e-136 gi|218681771|pdb|3DM6|A Chain A, Beta-Secretase 1 ( 406) 2130 491.9 1e-136 gi|221046544|pdb|2ZJK|A Chain A, Crystal Structure ( 405) 2124 490.5 2.6e-136 gi|221046542|pdb|2ZJI|A Chain A, Crystal Structure ( 405) 2124 490.5 2.6e-136 gi|221046541|pdb|2ZJH|A Chain A, Crystal Structure ( 405) 2124 490.5 2.6e-136 gi|109108798|ref|XP_001093918.1| PREDICTED: beta-s ( 457) 2119 489.4 6.3e-136 gi|41944860|gb|AAH65973.1| Zgc:77409 [Danio rerio] ( 505) 2119 489.5 6.8e-136 gi|13699248|gb|AAK38375.1|AF338817_1 beta-site APP ( 457) 2118 489.2 7.4e-136 gi|56966092|pdb|1TQF|A Chain A, Crystal Structure ( 405) 2116 488.7 9.3e-136 gi|185177596|pdb|2QZL|A Chain A, Crystal Structure ( 411) 2116 488.7 9.4e-136 gi|221046543|pdb|2ZJJ|A Chain A, Crystal Structure ( 405) 2110 487.3 2.4e-135 gi|157835827|pdb|2Q15|A Chain A, Structure Of Bace ( 385) 2102 485.5 8e-135 >>gi|26340362|dbj|BAC33844.1| unnamed protein product [M (501 aa) initn: 2541 init1: 2541 opt: 2541 Z-score: 3113.4 bits: 585.2 E(): 1e-164 Smith-Waterman score: 2541; 100.000% identity (100.000% similar) in 373 aa overlap (1-373:129-501) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|263 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 100 110 120 130 140 150 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA 160 170 180 190 200 210 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 220 230 240 250 260 270 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 280 290 300 310 320 330 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI 340 350 360 370 380 390 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI 400 410 420 430 440 450 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK ::::::::::::::::::::::::::::::::::::::::::: gi|263 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|6685233|sp|P56819.1|BACE1_RAT RecName: Full=Beta-se (501 aa) initn: 2541 init1: 2541 opt: 2541 Z-score: 3113.4 bits: 585.2 E(): 1e-164 Smith-Waterman score: 2541; 100.000% identity (100.000% similar) in 373 aa overlap (1-373:129-501) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|668 FAVGAAPHPFLHRYYQRQLSSTYRDLRKSVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 100 110 120 130 140 150 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA 160 170 180 190 200 210 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 220 230 240 250 260 270 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 280 290 300 310 320 330 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI 340 350 360 370 380 390 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|668 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI 400 410 420 430 440 450 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK ::::::::::::::::::::::::::::::::::::::::::: gi|668 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|18268203|sp|P56818.2|BACE1_MOUSE RecName: Full=Beta (501 aa) initn: 2541 init1: 2541 opt: 2541 Z-score: 3113.4 bits: 585.2 E(): 1e-164 Smith-Waterman score: 2541; 100.000% identity (100.000% similar) in 373 aa overlap (1-373:129-501) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|182 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 100 110 120 130 140 150 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA 160 170 180 190 200 210 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 220 230 240 250 260 270 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 280 290 300 310 320 330 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI 340 350 360 370 380 390 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI 400 410 420 430 440 450 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK ::::::::::::::::::::::::::::::::::::::::::: gi|182 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|26337869|dbj|BAC32620.1| unnamed protein product [M (501 aa) initn: 2535 init1: 2535 opt: 2535 Z-score: 3106.0 bits: 583.8 E(): 2.7e-164 Smith-Waterman score: 2535; 99.732% identity (99.732% similar) in 373 aa overlap (1-373:129-501) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|263 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 100 110 120 130 140 150 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA 160 170 180 190 200 210 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: gi|263 GFPLNQTEALASVGGSMIIGGIDHSLYTGRLWYTPIRREWYYEVIIVRVEINGQDLKMDC 220 230 240 250 260 270 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 280 290 300 310 320 330 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI 340 350 360 370 380 390 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|263 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI 400 410 420 430 440 450 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK ::::::::::::::::::::::::::::::::::::::::::: gi|263 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|110278889|sp|Q2HJ40.1|BACE1_BOVIN RecName: Full=Bet (501 aa) initn: 2521 init1: 2521 opt: 2521 Z-score: 3088.8 bits: 580.6 E(): 2.4e-163 Smith-Waterman score: 2521; 98.391% identity (99.464% similar) in 373 aa overlap (1-373:129-501) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|110 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 100 110 120 130 140 150 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA ::::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::: gi|110 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA 160 170 180 190 200 210 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC ::::::.:::::::::::::::::::: :::::::::::::::::::::::::::::::: gi|110 GFPLNQSEALASVGGSMIIGGIDHSLYMGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 220 230 240 250 260 270 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|110 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 280 290 300 310 320 330 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|110 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVI 340 350 360 370 380 390 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: gi|110 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTI 400 410 420 430 440 450 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK ::::::::::::::::::::::::::::::::::::::::::: gi|110 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 460 470 480 490 500 >>gi|73955096|ref|XP_546508.2| PREDICTED: similar to Bet (429 aa) initn: 2520 init1: 2520 opt: 2520 Z-score: 3088.5 bits: 580.3 E(): 2.5e-163 Smith-Waterman score: 2520; 98.123% identity (99.732% similar) in 373 aa overlap (1-373:57-429) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|739 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 30 40 50 60 70 80 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA ::::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::: gi|739 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA 90 100 110 120 130 140 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC ::::::.:.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 150 160 170 180 190 200 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 210 220 230 240 250 260 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|739 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVI 270 280 290 300 310 320 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI :::::::::::::::::::::::::::::::::::::.: :::::::::::::::::::: gi|739 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFITLDMEDCGYNIPQTDESTLMTI 330 340 350 360 370 380 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK ::::::::::::::::::::::::::::::::::::::::::: gi|739 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK 390 400 410 420 >>gi|114640542|ref|XP_001158264.1| PREDICTED: beta-site (401 aa) initn: 2512 init1: 2512 opt: 2512 Z-score: 3079.1 bits: 578.5 E(): 8.4e-163 Smith-Waterman score: 2512; 98.123% identity (99.732% similar) in 373 aa overlap (1-373:29-401) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANI :::::::::::::::::::::::::::::::: gi|114 MVPFIYLQGHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI 10 20 30 40 50 60 40 50 60 70 80 90 mKIAA1 AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGF ::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::::: gi|114 AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGF 70 80 90 100 110 120 100 110 120 130 140 150 mKIAA1 PLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKE ::::.:.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKE 130 140 150 160 170 180 160 170 180 190 200 210 mKIAA1 YNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNI 190 200 210 220 230 240 220 230 240 250 260 270 mKIAA1 FPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIME ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|114 FPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIME 250 260 270 280 290 300 280 290 300 310 320 330 mKIAA1 GFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAY ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: gi|114 GFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAY 310 320 330 340 350 360 340 350 360 370 mKIAA1 VMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK :::::::::::::::::::::::::::.::::::::::::: gi|114 VMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 370 380 390 400 >>gi|119587719|gb|EAW67315.1| beta-site APP-cleaving enz (401 aa) initn: 2512 init1: 2512 opt: 2512 Z-score: 3079.1 bits: 578.5 E(): 8.4e-163 Smith-Waterman score: 2512; 98.123% identity (99.732% similar) in 373 aa overlap (1-373:29-401) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANI :::::::::::::::::::::::::::::::: gi|119 MVPFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANI 10 20 30 40 50 60 40 50 60 70 80 90 mKIAA1 AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGF ::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::::: gi|119 AAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGF 70 80 90 100 110 120 100 110 120 130 140 150 mKIAA1 PLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKE ::::.:.::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKE 130 140 150 160 170 180 160 170 180 190 200 210 mKIAA1 YNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNI 190 200 210 220 230 240 220 230 240 250 260 270 mKIAA1 FPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIME ::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::: gi|119 FPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIME 250 260 270 280 290 300 280 290 300 310 320 330 mKIAA1 GFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAY ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: gi|119 GFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAY 310 320 330 340 350 360 340 350 360 370 mKIAA1 VMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK :::::::::::::::::::::::::::.::::::::::::: gi|119 VMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 370 380 390 400 >>gi|109108794|ref|XP_001094263.1| PREDICTED: beta-site (501 aa) initn: 2513 init1: 2513 opt: 2513 Z-score: 3079.0 bits: 578.8 E(): 8.5e-163 Smith-Waterman score: 2513; 98.123% identity (99.732% similar) in 373 aa overlap (1-373:129-501) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|109 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 100 110 120 130 140 150 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA ::::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::: gi|109 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA 160 170 180 190 200 210 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC ::::::.:.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 220 230 240 250 260 270 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 280 290 300 310 320 330 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|109 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVI 340 350 360 370 380 390 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: gi|109 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTPDMEDCGYNIPQTDESTLMTI 400 410 420 430 440 450 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK :::::::::::::::::::::::::::::.::::::::::::: gi|109 AYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 460 470 480 490 500 >>gi|114640540|ref|XP_508778.2| PREDICTED: beta-site APP (415 aa) initn: 2512 init1: 2512 opt: 2512 Z-score: 3078.9 bits: 578.5 E(): 8.6e-163 Smith-Waterman score: 2512; 98.123% identity (99.732% similar) in 373 aa overlap (1-373:43-415) 10 20 30 mKIAA1 YVPYTQGKWEGELGTDLVSIPHGPNVTVRA :::::::::::::::::::::::::::::: gi|114 FAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRA 20 30 40 50 60 70 40 50 60 70 80 90 mKIAA1 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGA ::::::::::::::::::::::::::::::::::::::::::::::::.::.:::::::: gi|114 NIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGA 80 90 100 110 120 130 100 110 120 130 140 150 mKIAA1 GFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC ::::::.:.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDC 140 150 160 170 180 190 160 170 180 190 200 210 mKIAA1 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 KEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPW 200 210 220 230 240 250 220 230 240 250 260 270 mKIAA1 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVI ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|114 NIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVI 260 270 280 290 300 310 280 290 300 310 320 330 mKIAA1 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTI ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: gi|114 MEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTI 320 330 340 350 360 370 340 350 360 370 mKIAA1 AYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK :::::::::::::::::::::::::::::.::::::::::::: gi|114 AYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 380 390 400 410 373 residues in 1 query sequences 2727779818 residues in 7921681 library sequences Tcomplib [34.26] (2 proc) start: Thu Mar 12 22:56:26 2009 done: Thu Mar 12 23:02:36 2009 Total Scan time: 845.920 Total Display time: 0.100 Function used was FASTA [version 34.26.5 April 26, 2007]