FASTA searches a protein or DNA sequence data bank
version 3.4t11 Apr 17, 2002
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
../query/mKIAA1090.ptfa, 857 aa
vs ./tmplib.26680 library
1768160 residues in 2168 sequences
Expectation_n fit: rho(ln(x))= 5.5279+/-0.00609; mu= 15.9265+/- 0.407
mean_var=175.0082+/-39.972, 0's: 0 Z-trim: 16 B-trim: 8 in 1/35
Lambda= 0.0969
FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 38, opt: 26, open/ext: -10/-2, width: 16
The best scores are: opt bits E(2168)
mKIAA1420 ( 907 res) mfj05028 ( 907) 662 106 2.9e-23
mKIAA0388 ( 758 res) mbh00510 ( 758) 353 62 2.7e-10
mKIAA4065 ( 779 res) mpj03374 ( 779) 338 60 1.2e-09
mKIAA1076 ( 855 res) mbh01320 ( 855) 307 56 2.5e-08
mKIAA1876 ( 348 res) mpj00624 ( 348) 301 54 2.8e-08
mKIAA1506 ( 1520 res) mbg19167 (1520) 276 52 6.9e-07
mKIAA0339 ( 822 res) mph02448 ( 822) 271 51 8.1e-07
mKIAA0304 ( 1744 res) mbg06324 (1744) 275 52 8.2e-07
mKIAA4075 ( 1945 res) mbg09037 (1945) 211 43 0.00043
mKIAA1113 ( 1071 res) mpm06042 (1071) 206 42 0.00051
mKIAA1125 ( 1253 res) mbg01394 (1253) 183 39 0.0051
>>mKIAA1420 ( 907 res) mfj05028 (907 aa)
initn: 414 init1: 368 opt: 662 Z-score: 509.9 bits: 105.5 E(): 2.9e-23
Smith-Waterman score: 662; 39.382% identity (41.129% ungapped) in 259 aa overlap (478-731:6-258)
450 460 470 480 490 500
mKIAA1 RVFKNALQEAEARFNEVKLQREARETQESERKP--PPYKHIKVNKPYGKVQIYTADISEI
.:: : ::.:. : : :. .. :
mKIAA1 HNQLYKKPDVPLYKKIRSNV-YVDVKPLSG--YEA
10 20 30
510 520 530 540 550 560
mKIAA1 PKCNCK-PTDENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPET-KIIKTD
:::: : :.. : ..:::::.. :: :..:: :: : :: . .... . . ....
mKIAA1 TTCNCKKPDDDTRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAE
40 50 60 70 80 90
570 580 590 600 610 620
mKIAA1 GKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAG
::::. .:. .. :.:. ::.::...:.: :. ..: : : :..:. .::.
mKIAA1 EKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH-YCLNLDSGMVIDSY
100 110 120 130 140 150
630 640 650 660 670 680
mKIAA1 PKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKT-V
:: .::.::::.:::: ::.::: :.::.:. :.:::::::..::. .. :: .
mKIAA1 RMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQL
160 170 180 190 200 210
690 700 710 720 730 740
mKIAA1 CRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQ
:.:: .: :..: . . .: :. ::..... :.:. :... ::.:.
mKIAA1 CKCGFEKCRGIIGGKSQRMNGLPSH-KGSQSSS-THRKSARAKEKRKSKHKLKKRKGHPS
220 230 240 250 260
750 760 770 780 790 800
mKIAA1 LVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDG
mKIAA1 EEPSENINTPTRLTPQLQMKPMSNRERNFVLKHHVFLVRNWEKIHQKQEEVKHTRDIHSA
270 280 290 300 310 320
>>mKIAA0388 ( 758 res) mbh00510 (758 aa)
initn: 335 init1: 171 opt: 353 Z-score: 277.1 bits: 62.2 E(): 2.7e-10
Smith-Waterman score: 360; 31.818% identity (36.493% ungapped) in 242 aa overlap (451-671:507-738)
430 440 450 460 470 480
mKIAA1 YWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKP
:. : :. : ...:... :: . .:
mKIAA0 KQVFQFAVKESLILKLPTDELMNPAQKKKRKHRLWAAHCR--KIQLKKDNNSTQVYNYQP
480 490 500 510 520 530
490 500 510 520 530
mKIAA1 --PPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDEN--P-CGSDSECLNR-----MLM
: . . : :.: .. : :.:.: .: : : ..: .. . .
mKIAA0 CDHPDRPCDSTCPC----IMTQNFCE-KFCQCSPDCQNRFPGCRCKTQCNTKQCPCYLAV
540 550 560 570 580
540 550 560 570
mKIAA1 FECHPQV---CPAGEY-------CQNQCFTKRQYPETKIIK-TDGKGWGLVAKRDIRKGE
:: :.. : :.:. :.: : .: . .. .: ::: :....:.:
mKIAA0 RECDPDLCLTCGASEHWDCKVVSCKN-CSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNE
590 600 610 620 630 640
580 590 600 610 620 630
mKIAA1 FVNEYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPN
:..:: ::::...: : : .... .. : ......: ..:: ::: :: ::: .::
mKIAA0 FISEYCGELISQDEADRRGK-VYDKYMSSF-LFNLNNDFVVDATRKGNKIRFANHSVNPN
650 660 670 680 690 700
640 650 660 670 680 690
mKIAA1 CETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPK
: . :::: :.:.:: : :: :: :.:
mKIAA0 CYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVF
710 720 730 740 750
700 710 720 730 740 750
mKIAA1 TSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSC
>>mKIAA4065 ( 779 res) mpj03374 (779 aa)
initn: 390 init1: 168 opt: 338 Z-score: 265.6 bits: 60.1 E(): 1.2e-09
Smith-Waterman score: 338; 32.402% identity (35.802% ungapped) in 179 aa overlap (503-671:588-759)
480 490 500 510 520 530
mKIAA1 TQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFE
...: : :: :.. ..: . . :
mKIAA4 HPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQ----CNT-KQCPCYLAVRE
560 570 580 590 600 610
540 550 560 570 580
mKIAA1 CHPQVC---PAGEY-------CQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVN
: :..: :... :.: . . . . . .: :::. : ..:.::..
mKIAA4 CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFIS
620 630 640 650 660 670
590 600 610 620 630 640
mKIAA1 EYVGELIDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCET
:: ::.:...: : : .... . : ......: ..:: ::: :: ::: .::: .
mKIAA4 EYCGEIISQDEADRRGK-VYDKYMCSF-LFNLNNDFVVDATRKGNKIRFANHSVNPNCYA
680 690 700 710 720 730
650 660 670 680 690 700
mKIAA1 LKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSA
:::: :.:.:: : .: :: :.:
mKIAA4 KVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
740 750 760 770
>>mKIAA1076 ( 855 res) mbh01320 (855 aa)
initn: 291 init1: 214 opt: 307 Z-score: 241.8 bits: 55.8 E(): 2.5e-08
Smith-Waterman score: 307; 32.432% identity (33.520% ungapped) in 185 aa overlap (511-694:675-854)
490 500 510 520 530 540
mKIAA1 PPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFECHPQVCPA
.: . ::. . .: :. : .
mKIAA1 DKKDKLRYLNSSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLL-SSFTGSCDS
650 660 670 680 690 700
550 560 570 580 590
mKIAA1 GEYCQNQC-FTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIK
:: : :.. :. :. . ::: : . : :.: ::::. : . : :
mKIAA1 DLLKFNQLKFRKKKL---KFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREK
710 720 730 740 750 760
600 610 620 630 640 650
mKIAA1 YAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVC
... : ::. .:.: :::: ::..::.::::.::: . ::... .. ...
mKIAA1 RYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQ
770 780 790 800 810 820
660 670 680 690 700 710
mKIAA1 DIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKKTRR
: .. :.:..:.. . . : : ::. :: : :.
mKIAA1 HINVNEEITYDYKFP-IEDVKIPCLCGSENCRGTLN
830 840 850
720 730 740 750 760 770
mKIAA1 RRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHHCDV
>>mKIAA1876 ( 348 res) mpj00624 (348 aa)
initn: 238 init1: 113 opt: 301 Z-score: 241.0 bits: 54.4 E(): 2.8e-08
Smith-Waterman score: 311; 30.566% identity (35.683% ungapped) in 265 aa overlap (475-710:70-325)
450 460 470 480 490 500
mKIAA1 GIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISE
.:: : ::... : . ..: .:..
mKIAA1 PDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNI-DRNITH
40 50 60 70 80 90
510 520 530 540
mKIAA1 IPKCNCK---PTDENPCGSDS-ECL----NRML----------MFECHPQVCPAGEYCQN
. : : .. ::. : .: .:.: .:::. ..: . :.:
mKIAA1 LQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECN-HACSCWRNCRN
100 110 120 130 140 150
550 560 570 580 590 600
mKIAA1 QCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKYAHENDI
. . . .. .:. :::. . .:: : :: :::::::.. : .: :.:
mKIAA1 RVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVR-----EEDS
160 170 180 190 200 210
610 620 630 640 650 660
mKIAA1 THFYMLTIDKD-RIIDAGPKGNYSRFMNHSCQPNCETLK-WTVNGD---TRVGLFAVCDI
: . . : . ::: :: :::.:: :.:: .. . . : :...:.. :
mKIAA1 YLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLI
220 230 240 250 260 270
670 680 690 700 710
mKIAA1 PAGTELTFNYN---LDCLGNEKTVCRCGASNC---SGFLGDRPKTSASLSSEEKGKKAKK
:: .: :.:. : :. . ::::.:.: :. :..: ..::. .:.:
mKIAA1 QAGEQLGFDYGERFWDVKGKLFS-CRCGSSKCRHSSAALAQR-QASAAQEPQENGLPDTS
280 290 300 310 320 330
720 730 740 750 760 770
mKIAA1 KTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWH
mKIAA1 SAAAADPPLILMKCGFAF
340
>>mKIAA1506 ( 1520 res) mbg19167 (1520 aa)
initn: 288 init1: 154 opt: 276 Z-score: 216.0 bits: 51.9 E(): 6.9e-07
Smith-Waterman score: 276; 34.351% identity (34.884% ungapped) in 131 aa overlap (565-694:1390-1519)
540 550 560 570 580 590
mKIAA1 PQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEEC
.: :: : :::.: .: ::.: .: ..:
mKIAA1 SKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTII-RNEV
1360 1370 1380 1390 1400 1410
600 610 620 630 640 650
mKIAA1 MARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVG
: . .:.. ::. .:.:..::: :. .:..:::: ::: . : . ..
mKIAA1 ANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKII
1420 1430 1440 1450 1460 1470
660 670 680 690 700 710
mKIAA1 LFAVCDIPAGTELTFNYNLDCLGNEKTV-CRCGASNCSGFLGDRPKTSASLSSEEKGKKA
. . : : :: ..:..: ... . :.::: :: ...
mKIAA1 ISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN
1480 1490 1500 1510 1520
720 730 740 750 760 770
mKIAA1 KKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECP
>>mKIAA0339 ( 822 res) mph02448 (822 aa)
initn: 249 init1: 196 opt: 271 Z-score: 214.8 bits: 50.7 E(): 8.1e-07
Smith-Waterman score: 271; 35.156% identity (35.433% ungapped) in 128 aa overlap (567-694:695-821)
540 550 560 570 580 590
mKIAA1 VCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMA
::: : . : :.: ::::. : .
mKIAA0 SAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADM
670 680 690 700 710 720
600 610 620 630 640 650
mKIAA1 RIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLF
: : .. : :.. .:.: :::: :: .::.:: : ::: . :.... .. ..
mKIAA0 REKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIY
730 740 750 760 770 780
660 670 680 690 700 710
mKIAA1 AVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSASLSSEEKGKKAKKK
. : . :.:..:.. : ..: : ::. .: : :.
mKIAA0 SKQPIGVDEEITYDYKFP-LEDNKIPCLCGTESCRGSLN
790 800 810 820
720 730 740 750 760 770
mKIAA1 TRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWECPWHH
>>mKIAA0304 ( 1744 res) mbg06324 (1744 aa)
initn: 377 init1: 178 opt: 275 Z-score: 214.6 bits: 51.8 E(): 8.2e-07
Smith-Waterman score: 275; 36.496% identity (37.037% ungapped) in 137 aa overlap (559-694:1608-1743)
530 540 550 560 570 580
mKIAA1 LMFECHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGEL
. .. .: :: ::.: ::.: :: : .
mKIAA0 LRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIV
1580 1590 1600 1610 1620 1630
590 600 610 620 630 640
mKIAA1 IDEEECMARIKYAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVN
: : :. . : ::. .: ..:: .:: .::.::::.::: . :.
mKIAA0 IRSVLTDKREKFYDGKGIG-CYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVE
1640 1650 1660 1670 1680 1690
650 660 670 680 690 700
mKIAA1 GDTRVGLFAVCDIPAGTELTFNYNLDCL-GNEKTVCRCGASNCSGFLGDRPKTSASLSSE
:. .. .::. : : :::..:.. ...: : :::. : ::.
mKIAA0 GQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN
1700 1710 1720 1730 1740
710 720 730 740 750 760
mKIAA1 EKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPF
>>mKIAA4075 ( 1945 res) mbg09037 (1945 aa)
initn: 242 init1: 153 opt: 211 Z-score: 165.8 bits: 42.9 E(): 0.00043
Smith-Waterman score: 215; 23.219% identity (33.333% ungapped) in 379 aa overlap (60-415:279-565)
30 40 50 60 70 80
mKIAA1 VDVEDAPRKRLRADKHSLRKQRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPL
: .. : .. .. .. .. . :: ::
mKIAA4 AAAAAAVAVVESMVTATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPRVPDAKKP-
250 260 270 280 290 300
90 100 110 120 130 140
mKIAA1 KKRNRASATASSALGFNKSSSPSASLTEHEVSDSPGDEPSESPYESADETQTEASVSSKK
: .... . ::... . :.: . .: :. : . : .: . ...: : ::
mKIAA4 -KPKKVAPLKIKLGGFGSKRKRSSSEDDDLDVESDFDDASINSYSVSDGSTSRSSRSRKK
310 320 330 340 350 360
150 160 170 180 190
mKIAA1 SERGMAAKK--EYV-------------CQLCEKTGSLLLCEGPCCGAFHLACLG--LSRR
. . :: : : :..:.. : ..::. : :.:..:: . .
mKIAA4 LRTAKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCD-TCPRAYHMVCLDPDMEKA
370 380 390 400 410 420
200 210 220 230 240 250
mKIAA1 PEGRFTCTECAS-GIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRC
:::...: .: . ::. :.: . :. :.
mKIAA4 PEGKWSCPHCEKEGIQ-----WEAKED------NSEGE----------------------
430 440 450
260 270 280 290 300 310
mKIAA1 PLHSCMSCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTA
.... : :::
mKIAA4 ---------------------EILEEV-------GGDP----------------------
460
320 330 340 350 360
mKIAA1 RKGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDCLNI---EMPDGSWFCNDCRA-G
.. :: . .: ::. :: ::::..::...: ::: :.:.: :.: : .
mKIAA4 EEEDDHH----MEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPA
470 480 490 500 510
370 380 390 400 410 420
mKIAA1 KKLHFQDI-IWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQA
: . : : :: : :. :. : .: .. :: . : :. ::
mKIAA4 LKGKVQKILIW-KWGQPPS-PTPVPRPPDADPNTPSPKPLEGRPERQFFVKWQGMSYWHC
520 530 540 550 560 570
430 440 450 460 470 480
mKIAA1 RVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEVKLQREARETQESERKPPPYKHI
mKIAA4 SWVSELQLELHCQVMFRNYQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRY
580 590 600 610 620 630
>>mKIAA1113 ( 1071 res) mpm06042 (1071 aa)
initn: 209 init1: 152 opt: 206 Z-score: 164.5 bits: 41.8 E(): 0.00051
Smith-Waterman score: 206; 37.778% identity (41.975% ungapped) in 90 aa overlap (288-368:808-897)
260 270 280 290 300 310
mKIAA1 SCHASNPSNPRPSKGKMMRCVRCPVAYHGGDACLAAGCS--VIASNSIICTGHFTAR---
..: .: : : ... : : .::
mKIAA1 PLSTNLHLESELDTLTGLENHVKTEPTDISESCKQSGLSNLVNGKSPIRNLMHRSARIGG
780 790 800 810 820 830
320 330 340 350 360
mKIAA1 KGKRHHTHVNVSWCFVCSKGGSLLCCEACPAAFHPDC---LNIEMPDGSWFCNDCR-AGK
:. . : .:: ::..::.::::: :: .:: : . .:.:.:.:. :: ::
mKIAA1 DGNSKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGK
840 850 860 870 880 890
370 380 390 400 410 420
mKIAA1 KLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARV
mKIAA1 PEVEYDCDNMQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPVSIPNYYKI
900 910 920 930 940 950
857 residues in 1 query sequences
1768160 residues in 2168 library sequences
Scomplib [34t11]
start: Mon Mar 27 10:35:51 2006 done: Mon Mar 27 10:35:52 2006
Scan time: 0.900 Display time: 0.300
Function used was FASTA [version 3.4t11 Apr 17, 2002]