FASTA searches a protein or DNA sequence data bank
version 3.4t11 Apr 17, 2002
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
../query/mKIAA4179.ptfa, 500 aa
vs ./tmplib.26680 library
1768517 residues in 2168 sequences
Expectation_n fit: rho(ln(x))= 5.9341+/-0.00686; mu= 11.9197+/- 0.456
mean_var=235.4106+/-56.352, 0's: 0 Z-trim: 8 B-trim: 25 in 1/35
Lambda= 0.0836
FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 37, opt: 25, open/ext: -10/-2, width: 16
The best scores are: opt bits E(2168)
mFLJ00123 ( 490 res) msj07117 ( 490) 822 112 1e-25
mKIAA1098 ( 193 res) mpk01986 ( 193) 334 52 3.4e-08
mKIAA0898 ( 1006 res) mbg05750 (1006) 240 42 0.0002
mKIAA0129 ( 453 res) msh25292 ( 453) 199 37 0.0041
>>mFLJ00123 ( 490 res) msj07117 (490 aa)
initn: 956 init1: 440 opt: 822 Z-score: 554.0 bits: 112.0 E(): 1e-25
Smith-Waterman score: 940; 36.203% identity (39.423% ungapped) in 453 aa overlap (74-490:39-490)
50 60 70 80 90 100
mKIAA4 CLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIA
: : :: :::. ::.::: ::..::..
mFLJ00 DEDEEEEVLEEDEEEELDPITQLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVI
10 20 30 40 50 60
110 120 130 140 150 160
mKIAA4 KQLQ-TVKR--KIRDESLCSQHHEPLSLFCYEDQEAVCLICAISHTHRPHTVVPMDDATQ
.:.. : : .. ....: .:.: :.::: :.::.:..: :..:. :.:::.....:
mFLJ00 RQMHPTPGRGSRVNEQGICPRHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQ
70 80 90 100 110 120
170 180 190 200 210 220
mKIAA4 EYKEKLQKCLEPLEQKLQEITCCKASEEKKPGELKRLVESRRQQILKEFEELHRRLDEEQ
::: ::: .:::...:. . ::.::.. ::: ..:. . .:: .: : : :::
mFLJ00 EYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQ
130 140 150 160 170 180
230 240 250 260 270 280
mKIAA4 QTLLSRLEEEEQDILQRLRENAAHLGDRRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEK
: ::.: .. : : : .: .. .:..: ::.. . :.:...:.:.: :...
mFLJ00 AGLERRLREMHEAQLGRAGAAANRLEEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNR
190 200 210 220 230 240
290 300 310 320 330
mKIAA4 CEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI----ADVTLDPETAHPNLVLSE
::... . : . . :. .::. ... .:.::::.:::: :.::
mFLJ00 CEEIQLQPPEIWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALLLSP
250 260 270 280 290 300
340 350 360 370 380 390
mKIAA4 DRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSV
::..:...: : ...:. .::. :::...:: ::::::::::: . ::::. :.:.
mFLJ00 DRRGVRLAERR-QEVPEHSKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAAREST
310 320 330 340 350 360
400 410 420
mKIAA4 SRK------------GELTP-----------LPETGYWRVRLW----NGDKY-AATTTPF
.: :. . ::. . ..: .: .: : ..:
mFLJ00 HHKEKVGSGGSSVSSGDASSSRHHHRRRRLHLPQQLLLQREVWCVGTHGKRYQAQSSTEQ
370 380 390 400 410 420
430 440 450 460 470 480
mKIAA4 TPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFT-EKLWPLFYPGIRAGRKN
: : ::.: :..:::::: :.:::. .:..::. .: :...:.: .. : .
mFLJ00 TLLSPCEKPRRFGVYLDYEAGRLGFYNADTLAHVHTFSAAFLGERVFPFFRVLSKGTRIK
430 440 450 460 470 480
490 500
mKIAA4 AAPLTIRPPTDWE
:
mFLJ00 LCP
490
>>mKIAA1098 ( 193 res) mpk01986 (193 aa)
initn: 263 init1: 133 opt: 334 Z-score: 239.6 bits: 52.5 E(): 3.4e-08
Smith-Waterman score: 334; 31.410% identity (32.667% ungapped) in 156 aa overlap (11-163:4-156)
10 20 30 40 50 60
mKIAA4 ARHSGTRSREVIMAETSLLEAGTSAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNF
:. : . .: : :.. . .... : :.:: . ... : ..:::::
mKIAA1 TPVVVTAAAPAMEPGPSVSPGPS--RSFKEELLCAVCYDPFRDAVTLRCGHNF
10 20 30 40 50
70 80 90 100 110
mKIAA4 CKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVE-IAKQLQTVKRKI--RDES
:. :.. :: .. ::::.. . :: :. :...:: . .. : :.
mKIAA1 CRRCVSGCWE-VQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEAEGARWTGRRSPR
60 70 80 90 100 110
120 130 140 150 160 170
mKIAA4 LCSQHHEPLSLFCYEDQEAVCLICAISHTHRPHTVVPMDDATQEYKEKLQKCLEPLEQKL
: :. ::.::: ::.: .: : . :. : : :. :..:...
mKIAA1 PCRAHRAPLTLFCLEDKELLCCACQADARHQEHRVQPIKDTAQDFRVSTAPARPGDPRPA
120 130 140 150 160 170
180 190 200 210 220 230
mKIAA4 QEITCCKASEEKKPGELKRLVESRRQQILKEFEELHRRLDEEQQTLLSRLEEEEQDILQR
mKIAA1 PPPPPGLATILPPVQANLNNDGE
180 190
>>mKIAA0898 ( 1006 res) mbg05750 (1006 aa)
initn: 125 init1: 87 opt: 240 Z-score: 171.9 bits: 42.3 E(): 0.0002
Smith-Waterman score: 242; 24.561% identity (27.317% ungapped) in 228 aa overlap (56-266:82-303)
30 40 50 60 70 80
mKIAA4 ASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTS
:.. : .:: :: :. :: ::
mKIAA0 QWMSRVWRALLRFSDVSFVWRNCGMLDCPHCSKLCCFSCIRRWLT--EQRAQCPHCRAPL
60 70 80 90 100
90 100 110 120 130
mKIAA4 RYRSLRPNRQLGSMVEIAKQLQTV------KRKIRDESLCSQHHEPLSLFCYEDQEAVCL
. : : : :...::.:. :.. ... : .::: ::.::. .. .:
mKIAA0 QLRELVNCRW---AEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICH
110 120 130 140 150 160
140 150 160 170 180 190
mKIAA4 ICAI-SHTHRPHTVVPMDDATQEYKEKLQKCLEPLEQKLQEITCCKASEEKKPGELKRLV
::. . : :: :. . ... :... . :...:.:. :.. ..
mKIAA0 QCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAK
170 180 190 200 210 220
200 210 220 230 240
mKIAA4 ESRRQQILKEFEELHRRLDEE----------QQTLLSRLEEEEQDILQRLRENAAHLGDR
. : ..: . : . ::: . :.: :.. : ...::.. :. ..: ..
mKIAA0 DERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEV-ESKSELISK
230 240 250 260 270 280
250 260 270 280 290 300
mKIAA4 RRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYF
.. . .:. : . :
mKIAA0 SSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPP
290 300 310 320 330 340
>>mKIAA0129 ( 453 res) msh25292 (453 aa)
initn: 359 init1: 166 opt: 199 Z-score: 148.3 bits: 36.8 E(): 0.0041
Smith-Waterman score: 422; 28.747% identity (33.051% ungapped) in 407 aa overlap (119-475:35-438)
90 100 110 120 130 140
mKIAA4 SLRPNRQLGSMVEIAKQLQTVKRKIRDESLCSQHHE-PLSLFCYEDQEAVCLICAISHTH
: .: : : ::: . . :: .: . .:
mKIAA0 HREQRLPLRMASETTEARAPFQPDGAYGWRCPEHSERPAELFCRRCGRCVCALCPVLGAH
10 20 30 40 50 60
150 160 170 180 190 200
mKIAA4 RPHTVVPMDDATQEYKEKLQKCLEPLEQKLQEITCCKASEEKKPGELKRLVESRRQQILK
: : : .. . . .. .: ::: : : .. . : : .:: ..: . . .
mKIAA0 RGHPVGLAEEEAVRVQKLIQDCLECLATKKRQHADNIAHLEDAGERLKVYADSSKAWLTQ
70 80 90 100 110 120
210 220 230 240 250 260
mKIAA4 EFEELHRRLDEEQQTLLSRLEEEEQDILQRLRENAAHLGDRRRDLAHLAAEVEG------
.: ::. ::::. . ... : :: ::.: : . . . ....: :
mKIAA0 KFTELRLLLDEEEVLAKKFIDKSTQLTLQVYREQAETCGKQIEVMDDFSTRVWGIGQEPN
130 140 150 160 170 180
270 280 290
mKIAA4 --KCLQS--------GFEM------------LKDVKSTL-EKCEKVKTMEVTSVSIELEK
. ::. : .: .. ::. . : : . . : .. .:..
mKIAA0 PVQLLQAYIATKTEMGQQMSPSELSHPVPLSFEPVKNFFKEFVEAIGNTLQTPMDTRLKE
190 200 210 220 230 240
300 310 320 330 340
mKIAA4 NF--------SNFPRQYFAL-----RKILKQLIADVTLDPETAHPNLVLSEDRKSVKF-V
:. :. : . : .. . ::::.: : : :: : .:. .
mKIAA0 NINCQLSNSSSTKPGALLKTSPSPERALFLKYARTPTLDPDTMHARLRLSPDGLTVRCSL
250 260 270 280 290 300
350 360 370 380 390 400
mKIAA4 ETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDK-THWAVGVCRDSVSRKGELT
:: : .: :: ::. .::..:::::::.: . . : ::. :. :.: .
mKIAA0 LGRLGPRP-AP-RFDALRQVLGRDGFAAGRHYWEVDVQEAGVGWWVGAAYPSLRRRGA-S
310 320 330 340 350 360
410 420 430 440 450
mKIAA4 PLPETG----YWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD-
. : : :. .. . .: . :. . :.:.:.::::::: :.::.:.
mKIAA0 AAARLGCNRESWCVKRYDLEYWAFHDGQRSRLRPRRDPHRLGVFLDYEAGILAFYDVAGG
370 380 390 400 410 420
460 470 480 490 500
mKIAA4 RSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
::..:: .: : :.:
mKIAA0 MSHLHTFHAAFQEPLYPALRLWEGPISIPRLP
430 440 450
500 residues in 1 query sequences
1768517 residues in 2168 library sequences
Scomplib [34t11]
start: Mon Mar 27 11:04:15 2006 done: Mon Mar 27 11:04:16 2006
Scan time: 0.700 Display time: 0.060
Function used was FASTA [version 3.4t11 Apr 17, 2002]