FASTA searches a protein or DNA sequence data bank version 3.4t11 Apr 17, 2002 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 ../query/mKIAA4220.ptfa, 516 aa vs ./tmplib.26680 library 1768501 residues in 2168 sequences Expectation_n fit: rho(ln(x))= 5.0717+/-0.00434; mu= 14.1482+/- 0.290 mean_var=94.2419+/-21.793, 0's: 0 Z-trim: 6 B-trim: 0 in 0/36 Lambda= 0.1321 FASTA (3.45 Mar 2002) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 37, opt: 25, open/ext: -10/-2, width: 16 The best scores are: opt bits E(2168) mKIAA4128 ( 1002 res) mbf00283 (1002) 752 154 5.8e-38 mKIAA0704 ( 824 res) mbg11653 ( 824) 418 90 7.4e-19 mKIAA0772 ( 324 res) mib22030 ( 324) 394 85 9.4e-18 mKIAA1534 ( 493 res) mph00515 ( 493) 300 67 3.1e-12 mKIAA1451 ( 429 res) mth01486 ( 429) 247 57 3.1e-09 >>mKIAA4128 ( 1002 res) mbf00283 (1002 aa) initn: 768 init1: 363 opt: 752 Z-score: 774.0 bits: 153.8 E(): 5.8e-38 Smith-Waterman score: 944; 37.736% identity (42.654% ungapped) in 477 aa overlap (51-505:546-989) 30 40 50 60 70 80 mKIAA4 AKQHNHLERAFRGATVLPANPPGSAGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPEN : .... .: .. .::::: :.. . mKIAA4 STICDHVVSVNIIPSPDEPGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASS 520 530 540 550 560 570 90 100 110 120 mKIAA4 LGHKRTG--SNISGASSDVSLD-----EQYKHQL---EET----KKEKRTRIPYK-PNYS .. . : :: .:...: : .. ..:. : : .. .:: .: :. : mKIAA4 SENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRTCLPAPCPDTS 580 590 600 610 620 630 130 140 150 160 170 180 mKIAA4 -LNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCY .:::.:..: :::.:::. :::..::::. ::.: :..:: ::::.:.. .. :.. mKIAA4 NINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVL 640 650 660 670 680 690 190 200 210 220 230 240 mKIAA4 VAAFTVSSYSTTVFRT-SKPFNPLLGETFELDRLEENGYRSICEQVSHHPPAAAHHAESK ::::.::.: .: ::. ::::::.::::.: : :..:.: . :::::::: .: : ::: mKIAA4 VAAFAVSGYCSTYFRAGSKPFNPVLGETYECIR-EDKGFRFFSEQVSHHPPISACHCESK 700 710 720 730 740 750 250 260 270 280 290 300 mKIAA4 NGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNIIVGKLWIDQ : ... :.:. .:: :: . :.:.::.. . . : .:.:.:::: .:::. :. ::.. mKIAA4 N-FVFWQDIRWKNKFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEH 760 770 780 790 800 810 310 320 330 340 350 360 mKIAA4 SGEIDIVNHKTGDK-CNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCF ::. . : :.. :.: :: .:.. .: .: : : : ::: :.: : : . : mKIAA4 YGEVTLRNTKSSVCICKLTFVKVNYWNSNVN-EVQGVVIDQEGKVVHRLFGKWHEGLYCG 820 830 840 850 860 870 370 380 390 400 410 mKIAA4 KVQAASGENGGDARQRGHEAEDSRVMLWKRNPLPKNAENMYYFSELALTLNAWE----GG . .:. .:. . :: : : .: :...:. :: . mKIAA4 VAPSAK-------------------CIWRPGSLPTNYELYYGFTRFAVELNELDPVLKDL 880 890 900 910 420 430 440 450 460 470 mKIAA4 TAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAAKATEDGTPHDPYKA :::.:.:::::..:.: . : :::::.:: :: :. : :.. : : mKIAA4 LPPTDARFRPDQRFLEEGNLEAAAAEKQRVEELQRSRRRYME-------ENNLEHIPK-- 920 930 940 950 960 480 490 500 510 mKIAA4 LWFERKKDPVTRELTHIYSGEYWECKEKQDWGSCPDIF .:.. : :: . . . ::: .. mKIAA4 -FFKKVIDANQRE-AWVSNDTYWELRKDPGFSKVDSPVLW 970 980 990 1000 >>mKIAA0704 ( 824 res) mbg11653 (824 aa) initn: 760 init1: 309 opt: 418 Z-score: 430.9 bits: 90.0 E(): 7.4e-19 Smith-Waterman score: 800; 35.903% identity (43.467% ungapped) in 454 aa overlap (13-431:415-824) 10 20 30 40 mKIAA4 KSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATVL--PAN : .: : . ...:.: . .: :: mKIAA0 ISVEREKLKQLMELDTSPSPSAQVVGLKHALSSALAQNTDLKERLRRIHAESLLLDPPAV 390 400 410 420 430 440 50 60 70 80 mKIAA4 P-PGSAGSGKDQCCSGKG---DMSDE------DDENEFFDAPEIITMPENLGHKRTG--S : ::. . ... :.. ..:.: :. .::::: :.. : . .. . : mKIAA0 PKPGDNLAEENSRDEGRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDS 450 460 470 480 490 500 90 100 110 120 130 mKIAA4 NISGASSDVSLDE-----QYKHQ-----LE---ETKKEKRTRIPYK-PNYS-LNLWSIMK .: :...:::. . ..: :: :.....:: .: :: : ..::::.. mKIAA0 YVSDISDNLSLDNLSNDLDNERQTLGPVLESSGEARSKRRTSLPAPGPNTSSVSLWSILR 510 520 530 540 550 560 140 150 160 170 180 190 mKIAA4 NCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSY : :::.:::. :::..::::. :::: :.::: ::::.:.. . ::.. :::::..:.: mKIAA0 NNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYVAAFAISAY 570 580 590 600 610 620 200 210 220 230 240 250 mKIAA4 STTVFRT-SKPFNPLLGETFELDRLEENGYRSICEQVSHHPPAAAHHAESKNGWTLRQEI ... ::. ::::::.::::.: : ...:.. . ::. : mKIAA0 ASSYFRAGSKPFNPVLGETYECIR-QDKGFQFFAEQMR---------------WK----- 630 640 650 660 260 270 280 290 300 310 mKIAA4 KITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVN- .:: :: . :.:.:: : . . : :. :.:::. .:::. :. ::.. ::::: : mKIAA0 ---NKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGEIDIKNL 670 680 690 700 710 720 320 330 340 350 360 370 mKIAA4 HKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQAASGEN . . .:...:. .:.: . :... : : : :::. :.: : :.. : mKIAA0 NDDSCHCKVNFIKAKYWSTN-AHEIEGTVFDRSGKAVHRLFGKWHESIYC---------- 730 740 750 760 380 390 400 410 420 mKIAA4 GGDARQRGHEAEDSRVMLWKRNPLPKNAENMYYFSELALTLNAWEGGT----APTDSRLR :: . : . .:. ::.::. :..: :...:: :: . . :::.:.: mKIAA0 GGAS---------SSTCVWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFR 770 780 790 800 810 820 430 440 450 460 470 480 mKIAA4 PDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAAKATEDGTPHDPYKALWFERKKDP :::: mKIAA0 PDQR >>mKIAA0772 ( 324 res) mib22030 (324 aa) initn: 580 init1: 244 opt: 394 Z-score: 411.1 bits: 85.0 E(): 9.4e-18 Smith-Waterman score: 632; 36.765% identity (43.403% ungapped) in 340 aa overlap (213-516:1-324) 190 200 210 220 230 240 mKIAA4 CYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSICEQVSHHPPAAAHHAES :: : :. :.: : :::::::: .: ..:. mKIAA0 ELIR-EDLGFRFISEQVSHHPPISAFYSEG 10 20 250 260 270 280 290 300 mKIAA4 KN-GWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNIIVGKLWI : . .. : :: :: . : ::: . . .. ::: . : :::.:.:.::: mKIAA0 LNQDFRFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWI 30 40 50 60 70 80 310 320 330 340 350 mKIAA4 DQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKM-- .: : ..::::.::::: :.: : . :.... : : : . : . : : . : : : . mKIAA0 EQYGIVEIVNHRTGDKCILHFKPCGLFGKELHR-VEGYIQDKNRKKLFIMYGKWTECLWG 90 100 110 120 130 140 360 370 380 390 mKIAA4 ------DCFKVQAASGENGGDARQR-GHEAEDSRV----------------------MLW . :: : :... :.. : : .: : .:: mKIAA0 IDPASYESFKKQEKRGDQARKAKMDDGPEKANSDVPGDVADDVPVAQETVQVIPGSKLLW 150 160 170 180 190 200 400 410 420 430 440 mKIAA4 KRNPLPKNAENMYYFSELALTLNAWEGGTA----PTDSRLRPDQRLMENGRWDEANAEKQ . : : :. .:: :. ....:: :.: ::: ::::: : :::: : :. ::. mKIAA0 RINSRPPNSAQMYNFTSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKE 210 220 230 240 250 260 450 460 470 480 490 500 mKIAA4 RLEEKQRLSRKKREAEAAKATEDGTPHDPYKALWFERKKDPVTRELTHIYSGEYWECKEK ::::::: .::.: : :. ... :: ..: : .:.:.:.: mKIAA0 RLEEKQREARKERAKEDAE----------WRTRWFSPGNNPYTGAPDWLYAGHYFE---- 270 280 290 300 310 510 mKIAA4 QDWGSCPDIF .....::::. mKIAA0 RNFSDCPDIY 320 >>mKIAA1534 ( 493 res) mph00515 (493 aa) initn: 346 init1: 143 opt: 300 Z-score: 312.1 bits: 67.3 E(): 3.1e-12 Smith-Waterman score: 300; 28.870% identity (30.396% ungapped) in 239 aa overlap (106-337:21-254) 80 90 100 110 120 130 mKIAA4 TMPENLGHKRTGSNISGASSDVSLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNC ::.::.. . . . : :: .: .... mKIAA1 AAQSRGFTAQLMGSGHVPLPQLDETSQVETVS---EENKSL-MWVLLRQL 10 20 30 40 140 150 160 170 180 190 mKIAA4 -IGKELSKIPMPVNFNEPLSMLQRLTEDLEYH-ELLDRAAKCENSLEQLCYVAAFTVSSY : .::.. .:. :: :.: .:. : :: .::.::: .. .. : . .:.. mKIAA1 RPGMDLSRVVLPTFVLEPRSFLGKLS-DYYYHGDLLSRAAAEDDPYCRMKLVLRWYLSGF 50 60 70 80 90 100 200 210 220 230 240 mKIAA4 STTVFRTSKPFNPLLGETFELDRL--EENGYR-SICEQVSHHPPAAAHH-AESKNGWTLR .::.::.:::::. : . :.. : ::::::::..: . .. :.:. . mKIAA1 YKKPKGIKKPYNPILGETFRCRWLHPQTNSHTFYIAEQVSHHPPVSAFYVSNRKDGFCMS 110 120 130 140 150 160 250 260 270 280 290 300 mKIAA4 QEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI : ::: :. :: . : . : . ..:: . ..:. : . .. .:..:. mKIAA1 GSITAKSKFYGNSLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGILYGTMTMELGGKVDV 170 180 190 200 210 220 310 320 330 340 350 360 mKIAA4 -VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMDCFKVQAAS ...... .: ..: :. .. : mKIAA1 FIKEESSGGTELFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIREGDQHKAT 230 240 250 260 270 280 >>mKIAA1451 ( 429 res) mth01486 (429 aa) initn: 176 init1: 76 opt: 247 Z-score: 258.2 bits: 57.1 E(): 3.1e-09 Smith-Waterman score: 266; 26.027% identity (29.344% ungapped) in 292 aa overlap (202-486:22-287) 180 190 200 210 220 mKIAA4 AAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFEL----DRLEENGYRSICE ::.::.:::::. : . . . : : mKIAA1 RLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFY-IAE 10 20 30 40 50 230 240 250 260 270 280 mKIAA4 QVSHHPPAAAHH-AESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHSTGHHYTWKK ::::::: .: . .. :.:. : : ::: :. :: . : . : . :. :. mKIAA1 QVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTM 60 70 80 90 100 110 290 300 310 320 330 340 mKIAA4 VTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYF-SRDVARKVTGEVTDPSG . ..:. : . .. .: ..:. .::: . :.: .. : : . ...:.. : mKIAA1 PYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKLK--LG 120 130 140 150 160 350 360 370 380 390 400 mKIAA4 KVHFALL-GTWDEKMDCFKVQAASGENGGDARQRGHEAEDSRVMLWKRNPLPKNAENMYY : .: : : :: .. : .: . :. ..: :: : .. mKIAA1 KEVLATLEGHWDSEV--FI---------NDKKT------DNSEIFW--NPTP----DIKQ 170 180 190 200 410 420 430 440 450 460 mKIAA4 FSELALTLNAWEGGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAA . . :.. : ... . . .. ::. :: ::: :: . . :.... mKIAA1 WRLIRHTVKFEEQDDFESEKLWQRVTKAINAKDQTEATQEKYVLEEAQRQAARDRKTKTQ 210 220 230 240 250 260 470 480 490 500 510 mKIAA4 KATEDGTPHDPYKALWFERKKDPVTRELTHIYSGEYWECKEKQDWGSCPDIF . . :: . : . .: mKIAA1 EWVCKLFELDPLTGEWHYKFSDTRPWDPLNDMIQFEKDGVIQTKVKHRTPMVSVPKMKHK 270 280 290 300 310 320 516 residues in 1 query sequences 1768501 residues in 2168 library sequences Scomplib [34t11] start: Mon Mar 27 11:05:32 2006 done: Mon Mar 27 11:05:33 2006 Scan time: 0.690 Display time: 0.100 Function used was FASTA [version 3.4t11 Apr 17, 2002]