# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mfj39041.fasta.nr -Q ../query/mKIAA0608.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 mKIAA0608, 738 aa vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library 2727779818 residues in 7921681 sequences statistics sampled from 60000 to 7910797 sequences Expectation_n fit: rho(ln(x))= 5.9509+/-0.000197; mu= 10.8799+/- 0.011 mean_var=111.1692+/-21.395, 0's: 41 Z-trim: 69 B-trim: 0 in 0/64 Lambda= 0.121642 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7921681) gi|182701375|sp|Q6A039.2|TBC12_MOUSE RecName: Full ( 696) 4665 829.7 0 gi|119943133|ref|NP_666064.3| TBC1D12: TBC1 domain ( 698) 4651 827.3 0 gi|148709865|gb|EDL41811.1| TBC1D12: TBC1 domain f ( 599) 4012 715.1 1.9e-203 gi|73998064|ref|XP_859120.1| PREDICTED: similar to ( 698) 3787 675.6 1.7e-191 gi|109090045|ref|XP_001090278.1| PREDICTED: TBC1 d ( 732) 3286 587.7 5e-165 gi|168267440|dbj|BAG09776.1| TBC1 domain family me ( 769) 3284 587.4 6.7e-165 gi|115502463|sp|O60347.3|TBC12_HUMAN RecName: Full ( 775) 3284 587.4 6.7e-165 gi|114632000|ref|XP_507936.2| PREDICTED: TBC1 doma ( 862) 3284 587.5 7.2e-165 gi|194205839|ref|XP_001500836.2| PREDICTED: TBC1 d ( 742) 3248 581.1 5.2e-163 gi|73998066|ref|XP_849591.1| PREDICTED: similar to ( 772) 3212 574.8 4.3e-161 gi|126273232|ref|XP_001374921.1| PREDICTED: simila ( 777) 3193 571.4 4.3e-160 gi|224052573|ref|XP_002189388.1| PREDICTED: simila ( 716) 2900 520.0 1.2e-144 gi|194041748|ref|XP_001926666.1| PREDICTED: TBC1 d ( 451) 2886 517.4 4.8e-144 gi|169642000|gb|AAI60725.1| LOC100158296 protein [ ( 596) 2725 489.2 1.9e-135 gi|224052571|ref|XP_002189334.1| PREDICTED: simila ( 737) 2503 450.3 1.2e-123 gi|118092832|ref|XP_001231528.1| PREDICTED: simila ( 404) 2456 441.8 2.3e-121 gi|123914313|sp|Q0IHY4.1|TBC12_XENTR RecName: Full ( 684) 2415 434.9 5e-119 gi|219519808|gb|AAI45130.1| Unknown (protein for M ( 621) 2403 432.7 2e-118 gi|189530860|ref|XP_692080.2| PREDICTED: wu:fc59a0 ( 823) 2375 427.9 7.3e-117 gi|149062801|gb|EDM13224.1| rCG47282 [Rattus norve ( 352) 2300 414.4 3.6e-113 gi|50949274|emb|CAB43225.2| hypothetical protein [ ( 352) 2299 414.2 4.1e-113 gi|194678953|ref|XP_585982.4| PREDICTED: similar t ( 352) 2292 413.0 9.6e-113 gi|118090700|ref|XP_001232770.1| PREDICTED: simila ( 675) 2221 400.8 8.7e-109 gi|126332070|ref|XP_001372247.1| PREDICTED: simila ( 692) 2205 398.0 6.2e-108 gi|109073654|ref|XP_001118829.1| PREDICTED: simila ( 841) 2206 398.3 6.3e-108 gi|27371020|gb|AAH41167.1| TBC1 domain family, mem ( 678) 2204 397.8 6.9e-108 gi|172044690|sp|Q9P2M4.3|TBC14_HUMAN RecName: Full ( 693) 2204 397.8 7e-108 gi|168269810|dbj|BAG10032.1| TBC1 domain family me ( 693) 2204 397.8 7e-108 gi|114593160|ref|XP_526514.2| PREDICTED: TBC1 doma ( 816) 2204 397.9 7.9e-108 gi|194209331|ref|XP_001500016.2| PREDICTED: TBC1 d ( 693) 2193 395.9 2.7e-107 gi|148878131|gb|AAI46263.1| TBC1D14 protein [Bos t ( 677) 2186 394.7 6.2e-107 gi|189037433|sp|A6H7I8.2|TBC14_BOVIN RecName: Full ( 692) 2186 394.7 6.3e-107 gi|73951733|ref|XP_545899.2| PREDICTED: similar to ( 718) 2181 393.8 1.2e-106 gi|55728558|emb|CAH91021.1| hypothetical protein [ ( 518) 2166 391.1 5.8e-106 gi|68363916|ref|XP_683181.1| PREDICTED: similar to ( 711) 2142 387.0 1.3e-104 gi|71122315|gb|AAH99760.1| TBC1 domain family, mem ( 679) 2138 386.2 2.1e-104 gi|164565385|ref|NP_001029193.2| TBC1 domain famil ( 694) 2138 386.3 2.2e-104 gi|149047374|gb|EDM00044.1| TBC1 domain family, me ( 714) 2138 386.3 2.2e-104 gi|66396636|gb|AAH96446.1| TBC1 domain family, mem ( 679) 2135 385.7 3.1e-104 gi|27502771|gb|AAH42515.1| TBC1 domain family, mem ( 679) 2135 385.7 3.1e-104 gi|189037431|sp|Q8CGA2.2|TBC14_MOUSE RecName: Full ( 694) 2135 385.7 3.1e-104 gi|164565373|ref|NP_598671.3| TBC1 domain family, ( 694) 2135 385.7 3.1e-104 gi|148705561|gb|EDL37508.1| TBC1 domain family, me ( 714) 2135 385.7 3.2e-104 gi|189037432|sp|Q5CD77.2|TBC14_RAT RecName: Full=T ( 694) 2129 384.7 6.4e-104 gi|149784077|gb|ABR29562.1| spermatogenesis-relate ( 470) 2098 379.1 2.1e-102 gi|164565381|ref|NP_001106834.1| TBC1 domain famil ( 413) 2043 369.4 1.5e-99 gi|164565387|ref|NP_001012152.2| TBC1 domain famil ( 413) 2008 363.2 1.1e-97 gi|164565383|ref|NP_001106835.1| TBC1 domain famil ( 413) 2005 362.7 1.6e-97 gi|60735069|dbj|BAD91010.1| hypothetical protein [ ( 718) 1984 359.2 3e-96 gi|21739363|emb|CAD38726.1| hypothetical protein [ ( 381) 1955 353.9 6.5e-95 >>gi|182701375|sp|Q6A039.2|TBC12_MOUSE RecName: Full=TBC (696 aa) initn: 4665 init1: 4665 opt: 4665 Z-score: 4427.2 bits: 829.7 E(): 0 Smith-Waterman score: 4665; 100.000% identity (100.000% similar) in 696 aa overlap (43-738:1-696) 20 30 40 50 60 70 mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGPMGQDGKT :::::::::::::::::::::::::::::: gi|182 MMGPEDAGACSGRNAELLPVPGPMGQDGKT 10 20 30 80 90 100 110 120 130 mKIAA0 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEEAAAAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEEAAAAAV 40 50 60 70 80 90 140 150 160 170 180 190 mKIAA0 PAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 PAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLE 100 110 120 130 140 150 200 210 220 230 240 250 mKIAA0 DPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 DPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLL 160 170 180 190 200 210 260 270 280 290 300 310 mKIAA0 PSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 PSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGK 220 230 240 250 260 270 320 330 340 350 360 370 mKIAA0 VPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 VPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAK 280 290 300 310 320 330 380 390 400 410 420 430 mKIAA0 SVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 SVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWE 340 350 360 370 380 390 440 450 460 470 480 490 mKIAA0 VMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 VMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSE 400 410 420 430 440 450 500 510 520 530 540 550 mKIAA0 NDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 NDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQ 460 470 480 490 500 510 560 570 580 590 600 610 mKIAA0 GMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 GMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKL 520 530 540 550 560 570 620 630 640 650 660 670 mKIAA0 FLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 FLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYED 580 590 600 610 620 630 680 690 700 710 720 730 mKIAA0 ILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|182 ILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNT 640 650 660 670 680 690 mKIAA0 SPALKS :::::: gi|182 SPALKS >>gi|119943133|ref|NP_666064.3| TBC1D12: TBC1 domain fam (698 aa) initn: 4119 init1: 4119 opt: 4651 Z-score: 4413.9 bits: 827.3 E(): 0 Smith-Waterman score: 4651; 99.713% identity (99.713% similar) in 698 aa overlap (43-738:1-698) 20 30 40 50 60 70 mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGPMGQDGKT :::::::::::::::::::::::::::::: gi|119 MMGPEDAGACSGRNAELLPVPGPMGQDGKT 10 20 30 80 90 100 110 120 130 mKIAA0 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAE--EAAAA ::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: gi|119 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEAEEAAAA 40 50 60 70 80 90 140 150 160 170 180 190 mKIAA0 AVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAP 100 110 120 130 140 150 200 210 220 230 240 250 mKIAA0 LEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGD 160 170 180 190 200 210 260 270 280 290 300 310 mKIAA0 LLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLF 220 230 240 250 260 270 320 330 340 350 360 370 mKIAA0 GKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLP 280 290 300 310 320 330 380 390 400 410 420 430 mKIAA0 AKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 AKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPN 340 350 360 370 380 390 440 450 460 470 480 490 mKIAA0 WEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 WEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESS 400 410 420 430 440 450 500 510 520 530 540 550 mKIAA0 SENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGY 460 470 480 490 500 510 560 570 580 590 600 610 mKIAA0 VQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 VQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLS 520 530 540 550 560 570 620 630 640 650 660 670 mKIAA0 KLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLY 580 590 600 610 620 630 680 690 700 710 720 730 mKIAA0 EDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDK 640 650 660 670 680 690 mKIAA0 NTSPALKS :::::::: gi|119 NTSPALKS >>gi|148709865|gb|EDL41811.1| TBC1D12: TBC1 domain famil (599 aa) initn: 4012 init1: 4012 opt: 4012 Z-score: 3808.7 bits: 715.1 E(): 1.9e-203 Smith-Waterman score: 4012; 100.000% identity (100.000% similar) in 599 aa overlap (140-738:1-599) 110 120 130 140 150 160 mKIAA0 AAAGPLKPGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPC :::::::::::::::::::::::::::::: gi|148 MTNGDSGFLLRQDRRGPEEARRRRTCGRPC 10 20 30 170 180 190 200 210 220 mKIAA0 LLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 LLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGL 40 50 60 70 80 90 230 240 250 260 270 280 mKIAA0 PDARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 PDARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNL 100 110 120 130 140 150 290 300 310 320 330 340 mKIAA0 FPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 FPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKS 160 170 180 190 200 210 350 360 370 380 390 400 mKIAA0 FALEPLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 FALEPLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKER 220 230 240 250 260 270 410 420 430 440 450 460 mKIAA0 FKQEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 FKQEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITP 280 290 300 310 320 330 470 480 490 500 510 520 mKIAA0 ELYEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 ELYEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGP 340 350 360 370 380 390 530 540 550 560 570 580 mKIAA0 YHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 YHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRV 400 410 420 430 440 450 590 600 610 620 630 640 mKIAA0 DHSMMLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 DHSMMLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWD 460 470 480 490 500 510 650 660 670 680 690 700 mKIAA0 VFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|148 VFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQN 520 530 540 550 560 570 710 720 730 mKIAA0 STKKWTQVFASVAKDIKEGDKNTSPALKS ::::::::::::::::::::::::::::: gi|148 STKKWTQVFASVAKDIKEGDKNTSPALKS 580 590 >>gi|73998064|ref|XP_859120.1| PREDICTED: similar to TBC (698 aa) initn: 3360 init1: 3241 opt: 3787 Z-score: 3594.4 bits: 675.6 E(): 1.7e-191 Smith-Waterman score: 3787; 83.333% identity (89.689% similar) in 708 aa overlap (43-738:1-698) 20 30 40 50 60 70 mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPG--PMGQDG :.:::::::::::: .:::::. :.:::: gi|739 MVGPEDAGACSGRNPKLLPVPALEPVGQDG 10 20 30 80 90 100 110 120 mKIAA0 KTVPATSGFSGGAVAAEPP---EEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEEA : . ::.::.::. :.::: :: ::: ::.:::.::::::.: : .: .: gi|739 KMIRATGGFGGGVGAVEPPAEEEEEEEEEETPPQQLLRRYLAAAGGGQ---LESALCSRA 40 50 60 70 80 130 140 150 160 170 180 mKIAA0 AAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARR-RRTCGR-PCLLE-----PADEGVDG ::: : : : :::::::::: :: : :::: :. :: : . :.:::.:: gi|739 AAADVRAPRHRGMTNGDSGFLAGQDSRDLEEARGLARAGGRDPSRRRLRPQGPGDEGADG 90 100 110 120 130 140 190 200 210 220 230 240 mKIAA0 AGGLDDWAAPLEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTF .:. .:::::::::::::::::.:.: :. :: .: : .::: :.::.: .::::: gi|739 SGSASDWAAPLEDPLRSCCLAAADADKPQGAAERISGGA--GAEPRPGVPDVRVNSRNTF 150 160 170 180 190 200 250 260 270 280 290 300 mKIAA0 EVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSV :::: : :: :.: .: :::::: .::.::::::::.::::::::::::::::::: gi|739 EVSR-----DHLPPASPPVPAPAAEQGAAGTSARARRSGGLADFFARNLFPKRTKELKSV 210 220 230 240 250 260 310 320 330 340 350 360 mKIAA0 VHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTAL ::::::::::::::::::::::::::::::::::::::: :::::::.: .:::::::: gi|739 VHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTAL 270 280 290 300 310 320 370 380 390 400 410 420 mKIAA0 ILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAM :::::: ::::::::::::::::::::::::::::::::.:::.::::::::::.::::: gi|739 ILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAYKRKKIMKERFKQEENIASAM 330 340 350 360 370 380 430 440 450 460 470 480 mKIAA0 VIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 VIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAK 390 400 410 420 430 440 490 500 510 520 530 540 mKIAA0 ERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGA ::::::::.::::: ::.:.:::::::::::::::::::::::::::::::::::::::: gi|739 ERWKSFSETSSENDMEGVSLADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGA 450 460 470 480 490 500 550 560 570 580 590 600 mKIAA0 YTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFAT :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: gi|739 YTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHNMMLKYFAT 510 520 530 540 550 560 610 620 630 640 650 660 mKIAA0 FEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLF :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: gi|739 FEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLF 570 580 590 600 610 620 670 680 690 700 710 720 mKIAA0 RTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 RTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFAS 630 640 650 660 670 680 730 mKIAA0 VAKDIKEGDKNTSPALKS : :::::::::.:::::: gi|739 VMKDIKEGDKNNSPALKS 690 >>gi|109090045|ref|XP_001090278.1| PREDICTED: TBC1 domai (732 aa) initn: 3371 init1: 3225 opt: 3286 Z-score: 3119.0 bits: 587.7 E(): 5e-165 Smith-Waterman score: 3444; 74.267% identity (79.733% similar) in 750 aa overlap (30-738:59-732) 10 20 30 40 50 mKIAA0 IPARARPPATAPAAGWEGWVRGRRGGRGREPCTQGSPPPP------PQMMGPEDAGACS . :. . :: :::.::::::::: gi|109 NCLTPRVGGVGLGTLRRLSPRLQHSELFCGQACAWSPSLPPGAAATRPQMVGPEDAGACS 30 40 50 60 70 80 60 70 80 90 100 110 mKIAA0 GRNAELLPVPGP--MGQDGKTVPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAA ::: .:::::.: .::::: gi|109 GRNPKLLPVPAPEPVGQDGK---------------------------------------- 90 100 120 130 140 150 160 170 mKIAA0 AGPLKPGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLL ::: . : : .:.:::: ::: : gi|109 -----------------------ARGLA-------------RAGGRESRRRRPCGRLRLE 110 120 130 180 190 200 210 mKIAA0 EPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD---------PAA---------- :.:: .::::. .:::.:::::::::::.:.:...:. :: gi|109 GPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAEEPEGAGSGSGDSPANSCSGSEDSEQ 140 150 160 170 180 190 220 230 240 250 mKIAA0 --------------ATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLLPSAGPS :: : :. .:: ::. : ...::::::::: .::.: :: :::: gi|109 PGVGAGGPEEGSPPATSAERTSGGAESRLGFSDIHLNSRNTFEVSRGHSASDHLPPAGPS 200 210 220 230 240 250 260 270 280 290 300 310 mKIAA0 APLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPREN .:::.:::::. : :::::::::::::::::::::::::::::::::::::::::::::: gi|109 VPLPTAEQGPAETLARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPREN 260 270 280 290 300 310 320 330 340 350 360 370 mKIAA0 LQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAKSVEEAL :::::.::::::::::::::: :::::::.: .:::::::::::::: ::::::::::: gi|109 LQKTSRIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEAL 320 330 340 350 360 370 380 390 400 410 420 430 mKIAA0 RHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWEVMRSTR ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: gi|109 RHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTR 380 390 400 410 420 430 440 450 460 470 480 490 mKIAA0 RVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSENDTEGL ::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::. gi|109 RVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGV 440 450 460 470 480 490 500 510 520 530 540 550 mKIAA0 SVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIA 500 510 520 530 540 550 560 570 580 590 600 610 mKIAA0 AVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 AVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKS 560 570 580 590 600 610 620 630 640 650 660 670 mKIAA0 YNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMD :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 YSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMD 620 630 640 650 660 670 680 690 700 710 720 730 mKIAA0 FIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNTSPALKS ::::::::::::::::::::::::::::::::::::::::::: ::::::.::.:::::: gi|109 FIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGEKNSSPALKS 680 690 700 710 720 730 >>gi|168267440|dbj|BAG09776.1| TBC1 domain family member (769 aa) initn: 3596 init1: 3253 opt: 3284 Z-score: 3116.8 bits: 587.4 E(): 6.7e-165 Smith-Waterman score: 3781; 78.283% identity (84.395% similar) in 769 aa overlap (43-738:1-769) 20 30 40 50 60 70 mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGP--MGQDG :.:::::::::::: .:::::.: .::: gi|168 MVGPEDAGACSGRNPKLLPVPAPDPVGQDR 10 20 30 80 90 100 110 120 mKIAA0 KTVPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGL-------GGAE :.. ::.::.::. :.:::::: ::: :::::::::::::. :.::: : : gi|168 KVIRATGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAG 40 50 60 70 80 90 130 140 150 mKIAA0 AEEAAAAAVPAA---------RGS-----------GMTNGDSGFLLRQD----------- : .:: : ::. :::::::::: .: gi|168 APPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLA 100 110 120 130 140 150 160 170 180 190 200 mKIAA0 RRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD--- : : .:.:::: :: : :.:: .::::. .:::.:::::::::::.:.:...:. gi|168 RAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAG 160 170 180 190 200 210 210 220 230 mKIAA0 ------PAA------------------------ATPAGRAVESAEPSLGLPDARFGSRNT ::. :: : :. .::: ::. : .:.:::: gi|168 SDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNT 220 230 240 250 260 270 240 250 260 270 280 290 mKIAA0 FEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKS :.::: ::: : :: ::: .:::::::::.:..:::::::::::::.::::::::::::: gi|168 FQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKS 280 290 300 310 320 330 300 310 320 330 340 350 mKIAA0 VVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTA :::::::::::::::::::::::::::::::::::::::: :::::::.: .::::::: gi|168 VVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTA 340 350 360 370 380 390 360 370 380 390 400 410 mKIAA0 LILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASA ::::::: :::::::::::::::::::::::::::::::::::::::::::::::.:::: gi|168 LILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASA 400 410 420 430 440 450 420 430 440 450 460 470 mKIAA0 MVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 MVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRA 460 470 480 490 500 510 480 490 500 510 520 530 mKIAA0 KERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILG :::::::::.::::::::.::::::::::::::::::::::::::::::::::::::::: gi|168 KERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILG 520 530 540 550 560 570 540 550 560 570 580 590 mKIAA0 AYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 AYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFA 580 590 600 610 620 630 600 610 620 630 640 650 mKIAA0 TFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFL ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: gi|168 TFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFL 640 650 660 670 680 690 660 670 680 690 700 710 mKIAA0 FRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|168 FRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFA 700 710 720 730 740 750 720 730 mKIAA0 SVAKDIKEGDKNTSPALKS :: :::::::::.:::::: gi|168 SVMKDIKEGDKNSSPALKS 760 >>gi|115502463|sp|O60347.3|TBC12_HUMAN RecName: Full=TBC (775 aa) initn: 3603 init1: 3253 opt: 3284 Z-score: 3116.8 bits: 587.4 E(): 6.7e-165 Smith-Waterman score: 3759; 77.677% identity (83.742% similar) in 775 aa overlap (43-738:1-775) 20 30 40 50 60 70 mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGP--MGQDG :.:::::::::::: .:::::.: .::: gi|115 MVGPEDAGACSGRNPKLLPVPAPDPVGQDR 10 20 30 80 90 100 110 mKIAA0 KTVPATSGFSGGAVAAEPPEEAGEEEAP------PPRQLLQRYLAAAAGPLKPGL----- :.. ::.::.::. :.:::::: ::: :::::::::::::. :.::: gi|115 KVIRATGGFGGGVGAVEPPEEADEEEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPL 40 50 60 70 80 90 120 130 140 150 mKIAA0 --GGAEAEEAAAAAVPAA---------RGS-----------GMTNGDSGFLLRQD----- : : : .:: : ::. :::::::::: .: gi|115 PAGQAGAPPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLE 100 110 120 130 140 150 160 170 180 190 200 mKIAA0 ------RRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTD : : .:.:::: :: : :.:: .::::. .:::.:::::::::::.:.:.. gi|115 EARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQ 160 170 180 190 200 210 210 220 230 mKIAA0 DPD---------PAA------------------------ATPAGRAVESAEPSLGLPDAR .:. ::. :: : :. .::: ::. : . gi|115 EPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIH 220 230 240 250 260 270 240 250 260 270 280 290 mKIAA0 FGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKR :.:::::.::: ::: : :: ::: .:::::::::.:..:::::::::::::.::::::: gi|115 FNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKR 280 290 300 310 320 330 300 310 320 330 340 350 mKIAA0 TKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALE :::::::::::::::::::::::::::::::::::::::::::::: :::::::.: .: gi|115 TKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFE 340 350 360 370 380 390 360 370 380 390 400 410 mKIAA0 PLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE ::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::: gi|115 PLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE 400 410 420 430 440 450 420 430 440 450 460 470 mKIAA0 ESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYE :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 ENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYE 460 470 480 490 500 510 480 490 500 510 520 530 mKIAA0 IFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDV :::::::::::::::.::::::::.::::::::::::::::::::::::::::::::::: gi|115 IFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDV 520 530 540 550 560 570 540 550 560 570 580 590 mKIAA0 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM 580 590 600 610 620 630 600 610 620 630 640 650 mKIAA0 MLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCR ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: gi|115 MLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCR 640 650 660 670 680 690 660 670 680 690 700 710 mKIAA0 DGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|115 DGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK 700 710 720 730 740 750 720 730 mKIAA0 WTQVFASVAKDIKEGDKNTSPALKS :::::::: :::::::::.:::::: gi|115 WTQVFASVMKDIKEGDKNSSPALKS 760 770 >>gi|114632000|ref|XP_507936.2| PREDICTED: TBC1 domain f (862 aa) initn: 3630 init1: 3253 opt: 3284 Z-score: 3116.2 bits: 587.5 E(): 7.2e-165 Smith-Waterman score: 3811; 74.879% identity (81.675% similar) in 824 aa overlap (5-738:39-862) 10 20 30 mKIAA0 IPARARPPAT---APAAGWEGWVRGRR-GGRGRE : ::.. .: .: : :: . : .. gi|114 CVSLATVSMVRGISRSGLDGSDFCACASPGACPPSSNCPTPRVGGVGLGTLRRLSPRPQH 10 20 30 40 50 60 40 50 60 70 mKIAA0 P---------CTQGSPPPP----PQMMGPEDAGACSGRNAELLPVPGP--MGQDGKTVPA : :. . :: :::.:::::::::::: .:::::.: .::: :.. : gi|114 PELFSGQACACSPSLPPGAAATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRA 70 80 90 100 110 120 80 90 100 110 120 mKIAA0 TSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGL-------GGAEAEEAA :.::.::. :.:::::: ::: :::::::::::::. :.::: : : : . gi|114 TGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPS 130 140 150 160 170 180 130 140 150 mKIAA0 AAAVPAA---------RGS-----------GMTNGDSGFLLRQD-----------RRGPE :: : ::. :::::::::: .: : : . gi|114 AAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGR 190 200 210 220 230 240 160 170 180 190 200 mKIAA0 EARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD-------- :.:::: :: : :.:: .::::. .:::.:::::::::::.:.:...:. gi|114 ESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGD 250 260 270 280 290 300 210 220 230 240 mKIAA0 -PAA------------------------ATPAGRAVESAEPSLGLPDARFGSRNTFEVSR ::. :: : :. .::: ::. : .:.:::::.::: gi|114 SPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSR 310 320 330 340 350 360 250 260 270 280 290 300 mKIAA0 RQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSA ::: : :: ::: .:::::::::.:..:::::::::::::.:::::::::::::::::: gi|114 GQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSA 370 380 390 400 410 420 310 320 330 340 350 360 mKIAA0 PGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILED ::::::::::::::::::::::::::::::::::: :::::::.: .:::::::::::: gi|114 PGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILED 430 440 450 460 470 480 370 380 390 400 410 420 mKIAA0 RPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWI :: :::::::::::::::::::::::::::::::::::::::::::::::.::::::::: gi|114 RPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWI 490 500 510 520 530 540 430 440 450 460 470 480 mKIAA0 NEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 NEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWK 550 560 570 580 590 600 490 500 510 520 530 540 mKIAA0 SFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCY ::::.::::::::.:::::::::::::::::::::::::::::::::::::::::::::: gi|114 SFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCY 610 620 630 640 650 660 550 560 570 580 590 600 mKIAA0 RPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 RPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVF 670 680 690 700 710 720 610 620 630 640 650 660 mKIAA0 FEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGL :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|114 FEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGL 730 740 750 760 770 780 670 680 690 700 710 720 mKIAA0 GILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: gi|114 GILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKD 790 800 810 820 830 840 730 mKIAA0 IKEGDKNTSPALKS :::::::.:::::: gi|114 IKEGDKNSSPALKS 850 860 >>gi|194205839|ref|XP_001500836.2| PREDICTED: TBC1 domai (742 aa) initn: 3347 init1: 3215 opt: 3248 Z-score: 3082.9 bits: 581.1 E(): 5.2e-163 Smith-Waterman score: 3460; 74.308% identity (82.213% similar) in 759 aa overlap (24-738:8-742) 10 20 30 40 50 mKIAA0 IPARARPPATAPAAGWEGWVRGRRGGRGREPCTQGSPP-PPPQMMGPEDAGACSGRNAEL : : .:. : .:: ::: :: :: gi|194 MTHVPNPRHGASRK--LQLAPPHPPPPEMG---AG--------- 10 20 30 60 70 80 90 100 110 mKIAA0 LPVPGPMGQDGKTVPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGP----- :: :: : .: .. ... . ..: : ... : :: gi|194 LPHTGP-GARPLAVTVSRSWAD--------RTSSEYLLSEPYPCFRKNCHARNGPTSLHH 40 50 60 70 80 120 130 140 150 160 mKIAA0 --LKPGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARR-RRTCGR-P-- ..: :.. . : :: . : : .:::::::::: :: . :::: :. :: : gi|194 PDVNPRLAAKVYRGAEAADTRAPRHGGMTNGDSGFLPGQDCHDLEEARGLARAGGREPRH 90 100 110 120 130 140 170 180 190 200 mKIAA0 ---CLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD---------------- :: :.:::.::::. ..:: ::::::.:::::.::..:. gi|194 RRLCLEGPGDEGADGAGSRSNWAQ-LEDPLRTCCLAAADTEEPEGAGSGGSGSGSEDLEQ 150 160 170 180 190 200 210 220 230 240 250 mKIAA0 PAA--------ATPAGRAVES-----AEPSLGLPDARFGSRNTFEVSRRQSAGDLLPSAG :.: :.::. : .. ::: ::. : ..::::::::::::: : :: :: gi|194 PGAGAGRPEEGASPAASAERTSGAAGAEPRLGFAGALLNSRNTFEVSRRQSARDHLPPAG 210 220 230 240 250 260 260 270 280 290 300 310 mKIAA0 PSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPR :.:: ::.::::.::..::::::::::::::::: :::::.::::::::::::::::::: gi|194 PQAPSPAVEQGPAGTSTRARRSGGFADFFARNLFSKRTKEFKSVVHSAPGWKLFGKVPPR 270 280 290 300 310 320 320 330 340 350 360 370 mKIAA0 ENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAKSVEE ::::::::::::::::::::::: :::::::.: .:::::::::::::: ::::::.:: gi|194 ENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSMEE 330 340 350 360 370 380 380 390 400 410 420 430 mKIAA0 ALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWEVMRS :::::::::::::::::::::::::::.::::::::::.::::::::::::::::::::: gi|194 ALRHRQEYDEMVAEAKKREIKEAHKRKKIMKERFKQEENIASAMVIWINEILPNWEVMRS 390 400 410 420 430 440 440 450 460 470 480 490 mKIAA0 TRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSENDTE ::::::::::::::::::::::::::::::::::::::::::::::::::::..:::.:: gi|194 TRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETNSENNTE 450 460 470 480 490 500 500 510 520 530 540 550 mKIAA0 GLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSF :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 GVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSF 510 520 530 540 550 560 560 570 580 590 600 610 mKIAA0 IAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 IAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHF 570 580 590 600 610 620 620 630 640 650 660 670 mKIAA0 KSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQ :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 KSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQ 630 640 650 660 670 680 680 690 700 710 720 730 mKIAA0 MDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNTSPAL ::::::::::::::::::::::::::::::::::::::::::.:: :::::::::.:::: gi|194 MDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFSSVMKDIKEGDKNNSPAL 690 700 710 720 730 740 mKIAA0 KS :: gi|194 KS >>gi|73998066|ref|XP_849591.1| PREDICTED: similar to TBC (772 aa) initn: 3604 init1: 3080 opt: 3212 Z-score: 3048.5 bits: 574.8 E(): 4.3e-161 Smith-Waterman score: 3678; 76.319% identity (82.883% similar) in 777 aa overlap (43-738:1-772) 20 30 40 50 60 70 mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPG--PMGQDG :.:::::::::::: .:::::. :.:::: gi|739 MVGPEDAGACSGRNPKLLPVPALEPVGQDG 10 20 30 80 90 100 110 mKIAA0 KTVPATSGFSGGAVAAEPP---EEAGEEEAPPPRQLLQRYLAAAAG----------PLK- : . ::.::.::. :.::: :: ::: ::.:::.::::::.: :: gi|739 KMIRATGGFGGGVGAVEPPAEEEEEEEEEETPPQQLLRRYLAAAGGGQLESALCSRPLPA 40 50 60 70 80 90 120 130 140 150 mKIAA0 -----------------PGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEA : .:.. . :::: : : : :::::::::: :: : ::: gi|739 RQPRAAPPPAAPRPDACPRDSGSKRRGAAAADVRAPRHRGMTNGDSGFLAGQDSRDLEEA 100 110 120 130 140 150 160 170 180 190 200 mKIAA0 RR-RRTCGR-PCLLE-----PADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD--- : :. :: : . :.:::.::.:. .:::::::::::::::::.:.: :. gi|739 RGLARAGGRDPSRRRLRPQGPGDEGADGSGSASDWAAPLEDPLRSCCLAAADADKPQGAG 160 170 180 190 200 210 210 220 230 mKIAA0 --------------------------------PAAATPAGRAVE------SAEPSLGLPD :.::. :. ..: .::: :.:: gi|739 GGSEGGAGGDGGSSGDSERPGAGAGAGGCEEGPSAAAAAAAGAERISGGAGAEPRPGVPD 220 230 240 250 260 270 240 250 260 270 280 290 mKIAA0 ARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFP .: .::::::::: : :: :.: .: :::::: .::.::::::::.:::::::::: gi|739 VRVNSRNTFEVSR-----DHLPPASPPVPAPAAEQGAAGTSARARRSGGLADFFARNLFP 280 290 300 310 320 300 310 320 330 340 350 mKIAA0 KRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFA :::::::::::::::::::::::::::::::::::::::::::::::: :::::::.: gi|739 KRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFE 330 340 350 360 370 380 360 370 380 390 400 410 mKIAA0 LEPLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFK .:::::::::::::: ::::::::::::::::::::::::::::::::.:::.::::::: gi|739 FEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAYKRKKIMKERFK 390 400 410 420 430 440 420 430 440 450 460 470 mKIAA0 QEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 QEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL 450 460 470 480 490 500 480 490 500 510 520 530 mKIAA0 YEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYH :::::::::::::::::.::::: ::.:.::::::::::::::::::::::::::::::: gi|739 YEIFLSRAKERWKSFSETSSENDMEGVSLADREASLELIKLDISRTFPSLYIFQKGGPYH 510 520 530 540 550 560 540 550 560 570 580 590 mKIAA0 DVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 DVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDH 570 580 590 600 610 620 600 610 620 630 640 650 mKIAA0 SMMLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF .:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: gi|739 NMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF 630 640 650 660 670 680 660 670 680 690 700 710 mKIAA0 CRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 CRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNST 690 700 710 720 730 740 720 730 mKIAA0 KKWTQVFASVAKDIKEGDKNTSPALKS :::::::::: :::::::::.:::::: gi|739 KKWTQVFASVMKDIKEGDKNNSPALKS 750 760 770 738 residues in 1 query sequences 2727779818 residues in 7921681 library sequences Tcomplib [34.26] (2 proc) start: Sun Mar 15 11:17:03 2009 done: Sun Mar 15 11:25:13 2009 Total Scan time: 1076.710 Total Display time: 0.310 Function used was FASTA [version 34.26.5 April 26, 2007]