# /usr/local/bin/fasta34_t -T 4 -b50 -d10 -E0.01 -H -O./tmp/mfj39041.fasta.nr -Q ../query/mKIAA0608.ptfa /cdna4/rodent/rouge_util/new.rouge/nfasta/nr 2
FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
mKIAA0608, 738 aa
vs /cdna4/rodent/rouge_util/new.rouge/nfasta/nr library
2727779818 residues in 7921681 sequences
statistics sampled from 60000 to 7910797 sequences
Expectation_n fit: rho(ln(x))= 5.9509+/-0.000197; mu= 10.8799+/- 0.011
mean_var=111.1692+/-21.395, 0's: 41 Z-trim: 69 B-trim: 0 in 0/64
Lambda= 0.121642
FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2
join: 38, opt: 26, open/ext: -10/-2, width: 16
The best scores are: opt bits E(7921681)
gi|182701375|sp|Q6A039.2|TBC12_MOUSE RecName: Full ( 696) 4665 829.7 0
gi|119943133|ref|NP_666064.3| TBC1D12: TBC1 domain ( 698) 4651 827.3 0
gi|148709865|gb|EDL41811.1| TBC1D12: TBC1 domain f ( 599) 4012 715.1 1.9e-203
gi|73998064|ref|XP_859120.1| PREDICTED: similar to ( 698) 3787 675.6 1.7e-191
gi|109090045|ref|XP_001090278.1| PREDICTED: TBC1 d ( 732) 3286 587.7 5e-165
gi|168267440|dbj|BAG09776.1| TBC1 domain family me ( 769) 3284 587.4 6.7e-165
gi|115502463|sp|O60347.3|TBC12_HUMAN RecName: Full ( 775) 3284 587.4 6.7e-165
gi|114632000|ref|XP_507936.2| PREDICTED: TBC1 doma ( 862) 3284 587.5 7.2e-165
gi|194205839|ref|XP_001500836.2| PREDICTED: TBC1 d ( 742) 3248 581.1 5.2e-163
gi|73998066|ref|XP_849591.1| PREDICTED: similar to ( 772) 3212 574.8 4.3e-161
gi|126273232|ref|XP_001374921.1| PREDICTED: simila ( 777) 3193 571.4 4.3e-160
gi|224052573|ref|XP_002189388.1| PREDICTED: simila ( 716) 2900 520.0 1.2e-144
gi|194041748|ref|XP_001926666.1| PREDICTED: TBC1 d ( 451) 2886 517.4 4.8e-144
gi|169642000|gb|AAI60725.1| LOC100158296 protein [ ( 596) 2725 489.2 1.9e-135
gi|224052571|ref|XP_002189334.1| PREDICTED: simila ( 737) 2503 450.3 1.2e-123
gi|118092832|ref|XP_001231528.1| PREDICTED: simila ( 404) 2456 441.8 2.3e-121
gi|123914313|sp|Q0IHY4.1|TBC12_XENTR RecName: Full ( 684) 2415 434.9 5e-119
gi|219519808|gb|AAI45130.1| Unknown (protein for M ( 621) 2403 432.7 2e-118
gi|189530860|ref|XP_692080.2| PREDICTED: wu:fc59a0 ( 823) 2375 427.9 7.3e-117
gi|149062801|gb|EDM13224.1| rCG47282 [Rattus norve ( 352) 2300 414.4 3.6e-113
gi|50949274|emb|CAB43225.2| hypothetical protein [ ( 352) 2299 414.2 4.1e-113
gi|194678953|ref|XP_585982.4| PREDICTED: similar t ( 352) 2292 413.0 9.6e-113
gi|118090700|ref|XP_001232770.1| PREDICTED: simila ( 675) 2221 400.8 8.7e-109
gi|126332070|ref|XP_001372247.1| PREDICTED: simila ( 692) 2205 398.0 6.2e-108
gi|109073654|ref|XP_001118829.1| PREDICTED: simila ( 841) 2206 398.3 6.3e-108
gi|27371020|gb|AAH41167.1| TBC1 domain family, mem ( 678) 2204 397.8 6.9e-108
gi|172044690|sp|Q9P2M4.3|TBC14_HUMAN RecName: Full ( 693) 2204 397.8 7e-108
gi|168269810|dbj|BAG10032.1| TBC1 domain family me ( 693) 2204 397.8 7e-108
gi|114593160|ref|XP_526514.2| PREDICTED: TBC1 doma ( 816) 2204 397.9 7.9e-108
gi|194209331|ref|XP_001500016.2| PREDICTED: TBC1 d ( 693) 2193 395.9 2.7e-107
gi|148878131|gb|AAI46263.1| TBC1D14 protein [Bos t ( 677) 2186 394.7 6.2e-107
gi|189037433|sp|A6H7I8.2|TBC14_BOVIN RecName: Full ( 692) 2186 394.7 6.3e-107
gi|73951733|ref|XP_545899.2| PREDICTED: similar to ( 718) 2181 393.8 1.2e-106
gi|55728558|emb|CAH91021.1| hypothetical protein [ ( 518) 2166 391.1 5.8e-106
gi|68363916|ref|XP_683181.1| PREDICTED: similar to ( 711) 2142 387.0 1.3e-104
gi|71122315|gb|AAH99760.1| TBC1 domain family, mem ( 679) 2138 386.2 2.1e-104
gi|164565385|ref|NP_001029193.2| TBC1 domain famil ( 694) 2138 386.3 2.2e-104
gi|149047374|gb|EDM00044.1| TBC1 domain family, me ( 714) 2138 386.3 2.2e-104
gi|66396636|gb|AAH96446.1| TBC1 domain family, mem ( 679) 2135 385.7 3.1e-104
gi|27502771|gb|AAH42515.1| TBC1 domain family, mem ( 679) 2135 385.7 3.1e-104
gi|189037431|sp|Q8CGA2.2|TBC14_MOUSE RecName: Full ( 694) 2135 385.7 3.1e-104
gi|164565373|ref|NP_598671.3| TBC1 domain family, ( 694) 2135 385.7 3.1e-104
gi|148705561|gb|EDL37508.1| TBC1 domain family, me ( 714) 2135 385.7 3.2e-104
gi|189037432|sp|Q5CD77.2|TBC14_RAT RecName: Full=T ( 694) 2129 384.7 6.4e-104
gi|149784077|gb|ABR29562.1| spermatogenesis-relate ( 470) 2098 379.1 2.1e-102
gi|164565381|ref|NP_001106834.1| TBC1 domain famil ( 413) 2043 369.4 1.5e-99
gi|164565387|ref|NP_001012152.2| TBC1 domain famil ( 413) 2008 363.2 1.1e-97
gi|164565383|ref|NP_001106835.1| TBC1 domain famil ( 413) 2005 362.7 1.6e-97
gi|60735069|dbj|BAD91010.1| hypothetical protein [ ( 718) 1984 359.2 3e-96
gi|21739363|emb|CAD38726.1| hypothetical protein [ ( 381) 1955 353.9 6.5e-95
>>gi|182701375|sp|Q6A039.2|TBC12_MOUSE RecName: Full=TBC (696 aa)
initn: 4665 init1: 4665 opt: 4665 Z-score: 4427.2 bits: 829.7 E(): 0
Smith-Waterman score: 4665; 100.000% identity (100.000% similar) in 696 aa overlap (43-738:1-696)
20 30 40 50 60 70
mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGPMGQDGKT
::::::::::::::::::::::::::::::
gi|182 MMGPEDAGACSGRNAELLPVPGPMGQDGKT
10 20 30
80 90 100 110 120 130
mKIAA0 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEEAAAAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEEAAAAAV
40 50 60 70 80 90
140 150 160 170 180 190
mKIAA0 PAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 PAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLE
100 110 120 130 140 150
200 210 220 230 240 250
mKIAA0 DPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 DPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLL
160 170 180 190 200 210
260 270 280 290 300 310
mKIAA0 PSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 PSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGK
220 230 240 250 260 270
320 330 340 350 360 370
mKIAA0 VPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 VPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAK
280 290 300 310 320 330
380 390 400 410 420 430
mKIAA0 SVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 SVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWE
340 350 360 370 380 390
440 450 460 470 480 490
mKIAA0 VMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 VMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSE
400 410 420 430 440 450
500 510 520 530 540 550
mKIAA0 NDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 NDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQ
460 470 480 490 500 510
560 570 580 590 600 610
mKIAA0 GMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 GMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKL
520 530 540 550 560 570
620 630 640 650 660 670
mKIAA0 FLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 FLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYED
580 590 600 610 620 630
680 690 700 710 720 730
mKIAA0 ILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|182 ILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNT
640 650 660 670 680 690
mKIAA0 SPALKS
::::::
gi|182 SPALKS
>>gi|119943133|ref|NP_666064.3| TBC1D12: TBC1 domain fam (698 aa)
initn: 4119 init1: 4119 opt: 4651 Z-score: 4413.9 bits: 827.3 E(): 0
Smith-Waterman score: 4651; 99.713% identity (99.713% similar) in 698 aa overlap (43-738:1-698)
20 30 40 50 60 70
mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGPMGQDGKT
::::::::::::::::::::::::::::::
gi|119 MMGPEDAGACSGRNAELLPVPGPMGQDGKT
10 20 30
80 90 100 110 120 130
mKIAA0 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAE--EAAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
gi|119 VPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEAEEAAAA
40 50 60 70 80 90
140 150 160 170 180 190
mKIAA0 AVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 AVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAP
100 110 120 130 140 150
200 210 220 230 240 250
mKIAA0 LEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 LEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGD
160 170 180 190 200 210
260 270 280 290 300 310
mKIAA0 LLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 LLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLF
220 230 240 250 260 270
320 330 340 350 360 370
mKIAA0 GKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 GKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLP
280 290 300 310 320 330
380 390 400 410 420 430
mKIAA0 AKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 AKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPN
340 350 360 370 380 390
440 450 460 470 480 490
mKIAA0 WEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 WEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESS
400 410 420 430 440 450
500 510 520 530 540 550
mKIAA0 SENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 SENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGY
460 470 480 490 500 510
560 570 580 590 600 610
mKIAA0 VQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 VQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLS
520 530 540 550 560 570
620 630 640 650 660 670
mKIAA0 KLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 KLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLY
580 590 600 610 620 630
680 690 700 710 720 730
mKIAA0 EDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|119 EDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDK
640 650 660 670 680 690
mKIAA0 NTSPALKS
::::::::
gi|119 NTSPALKS
>>gi|148709865|gb|EDL41811.1| TBC1D12: TBC1 domain famil (599 aa)
initn: 4012 init1: 4012 opt: 4012 Z-score: 3808.7 bits: 715.1 E(): 1.9e-203
Smith-Waterman score: 4012; 100.000% identity (100.000% similar) in 599 aa overlap (140-738:1-599)
110 120 130 140 150 160
mKIAA0 AAAGPLKPGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPC
::::::::::::::::::::::::::::::
gi|148 MTNGDSGFLLRQDRRGPEEARRRRTCGRPC
10 20 30
170 180 190 200 210 220
mKIAA0 LLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 LLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGL
40 50 60 70 80 90
230 240 250 260 270 280
mKIAA0 PDARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 PDARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNL
100 110 120 130 140 150
290 300 310 320 330 340
mKIAA0 FPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 FPKRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKS
160 170 180 190 200 210
350 360 370 380 390 400
mKIAA0 FALEPLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 FALEPLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKER
220 230 240 250 260 270
410 420 430 440 450 460
mKIAA0 FKQEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 FKQEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITP
280 290 300 310 320 330
470 480 490 500 510 520
mKIAA0 ELYEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 ELYEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGP
340 350 360 370 380 390
530 540 550 560 570 580
mKIAA0 YHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 YHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRV
400 410 420 430 440 450
590 600 610 620 630 640
mKIAA0 DHSMMLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 DHSMMLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWD
460 470 480 490 500 510
650 660 670 680 690 700
mKIAA0 VFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|148 VFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQN
520 530 540 550 560 570
710 720 730
mKIAA0 STKKWTQVFASVAKDIKEGDKNTSPALKS
:::::::::::::::::::::::::::::
gi|148 STKKWTQVFASVAKDIKEGDKNTSPALKS
580 590
>>gi|73998064|ref|XP_859120.1| PREDICTED: similar to TBC (698 aa)
initn: 3360 init1: 3241 opt: 3787 Z-score: 3594.4 bits: 675.6 E(): 1.7e-191
Smith-Waterman score: 3787; 83.333% identity (89.689% similar) in 708 aa overlap (43-738:1-698)
20 30 40 50 60 70
mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPG--PMGQDG
:.:::::::::::: .:::::. :.::::
gi|739 MVGPEDAGACSGRNPKLLPVPALEPVGQDG
10 20 30
80 90 100 110 120
mKIAA0 KTVPATSGFSGGAVAAEPP---EEAGEEEAPPPRQLLQRYLAAAAGPLKPGLGGAEAEEA
: . ::.::.::. :.::: :: ::: ::.:::.::::::.: : .: .:
gi|739 KMIRATGGFGGGVGAVEPPAEEEEEEEEEETPPQQLLRRYLAAAGGGQ---LESALCSRA
40 50 60 70 80
130 140 150 160 170 180
mKIAA0 AAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARR-RRTCGR-PCLLE-----PADEGVDG
::: : : : :::::::::: :: : :::: :. :: : . :.:::.::
gi|739 AAADVRAPRHRGMTNGDSGFLAGQDSRDLEEARGLARAGGRDPSRRRLRPQGPGDEGADG
90 100 110 120 130 140
190 200 210 220 230 240
mKIAA0 AGGLDDWAAPLEDPLRSCCLAAGDTDDPDPAAATPAGRAVESAEPSLGLPDARFGSRNTF
.:. .:::::::::::::::::.:.: :. :: .: : .::: :.::.: .:::::
gi|739 SGSASDWAAPLEDPLRSCCLAAADADKPQGAAERISGGA--GAEPRPGVPDVRVNSRNTF
150 160 170 180 190 200
250 260 270 280 290 300
mKIAA0 EVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSV
:::: : :: :.: .: :::::: .::.::::::::.:::::::::::::::::::
gi|739 EVSR-----DHLPPASPPVPAPAAEQGAAGTSARARRSGGLADFFARNLFPKRTKELKSV
210 220 230 240 250 260
310 320 330 340 350 360
mKIAA0 VHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTAL
::::::::::::::::::::::::::::::::::::::: :::::::.: .::::::::
gi|739 VHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTAL
270 280 290 300 310 320
370 380 390 400 410 420
mKIAA0 ILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAM
:::::: ::::::::::::::::::::::::::::::::.:::.::::::::::.:::::
gi|739 ILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAYKRKKIMKERFKQEENIASAM
330 340 350 360 370 380
430 440 450 460 470 480
mKIAA0 VIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|739 VIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAK
390 400 410 420 430 440
490 500 510 520 530 540
mKIAA0 ERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGA
::::::::.::::: ::.:.::::::::::::::::::::::::::::::::::::::::
gi|739 ERWKSFSETSSENDMEGVSLADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGA
450 460 470 480 490 500
550 560 570 580 590 600
mKIAA0 YTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFAT
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
gi|739 YTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHNMMLKYFAT
510 520 530 540 550 560
610 620 630 640 650 660
mKIAA0 FEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLF
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
gi|739 FEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLF
570 580 590 600 610 620
670 680 690 700 710 720
mKIAA0 RTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|739 RTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFAS
630 640 650 660 670 680
730
mKIAA0 VAKDIKEGDKNTSPALKS
: :::::::::.::::::
gi|739 VMKDIKEGDKNNSPALKS
690
>>gi|109090045|ref|XP_001090278.1| PREDICTED: TBC1 domai (732 aa)
initn: 3371 init1: 3225 opt: 3286 Z-score: 3119.0 bits: 587.7 E(): 5e-165
Smith-Waterman score: 3444; 74.267% identity (79.733% similar) in 750 aa overlap (30-738:59-732)
10 20 30 40 50
mKIAA0 IPARARPPATAPAAGWEGWVRGRRGGRGREPCTQGSPPPP------PQMMGPEDAGACS
. :. . :: :::.:::::::::
gi|109 NCLTPRVGGVGLGTLRRLSPRLQHSELFCGQACAWSPSLPPGAAATRPQMVGPEDAGACS
30 40 50 60 70 80
60 70 80 90 100 110
mKIAA0 GRNAELLPVPGP--MGQDGKTVPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAA
::: .:::::.: .:::::
gi|109 GRNPKLLPVPAPEPVGQDGK----------------------------------------
90 100
120 130 140 150 160 170
mKIAA0 AGPLKPGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARRRRTCGRPCLL
::: . : : .:.:::: ::: :
gi|109 -----------------------ARGLA-------------RAGGRESRRRRPCGRLRLE
110 120 130
180 190 200 210
mKIAA0 EPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD---------PAA----------
:.:: .::::. .:::.:::::::::::.:.:...:. ::
gi|109 GPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAEEPEGAGSGSGDSPANSCSGSEDSEQ
140 150 160 170 180 190
220 230 240 250
mKIAA0 --------------ATPAGRAVESAEPSLGLPDARFGSRNTFEVSRRQSAGDLLPSAGPS
:: : :. .:: ::. : ...::::::::: .::.: :: ::::
gi|109 PGVGAGGPEEGSPPATSAERTSGGAESRLGFSDIHLNSRNTFEVSRGHSASDHLPPAGPS
200 210 220 230 240 250
260 270 280 290 300 310
mKIAA0 APLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPREN
.:::.:::::. : ::::::::::::::::::::::::::::::::::::::::::::::
gi|109 VPLPTAEQGPAETLARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPREN
260 270 280 290 300 310
320 330 340 350 360 370
mKIAA0 LQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAKSVEEAL
:::::.::::::::::::::: :::::::.: .:::::::::::::: :::::::::::
gi|109 LQKTSRIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEAL
320 330 340 350 360 370
380 390 400 410 420 430
mKIAA0 RHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWEVMRSTR
::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::
gi|109 RHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTR
380 390 400 410 420 430
440 450 460 470 480 490
mKIAA0 RVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSENDTEGL
::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::.
gi|109 RVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGV
440 450 460 470 480 490
500 510 520 530 540 550
mKIAA0 SVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 SVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIA
500 510 520 530 540 550
560 570 580 590 600 610
mKIAA0 AVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 AVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKS
560 570 580 590 600 610
620 630 640 650 660 670
mKIAA0 YNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMD
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 YSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMD
620 630 640 650 660 670
680 690 700 710 720 730
mKIAA0 FIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNTSPALKS
::::::::::::::::::::::::::::::::::::::::::: ::::::.::.::::::
gi|109 FIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKDIKEGEKNSSPALKS
680 690 700 710 720 730
>>gi|168267440|dbj|BAG09776.1| TBC1 domain family member (769 aa)
initn: 3596 init1: 3253 opt: 3284 Z-score: 3116.8 bits: 587.4 E(): 6.7e-165
Smith-Waterman score: 3781; 78.283% identity (84.395% similar) in 769 aa overlap (43-738:1-769)
20 30 40 50 60 70
mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGP--MGQDG
:.:::::::::::: .:::::.: .:::
gi|168 MVGPEDAGACSGRNPKLLPVPAPDPVGQDR
10 20 30
80 90 100 110 120
mKIAA0 KTVPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGL-------GGAE
:.. ::.::.::. :.:::::: ::: :::::::::::::. :.::: : :
gi|168 KVIRATGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAG
40 50 60 70 80 90
130 140 150
mKIAA0 AEEAAAAAVPAA---------RGS-----------GMTNGDSGFLLRQD-----------
: .:: : ::. :::::::::: .:
gi|168 APPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLA
100 110 120 130 140 150
160 170 180 190 200
mKIAA0 RRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD---
: : .:.:::: :: : :.:: .::::. .:::.:::::::::::.:.:...:.
gi|168 RAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAG
160 170 180 190 200 210
210 220 230
mKIAA0 ------PAA------------------------ATPAGRAVESAEPSLGLPDARFGSRNT
::. :: : :. .::: ::. : .:.::::
gi|168 SDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNT
220 230 240 250 260 270
240 250 260 270 280 290
mKIAA0 FEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKS
:.::: ::: : :: ::: .:::::::::.:..:::::::::::::.:::::::::::::
gi|168 FQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKS
280 290 300 310 320 330
300 310 320 330 340 350
mKIAA0 VVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTA
:::::::::::::::::::::::::::::::::::::::: :::::::.: .:::::::
gi|168 VVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTA
340 350 360 370 380 390
360 370 380 390 400 410
mKIAA0 LILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASA
::::::: :::::::::::::::::::::::::::::::::::::::::::::::.::::
gi|168 LILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASA
400 410 420 430 440 450
420 430 440 450 460 470
mKIAA0 MVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|168 MVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRA
460 470 480 490 500 510
480 490 500 510 520 530
mKIAA0 KERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILG
:::::::::.::::::::.:::::::::::::::::::::::::::::::::::::::::
gi|168 KERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILG
520 530 540 550 560 570
540 550 560 570 580 590
mKIAA0 AYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|168 AYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFA
580 590 600 610 620 630
600 610 620 630 640 650
mKIAA0 TFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFL
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
gi|168 TFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFL
640 650 660 670 680 690
660 670 680 690 700 710
mKIAA0 FRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|168 FRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFA
700 710 720 730 740 750
720 730
mKIAA0 SVAKDIKEGDKNTSPALKS
:: :::::::::.::::::
gi|168 SVMKDIKEGDKNSSPALKS
760
>>gi|115502463|sp|O60347.3|TBC12_HUMAN RecName: Full=TBC (775 aa)
initn: 3603 init1: 3253 opt: 3284 Z-score: 3116.8 bits: 587.4 E(): 6.7e-165
Smith-Waterman score: 3759; 77.677% identity (83.742% similar) in 775 aa overlap (43-738:1-775)
20 30 40 50 60 70
mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPGP--MGQDG
:.:::::::::::: .:::::.: .:::
gi|115 MVGPEDAGACSGRNPKLLPVPAPDPVGQDR
10 20 30
80 90 100 110
mKIAA0 KTVPATSGFSGGAVAAEPPEEAGEEEAP------PPRQLLQRYLAAAAGPLKPGL-----
:.. ::.::.::. :.:::::: ::: :::::::::::::. :.:::
gi|115 KVIRATGGFGGGVGAVEPPEEADEEEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPL
40 50 60 70 80 90
120 130 140 150
mKIAA0 --GGAEAEEAAAAAVPAA---------RGS-----------GMTNGDSGFLLRQD-----
: : : .:: : ::. :::::::::: .:
gi|115 PAGQAGAPPPSAAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLE
100 110 120 130 140 150
160 170 180 190 200
mKIAA0 ------RRGPEEARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTD
: : .:.:::: :: : :.:: .::::. .:::.:::::::::::.:.:..
gi|115 EARGLARAGGRESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQ
160 170 180 190 200 210
210 220 230
mKIAA0 DPD---------PAA------------------------ATPAGRAVESAEPSLGLPDAR
.:. ::. :: : :. .::: ::. : .
gi|115 EPEGAGSDSGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIH
220 230 240 250 260 270
240 250 260 270 280 290
mKIAA0 FGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKR
:.:::::.::: ::: : :: ::: .:::::::::.:..:::::::::::::.:::::::
gi|115 FNSRNTFQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKR
280 290 300 310 320 330
300 310 320 330 340 350
mKIAA0 TKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALE
:::::::::::::::::::::::::::::::::::::::::::::: :::::::.: .:
gi|115 TKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFE
340 350 360 370 380 390
360 370 380 390 400 410
mKIAA0 PLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
gi|115 PLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE
400 410 420 430 440 450
420 430 440 450 460 470
mKIAA0 ESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYE
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|115 ENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYE
460 470 480 490 500 510
480 490 500 510 520 530
mKIAA0 IFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDV
:::::::::::::::.::::::::.:::::::::::::::::::::::::::::::::::
gi|115 IFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDV
520 530 540 550 560 570
540 550 560 570 580 590
mKIAA0 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|115 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSM
580 590 600 610 620 630
600 610 620 630 640 650
mKIAA0 MLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCR
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
gi|115 MLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCR
640 650 660 670 680 690
660 670 680 690 700 710
mKIAA0 DGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|115 DGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKK
700 710 720 730 740 750
720 730
mKIAA0 WTQVFASVAKDIKEGDKNTSPALKS
:::::::: :::::::::.::::::
gi|115 WTQVFASVMKDIKEGDKNSSPALKS
760 770
>>gi|114632000|ref|XP_507936.2| PREDICTED: TBC1 domain f (862 aa)
initn: 3630 init1: 3253 opt: 3284 Z-score: 3116.2 bits: 587.5 E(): 7.2e-165
Smith-Waterman score: 3811; 74.879% identity (81.675% similar) in 824 aa overlap (5-738:39-862)
10 20 30
mKIAA0 IPARARPPAT---APAAGWEGWVRGRR-GGRGRE
: ::.. .: .: : :: . : ..
gi|114 CVSLATVSMVRGISRSGLDGSDFCACASPGACPPSSNCPTPRVGGVGLGTLRRLSPRPQH
10 20 30 40 50 60
40 50 60 70
mKIAA0 P---------CTQGSPPPP----PQMMGPEDAGACSGRNAELLPVPGP--MGQDGKTVPA
: :. . :: :::.:::::::::::: .:::::.: .::: :.. :
gi|114 PELFSGQACACSPSLPPGAAATHPQMVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRA
70 80 90 100 110 120
80 90 100 110 120
mKIAA0 TSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGPLKPGL-------GGAEAEEAA
:.::.::. :.:::::: ::: :::::::::::::. :.::: : : : .
gi|114 TGGFGGGVGAVEPPEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPS
130 140 150 160 170 180
130 140 150
mKIAA0 AAAVPAA---------RGS-----------GMTNGDSGFLLRQD-----------RRGPE
:: : ::. :::::::::: .: : : .
gi|114 AAPRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGR
190 200 210 220 230 240
160 170 180 190 200
mKIAA0 EARRRRTCGRPCLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD--------
:.:::: :: : :.:: .::::. .:::.:::::::::::.:.:...:.
gi|114 ESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSDSGD
250 260 270 280 290 300
210 220 230 240
mKIAA0 -PAA------------------------ATPAGRAVESAEPSLGLPDARFGSRNTFEVSR
::. :: : :. .::: ::. : .:.:::::.:::
gi|114 SPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNTFQVSR
310 320 330 340 350 360
250 260 270 280 290 300
mKIAA0 RQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSA
::: : :: ::: .:::::::::.:..:::::::::::::.::::::::::::::::::
gi|114 GQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKELKSVVHSA
370 380 390 400 410 420
310 320 330 340 350 360
mKIAA0 PGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILED
::::::::::::::::::::::::::::::::::: :::::::.: .::::::::::::
gi|114 PGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILED
430 440 450 460 470 480
370 380 390 400 410 420
mKIAA0 RPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWI
:: :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
gi|114 RPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEENIASAMVIWI
490 500 510 520 530 540
430 440 450 460 470 480
mKIAA0 NEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 NEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWK
550 560 570 580 590 600
490 500 510 520 530 540
mKIAA0 SFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCY
::::.::::::::.::::::::::::::::::::::::::::::::::::::::::::::
gi|114 SFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCY
610 620 630 640 650 660
550 560 570 580 590 600
mKIAA0 RPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 RPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVF
670 680 690 700 710 720
610 620 630 640 650 660
mKIAA0 FEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGL
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
gi|114 FEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGL
730 740 750 760 770 780
670 680 690 700 710 720
mKIAA0 GILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
gi|114 GILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVMKD
790 800 810 820 830 840
730
mKIAA0 IKEGDKNTSPALKS
:::::::.::::::
gi|114 IKEGDKNSSPALKS
850 860
>>gi|194205839|ref|XP_001500836.2| PREDICTED: TBC1 domai (742 aa)
initn: 3347 init1: 3215 opt: 3248 Z-score: 3082.9 bits: 581.1 E(): 5.2e-163
Smith-Waterman score: 3460; 74.308% identity (82.213% similar) in 759 aa overlap (24-738:8-742)
10 20 30 40 50
mKIAA0 IPARARPPATAPAAGWEGWVRGRRGGRGREPCTQGSPP-PPPQMMGPEDAGACSGRNAEL
: : .:. : .:: ::: :: ::
gi|194 MTHVPNPRHGASRK--LQLAPPHPPPPEMG---AG---------
10 20 30
60 70 80 90 100 110
mKIAA0 LPVPGPMGQDGKTVPATSGFSGGAVAAEPPEEAGEEEAPPPRQLLQRYLAAAAGP-----
:: :: : .: .. ... . ..: : ... : ::
gi|194 LPHTGP-GARPLAVTVSRSWAD--------RTSSEYLLSEPYPCFRKNCHARNGPTSLHH
40 50 60 70 80
120 130 140 150 160
mKIAA0 --LKPGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEARR-RRTCGR-P--
..: :.. . : :: . : : .:::::::::: :: . :::: :. :: :
gi|194 PDVNPRLAAKVYRGAEAADTRAPRHGGMTNGDSGFLPGQDCHDLEEARGLARAGGREPRH
90 100 110 120 130 140
170 180 190 200
mKIAA0 ---CLLEPADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD----------------
:: :.:::.::::. ..:: ::::::.:::::.::..:.
gi|194 RRLCLEGPGDEGADGAGSRSNWAQ-LEDPLRTCCLAAADTEEPEGAGSGGSGSGSEDLEQ
150 160 170 180 190 200
210 220 230 240 250
mKIAA0 PAA--------ATPAGRAVES-----AEPSLGLPDARFGSRNTFEVSRRQSAGDLLPSAG
:.: :.::. : .. ::: ::. : ..::::::::::::: : :: ::
gi|194 PGAGAGRPEEGASPAASAERTSGAAGAEPRLGFAGALLNSRNTFEVSRRQSARDHLPPAG
210 220 230 240 250 260
260 270 280 290 300 310
mKIAA0 PSAPLPAAEQGPGGTTARARRSGGFADFFARNLFPKRTKELKSVVHSAPGWKLFGKVPPR
:.:: ::.::::.::..::::::::::::::::: :::::.:::::::::::::::::::
gi|194 PQAPSPAVEQGPAGTSTRARRSGGFADFFARNLFSKRTKEFKSVVHSAPGWKLFGKVPPR
270 280 290 300 310 320
320 330 340 350 360 370
mKIAA0 ENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFALEPLSTTALILEDRPPNLPAKSVEE
::::::::::::::::::::::: :::::::.: .:::::::::::::: ::::::.::
gi|194 ENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTTALILEDRPSNLPAKSMEE
330 340 350 360 370 380
380 390 400 410 420 430
mKIAA0 ALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWEVMRS
:::::::::::::::::::::::::::.::::::::::.:::::::::::::::::::::
gi|194 ALRHRQEYDEMVAEAKKREIKEAHKRKKIMKERFKQEENIASAMVIWINEILPNWEVMRS
390 400 410 420 430 440
440 450 460 470 480 490
mKIAA0 TRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSESSSENDTE
::::::::::::::::::::::::::::::::::::::::::::::::::::..:::.::
gi|194 TRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETNSENNTE
450 460 470 480 490 500
500 510 520 530 540 550
mKIAA0 GLSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSF
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|194 GVSVADREASLELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSF
510 520 530 540 550 560
560 570 580 590 600 610
mKIAA0 IAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|194 IAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHF
570 580 590 600 610 620
620 630 640 650 660 670
mKIAA0 KSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQ
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|194 KSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQ
630 640 650 660 670 680
680 690 700 710 720 730
mKIAA0 MDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFASVAKDIKEGDKNTSPAL
::::::::::::::::::::::::::::::::::::::::::.:: :::::::::.::::
gi|194 MDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNSTKKWTQVFSSVMKDIKEGDKNNSPAL
690 700 710 720 730 740
mKIAA0 KS
::
gi|194 KS
>>gi|73998066|ref|XP_849591.1| PREDICTED: similar to TBC (772 aa)
initn: 3604 init1: 3080 opt: 3212 Z-score: 3048.5 bits: 574.8 E(): 4.3e-161
Smith-Waterman score: 3678; 76.319% identity (82.883% similar) in 777 aa overlap (43-738:1-772)
20 30 40 50 60 70
mKIAA0 AAGWEGWVRGRRGGRGREPCTQGSPPPPPQMMGPEDAGACSGRNAELLPVPG--PMGQDG
:.:::::::::::: .:::::. :.::::
gi|739 MVGPEDAGACSGRNPKLLPVPALEPVGQDG
10 20 30
80 90 100 110
mKIAA0 KTVPATSGFSGGAVAAEPP---EEAGEEEAPPPRQLLQRYLAAAAG----------PLK-
: . ::.::.::. :.::: :: ::: ::.:::.::::::.: ::
gi|739 KMIRATGGFGGGVGAVEPPAEEEEEEEEEETPPQQLLRRYLAAAGGGQLESALCSRPLPA
40 50 60 70 80 90
120 130 140 150
mKIAA0 -----------------PGLGGAEAEEAAAAAVPAARGSGMTNGDSGFLLRQDRRGPEEA
: .:.. . :::: : : : :::::::::: :: : :::
gi|739 RQPRAAPPPAAPRPDACPRDSGSKRRGAAAADVRAPRHRGMTNGDSGFLAGQDSRDLEEA
100 110 120 130 140 150
160 170 180 190 200
mKIAA0 RR-RRTCGR-PCLLE-----PADEGVDGAGGLDDWAAPLEDPLRSCCLAAGDTDDPD---
: :. :: : . :.:::.::.:. .:::::::::::::::::.:.: :.
gi|739 RGLARAGGRDPSRRRLRPQGPGDEGADGSGSASDWAAPLEDPLRSCCLAAADADKPQGAG
160 170 180 190 200 210
210 220 230
mKIAA0 --------------------------------PAAATPAGRAVE------SAEPSLGLPD
:.::. :. ..: .::: :.::
gi|739 GGSEGGAGGDGGSSGDSERPGAGAGAGGCEEGPSAAAAAAAGAERISGGAGAEPRPGVPD
220 230 240 250 260 270
240 250 260 270 280 290
mKIAA0 ARFGSRNTFEVSRRQSAGDLLPSAGPSAPLPAAEQGPGGTTARARRSGGFADFFARNLFP
.: .::::::::: : :: :.: .: :::::: .::.::::::::.::::::::::
gi|739 VRVNSRNTFEVSR-----DHLPPASPPVPAPAAEQGAAGTSARARRSGGLADFFARNLFP
280 290 300 310 320
300 310 320 330 340 350
mKIAA0 KRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKAAPQSSRRKSFA
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::.:
gi|739 KRTKELKSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFE
330 340 350 360 370 380
360 370 380 390 400 410
mKIAA0 LEPLSTTALILEDRPPNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFK
.:::::::::::::: ::::::::::::::::::::::::::::::::.:::.:::::::
gi|739 FEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAYKRKKIMKERFK
390 400 410 420 430 440
420 430 440 450 460 470
mKIAA0 QEESIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|739 QEENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL
450 460 470 480 490 500
480 490 500 510 520 530
mKIAA0 YEIFLSRAKERWKSFSESSSENDTEGLSVADREASLELIKLDISRTFPSLYIFQKGGPYH
:::::::::::::::::.::::: ::.:.:::::::::::::::::::::::::::::::
gi|739 YEIFLSRAKERWKSFSETSSENDMEGVSLADREASLELIKLDISRTFPSLYIFQKGGPYH
510 520 530 540 550 560
540 550 560 570 580 590
mKIAA0 DVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|739 DVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDH
570 580 590 600 610 620
600 610 620 630 640 650
mKIAA0 SMMLKYFATFEVFFEENLSKLFLHFKSYNLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF
.:::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
gi|739 NMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF
630 640 650 660 670 680
660 670 680 690 700 710
mKIAA0 CRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|739 CRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQNST
690 700 710 720 730 740
720 730
mKIAA0 KKWTQVFASVAKDIKEGDKNTSPALKS
:::::::::: :::::::::.::::::
gi|739 KKWTQVFASVMKDIKEGDKNNSPALKS
750 760 770
738 residues in 1 query sequences
2727779818 residues in 7921681 library sequences
Tcomplib [34.26] (2 proc)
start: Sun Mar 15 11:17:03 2009 done: Sun Mar 15 11:25:13 2009
Total Scan time: 1076.710 Total Display time: 0.310
Function used was FASTA [version 34.26.5 April 26, 2007]